Q96GD3 (SCMH1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Polycomb protein SCMH1

Alternative name(s):
Sex comb on midleg homolog 1

Gene names

Name:

SCMH1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	660 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes By similarity.
Subunit structure	Interacts with the SAM domain of PHC1 via its SAM domain in vitro By similarity. Associates with a PRC1-like complex. UniProtKB Q8K214
Subcellular location	Nucleus Probable.
Tissue specificity	Strongly expressed in heart, muscle and pancreas. Weakly expressed in brain, placenta, lung, liver and kidney. Ref.1
Sequence similarities	Belongs to the SCM family. Contains 2 MBT repeats. Contains 1 SAM (sterile alpha motif) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat
Molecular function	Developmental protein Repressor
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anatomical structure morphogenesis Traceable author statement Ref.1. Source: ProtInc anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara chromatin remodeling Inferred from electronic annotation. Source: Compara gene silencing Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription, DNA-dependent Non-traceable author statement Ref.1. Source: UniProtKB spermatogenesis Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chromocenter Inferred from electronic annotation. Source: Compara nucleus Inferred by curator Ref.1. Source: UniProtKB
Molecular_function	DNA binding Traceable author statement Ref.1. Source: ProtInc sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.4 (identifier: Q96GD3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 Ref.4 (identifier: Q96GD3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MLVCYSVLACEILWDLPCSIMGSP → MQPNVIDWSDVRKHKYGHLSESASQYQEAADILD
     550-571: Missing.

Note: Gene prediction confirmed by EST data.

Isoform 3 Ref.4 (identifier: Q96GD3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Isoform 4 Ref.1 (identifier: Q96GD3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: MLVCYSVLACEILWDLPCSIMGSPLGHFTWDKYLKETCSVPAPVHCFK → M
     550-571: Missing.

Isoform 5 Ref.1 (identifier: Q96GD3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
     550-571: Missing.

Note: May be due to intron retention.

Isoform 6 (identifier: Q96GD3-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: MLVCYSVLACEILWDLPCSIMGSPLGHFTWDKYLKETCSVPAPVHCFK → M
     128-238: Missing.
     550-571: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 660

660

Polycomb protein SCMH1

PRO_0000114334

Regions

Repeat

28 – 126

99

MBT 1

Repeat

134 – 235

102

MBT 2

Domain

593 – 658

66

SAM

Natural variations

Alternative sequence

1 – 61

61

Missing in isoform 3 and isoform 5. Ref.1 Ref.4

VSP_051678

Alternative sequence

1 – 48

48

MLVCY…VHCFK → M in isoform 4 and isoform 6. Ref.1

VSP_051677

Alternative sequence

1 – 24

24

MLVCY…IMGSP → MQPNVIDWSDVRKHKYGHLS ESASQYQEAADILD in isoform 2. Ref.4

VSP_051676

Alternative sequence

128 – 238

111

Missing in isoform 6.

VSP_043395

Alternative sequence

550 – 571

22

Missing in isoform 2, isoform 4, isoform 5 and isoform 6. Ref.1 Ref.4

VSP_051679

Experimental info

Sequence conflict

463

1

F → L Ref.3

Secondary structure

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660

Helix Strand Turn

Details...

