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Q96GA7

- SDSL_HUMAN

UniProt

Q96GA7 - SDSL_HUMAN

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Protein

Serine dehydratase-like

Gene

SDSL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has low serine dehydratase and threonine dehydratase activity.

Catalytic activityi

L-serine = pyruvate + NH3.1 Publication
L-threonine = 2-oxobutanoate + NH3.1 Publication

Cofactori

Pyridoxal phosphate.

Kineticsi

  1. KM=30 mM for serine
  2. KM=7 mM for threonine

GO - Molecular functioni

  1. L-serine ammonia-lyase activity Source: UniProtKB-EC
  2. L-threonine ammonia-lyase activity Source: UniProtKB-EC
  3. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS06616-MONOMER.
SABIO-RKQ96GA7.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine dehydratase-like
Alternative name(s):
L-serine deaminase
L-serine dehydratase/L-threonine deaminase
L-threonine dehydratase (EC:4.3.1.19)
Short name:
TDH
Serine dehydratase 2 (EC:4.3.1.17)
Short name:
SDH 2
Gene namesi
Name:SDSL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:30404. SDSL.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. mitochondrion Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi72 – 721G → A: Strongly increased enzyme activity towards threonine. 1 Publication
Mutagenesisi309 – 3091C → A: Loss of enzyme activity. 1 Publication

Organism-specific databases

PharmGKBiPA134862016.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Serine dehydratase-likePRO_0000264624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei48 – 481N6-(pyridoxal phosphate)lysine

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96GA7.
PaxDbiQ96GA7.
PRIDEiQ96GA7.

PTM databases

PhosphoSiteiQ96GA7.

Expressioni

Gene expression databases

BgeeiQ96GA7.
CleanExiHS_SDSL.
ExpressionAtlasiQ96GA7. baseline and differential.
GenevestigatoriQ96GA7.

Organism-specific databases

HPAiHPA005740.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi125255. 3 interactions.
IntActiQ96GA7. 2 interactions.
MINTiMINT-1456379.
STRINGi9606.ENSP00000341117.

Structurei

Secondary structure

1
329
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi20 – 234
Helixi24 – 307
Beta strandi34 – 385
Helixi39 – 413
Helixi49 – 6113
Beta strandi66 – 694
Helixi74 – 8512
Beta strandi90 – 945
Helixi100 – 1089
Beta strandi112 – 1154
Helixi120 – 13213
Beta strandi136 – 1383
Helixi145 – 16117
Beta strandi162 – 1643
Beta strandi167 – 1726
Beta strandi174 – 1763
Helixi177 – 18913
Beta strandi196 – 2016
Helixi206 – 2138
Helixi227 – 2293
Helixi236 – 2449
Beta strandi247 – 2526
Helixi254 – 26815
Helixi274 – 28411
Helixi287 – 2937
Beta strandi304 – 3085
Helixi316 – 32510

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RKBX-ray2.80A/B/C/D/E11-328[»]
ProteinModelPortaliQ96GA7.
SMRiQ96GA7. Positions 11-328.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96GA7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1171.
GeneTreeiENSGT00550000074775.
HOGENOMiHOG000046976.
HOVERGENiHBG017784.
InParanoidiQ96GA7.
KOiK17989.
OMAiETHGAHC.
OrthoDBiEOG7VDXQ1.
PhylomeDBiQ96GA7.
TreeFamiTF329014.

Family and domain databases

InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96GA7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGPVAEHAK QEPFHVVTPL LESWALSQVA GMPVFLKCEN VQPSGSFKIR
60 70 80 90 100
GIGHFCQEMA KKGCRHLVCS SGGNAGIAAA YAARKLGIPA TIVLPESTSL
110 120 130 140 150
QVVQRLQGEG AEVQLTGKVW DEANLRAQEL AKRDGWENVP PFDHPLIWKG
160 170 180 190 200
HASLVQELKA VLRTPPGALV LAVGGGGLLA GVVAGLLEVG WQHVPIIAME
210 220 230 240 250
THGAHCFNAA ITAGKLVTLP DITSVAKSLG AKTVAARALE CMQVCKIHSE
260 270 280 290 300
VVEDTEAVSA VQQLLDDERM LVEPACGAAL AAIYSGLLRR LQAEGCLPPS
310 320
LTSVVVIVCG GNNINSRELQ ALKTHLGQV
Length:329
Mass (Da):34,674
Last modified:December 1, 2001 - v1
Checksum:iCEAD30E570A43B7E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF134473 mRNA. Translation: AAP97250.1.
BC009849 mRNA. Translation: AAH09849.1.
BC091479 mRNA. Translation: AAH91479.1.
CCDSiCCDS9170.1.
RefSeqiNP_612441.1. NM_138432.2.
XP_005253887.1. XM_005253830.2.
XP_005253888.1. XM_005253831.2.
UniGeneiHs.337594.

