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Q96GE6

- CALL4_HUMAN

UniProt

Q96GE6 - CALL4_HUMAN

Protein

Calmodulin-like protein 4

Gene

CALML4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 3 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calmodulin-like protein 4
    Alternative name(s):
    Serologically defined breast cancer antigen NY-BR-20
    Gene namesi
    Name:CALML4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:18445. CALML4.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134903345.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 196196Calmodulin-like protein 4PRO_0000314933Add
    BLAST

    Proteomic databases

    MaxQBiQ96GE6.
    PaxDbiQ96GE6.
    PRIDEiQ96GE6.

    PTM databases

    PhosphoSiteiQ96GE6.

    Expressioni

    Tissue specificityi

    Expressed in breast cancer cell lines.1 Publication

    Gene expression databases

    ArrayExpressiQ96GE6.
    BgeeiQ96GE6.
    CleanExiHS_CALML4.
    GenevestigatoriQ96GE6.

    Organism-specific databases

    HPAiHPA051109.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96GE6.
    SMRiQ96GE6. Positions 48-187.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 8636EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini87 – 12236EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini124 – 15936EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini160 – 19536EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the calmodulin family.Curated
    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    HOGENOMiHOG000233018.
    HOVERGENiHBG012180.
    InParanoidiQ96GE6.
    OMAiYDKQQRG.
    PhylomeDBiQ96GE6.
    TreeFamiTF300912.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 4 hits.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 4 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96GE6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAEHLLPGP PPSLADFRLE AGGKGTERGS GSSKPTGSSR GPRMAKFLSQ    50
    DQINEYKECF SLYDKQQRGK IKATDLMVAM RCLGASPTPG EVQRHLQTHG 100
    IDGNGELDFS TFLTIMHMQI KQEDPKKEIL LAMLMVDKEK KGYVMASDLR 150
    SKLTSLGEKL THKEVDDLFR EADIEPNGKV KYDEFIHKIT LPGRDY 196
    Length:196
    Mass (Da):21,883
    Last modified:October 14, 2008 - v3
    Checksum:i547C558AC7EDFABD
    GO
    Isoform 2 (identifier: Q96GE6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-76: Missing.

    Show »
    Length:120
    Mass (Da):13,661
    Checksum:i8409F82E7385FB69
    GO
    Isoform 3 (identifier: Q96GE6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-115: Missing.

    Show »
    Length:81
    Mass (Da):9,478
    Checksum:iF176C12A51C39F12
    GO
    Isoform 4 (identifier: Q96GE6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         55-101: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:149
    Mass (Da):16,565
    Checksum:i786A439E7C07B5F7
    GO
    Isoform 5 (identifier: Q96GE6-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         45-59: AKFLSQDQINEYKEC → WMISSGKQISNPMAK
         60-196: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:59
    Mass (Da):6,109
    Checksum:i4CEC0C6C37F9ACC4
    GO

    Sequence cautioni

    The sequence AAG48255.1 differs from that shown. Reason: Frameshift at several positions.
    The sequence BAG59377.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401R → G in AAG48255. (PubMed:12747765)Curated
    Sequence conflicti60 – 601F → S in AAG48255. (PubMed:12747765)Curated
    Sequence conflicti76 – 761L → F in AAG48255. (PubMed:12747765)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281R → C.
    Corresponds to variant rs3803381 [ dbSNP | Ensembl ].
    VAR_048586
    Natural varianti154 – 1541T → K.
    Corresponds to variant rs2280217 [ dbSNP | Ensembl ].
    VAR_048587

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 115115Missing in isoform 3. 1 PublicationVSP_030435Add
    BLAST
    Alternative sequencei1 – 7676Missing in isoform 2. 2 PublicationsVSP_030436Add
    BLAST
    Alternative sequencei45 – 5915AKFLS…EYKEC → WMISSGKQISNPMAK in isoform 5. 1 PublicationVSP_055513Add
    BLAST
    Alternative sequencei55 – 10147Missing in isoform 4. CuratedVSP_047150Add
    BLAST
    Alternative sequencei60 – 196137Missing in isoform 5. 1 PublicationVSP_055514Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF308287 mRNA. Translation: AAG48255.1. Sequence problems.
    CR598967 mRNA. No translation available.
    BX640702 mRNA. Translation: CAE45822.1.
    BX640817 mRNA. Translation: CAE45894.1.
    AC107871 Genomic DNA. No translation available.
    CH471082 Genomic DNA. Translation: EAW77810.1.
    BC009516 mRNA. No translation available.
    AK296804 mRNA. Translation: BAG59377.1. Different initiation.
    CCDSiCCDS10226.2. [Q96GE6-1]
    CCDS42052.1. [Q96GE6-4]
    CCDS66808.1. [Q96GE6-2]
    RefSeqiNP_001026903.2. NM_001031733.2. [Q96GE6-4]
    NP_001273623.1. NM_001286694.1. [Q96GE6-2]
    NP_001273624.1. NM_001286695.1. [Q96GE6-3]
    NP_219501.2. NM_033429.2. [Q96GE6-1]
    UniGeneiHs.709550.

