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Q96GE5

- ZN799_HUMAN

UniProt

Q96GE5 - ZN799_HUMAN

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Protein

Zinc finger protein 799

Gene

ZNF799

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri134 – 16330C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19123C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47022C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri476 – 49823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri504 – 52623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri532 – 55423C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri560 – 58223C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri588 – 61528C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 799
Alternative name(s):
Zinc finger protein 842
Gene namesi
Name:ZNF799
Synonyms:ZNF842
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:28071. ZNF799.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410569.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 643643Zinc finger protein 799PRO_0000271017Add
BLAST

Proteomic databases

PaxDbiQ96GE5.
PRIDEiQ96GE5.

Expressioni

Gene expression databases

BgeeiQ96GE5.
CleanExiHS_ZNF799.
ExpressionAtlasiQ96GE5. baseline.
GenevestigatoriQ96GE5.

Organism-specific databases

HPAiHPA003150.

Interactioni

Protein-protein interaction databases

BioGridi124735. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96GE5.
SMRiQ96GE5. Positions 2-54, 102-643.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8683KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri134 – 16330C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19123C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47022C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri476 – 49823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri504 – 52623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri532 – 55423C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri560 – 58223C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri588 – 61528C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96GE5.
KOiK09228.
OMAiMHTRDGP.
PhylomeDBiQ96GE5.
TreeFamiTF338854.

Family and domain databases

Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96GE5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVALEDVA VNFTREEWAL LGPCQKNLYK DVMQETIRNL DCVGMKWKDQ
60 70 80 90 100
NIEDQYRYPR KNLRCRMLER FVESKDGTQC GETSSQIQDS IVTKNTLPGV
110 120 130 140 150
GPYESRMSGE VIMGHSSLNC YIRVGAGHKP YEYHECGEKP DTHKQRGKAF
160 170 180 190 200
SYHNSLQTHE RLHTGKKPYN CKECGKSFSS LGNLQRHMAV QRGDGPYKCK
210 220 230 240 250
LCGKAFFWPS LLHMHERTHT GEKPYECKQC SKAFSFYSSY LRHERTHTGE
260 270 280 290 300
KLYECKQCSK AFPDYSSCLR HERTHTGKKP YTCKQCGKAF SASTSLRRHE
310 320 330 340 350
TTHTDEKPYA CQQCGKAFHH LGSFQRHMVM HTRDGPHKCK ICGKGFDCPS
360 370 380 390 400
SLKSHERTHT GEKLYECKQC GKALSHSSSF RRHMTMHTGD GPHKCKICGK
410 420 430 440 450
AFVYPSVFQR HEKTHTAEKP YKCKQCGKAY RISSSLRRHE TTHTGEKPYK
460 470 480 490 500
CKCGKAFIDF YSFQNHKTTH AGEKPYECKE CGKAFSCFQY LSQHRRTHTG
510 520 530 540 550
EKPYECNTCK KAFSHFGNLK VHERIHSGEK PYECKECGKA FSWLTCFLRH
560 570 580 590 600
ERIHMREKPY ECQQCGKAFT HSRFLQGHEK THTGENPYEC KECGKAFASL
610 620 630 640
SSLHRHKKTH WKKTHTGENP YGCKECGKAF ASLSSLHRHK KTH
Length:643
Mass (Da):74,288
Last modified:May 18, 2010 - v4
Checksum:iD15435746A10855C
GO
Isoform 2 (identifier: Q96GE5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MDQ

Show »
Length:645
Mass (Da):74,532
Checksum:iA4E68F40679062F3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti252 – 2521L → P in AL832890. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441G → V.
Corresponds to variant rs1134387 [ dbSNP | Ensembl ].
VAR_029846
Natural varianti593 – 5931C → R.
Corresponds to variant rs8112445 [ dbSNP | Ensembl ].
VAR_029847

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MDQ in isoform 2. 1 PublicationVSP_039164

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832890 mRNA. No translation available.
AC008758 Genomic DNA. No translation available.
BC009517 mRNA. Translation: AAH09517.1.
CCDSiCCDS45989.1. [Q96GE5-1]
RefSeqiNP_001074290.1. NM_001080821.2. [Q96GE5-1]
UniGeneiHs.546637.

Genome annotation databases

EnsembliENST00000430385; ENSP00000411084; ENSG00000196466. [Q96GE5-1]
GeneIDi90576.
KEGGihsa:90576.
UCSCiuc010dyt.3. human. [Q96GE5-1]

Polymorphism databases

DMDMi296453084.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832890 mRNA. No translation available.
AC008758 Genomic DNA. No translation available.
BC009517 mRNA. Translation: AAH09517.1 .
CCDSi CCDS45989.1. [Q96GE5-1 ]
RefSeqi NP_001074290.1. NM_001080821.2. [Q96GE5-1 ]
UniGenei Hs.546637.

3D structure databases

ProteinModelPortali Q96GE5.
SMRi Q96GE5. Positions 2-54, 102-643.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124735. 1 interaction.

Polymorphism databases

DMDMi 296453084.

Proteomic databases

PaxDbi Q96GE5.
PRIDEi Q96GE5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000430385 ; ENSP00000411084 ; ENSG00000196466 . [Q96GE5-1 ]
GeneIDi 90576.
KEGGi hsa:90576.
UCSCi uc010dyt.3. human. [Q96GE5-1 ]

Organism-specific databases

CTDi 90576.
GeneCardsi GC19M012500.
HGNCi HGNC:28071. ZNF799.
HPAi HPA003150.
neXtProti NX_Q96GE5.
PharmGKBi PA162410569.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000119089.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q96GE5.
KOi K09228.
OMAi MHTRDGP.
PhylomeDBi Q96GE5.
TreeFami TF338854.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 90576.
NextBioi 76837.
PROi Q96GE5.

Gene expression databases

Bgeei Q96GE5.
CleanExi HS_ZNF799.
ExpressionAtlasi Q96GE5. baseline.
Genevestigatori Q96GE5.

Family and domain databases

Gene3Di 3.30.160.60. 18 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lymph.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 277-643 (ISOFORM 1/2).
    Tissue: Uterus.

Entry informationi

Entry nameiZN799_HUMAN
AccessioniPrimary (citable) accession number: Q96GE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 101 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3