Helix

30 – 36

7

Helix

44 – 46

3

Beta strand

47 – 49

3

Beta strand

63 – 68

6

Beta strand

71 – 84

14

Beta strand

87 – 92

6

Beta strand

101 – 104

4

Helix

115 – 118

4

Helix

133 – 135

3

Helix

136 – 144

9

Helix

152 – 154

3

Beta strand

172 – 176

5

Beta strand

184 – 193

10

Beta strand

196 – 201

6

Turn

205 – 208

4

Beta strand

210 – 213

4

Helix

224 – 228

5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 6544DD484DA8D037	FASTA	660	73,354
	10 20 30 40 50 60 MLVCYSVLAC EILWDLPCSI MGSPLGHFTW DKYLKETCSV PAPVHCFKQS YTPPSNEFKI 70 80 90 100 110 120 SMKLEAQDPR NTTSTCIATV VGLTGARLRL RLDGSDNKND FWRLVDSAEI QPIGNCEKNG 130 140 150 160 170 180 GMLQPPLGFR LNASSWPMFL LKTLNGAEMA PIRIFHKEPP SPSHNFFKMG MKLEAVDRKN 190 200 210 220 230 240 PHFICPATIG EVRGSEVLVT FDGWRGAFDY WCRFDSRDIF PVGWCSLTGD NLQPPGTKVV 250 260 270 280 290 300 IPKNPYPASD VNTEKPSIHS STKTVLEHQP GQRGRKPGKK RGRTPKTLIS HPISAPSKTA 310 320 330 340 350 360 EPLKFPKKRG PKPGSKRKPR TLLNPPPASP TTSTPEPDTS TVPQDAATIP SSAMQAPTVC 370 380 390 400 410 420 IYLNKNGSTG PHLDKKKVQQ LPDHFGPARA SVVLQQAVQA CIDCAYHQKT VFSFLKQGHG 430 440 450 460 470 480 GEVISAVFDR EQHTLNLPAV NSITYVLRFL EKLCHNLRSD NLFGNQPFTQ THLSLTAIEY 490 500 510 520 530 540 SHSHDRYLPG ETFVLGNSLA RSLEPHSDSM DSASNPTNLV STSQRHRPLL SSCGLPPSTA 550 560 570 580 590 600 SAVRRLCSRG VLKGSNERRD MESFWKLNRS PGSDRYLESR DASRLSGRDP SSWTVEDVMQ 610 620 630 640 650 660 FVREADPQLG PHADLFRKHE IDGKALLLLR SDMMMKYMGL KLGPALKLSY HIDRLKQGKF
	Isoform 2 [UniParc]. Checksum: 5DBA4803D9E8B3B5	FASTA	648	72,053
	10 20 30 40 50 60 MQPNVIDWSD VRKHKYGHLS ESASQYQEAA DILDLGHFTW DKYLKETCSV PAPVHCFKQS 70 80 90 100 110 120 YTPPSNEFKI SMKLEAQDPR NTTSTCIATV VGLTGARLRL RLDGSDNKND FWRLVDSAEI 130 140 150 160 170 180 QPIGNCEKNG GMLQPPLGFR LNASSWPMFL LKTLNGAEMA PIRIFHKEPP SPSHNFFKMG 190 200 210 220 230 240 MKLEAVDRKN PHFICPATIG EVRGSEVLVT FDGWRGAFDY WCRFDSRDIF PVGWCSLTGD 250 260 270 280 290 300 NLQPPGTKVV IPKNPYPASD VNTEKPSIHS STKTVLEHQP GQRGRKPGKK RGRTPKTLIS 310 320 330 340 350 360 HPISAPSKTA EPLKFPKKRG PKPGSKRKPR TLLNPPPASP TTSTPEPDTS TVPQDAATIP 370 380 390 400 410 420 SSAMQAPTVC IYLNKNGSTG PHLDKKKVQQ LPDHFGPARA SVVLQQAVQA CIDCAYHQKT 430 440 450 460 470 480 VFSFLKQGHG GEVISAVFDR EQHTLNLPAV NSITYVLRFL EKLCHNLRSD NLFGNQPFTQ 490 500 510 520 530 540 THLSLTAIEY SHSHDRYLPG ETFVLGNSLA RSLEPHSDSM DSASNPTNLV STSQRHRPLL 550 560 570 580 590 600 SSCGLPPSTA SAVRRLCSRG SDRYLESRDA SRLSGRDPSS WTVEDVMQFV READPQLGPH 610 620 630 640 ADLFRKHEID GKALLLLRSD MMMKYMGLKL GPALKLSYHI DRLKQGKF
	Isoform 3 [UniParc]. Checksum: AC9C5AB96BDF79E1	FASTA	599	66,459
