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Q96GE5

- ZN799_HUMAN

UniProt

Q96GE5 - ZN799_HUMAN

Protein

Zinc finger protein 799

Gene

ZNF799

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 4 (18 May 2010)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri134 – 16330C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri169 – 19123C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri197 – 21923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri225 – 24723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri253 – 27523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri281 – 30323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri309 – 33123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri337 – 35923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri365 – 38723C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri393 – 41523C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri421 – 44323C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri449 – 47022C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri476 – 49823C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri504 – 52623C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri532 – 55423C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri560 – 58223C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri588 – 61528C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri621 – 64323C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 799
    Alternative name(s):
    Zinc finger protein 842
    Gene namesi
    Name:ZNF799
    Synonyms:ZNF842
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:28071. ZNF799.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162410569.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 643643Zinc finger protein 799PRO_0000271017Add
    BLAST

    Proteomic databases

    PaxDbiQ96GE5.
    PRIDEiQ96GE5.

    Expressioni

    Gene expression databases

    BgeeiQ96GE5.
    CleanExiHS_ZNF799.
    GenevestigatoriQ96GE5.

    Organism-specific databases

    HPAiHPA003150.

    Interactioni

    Protein-protein interaction databases

    BioGridi124735. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96GE5.
    SMRiQ96GE5. Positions 2-54, 102-643.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 8683KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri134 – 16330C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri169 – 19123C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri197 – 21923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri225 – 24723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri253 – 27523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri281 – 30323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri309 – 33123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri337 – 35923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri365 – 38723C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri393 – 41523C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri421 – 44323C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri449 – 47022C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri476 – 49823C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri504 – 52623C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri532 – 55423C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri560 – 58223C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri588 – 61528C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri621 – 64323C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ96GE5.
    KOiK09228.
    OMAiMHTRDGP.
    PhylomeDBiQ96GE5.
    TreeFamiTF338854.

    Family and domain databases

    Gene3Di3.30.160.60. 18 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 18 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 15 hits.
    PS50157. ZINC_FINGER_C2H2_2. 18 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96GE5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASVALEDVA VNFTREEWAL LGPCQKNLYK DVMQETIRNL DCVGMKWKDQ    50
    NIEDQYRYPR KNLRCRMLER FVESKDGTQC GETSSQIQDS IVTKNTLPGV 100
    GPYESRMSGE VIMGHSSLNC YIRVGAGHKP YEYHECGEKP DTHKQRGKAF 150
    SYHNSLQTHE RLHTGKKPYN CKECGKSFSS LGNLQRHMAV QRGDGPYKCK 200
    LCGKAFFWPS LLHMHERTHT GEKPYECKQC SKAFSFYSSY LRHERTHTGE 250
    KLYECKQCSK AFPDYSSCLR HERTHTGKKP YTCKQCGKAF SASTSLRRHE 300
    TTHTDEKPYA CQQCGKAFHH LGSFQRHMVM HTRDGPHKCK ICGKGFDCPS 350
    SLKSHERTHT GEKLYECKQC GKALSHSSSF RRHMTMHTGD GPHKCKICGK 400
    AFVYPSVFQR HEKTHTAEKP YKCKQCGKAY RISSSLRRHE TTHTGEKPYK 450
    CKCGKAFIDF YSFQNHKTTH AGEKPYECKE CGKAFSCFQY LSQHRRTHTG 500
    EKPYECNTCK KAFSHFGNLK VHERIHSGEK PYECKECGKA FSWLTCFLRH 550
    ERIHMREKPY ECQQCGKAFT HSRFLQGHEK THTGENPYEC KECGKAFASL 600
    SSLHRHKKTH WKKTHTGENP YGCKECGKAF ASLSSLHRHK KTH 643
    Length:643
    Mass (Da):74,288
    Last modified:May 18, 2010 - v4
    Checksum:iD15435746A10855C
    GO
    Isoform 2 (identifier: Q96GE5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MDQ

    Show »
    Length:645
    Mass (Da):74,532
    Checksum:iA4E68F40679062F3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti252 – 2521L → P in AL832890. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti44 – 441G → V.
    Corresponds to variant rs1134387 [ dbSNP | Ensembl ].
    VAR_029846
    Natural varianti593 – 5931C → R.
    Corresponds to variant rs8112445 [ dbSNP | Ensembl ].
    VAR_029847

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MDQ in isoform 2. 1 PublicationVSP_039164

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL832890 mRNA. No translation available.
    AC008758 Genomic DNA. No translation available.
    BC009517 mRNA. Translation: AAH09517.1.
    CCDSiCCDS45989.1. [Q96GE5-1]
    RefSeqiNP_001074290.1. NM_001080821.2. [Q96GE5-1]
    UniGeneiHs.546637.

    Genome annotation databases

    EnsembliENST00000430385; ENSP00000411084; ENSG00000196466. [Q96GE5-1]
    GeneIDi90576.
    KEGGihsa:90576.
    UCSCiuc010dyt.3. human. [Q96GE5-1]

    Polymorphism databases

    DMDMi296453084.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL832890 mRNA. No translation available.
    AC008758 Genomic DNA. No translation available.
    BC009517 mRNA. Translation: AAH09517.1 .
    CCDSi CCDS45989.1. [Q96GE5-1 ]
    RefSeqi NP_001074290.1. NM_001080821.2. [Q96GE5-1 ]
    UniGenei Hs.546637.

    3D structure databases

    ProteinModelPortali Q96GE5.
    SMRi Q96GE5. Positions 2-54, 102-643.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124735. 1 interaction.

    Polymorphism databases

    DMDMi 296453084.

    Proteomic databases

    PaxDbi Q96GE5.
    PRIDEi Q96GE5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000430385 ; ENSP00000411084 ; ENSG00000196466 . [Q96GE5-1 ]
    GeneIDi 90576.
    KEGGi hsa:90576.
    UCSCi uc010dyt.3. human. [Q96GE5-1 ]

    Organism-specific databases

    CTDi 90576.
    GeneCardsi GC19M012500.
    HGNCi HGNC:28071. ZNF799.
    HPAi HPA003150.
    neXtProti NX_Q96GE5.
    PharmGKBi PA162410569.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q96GE5.
    KOi K09228.
    OMAi MHTRDGP.
    PhylomeDBi Q96GE5.
    TreeFami TF338854.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 90576.
    NextBioi 76837.
    PROi Q96GE5.

    Gene expression databases

    Bgeei Q96GE5.
    CleanExi HS_ZNF799.
    Genevestigatori Q96GE5.

    Family and domain databases

    Gene3Di 3.30.160.60. 18 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 18 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 15 hits.
    PS50157. ZINC_FINGER_C2H2_2. 18 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lymph.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 277-643 (ISOFORM 1/2).
      Tissue: Uterus.

    Entry informationi

    Entry nameiZN799_HUMAN
    AccessioniPrimary (citable) accession number: Q96GE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 100 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3