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Q96GE6

- CALL4_HUMAN

UniProt

Q96GE6 - CALL4_HUMAN

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Protein

Calmodulin-like protein 4

Gene

CALML4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-like protein 4
Alternative name(s):
Serologically defined breast cancer antigen NY-BR-20
Gene namesi
Name:CALML4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:18445. CALML4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903345.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Calmodulin-like protein 4PRO_0000314933Add
BLAST

Proteomic databases

MaxQBiQ96GE6.
PaxDbiQ96GE6.
PRIDEiQ96GE6.

PTM databases

PhosphoSiteiQ96GE6.

Expressioni

Tissue specificityi

Expressed in breast cancer cell lines.1 Publication

Gene expression databases

BgeeiQ96GE6.
CleanExiHS_CALML4.
ExpressionAtlasiQ96GE6. baseline and differential.
GenevestigatoriQ96GE6.

Organism-specific databases

HPAiHPA051109.

Structurei

3D structure databases

ProteinModelPortaliQ96GE6.
SMRiQ96GE6. Positions 48-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 8636EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini87 – 12236EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini124 – 15936EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini160 – 19536EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the calmodulin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ96GE6.
OMAiYDKQQRG.
PhylomeDBiQ96GE6.
TreeFamiTF300912.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96GE6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAEHLLPGP PPSLADFRLE AGGKGTERGS GSSKPTGSSR GPRMAKFLSQ
60 70 80 90 100
DQINEYKECF SLYDKQQRGK IKATDLMVAM RCLGASPTPG EVQRHLQTHG
110 120 130 140 150
IDGNGELDFS TFLTIMHMQI KQEDPKKEIL LAMLMVDKEK KGYVMASDLR
160 170 180 190
SKLTSLGEKL THKEVDDLFR EADIEPNGKV KYDEFIHKIT LPGRDY
Length:196
Mass (Da):21,883
Last modified:October 14, 2008 - v3
Checksum:i547C558AC7EDFABD
GO
Isoform 2 (identifier: Q96GE6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Show »
Length:120
Mass (Da):13,661
Checksum:i8409F82E7385FB69
GO
Isoform 3 (identifier: Q96GE6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.

Show »
Length:81
Mass (Da):9,478
Checksum:iF176C12A51C39F12
GO
Isoform 4 (identifier: Q96GE6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-101: Missing.

Note: Gene prediction based on EST data.

Show »
Length:149
Mass (Da):16,565
Checksum:i786A439E7C07B5F7
GO
Isoform 5 (identifier: Q96GE6-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-59: AKFLSQDQINEYKEC → WMISSGKQISNPMAK
     60-196: Missing.

Note: No experimental confirmation available.

Show »
Length:59
Mass (Da):6,109
Checksum:i4CEC0C6C37F9ACC4
GO

Sequence cautioni

The sequence AAG48255.1 differs from that shown. Reason: Frameshift at several positions.
The sequence BAG59377.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401R → G in AAG48255. (PubMed:12747765)Curated
Sequence conflicti60 – 601F → S in AAG48255. (PubMed:12747765)Curated
Sequence conflicti76 – 761L → F in AAG48255. (PubMed:12747765)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281R → C.
Corresponds to variant rs3803381 [ dbSNP | Ensembl ].
VAR_048586
Natural varianti154 – 1541T → K.
Corresponds to variant rs2280217 [ dbSNP | Ensembl ].
VAR_048587

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 115115Missing in isoform 3. 1 PublicationVSP_030435Add
BLAST
Alternative sequencei1 – 7676Missing in isoform 2. 2 PublicationsVSP_030436Add
BLAST
Alternative sequencei45 – 5915AKFLS…EYKEC → WMISSGKQISNPMAK in isoform 5. 1 PublicationVSP_055513Add
BLAST
Alternative sequencei55 – 10147Missing in isoform 4. CuratedVSP_047150Add
BLAST
Alternative sequencei60 – 196137Missing in isoform 5. 1 PublicationVSP_055514Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF308287 mRNA. Translation: AAG48255.1. Sequence problems.
CR598967 mRNA. No translation available.
BX640702 mRNA. Translation: CAE45822.1.
BX640817 mRNA. Translation: CAE45894.1.
AC107871 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77810.1.
BC009516 mRNA. No translation available.
AK296804 mRNA. Translation: BAG59377.1. Different initiation.
CCDSiCCDS10226.2. [Q96GE6-1]
CCDS42052.1. [Q96GE6-4]
CCDS66808.1. [Q96GE6-2]
RefSeqiNP_001026903.2. NM_001031733.2. [Q96GE6-4]
NP_001273623.1. NM_001286694.1. [Q96GE6-2]
NP_001273624.1. NM_001286695.1. [Q96GE6-3]
NP_219501.2. NM_033429.2. [Q96GE6-1]
UniGeneiHs.709550.

