Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FAM163A

Gene

FAM163A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM163A
Alternative name(s):
Cebelin
Neuroblastoma-derived secretory protein
Gene namesi
Name:FAM163A
Synonyms:C1orf76, NDSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28274. FAM163A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386944.

Polymorphism and mutation databases

BioMutaiFAM163A.
DMDMi74751887.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Protein FAM163APRO_0000280256Add
BLAST

Proteomic databases

PRIDEiQ96GL9.

Expressioni

Tissue specificityi

Highly expressed in neuroblastoma compared to other tissues, suggesting that it may be used as a marker for metastasis in bone marrow.1 Publication

Gene expression databases

BgeeiQ96GL9.
CleanExiHS_FAM163A.
GenevisibleiQ96GL9. HS.

Organism-specific databases

HPAiHPA010778.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354891.

Structurei

3D structure databases

ProteinModelPortaliQ96GL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM163 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25722.
GeneTreeiENSGT00390000002397.
HOGENOMiHOG000013172.
HOVERGENiHBG100700.
InParanoidiQ96GL9.
OMAiYIRTADM.
OrthoDBiEOG7ZD1WQ.
PhylomeDBiQ96GL9.
TreeFamiTF333084.

Family and domain databases

InterProiIPR029379. FAM163.
[Graphical view]
PfamiPF15069. FAM163. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96GL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAGTVVITG GILATVILLC IIAVLCYCRL QYYCCKKSGT EVADEEEERE
60 70 80 90 100
HDLPTHPRGP TCNACSSQAL DGRGSLAPLT SEPCSQPCGV AASHCTTCSP
110 120 130 140 150
YSSPFYIRTA DMVPNGGGGE RLSFAPTYYK EGGPPSLKLA APQSYPVTWP
160
GSGREAFTNP RAISTDV
Length:167
Mass (Da):17,641
Last modified:December 1, 2001 - v1
Checksum:i8BF4D4A6C59046F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY902195 mRNA. Translation: AAX07133.1.
AB299025 mRNA. Translation: BAF96730.1.
AK292432 mRNA. Translation: BAF85121.1.
AK313887 mRNA. Translation: BAG36612.1.
AL359853 Genomic DNA. Translation: CAH70381.1.
CH471067 Genomic DNA. Translation: EAW91055.1.
BC009382 mRNA. Translation: AAH09382.1.
CCDSiCCDS1333.1.
RefSeqiNP_775780.1. NM_173509.2.
XP_005244970.1. XM_005244913.1.
XP_006711237.1. XM_006711174.2.
XP_006711238.1. XM_006711175.2.
XP_006711239.1. XM_006711176.2.
XP_006711240.1. XM_006711177.1.
XP_011507518.1. XM_011509216.1.
XP_011507519.1. XM_011509217.1.
XP_011507520.1. XM_011509218.1.
XP_011507521.1. XM_011509219.1.
XP_011507522.1. XM_011509220.1.
XP_011507523.1. XM_011509221.1.
XP_011507524.1. XM_011509222.1.
XP_011507525.1. XM_011509223.1.
XP_011507526.1. XM_011509224.1.
XP_011507527.1. XM_011509225.1.
XP_011507528.1. XM_011509226.1.
XP_011507529.1. XM_011509227.1.
XP_011507530.1. XM_011509228.1.
UniGeneiHs.729631.

Genome annotation databases

EnsembliENST00000341785; ENSP00000354891; ENSG00000143340.
GeneIDi148753.
KEGGihsa:148753.
UCSCiuc001gnj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY902195 mRNA. Translation: AAX07133.1.
AB299025 mRNA. Translation: BAF96730.1.
AK292432 mRNA. Translation: BAF85121.1.
AK313887 mRNA. Translation: BAG36612.1.
AL359853 Genomic DNA. Translation: CAH70381.1.
CH471067 Genomic DNA. Translation: EAW91055.1.
BC009382 mRNA. Translation: AAH09382.1.
CCDSiCCDS1333.1.
RefSeqiNP_775780.1. NM_173509.2.
XP_005244970.1. XM_005244913.1.
XP_006711237.1. XM_006711174.2.
XP_006711238.1. XM_006711175.2.
XP_006711239.1. XM_006711176.2.
XP_006711240.1. XM_006711177.1.
XP_011507518.1. XM_011509216.1.
XP_011507519.1. XM_011509217.1.
XP_011507520.1. XM_011509218.1.
XP_011507521.1. XM_011509219.1.
XP_011507522.1. XM_011509220.1.
XP_011507523.1. XM_011509221.1.
XP_011507524.1. XM_011509222.1.
XP_011507525.1. XM_011509223.1.
XP_011507526.1. XM_011509224.1.
XP_011507527.1. XM_011509225.1.
XP_011507528.1. XM_011509226.1.
XP_011507529.1. XM_011509227.1.
XP_011507530.1. XM_011509228.1.
UniGeneiHs.729631.

3D structure databases

ProteinModelPortaliQ96GL9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354891.

Polymorphism and mutation databases

BioMutaiFAM163A.
DMDMi74751887.

Proteomic databases

PRIDEiQ96GL9.

Protocols and materials databases

DNASUi148753.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341785; ENSP00000354891; ENSG00000143340.
GeneIDi148753.
KEGGihsa:148753.
UCSCiuc001gnj.3. human.

Organism-specific databases

CTDi148753.
GeneCardsiGC01P179712.
HGNCiHGNC:28274. FAM163A.
HPAiHPA010778.
MIMi611727. gene.
neXtProtiNX_Q96GL9.
PharmGKBiPA162386944.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG25722.
GeneTreeiENSGT00390000002397.
HOGENOMiHOG000013172.
HOVERGENiHBG100700.
InParanoidiQ96GL9.
OMAiYIRTADM.
OrthoDBiEOG7ZD1WQ.
PhylomeDBiQ96GL9.
TreeFamiTF333084.

Miscellaneous databases

GenomeRNAii148753.
NextBioi85992.
PROiQ96GL9.
SOURCEiSearch...

Gene expression databases

BgeeiQ96GL9.
CleanExiHS_FAM163A.
GenevisibleiQ96GL9. HS.

Family and domain databases

InterProiIPR029379. FAM163.
[Graphical view]
PfamiPF15069. FAM163. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Neuroblastoma-derived secretory protein messenger RNA levels correlate with high-risk neuroblastoma."
    Vasudevan S.A., Russell H.V., Okcu M.F., Burlingame S.M., Liu Z.J., Yang J., Nuchtern J.G.
    J. Pediatr. Surg. 42:148-152(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Human Cebelin."
    Itoh N.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiF163A_HUMAN
AccessioniPrimary (citable) accession number: Q96GL9
Secondary accession number(s): A8K8R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.