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Q96GL9

- F163A_HUMAN

UniProt

Q96GL9 - F163A_HUMAN

Protein

Protein FAM163A

Gene

FAM163A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM163A
    Alternative name(s):
    Cebelin
    Neuroblastoma-derived secretory protein
    Gene namesi
    Name:FAM163A
    Synonyms:C1orf76, NDSP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:28274. FAM163A.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162386944.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 167167Protein FAM163APRO_0000280256Add
    BLAST

    Proteomic databases

    PRIDEiQ96GL9.

    Expressioni

    Tissue specificityi

    Highly expressed in neuroblastoma compared to other tissues, suggesting that it may be used as a marker for metastasis in bone marrow.1 Publication

    Gene expression databases

    BgeeiQ96GL9.
    CleanExiHS_FAM163A.
    GenevestigatoriQ96GL9.

    Organism-specific databases

    HPAiHPA010778.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000354891.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96GL9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM163 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG25722.
    HOGENOMiHOG000013172.
    HOVERGENiHBG100700.
    InParanoidiQ96GL9.
    OMAiYIRTADM.
    OrthoDBiEOG7ZD1WQ.
    PhylomeDBiQ96GL9.
    TreeFamiTF333084.

    Family and domain databases

    InterProiIPR029379. FAM163.
    [Graphical view]
    PfamiPF15069. FAM163. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96GL9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAGTVVITG GILATVILLC IIAVLCYCRL QYYCCKKSGT EVADEEEERE    50
    HDLPTHPRGP TCNACSSQAL DGRGSLAPLT SEPCSQPCGV AASHCTTCSP 100
    YSSPFYIRTA DMVPNGGGGE RLSFAPTYYK EGGPPSLKLA APQSYPVTWP 150
    GSGREAFTNP RAISTDV 167
    Length:167
    Mass (Da):17,641
    Last modified:December 1, 2001 - v1
    Checksum:i8BF4D4A6C59046F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY902195 mRNA. Translation: AAX07133.1.
    AB299025 mRNA. Translation: BAF96730.1.
    AK292432 mRNA. Translation: BAF85121.1.
    AK313887 mRNA. Translation: BAG36612.1.
    AL359853 Genomic DNA. Translation: CAH70381.1.
    CH471067 Genomic DNA. Translation: EAW91055.1.
    BC009382 mRNA. Translation: AAH09382.1.
    CCDSiCCDS1333.1.
    RefSeqiNP_775780.1. NM_173509.2.
    XP_005244970.1. XM_005244913.1.
    XP_006711237.1. XM_006711174.1.
    XP_006711238.1. XM_006711175.1.
    XP_006711239.1. XM_006711176.1.
    XP_006711240.1. XM_006711177.1.
    UniGeneiHs.729631.

    Genome annotation databases

    EnsembliENST00000341785; ENSP00000354891; ENSG00000143340.
    GeneIDi148753.
    KEGGihsa:148753.
    UCSCiuc001gnj.3. human.

    Polymorphism databases

    DMDMi74751887.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY902195 mRNA. Translation: AAX07133.1 .
    AB299025 mRNA. Translation: BAF96730.1 .
    AK292432 mRNA. Translation: BAF85121.1 .
    AK313887 mRNA. Translation: BAG36612.1 .
    AL359853 Genomic DNA. Translation: CAH70381.1 .
    CH471067 Genomic DNA. Translation: EAW91055.1 .
    BC009382 mRNA. Translation: AAH09382.1 .
    CCDSi CCDS1333.1.
    RefSeqi NP_775780.1. NM_173509.2.
    XP_005244970.1. XM_005244913.1.
    XP_006711237.1. XM_006711174.1.
    XP_006711238.1. XM_006711175.1.
    XP_006711239.1. XM_006711176.1.
    XP_006711240.1. XM_006711177.1.
    UniGenei Hs.729631.

    3D structure databases

    ProteinModelPortali Q96GL9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000354891.

    Polymorphism databases

    DMDMi 74751887.

    Proteomic databases

    PRIDEi Q96GL9.

    Protocols and materials databases

    DNASUi 148753.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341785 ; ENSP00000354891 ; ENSG00000143340 .
    GeneIDi 148753.
    KEGGi hsa:148753.
    UCSCi uc001gnj.3. human.

    Organism-specific databases

    CTDi 148753.
    GeneCardsi GC01P179712.
    HGNCi HGNC:28274. FAM163A.
    HPAi HPA010778.
    MIMi 611727. gene.
    neXtProti NX_Q96GL9.
    PharmGKBi PA162386944.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25722.
    HOGENOMi HOG000013172.
    HOVERGENi HBG100700.
    InParanoidi Q96GL9.
    OMAi YIRTADM.
    OrthoDBi EOG7ZD1WQ.
    PhylomeDBi Q96GL9.
    TreeFami TF333084.

    Miscellaneous databases

    GenomeRNAii 148753.
    NextBioi 85992.
    PROi Q96GL9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96GL9.
    CleanExi HS_FAM163A.
    Genevestigatori Q96GL9.

    Family and domain databases

    InterProi IPR029379. FAM163.
    [Graphical view ]
    Pfami PF15069. FAM163. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Neuroblastoma-derived secretory protein messenger RNA levels correlate with high-risk neuroblastoma."
      Vasudevan S.A., Russell H.V., Okcu M.F., Burlingame S.M., Liu Z.J., Yang J., Nuchtern J.G.
      J. Pediatr. Surg. 42:148-152(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Human Cebelin."
      Itoh N.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiF163A_HUMAN
    AccessioniPrimary (citable) accession number: Q96GL9
    Secondary accession number(s): A8K8R7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families
    4. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3