    Genome annotation databases

    EnsembliENST00000395465; ENSP00000378848; ENSG00000129007. [Q96GE6-5]
    ENST00000448060; ENSP00000400755; ENSG00000129007. [Q96GE6-4]
    ENST00000467889; ENSP00000419081; ENSG00000129007. [Q96GE6-1]
    ENST00000540479; ENSP00000438177; ENSG00000129007. [Q96GE6-2]
    GeneIDi91860.
    KEGGihsa:91860.
    UCSCiuc002arb.3. human. [Q96GE6-1]

    Polymorphism databases

    DMDMi209572745.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF308287 mRNA. Translation: AAG48255.1 . Sequence problems.
    CR598967 mRNA. No translation available.
    BX640702 mRNA. Translation: CAE45822.1 .
    BX640817 mRNA. Translation: CAE45894.1 .
    AC107871 Genomic DNA. No translation available.
    CH471082 Genomic DNA. Translation: EAW77810.1 .
    BC009516 mRNA. No translation available.
    AK296804 mRNA. Translation: BAG59377.1 . Different initiation.
    CCDSi CCDS10226.2. [Q96GE6-1 ]
    CCDS42052.1. [Q96GE6-4 ]
    CCDS66808.1. [Q96GE6-2 ]
    RefSeqi NP_001026903.2. NM_001031733.2. [Q96GE6-4 ]
    NP_001273623.1. NM_001286694.1. [Q96GE6-2 ]
    NP_001273624.1. NM_001286695.1. [Q96GE6-3 ]
    NP_219501.2. NM_033429.2. [Q96GE6-1 ]
    UniGenei Hs.709550.

    3D structure databases

    ProteinModelPortali Q96GE6.
    SMRi Q96GE6. Positions 48-187.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q96GE6.

    Polymorphism databases

    DMDMi 209572745.

    Proteomic databases

    MaxQBi Q96GE6.
    PaxDbi Q96GE6.
    PRIDEi Q96GE6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395465 ; ENSP00000378848 ; ENSG00000129007 . [Q96GE6-5 ]
    ENST00000448060 ; ENSP00000400755 ; ENSG00000129007 . [Q96GE6-4 ]
    ENST00000467889 ; ENSP00000419081 ; ENSG00000129007 . [Q96GE6-1 ]
    ENST00000540479 ; ENSP00000438177 ; ENSG00000129007 . [Q96GE6-2 ]
    GeneIDi 91860.
    KEGGi hsa:91860.
    UCSCi uc002arb.3. human. [Q96GE6-1 ]

    Organism-specific databases

    CTDi 91860.
    GeneCardsi GC15M068483.
    H-InvDB HIX0012375.
    HGNCi HGNC:18445. CALML4.
    HPAi HPA051109.
    neXtProti NX_Q96GE6.
    PharmGKBi PA134903345.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5126.
    HOGENOMi HOG000233018.
    HOVERGENi HBG012180.
    InParanoidi Q96GE6.
    OMAi YDKQQRG.
    PhylomeDBi Q96GE6.
    TreeFami TF300912.

    Miscellaneous databases

    GenomeRNAii 91860.
    NextBioi 77492.
    PROi Q96GE6.

    Gene expression databases

    ArrayExpressi Q96GE6.
    Bgeei Q96GE6.
    CleanExi HS_CALML4.
    Genevestigatori Q96GE6.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 4 hits.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression."
      Scanlan M.J., Gout I., Gordon C.M., Williamson B., Stockert E., Gure A.O., Jaeger D., Chen Y.-T., Mackay A., O'Hare M.J., Old L.J.
      Cancer Immun. 1:4-4(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Mammary gland.
    2. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
      Tissue: Prostate and Uterine endothelium.
    4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Colon.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-196 (ISOFORM 1).

    Entry informationi

    Entry nameiCALL4_HUMAN
    AccessioniPrimary (citable) accession number: Q96GE6
    Secondary accession number(s): B4DL15
    , F8W6Y4, Q6MZY3, Q6N048, Q9H286
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 99 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3