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Protein

Vacuole membrane protein 1

Gene

VMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions.By similarity1 Publication

GO - Biological processi

  • autophagy Source: UniProtKB-KW
  • cell junction assembly Source: UniProtKB
  • embryo implantation Source: Ensembl
  • endoplasmic reticulum organization Source: GO_Central
  • exocytosis Source: GO_Central
  • Golgi organization Source: GO_Central
  • regulation of autophagy Source: UniProtKB
  • single organismal cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Autophagy, Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuole membrane protein 1
Alternative name(s):
Transmembrane protein 49
Gene namesi
Name:VMP1
Synonyms:TDC1, TMEM49
ORF Names:HSPC292
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29559. VMP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 4342CytoplasmicSequence analysisAdd
BLAST
Transmembranei44 – 6421HelicalSequence analysisAdd
BLAST
Topological domaini65 – 7713ExtracellularSequence analysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence analysisAdd
BLAST
Topological domaini99 – 10911CytoplasmicSequence analysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence analysisAdd
BLAST
Topological domaini131 – 250120ExtracellularSequence analysisAdd
BLAST
Transmembranei251 – 27121HelicalSequence analysisAdd
BLAST
Topological domaini272 – 2732CytoplasmicSequence analysis
Transmembranei274 – 29421HelicalSequence analysisAdd
BLAST
Topological domaini295 – 30511ExtracellularSequence analysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence analysisAdd
BLAST
Topological domaini327 – 36337CytoplasmicSequence analysisAdd
BLAST
Transmembranei364 – 38421HelicalSequence analysisAdd
BLAST
Topological domaini385 – 40622ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Vacuole

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670765.

Polymorphism and mutation databases

BioMutaiVMP1.
DMDMi74731809.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 406405Vacuole membrane protein 1PRO_0000284546Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96GC9.
MaxQBiQ96GC9.
PaxDbiQ96GC9.
PeptideAtlasiQ96GC9.
PRIDEiQ96GC9.
TopDownProteomicsiQ96GC9-1. [Q96GC9-1]

PTM databases

iPTMnetiQ96GC9.
PhosphoSiteiQ96GC9.
SwissPalmiQ96GC9.

Expressioni

Gene expression databases

BgeeiQ96GC9.
CleanExiHS_TMEM49.
ExpressionAtlasiQ96GC9. baseline and differential.
GenevisibleiQ96GC9. HS.

Organism-specific databases

HPAiHPA030773.

Interactioni

Subunit structurei

Interacts with BECN1. Interacts with TJP1. Interacts with TP53INP2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BECN1Q144573EBI-2800296,EBI-949378

Protein-protein interaction databases

BioGridi123567. 14 interactions.
IntActiQ96GC9. 9 interactions.
MINTiMINT-4721802.
STRINGi9606.ENSP00000262291.

Structurei

3D structure databases

ProteinModelPortaliQ96GC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VMP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1109. Eukaryota.
ENOG410XQHA. LUCA.
GeneTreeiENSGT00390000007230.
HOVERGENiHBG057290.
InParanoidiQ96GC9.
OMAiFVRRNTW.
OrthoDBiEOG7BW0JG.
PhylomeDBiQ96GC9.
TreeFamiTF313699.

Family and domain databases

InterProiIPR032816. SNARE_assoc.
[Graphical view]
PfamiPF09335. SNARE_assoc. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96GC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAENGKNCDQ RRVAMNKEHH NGNFTDPSSV NEKKRREREE RQNIVLWRQP
60 70 80 90 100
LITLQYFSLE ILVILKEWTS KLWHRQSIVV SFLLLLAVLI ATYYVEGVHQ
110 120 130 140 150
QYVQRIEKQF LLYAYWIGLG ILSSVGLGTG LHTFLLYLGP HIASVTLAAY
160 170 180 190 200
ECNSVNFPEP PYPDQIICPD EEGTEGTISL WSIISKVRIE ACMWGIGTAI
210 220 230 240 250
GELPPYFMAR AARLSGAEPD DEEYQEFEEM LEHAESAQDF ASRAKLAVQK
260 270 280 290 300
LVQKVGFFGI LACASIPNPL FDLAGITCGH FLVPFWTFFG ATLIGKAIIK
310 320 330 340 350
MHIQKIFVII TFSKHIVEQM VAFIGAVPGI GPSLQKPFQE YLEAQRQKLH
360 370 380 390 400
HKSEMGTPQG ENWLSWMFEK LVVVMVCYFI LSIINSMAQS YAKRIQQRLN

SEEKTK
Length:406
Mass (Da):46,238
Last modified:December 1, 2001 - v1
Checksum:iE9DDE63F80143091
GO
Isoform 2 (identifier: Q96GC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-192: Missing.

Note: No experimental confirmation available.
Show »
Length:214
Mass (Da):24,148
Checksum:i12E4B3C1A5594A3E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791S → F in CAB66646 (PubMed:11230166).Curated
Sequence conflicti179 – 1791S → F in CAG38552 (Ref. 5) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 192192Missing in isoform 2. 1 PublicationVSP_056106Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214006 mRNA. Translation: AAL36461.1.
AB047551 mRNA. Translation: BAF47368.1.
AL136711 mRNA. Translation: CAB66646.1.
AK301254 mRNA. Translation: BAG62821.1.
CR533521 mRNA. Translation: CAG38552.1.
AC004686 Genomic DNA. No translation available.
AC025858 Genomic DNA. No translation available.
AC040904 Genomic DNA. No translation available.
AC091271 Genomic DNA. No translation available.
BC009758 mRNA. Translation: AAH09758.1.
AF161410 mRNA. Translation: AAF28970.1.
CCDSiCCDS11619.1. [Q96GC9-1]
RefSeqiNP_112200.2. NM_030938.3. [Q96GC9-1]
UniGeneiHs.444569.
Hs.708260.

Genome annotation databases

EnsembliENST00000262291; ENSP00000262291; ENSG00000062716. [Q96GC9-1]
GeneIDi81671.
KEGGihsa:81671.
UCSCiuc002ixu.5. human. [Q96GC9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214006 mRNA. Translation: AAL36461.1.
AB047551 mRNA. Translation: BAF47368.1.
AL136711 mRNA. Translation: CAB66646.1.
AK301254 mRNA. Translation: BAG62821.1.
CR533521 mRNA. Translation: CAG38552.1.
AC004686 Genomic DNA. No translation available.
AC025858 Genomic DNA. No translation available.
AC040904 Genomic DNA. No translation available.
AC091271 Genomic DNA. No translation available.
BC009758 mRNA. Translation: AAH09758.1.
AF161410 mRNA. Translation: AAF28970.1.
CCDSiCCDS11619.1. [Q96GC9-1]
RefSeqiNP_112200.2. NM_030938.3. [Q96GC9-1]
UniGeneiHs.444569.
Hs.708260.

3D structure databases

ProteinModelPortaliQ96GC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123567. 14 interactions.
IntActiQ96GC9. 9 interactions.
MINTiMINT-4721802.
STRINGi9606.ENSP00000262291.

PTM databases

iPTMnetiQ96GC9.
PhosphoSiteiQ96GC9.
SwissPalmiQ96GC9.

Polymorphism and mutation databases

BioMutaiVMP1.
DMDMi74731809.

Proteomic databases

EPDiQ96GC9.
MaxQBiQ96GC9.
PaxDbiQ96GC9.
PeptideAtlasiQ96GC9.
PRIDEiQ96GC9.
TopDownProteomicsiQ96GC9-1. [Q96GC9-1]

Protocols and materials databases

DNASUi81671.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262291; ENSP00000262291; ENSG00000062716. [Q96GC9-1]
GeneIDi81671.
KEGGihsa:81671.
UCSCiuc002ixu.5. human. [Q96GC9-1]

Organism-specific databases

CTDi81671.
GeneCardsiVMP1.
H-InvDBHIX0039412.
HGNCiHGNC:29559. VMP1.
HPAiHPA030773.
MIMi611753. gene.
neXtProtiNX_Q96GC9.
PharmGKBiPA142670765.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1109. Eukaryota.
ENOG410XQHA. LUCA.
GeneTreeiENSGT00390000007230.
HOVERGENiHBG057290.
InParanoidiQ96GC9.
OMAiFVRRNTW.
OrthoDBiEOG7BW0JG.
PhylomeDBiQ96GC9.
TreeFamiTF313699.

Miscellaneous databases

ChiTaRSiVMP1. human.
GeneWikiiTMEM49.
GenomeRNAii81671.
PROiQ96GC9.
SOURCEiSearch...

Gene expression databases

BgeeiQ96GC9.
CleanExiHS_TMEM49.
ExpressionAtlasiQ96GC9. baseline and differential.
GenevisibleiQ96GC9. HS.

Family and domain databases

InterProiIPR032816. SNARE_assoc.
[Graphical view]
PfamiPF09335. SNARE_assoc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gene Tdc1 is a transmembrane domain containing gene that amplified and overexpressed in human breast cancer."
    Wu G., Couch F.J.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "A novel lipopolysaccharide-inducible gene (#25)."
    Yamazaki S., Muta T., Takeshige K.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ovary.
  8. "Human partial CDS from CD34+ stem cells."
    Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 243-406 (ISOFORM 1).
    Tissue: Blood.
  9. "Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells."
    Sauermann M., Sahin O., Sultmann H., Hahne F., Blaszkiewicz S., Majety M., Zatloukal K., Fuzesi L., Poustka A., Wiemann S., Arlt D.
    Oncogene 27:1320-1326(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TJP1, SUBCELLULAR LOCATION.
  10. Cited for: INTERACTION WITH TP53INP2.
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVMP1_HUMAN
AccessioniPrimary (citable) accession number: Q96GC9
Secondary accession number(s): B4DVV9, Q9H0P4, Q9P089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.