	10 20 30 40 50 60 MKLEAQDPRN TTSTCIATVV GLTGARLRLR LDGSDNKNDF WRLVDSAEIQ PIGNCEKNGG 70 80 90 100 110 120 MLQPPLGFRL NASSWPMFLL KTLNGAEMAP IRIFHKEPPS PSHNFFKMGM KLEAVDRKNP 130 140 150 160 170 180 HFICPATIGE VRGSEVLVTF DGWRGAFDYW CRFDSRDIFP VGWCSLTGDN LQPPGTKVVI 190 200 210 220 230 240 PKNPYPASDV NTEKPSIHSS TKTVLEHQPG QRGRKPGKKR GRTPKTLISH PISAPSKTAE 250 260 270 280 290 300 PLKFPKKRGP KPGSKRKPRT LLNPPPASPT TSTPEPDTST VPQDAATIPS SAMQAPTVCI 310 320 330 340 350 360 YLNKNGSTGP HLDKKKVQQL PDHFGPARAS VVLQQAVQAC IDCAYHQKTV FSFLKQGHGG 370 380 390 400 410 420 EVISAVFDRE QHTLNLPAVN SITYVLRFLE KLCHNLRSDN LFGNQPFTQT HLSLTAIEYS 430 440 450 460 470 480 HSHDRYLPGE TFVLGNSLAR SLEPHSDSMD SASNPTNLVS TSQRHRPLLS SCGLPPSTAS 490 500 510 520 530 540 AVRRLCSRGV LKGSNERRDM ESFWKLNRSP GSDRYLESRD ASRLSGRDPS SWTVEDVMQF 550 560 570 580 590 VREADPQLGP HADLFRKHEI DGKALLLLRS DMMMKYMGLK LGPALKLSYH IDRLKQGKF
	Isoform 4 [UniParc]. Checksum: E5F43403878E53BA	FASTA	591	65,481
	10 20 30 40 50 60 MQSYTPPSNE FKISMKLEAQ DPRNTTSTCI ATVVGLTGAR LRLRLDGSDN KNDFWRLVDS 70 80 90 100 110 120 AEIQPIGNCE KNGGMLQPPL GFRLNASSWP MFLLKTLNGA EMAPIRIFHK EPPSPSHNFF 130 140 150 160 170 180 KMGMKLEAVD RKNPHFICPA TIGEVRGSEV LVTFDGWRGA FDYWCRFDSR DIFPVGWCSL 190 200 210 220 230 240 TGDNLQPPGT KVVIPKNPYP ASDVNTEKPS IHSSTKTVLE HQPGQRGRKP GKKRGRTPKT 250 260 270 280 290 300 LISHPISAPS KTAEPLKFPK KRGPKPGSKR KPRTLLNPPP ASPTTSTPEP DTSTVPQDAA 310 320 330 340 350 360 TIPSSAMQAP TVCIYLNKNG STGPHLDKKK VQQLPDHFGP ARASVVLQQA VQACIDCAYH 370 380 390 400 410 420 QKTVFSFLKQ GHGGEVISAV FDREQHTLNL PAVNSITYVL RFLEKLCHNL RSDNLFGNQP 430 440 450 460 470 480 FTQTHLSLTA IEYSHSHDRY LPGETFVLGN SLARSLEPHS DSMDSASNPT NLVSTSQRHR 490 500 510 520 530 540 PLLSSCGLPP STASAVRRLC SRGSDRYLES RDASRLSGRD PSSWTVEDVM QFVREADPQL 550 560 570 580 590 GPHADLFRKH EIDGKALLLL RSDMMMKYMG LKLGPALKLS YHIDRLKQGK F
	Isoform 5 [UniParc]. Checksum: 1EC4A9E8452B66F0	FASTA	577	63,870
	10 20 30 40 50 60 MKLEAQDPRN TTSTCIATVV GLTGARLRLR LDGSDNKNDF WRLVDSAEIQ PIGNCEKNGG 70 80 90 100 110 120 MLQPPLGFRL NASSWPMFLL KTLNGAEMAP IRIFHKEPPS PSHNFFKMGM KLEAVDRKNP 130 140 150 160 170 180 HFICPATIGE VRGSEVLVTF DGWRGAFDYW CRFDSRDIFP VGWCSLTGDN LQPPGTKVVI 190 200 210 220 230 240 PKNPYPASDV NTEKPSIHSS TKTVLEHQPG QRGRKPGKKR GRTPKTLISH PISAPSKTAE 250 260 270 280 290 300 PLKFPKKRGP KPGSKRKPRT LLNPPPASPT TSTPEPDTST VPQDAATIPS SAMQAPTVCI 310 320 330 340 350 360 YLNKNGSTGP HLDKKKVQQL PDHFGPARAS VVLQQAVQAC IDCAYHQKTV FSFLKQGHGG 370 380 390 400 410 420 EVISAVFDRE QHTLNLPAVN SITYVLRFLE KLCHNLRSDN LFGNQPFTQT HLSLTAIEYS 430 440 450 460 470 480 HSHDRYLPGE TFVLGNSLAR SLEPHSDSMD SASNPTNLVS TSQRHRPLLS SCGLPPSTAS 490 500 510 520 530 540 AVRRLCSRGS DRYLESRDAS RLSGRDPSSW TVEDVMQFVR EADPQLGPHA DLFRKHEIDG 550 560 570 KALLLLRSDM MMKYMGLKLG PALKLSYHID RLKQGKF