Genome annotation databases

EnsembliENST00000395465; ENSP00000378848; ENSG00000129007. [Q96GE6-5]
ENST00000448060; ENSP00000400755; ENSG00000129007. [Q96GE6-4]
ENST00000467889; ENSP00000419081; ENSG00000129007. [Q96GE6-1]
ENST00000540479; ENSP00000438177; ENSG00000129007. [Q96GE6-2]
GeneIDi91860.
KEGGihsa:91860.
UCSCiuc002arb.3. human. [Q96GE6-1]

Polymorphism databases

DMDMi209572745.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF308287 mRNA. Translation: AAG48255.1 . Sequence problems.
CR598967 mRNA. No translation available.
BX640702 mRNA. Translation: CAE45822.1 .
BX640817 mRNA. Translation: CAE45894.1 .
AC107871 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77810.1 .
BC009516 mRNA. No translation available.
AK296804 mRNA. Translation: BAG59377.1 . Different initiation.
CCDSi CCDS10226.2. [Q96GE6-1 ]
CCDS42052.1. [Q96GE6-4 ]
CCDS66808.1. [Q96GE6-2 ]
RefSeqi NP_001026903.2. NM_001031733.2. [Q96GE6-4 ]
NP_001273623.1. NM_001286694.1. [Q96GE6-2 ]
NP_001273624.1. NM_001286695.1. [Q96GE6-3 ]
NP_219501.2. NM_033429.2. [Q96GE6-1 ]
UniGenei Hs.709550.

3D structure databases

ProteinModelPortali Q96GE6.
SMRi Q96GE6. Positions 48-187.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q96GE6.

Polymorphism databases

DMDMi 209572745.

Proteomic databases

MaxQBi Q96GE6.
PaxDbi Q96GE6.
PRIDEi Q96GE6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000395465 ; ENSP00000378848 ; ENSG00000129007 . [Q96GE6-5 ]
ENST00000448060 ; ENSP00000400755 ; ENSG00000129007 . [Q96GE6-4 ]
ENST00000467889 ; ENSP00000419081 ; ENSG00000129007 . [Q96GE6-1 ]
ENST00000540479 ; ENSP00000438177 ; ENSG00000129007 . [Q96GE6-2 ]
GeneIDi 91860.
KEGGi hsa:91860.
UCSCi uc002arb.3. human. [Q96GE6-1 ]

Organism-specific databases

CTDi 91860.
GeneCardsi GC15M068483.
H-InvDB HIX0012375.
HGNCi HGNC:18445. CALML4.
HPAi HPA051109.
neXtProti NX_Q96GE6.
PharmGKBi PA134903345.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5126.
GeneTreei ENSGT00760000118901.
HOGENOMi HOG000233018.
HOVERGENi HBG012180.
InParanoidi Q96GE6.
OMAi YDKQQRG.
PhylomeDBi Q96GE6.
TreeFami TF300912.

Miscellaneous databases

GenomeRNAii 91860.
NextBioi 77492.
PROi Q96GE6.

Gene expression databases

Bgeei Q96GE6.
CleanExi HS_CALML4.
ExpressionAtlasi Q96GE6. baseline and differential.
Genevestigatori Q96GE6.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 4 hits.
[Graphical view ]
PROSITEi PS50222. EF_HAND_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression."
    Scanlan M.J., Gout I., Gordon C.M., Williamson B., Stockert E., Gure A.O., Jaeger D., Chen Y.-T., Mackay A., O'Hare M.J., Old L.J.
    Cancer Immun. 1:4-4(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Mammary gland.
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
    Tissue: Prostate and Uterine endothelium.
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-196 (ISOFORM 1).

Entry informationi

Entry nameiCALL4_HUMAN
AccessioniPrimary (citable) accession number: Q96GE6
Secondary accession number(s): B4DL15
, F8W6Y4, Q6MZY3, Q6N048, Q9H286
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 14, 2008
Last modified: October 29, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3