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Protein

Zinc finger protein 799

Gene

ZNF799

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 163C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST30
Zinc fingeri169 – 191C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 470C2H2-type 12PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri476 – 498C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri532 – 554C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri560 – 582C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri588 – 615C2H2-type 17PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri621 – 643C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 799
Alternative name(s):
Zinc finger protein 842
Gene namesi
Name:ZNF799
Synonyms:ZNF842
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000196466.10
HGNCiHGNC:28071 ZNF799
neXtProtiNX_Q96GE5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196466
PharmGKBiPA162410569

Polymorphism and mutation databases

BioMutaiZNF799
DMDMi296453084

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710171 – 643Zinc finger protein 799Add BLAST643

Proteomic databases

MaxQBiQ96GE5
PaxDbiQ96GE5
PeptideAtlasiQ96GE5
PRIDEiQ96GE5

PTM databases

iPTMnetiQ96GE5
PhosphoSitePlusiQ96GE5

Expressioni

Gene expression databases

BgeeiENSG00000196466
CleanExiHS_ZNF799
ExpressionAtlasiQ96GE5 baseline and differential
GenevisibleiQ96GE5 HS

Organism-specific databases

HPAiHPA003150
HPA018683

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000411084

Structurei

3D structure databases

ProteinModelPortaliQ96GE5
SMRiQ96GE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 86KRABPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 163C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST30
Zinc fingeri169 – 191C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 470C2H2-type 12PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri476 – 498C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri532 – 554C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri560 – 582C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri588 – 615C2H2-type 17PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri621 – 643C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ96GE5
KOiK09228
OMAiSFQRHMV
OrthoDBiEOG091G02KC
PhylomeDBiQ96GE5
TreeFamiTF338854

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 18 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 18 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96GE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVALEDVA VNFTREEWAL LGPCQKNLYK DVMQETIRNL DCVGMKWKDQ
60 70 80 90 100
NIEDQYRYPR KNLRCRMLER FVESKDGTQC GETSSQIQDS IVTKNTLPGV
110 120 130 140 150
GPYESRMSGE VIMGHSSLNC YIRVGAGHKP YEYHECGEKP DTHKQRGKAF
160 170 180 190 200
SYHNSLQTHE RLHTGKKPYN CKECGKSFSS LGNLQRHMAV QRGDGPYKCK
210 220 230 240 250
LCGKAFFWPS LLHMHERTHT GEKPYECKQC SKAFSFYSSY LRHERTHTGE
260 270 280 290 300
KLYECKQCSK AFPDYSSCLR HERTHTGKKP YTCKQCGKAF SASTSLRRHE
310 320 330 340 350
TTHTDEKPYA CQQCGKAFHH LGSFQRHMVM HTRDGPHKCK ICGKGFDCPS
360 370 380 390 400
SLKSHERTHT GEKLYECKQC GKALSHSSSF RRHMTMHTGD GPHKCKICGK
410 420 430 440 450
AFVYPSVFQR HEKTHTAEKP YKCKQCGKAY RISSSLRRHE TTHTGEKPYK
460 470 480 490 500
CKCGKAFIDF YSFQNHKTTH AGEKPYECKE CGKAFSCFQY LSQHRRTHTG
510 520 530 540 550
EKPYECNTCK KAFSHFGNLK VHERIHSGEK PYECKECGKA FSWLTCFLRH
560 570 580 590 600
ERIHMREKPY ECQQCGKAFT HSRFLQGHEK THTGENPYEC KECGKAFASL
610 620 630 640
SSLHRHKKTH WKKTHTGENP YGCKECGKAF ASLSSLHRHK KTH
Length:643
Mass (Da):74,288
Last modified:May 18, 2010 - v4
Checksum:iD15435746A10855C
GO
Isoform 2 (identifier: Q96GE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MDQ

Show »
Length:645
Mass (Da):74,532
Checksum:iA4E68F40679062F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti252L → P in AL832890 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02984644G → V. Corresponds to variant dbSNP:rs1134387Ensembl.1
Natural variantiVAR_029847593C → R. Corresponds to variant dbSNP:rs8112445Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0391641M → MDQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832890 mRNA No translation available.
AC008758 Genomic DNA No translation available.
BC009517 mRNA Translation: AAH09517.1
CCDSiCCDS45989.1 [Q96GE5-1]
RefSeqiNP_001074290.1, NM_001080821.2 [Q96GE5-1]
UniGeneiHs.546637

Genome annotation databases

EnsembliENST00000430385; ENSP00000411084; ENSG00000196466 [Q96GE5-1]
GeneIDi90576
KEGGihsa:90576
UCSCiuc010dyt.4 human [Q96GE5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN799_HUMAN
AccessioniPrimary (citable) accession number: Q96GE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 126 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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