	Isoform 6 [UniParc]. Checksum: CCD341EBF6748EF5	FASTA	480	52,908
	10 20 30 40 50 60 MQSYTPPSNE FKISMKLEAQ DPRNTTSTCI ATVVGLTGAR LRLRLDGSDN KNDFWRLVDS 70 80 90 100 110 120 AEIQPIGNCE KNGGMLQPPL VVIPKNPYPA SDVNTEKPSI HSSTKTVLEH QPGQRGRKPG 130 140 150 160 170 180 KKRGRTPKTL ISHPISAPSK TAEPLKFPKK RGPKPGSKRK PRTLLNPPPA SPTTSTPEPD 190 200 210 220 230 240 TSTVPQDAAT IPSSAMQAPT VCIYLNKNGS TGPHLDKKKV QQLPDHFGPA RASVVLQQAV 250 260 270 280 290 300 QACIDCAYHQ KTVFSFLKQG HGGEVISAVF DREQHTLNLP AVNSITYVLR FLEKLCHNLR 310 320 330 340 350 360 SDNLFGNQPF TQTHLSLTAI EYSHSHDRYL PGETFVLGNS LARSLEPHSD SMDSASNPTN 370 380 390 400 410 420 LVSTSQRHRP LLSSCGLPPS TASAVRRLCS RGSDRYLESR DASRLSGRDP SSWTVEDVMQ 430 440 450 460 470 480 FVREADPQLG PHADLFRKHE IDGKALLLLR SDMMMKYMGL KLGPALKLSY HIDRLKQGKF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34." Berger J., Kurahashi H., Takihara Y., Shimada K., Brock H.W., Randazzo F. Gene 237:185-191(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5), TISSUE SPECIFICITY. Tissue: Heart and Skeletal muscle.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Tongue.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Fetal brain.
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 2).
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Eye and Muscle.
[7]	"The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans." Levine S.S., Weiss A., Erdjument-Bromage H., Shao Z., Tempst P., Kingston R.E. Mol. Cell. Biol. 22:6070-6078(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, ASSOCIATION WITH A PRC1-LIKE COMPLEX.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF149045 mRNA. Translation: AAF01150.1.
AF149046 mRNA. Translation: AAF01151.1.
AK299383 mRNA. Translation: BAG61370.1.
CR457161 mRNA. Translation: CAG33442.1.
BX640721 mRNA. Translation: CAE45840.1.
AL110502, AL391730 Genomic DNA. Translation: CAI22109.1.
AL110502, AL391730 Genomic DNA. Translation: CAI22110.1.
AL110502, AL391730, AL606484 Genomic DNA. Translation: CAI22111.1.
AL110502, AL391730 Genomic DNA. Translation: CAI22112.1.
AL110502, AL391730 Genomic DNA. Translation: CAI22113.1.
AL391730, AL110502 Genomic DNA. Translation: CAH72791.1.
AL391730, AL110502 Genomic DNA. Translation: CAH72793.1.
AL391730, AL110502, AL606484 Genomic DNA. Translation: CAH72794.1.
AL391730, AL110502 Genomic DNA. Translation: CAH72795.1.
AL391730, AL110502 Genomic DNA. Translation: CAH72796.1.
AL606484, AL110502, AL391730 Genomic DNA. Translation: CAH72242.1.
BC009752 mRNA. Translation: AAH09752.1.
BC021252 mRNA. Translation: AAH21252.1.