Genome annotation databases

EnsembliENST00000345635; ENSP00000341117; ENSG00000139410.
ENST00000403593; ENSP00000385790; ENSG00000139410.
GeneIDi113675.
KEGGihsa:113675.
UCSCiuc001tvi.3. human.

Polymorphism databases

DMDMi74731799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF134473 mRNA. Translation: AAP97250.1 .
BC009849 mRNA. Translation: AAH09849.1 .
BC091479 mRNA. Translation: AAH91479.1 .
CCDSi CCDS9170.1.
RefSeqi NP_612441.1. NM_138432.2.
XP_005253887.1. XM_005253830.2.
XP_005253888.1. XM_005253831.2.
UniGenei Hs.337594.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2RKB X-ray 2.80 A/B/C/D/E 11-328 [» ]
ProteinModelPortali Q96GA7.
SMRi Q96GA7. Positions 11-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125255. 3 interactions.
IntActi Q96GA7. 2 interactions.
MINTi MINT-1456379.
STRINGi 9606.ENSP00000341117.

PTM databases

PhosphoSitei Q96GA7.

Polymorphism databases

DMDMi 74731799.

Proteomic databases

MaxQBi Q96GA7.
PaxDbi Q96GA7.
PRIDEi Q96GA7.

Protocols and materials databases

DNASUi 113675.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000345635 ; ENSP00000341117 ; ENSG00000139410 .
ENST00000403593 ; ENSP00000385790 ; ENSG00000139410 .
GeneIDi 113675.
KEGGi hsa:113675.
UCSCi uc001tvi.3. human.

Organism-specific databases

CTDi 113675.
GeneCardsi GC12P113860.
HGNCi HGNC:30404. SDSL.
HPAi HPA005740.
neXtProti NX_Q96GA7.
PharmGKBi PA134862016.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1171.
GeneTreei ENSGT00550000074775.
HOGENOMi HOG000046976.
HOVERGENi HBG017784.
InParanoidi Q96GA7.
KOi K17989.
OMAi ETHGAHC.
OrthoDBi EOG7VDXQ1.
PhylomeDBi Q96GA7.
TreeFami TF329014.

Enzyme and pathway databases

BioCyci MetaCyc:HS06616-MONOMER.
SABIO-RK Q96GA7.

Miscellaneous databases

ChiTaRSi SDSL. human.
EvolutionaryTracei Q96GA7.
GenomeRNAii 113675.
NextBioi 78888.
PROi Q96GA7.

Gene expression databases

Bgeei Q96GA7.
CleanExi HS_SDSL.
ExpressionAtlasi Q96GA7. baseline and differential.
Genevestigatori Q96GA7.

Family and domain databases

InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR001926. TrpB-like_PLP-dep.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
SUPFAMi SSF53686. SSF53686. 1 hit.
PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new human cDNA homologous to Homo sapiens serine dehydratase."
    Gong R.M., Yu L., Zhao S.Y.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Placenta.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies."
    Yamada T., Komoto J., Kasuya T., Takata Y., Ogawa H., Mori H., Takusagawa F.
    Biochim. Biophys. Acta 1780:809-818(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 11-328 IN COMPLEX WITH PYRIDOXAL PHOSPHATE, CATALYTIC ACTIVITY, SUBUNIT, MUTAGENESIS OF GLY-72 AND CYS-309.

Entry informationi

Entry nameiSDSL_HUMAN
AccessioniPrimary (citable) accession number: Q96GA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3