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Q96GE5 (ZN799_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 799
Alternative name(s):
Zinc finger protein 842
Gene names
Name:ZNF799
Synonyms:ZNF842
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length643 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 18 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96GE5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96GE5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MDQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 643643Zinc finger protein 799
PRO_0000271017

Regions

Domain4 – 8683KRAB
Zinc finger134 – 16330C2H2-type 1; degenerate
Zinc finger169 – 19123C2H2-type 2; degenerate
Zinc finger197 – 21923C2H2-type 3
Zinc finger225 – 24723C2H2-type 4
Zinc finger253 – 27523C2H2-type 5
Zinc finger281 – 30323C2H2-type 6
Zinc finger309 – 33123C2H2-type 7
Zinc finger337 – 35923C2H2-type 8
Zinc finger365 – 38723C2H2-type 9
Zinc finger393 – 41523C2H2-type 10
Zinc finger421 – 44323C2H2-type 11
Zinc finger449 – 47022C2H2-type 12
Zinc finger476 – 49823C2H2-type 13
Zinc finger504 – 52623C2H2-type 14
Zinc finger532 – 55423C2H2-type 15
Zinc finger560 – 58223C2H2-type 16
Zinc finger588 – 61528C2H2-type 17
Zinc finger621 – 64323C2H2-type 18

Natural variations

Alternative sequence11M → MDQ in isoform 2.
VSP_039164
Natural variant441G → V.
Corresponds to variant rs1134387 [ dbSNP | Ensembl ].
VAR_029846
Natural variant5931C → R.
Corresponds to variant rs8112445 [ dbSNP | Ensembl ].
VAR_029847

Experimental info

Sequence conflict2521L → P in AL832890. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 4.
Checksum: D15435746A10855C

FASTA64374,288
        10         20         30         40         50         60 
MASVALEDVA VNFTREEWAL LGPCQKNLYK DVMQETIRNL DCVGMKWKDQ NIEDQYRYPR 

        70         80         90        100        110        120 
KNLRCRMLER FVESKDGTQC GETSSQIQDS IVTKNTLPGV GPYESRMSGE VIMGHSSLNC 

       130        140        150        160        170        180 
YIRVGAGHKP YEYHECGEKP DTHKQRGKAF SYHNSLQTHE RLHTGKKPYN CKECGKSFSS 

       190        200        210        220        230        240 
LGNLQRHMAV QRGDGPYKCK LCGKAFFWPS LLHMHERTHT GEKPYECKQC SKAFSFYSSY 

       250        260        270        280        290        300 
LRHERTHTGE KLYECKQCSK AFPDYSSCLR HERTHTGKKP YTCKQCGKAF SASTSLRRHE 

       310        320        330        340        350        360 
TTHTDEKPYA CQQCGKAFHH LGSFQRHMVM HTRDGPHKCK ICGKGFDCPS SLKSHERTHT 

       370        380        390        400        410        420 
GEKLYECKQC GKALSHSSSF RRHMTMHTGD GPHKCKICGK AFVYPSVFQR HEKTHTAEKP 

       430        440        450        460        470        480 
YKCKQCGKAY RISSSLRRHE TTHTGEKPYK CKCGKAFIDF YSFQNHKTTH AGEKPYECKE 

       490        500        510        520        530        540 
CGKAFSCFQY LSQHRRTHTG EKPYECNTCK KAFSHFGNLK VHERIHSGEK PYECKECGKA 

       550        560        570        580        590        600 
FSWLTCFLRH ERIHMREKPY ECQQCGKAFT HSRFLQGHEK THTGENPYEC KECGKAFASL 

       610        620        630        640 
SSLHRHKKTH WKKTHTGENP YGCKECGKAF ASLSSLHRHK KTH 

« Hide

Isoform 2 [UniParc].

Checksum: A4E68F40679062F3
Show »

FASTA64574,532

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Lymph.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 277-643 (ISOFORM 1/2).
Tissue: Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL832890 mRNA. No translation available.
AC008758 Genomic DNA. No translation available.
BC009517 mRNA. Translation: AAH09517.1.
CCDSCCDS45989.1. [Q96GE5-1]
RefSeqNP_001074290.1. NM_001080821.2. [Q96GE5-1]
UniGeneHs.546637.

3D structure databases

ProteinModelPortalQ96GE5.
SMRQ96GE5. Positions 2-54, 102-643.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124735. 1 interaction.

Polymorphism databases

DMDM296453084.

Proteomic databases

PaxDbQ96GE5.
PRIDEQ96GE5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000430385; ENSP00000411084; ENSG00000196466. [Q96GE5-1]
GeneID90576.
KEGGhsa:90576.
UCSCuc010dyt.3. human. [Q96GE5-1]

Organism-specific databases

CTD90576.
GeneCardsGC19M012500.
HGNCHGNC:28071. ZNF799.
HPAHPA003150.
neXtProtNX_Q96GE5.
PharmGKBPA162410569.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ96GE5.
KOK09228.
OMAMHTRDGP.
PhylomeDBQ96GE5.
TreeFamTF338854.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

BgeeQ96GE5.
CleanExHS_ZNF799.
GenevestigatorQ96GE5.

Family and domain databases

Gene3D3.30.160.60. 18 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi90576.
NextBio76837.
PROQ96GE5.

Entry information

Entry nameZN799_HUMAN
AccessionPrimary (citable) accession number: Q96GE5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 98 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM