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Protein

39S ribosomal protein L48, mitochondrial

Gene

MRPL48

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L48, mitochondrial
Short name:
L48mt
Short name:
MRP-L48
Gene namesi
Name:MRPL48
ORF Names:CGI-118, HSPC290
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:16653. MRPL48.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30980.

Polymorphism and mutation databases

BioMutaiMRPL48.
DMDMi118573683.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2828MitochondrionSequence analysisAdd
BLAST
Chaini29 – 21218439S ribosomal protein L48, mitochondrialPRO_0000261657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei199 – 1991N6-succinyllysineBy similarity

Proteomic databases

EPDiQ96GC5.
MaxQBiQ96GC5.
PaxDbiQ96GC5.
PeptideAtlasiQ96GC5.
PRIDEiQ96GC5.
TopDownProteomicsiQ96GC5-1. [Q96GC5-1]

PTM databases

iPTMnetiQ96GC5.
PhosphoSiteiQ96GC5.

Expressioni

Gene expression databases

BgeeiENSG00000175581.
CleanExiHS_MRPL48.
ExpressionAtlasiQ96GC5. baseline and differential.
GenevisibleiQ96GC5. HS.

Organism-specific databases

HPAiHPA040241.
HPA040864.

Interactioni

Subunit structurei

Interacts with OXA1L.By similarity

Protein-protein interaction databases

BioGridi119652. 39 interactions.
IntActiQ96GC5. 16 interactions.
MINTiMINT-8052039.
STRINGi9606.ENSP00000308717.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40f1-194[»]
3J9Melectron microscopy3.50f1-194[»]
ProteinModelPortaliQ96GC5.
SMRiQ96GC5. Positions 48-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi69 – 746Poly-Lys

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4060. Eukaryota.
ENOG4111XHC. LUCA.
GeneTreeiENSGT00390000012955.
HOGENOMiHOG000070027.
HOVERGENiHBG055302.
InParanoidiQ96GC5.
KOiK17429.
OMAiPTHGIGK.
OrthoDBiEOG091G0PC2.
PhylomeDBiQ96GC5.
TreeFamiTF315130.

Family and domain databases

Gene3Di3.30.70.600. 1 hit.
InterProiIPR027487. Ribosomal_L48.
IPR027486. Ribosomal_S10_dom.
[Graphical view]
PANTHERiPTHR13473. PTHR13473. 1 hit.
PfamiPF00338. Ribosomal_S10. 1 hit.
[Graphical view]
SMARTiSM01403. Ribosomal_S10. 1 hit.
[Graphical view]
SUPFAMiSSF54999. SSF54999. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96GC5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGTLEKVLC LRNNTIFKQA FSLLRFRTSG EKPIYSVGGI LLSISRPYKT
60 70 80 90 100
KPTHGIGKYK HLIKAEEPKK KKGKVEVRAI NLGTDYEYGV LNIHLTAYDM
110 120 130 140 150
TLAESYAQYV HNLCNSLSIK VEESYAMPTK TIEVLQLQDQ GSKMLLDSVL
160 170 180 190 200
TTHERVVQIS GLSATFAEIF LEIIQSSLPE GVRLSVKEHT EEDFKGRFKA
210
RPELEELLAK LK
Length:212
Mass (Da):23,935
Last modified:November 28, 2006 - v2
Checksum:i0663B1751B57FFF5
GO
Isoform 2 (identifier: Q96GC5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MSGTLEKVLCLRNNTIFKQAFSLLRFRTSGEKPIYSV → MGLSSCRKTSSGLPLILHY

Note: No experimental confirmation available.
Show »
Length:194
Mass (Da):21,749
Checksum:i6856CF1F86AC535F
GO

Sequence cautioni

The sequence AAF28968 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61E → G.1 Publication
Corresponds to variant rs17850551 [ dbSNP | Ensembl ].
VAR_029473

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3737MSGTL…PIYSV → MGLSSCRKTSSGLPLILHY in isoform 2. 1 PublicationVSP_054130Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151876 mRNA. Translation: AAD34113.1.
AF161408 mRNA. Translation: AAF28968.1. Different initiation.
AK297746 mRNA. Translation: BAG60096.1.
AP002770 Genomic DNA. No translation available.
BC009764 mRNA. Translation: AAH09764.1.
CCDSiCCDS44676.1. [Q96GC5-1]
RefSeqiNP_001305427.1. NM_001318498.1. [Q96GC5-3]
NP_001305428.1. NM_001318499.1.
NP_001305429.1. NM_001318500.1.
NP_057139.1. NM_016055.5. [Q96GC5-1]
UniGeneiHs.503239.

Genome annotation databases

EnsembliENST00000310614; ENSP00000308717; ENSG00000175581. [Q96GC5-1]
GeneIDi51642.
KEGGihsa:51642.
UCSCiuc001ouh.5. human. [Q96GC5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151876 mRNA. Translation: AAD34113.1.
AF161408 mRNA. Translation: AAF28968.1. Different initiation.
AK297746 mRNA. Translation: BAG60096.1.
AP002770 Genomic DNA. No translation available.
BC009764 mRNA. Translation: AAH09764.1.
CCDSiCCDS44676.1. [Q96GC5-1]
RefSeqiNP_001305427.1. NM_001318498.1. [Q96GC5-3]
NP_001305428.1. NM_001318499.1.
NP_001305429.1. NM_001318500.1.
NP_057139.1. NM_016055.5. [Q96GC5-1]
UniGeneiHs.503239.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40f1-194[»]
3J9Melectron microscopy3.50f1-194[»]
ProteinModelPortaliQ96GC5.
SMRiQ96GC5. Positions 48-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119652. 39 interactions.
IntActiQ96GC5. 16 interactions.
MINTiMINT-8052039.
STRINGi9606.ENSP00000308717.

PTM databases

iPTMnetiQ96GC5.
PhosphoSiteiQ96GC5.

Polymorphism and mutation databases

BioMutaiMRPL48.
DMDMi118573683.

Proteomic databases

EPDiQ96GC5.
MaxQBiQ96GC5.
PaxDbiQ96GC5.
PeptideAtlasiQ96GC5.
PRIDEiQ96GC5.
TopDownProteomicsiQ96GC5-1. [Q96GC5-1]

Protocols and materials databases

DNASUi51642.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310614; ENSP00000308717; ENSG00000175581. [Q96GC5-1]
GeneIDi51642.
KEGGihsa:51642.
UCSCiuc001ouh.5. human. [Q96GC5-1]

Organism-specific databases

CTDi51642.
GeneCardsiMRPL48.
HGNCiHGNC:16653. MRPL48.
HPAiHPA040241.
HPA040864.
MIMi611853. gene.
neXtProtiNX_Q96GC5.
PharmGKBiPA30980.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4060. Eukaryota.
ENOG4111XHC. LUCA.
GeneTreeiENSGT00390000012955.
HOGENOMiHOG000070027.
HOVERGENiHBG055302.
InParanoidiQ96GC5.
KOiK17429.
OMAiPTHGIGK.
OrthoDBiEOG091G0PC2.
PhylomeDBiQ96GC5.
TreeFamiTF315130.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL48. human.
GenomeRNAii51642.
PROiQ96GC5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175581.
CleanExiHS_MRPL48.
ExpressionAtlasiQ96GC5. baseline and differential.
GenevisibleiQ96GC5. HS.

Family and domain databases

Gene3Di3.30.70.600. 1 hit.
InterProiIPR027487. Ribosomal_L48.
IPR027486. Ribosomal_S10_dom.
[Graphical view]
PANTHERiPTHR13473. PTHR13473. 1 hit.
PfamiPF00338. Ribosomal_S10. 1 hit.
[Graphical view]
SMARTiSM01403. Ribosomal_S10. 1 hit.
[Graphical view]
SUPFAMiSSF54999. SSF54999. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM48_HUMAN
AccessioniPrimary (citable) accession number: Q96GC5
Secondary accession number(s): B4DN34
, Q49AK7, Q4U2Q4, Q9P091, Q9Y5J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: September 7, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.