IPI

IPI00187110.
IPI00396653.
IPI00479699.
IPI00552451.
IPI00552650.
IPI00910048.

RefSeq

NP_001026864.1. NM_001031694.2.
NP_001165689.1. NM_001172218.1.
NP_001165690.1. NM_001172219.1.
NP_001165691.1. NM_001172220.1.
NP_001165692.1. NM_001172221.1.
NP_001165693.1. NM_001172222.1.
NP_036368.1. NM_012236.3.

UniGene

Hs.571874.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2P0K	X-ray	1.75	A	27-238	[»]

ProteinModelPortal

Q96GD3.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q96GD3. 10 interactions.

MINT

MINT-1422768.

STRING

9606.ENSP00000318094.

PTM databases

PhosphoSite

Q96GD3.

Polymorphism databases

DMDM

60390956.

Proteomic databases

PaxDb

Q96GD3.

PRIDE

Q96GD3.

Protocols and materials databases

DNASU

22955.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000326197; ENSP00000318094; ENSG00000010803.
ENST00000337495; ENSP00000337352; ENSG00000010803.
ENST00000361191; ENSP00000354656; ENSG00000010803.
ENST00000361705; ENSP00000354996; ENSG00000010803.
ENST00000372595; ENSP00000361676; ENSG00000010803.
ENST00000372596; ENSP00000361677; ENSG00000010803.
ENST00000372597; ENSP00000361678; ENSG00000010803.
ENST00000397171; ENSP00000380356; ENSG00000010803.
ENST00000402904; ENSP00000386079; ENSG00000010803.
ENST00000456518; ENSP00000403974; ENSG00000010803.

GeneID

22955.

KEGG

hsa:22955.

UCSC

uc001cgo.3. human.
uc001cgq.3. human.
uc001cgr.3. human.
uc001cgs.3. human.

Organism-specific databases

CTD

22955.

GeneCards

GC01M041527.

HGNC

HGNC:19003. SCMH1.

HPA

HPA053292.

neXtProt

NX_Q96GD3.

PharmGKB

PA134870272.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG315447.

HOGENOM

HOG000236280.

HOVERGEN

HBG056406.

InParanoid

Q96GD3.

KO

K11461.

OMA

TATEYSH.

PhylomeDB

Q96GD3.

Gene expression databases

Bgee

Q96GD3.

CleanEx

HS_SCMH1.

Genevestigator

Q96GD3.

GermOnline

ENSG00000010803. Homo sapiens.

Family and domain databases

Gene3D

1.10.150.50. 1 hit.

InterPro

IPR021987. DUF3588.
IPR004092. Mbt.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]

Pfam

PF12140. DUF3588. 1 hit.
PF02820. MBT. 2 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]

SMART

SM00561. MBT. 2 hits.
SM00454. SAM. 1 hit.
[Graphical view]

SUPFAM

SSF47769. SAM_homology. 1 hit.

PROSITE

PS51079. MBT. 2 hits.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q96GD3.

GenomeRNAi

22955.

NextBio

43747.

Entry information

Entry name

SCMH1_HUMAN

Accession

Primary (citable) accession number: Q96GD3
Secondary accession number(s): B4DRQ8 , Q5VT76, Q6IAJ4, Q8WU48, Q9UKM5, Q9UKM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.