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Protein

Protein LTV1 homolog

Gene

LTV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LTV1 homolog
Gene namesi
Name:LTV1
Synonyms:C6orf93
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21173. LTV1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134893631.

Polymorphism and mutation databases

BioMutaiLTV1.
DMDMi74751878.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Protein LTV1 homologPRO_0000302813Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481PhosphoserineBy similarity
Modified residuei331 – 3311PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96GA3.
MaxQBiQ96GA3.
PaxDbiQ96GA3.
PeptideAtlasiQ96GA3.
PRIDEiQ96GA3.

PTM databases

iPTMnetiQ96GA3.
PhosphoSiteiQ96GA3.

Expressioni

Gene expression databases

BgeeiQ96GA3.
CleanExiHS_LTV1.
GenevisibleiQ96GA3. HS.

Organism-specific databases

HPAiHPA030159.
HPA030160.
HPA030161.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BYSLQ138955EBI-2558389,EBI-358049

Protein-protein interaction databases

BioGridi124379. 32 interactions.
IntActiQ96GA3. 19 interactions.
STRINGi9606.ENSP00000356548.

Structurei

3D structure databases

ProteinModelPortaliQ96GA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili418 – 47558Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi137 – 21478Asp-richAdd
BLAST
Compositional biasi330 – 3356Poly-Glu

Sequence similaritiesi

Belongs to the LTV1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2637. Eukaryota.
ENOG410XP9T. LUCA.
GeneTreeiENSGT00390000002789.
HOGENOMiHOG000047205.
HOVERGENiHBG104438.
InParanoidiQ96GA3.
KOiK14798.
OMAiFWSEETK.
OrthoDBiEOG7P5T19.
PhylomeDBiQ96GA3.
TreeFamiTF314845.

Family and domain databases

InterProiIPR007307. LTV.
[Graphical view]
PfamiPF04180. LTV. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96GA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHRKKKPFI EKKKAVSFHL VHRSQRDPLA ADESAPQRVL LPTQKIDNEE
60 70 80 90 100
RRAEQRKYGV FFDDDYDYLQ HLKEPSGPSE LIPSSTFSAH NRREEKEETL
110 120 130 140 150
VIPSTGIKLP SSVFASEFEE DVGLLNKAAP VSGPRLDFDP DIVAALDDDF
160 170 180 190 200
DFDDPDNLLE DDFILQANKA TGEEEGMDIQ KSENEDDSEW EDVDDEKGDS
210 220 230 240 250
NDDYDSAGLL SDEDCMSVPG KTHRAIADHL FWSEETKSRF TEYSMTSSVM
260 270 280 290 300
RRNEQLTLHD ERFEKFYEQY DDDEIGALDN AELEGSIQVD SNRLQEVLND
310 320 330 340 350
YYKEKAENCV KLNTLEPLED QDLPMNELDE SEEEEMITVV LEEAKEKWDC
360 370 380 390 400
ESICSTYSNL YNHPQLIKYQ PKPKQIRISS KTGIPLNVLP KKGLTAKQTE
410 420 430 440 450
RIQMINGSDL PKVSTQPRSK NESKEDKRAR KQAIKEERKE RRVEKKANKL
460 470
AFKLEKRRQE KELLNLKKNV EGLKL
Length:475
Mass (Da):54,855
Last modified:December 1, 2001 - v1
Checksum:i76AB95901C5BF239
GO

Sequence cautioni

The sequence BAB55388.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049844 Genomic DNA. Translation: CAI21442.1.
CH471051 Genomic DNA. Translation: EAW47859.1.
BC009855 mRNA. Translation: AAH09855.1.
AK027815 mRNA. Translation: BAB55388.1. Different initiation.
CCDSiCCDS5201.1.
RefSeqiNP_116249.2. NM_032860.3.
UniGeneiHs.185675.

Genome annotation databases

EnsembliENST00000367576; ENSP00000356548; ENSG00000135521.
GeneIDi84946.
KEGGihsa:84946.
UCSCiuc003qjs.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049844 Genomic DNA. Translation: CAI21442.1.
CH471051 Genomic DNA. Translation: EAW47859.1.
BC009855 mRNA. Translation: AAH09855.1.
AK027815 mRNA. Translation: BAB55388.1. Different initiation.
CCDSiCCDS5201.1.
RefSeqiNP_116249.2. NM_032860.3.
UniGeneiHs.185675.

3D structure databases

ProteinModelPortaliQ96GA3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124379. 32 interactions.
IntActiQ96GA3. 19 interactions.
STRINGi9606.ENSP00000356548.

PTM databases

iPTMnetiQ96GA3.
PhosphoSiteiQ96GA3.

Polymorphism and mutation databases

BioMutaiLTV1.
DMDMi74751878.

Proteomic databases

EPDiQ96GA3.
MaxQBiQ96GA3.
PaxDbiQ96GA3.
PeptideAtlasiQ96GA3.
PRIDEiQ96GA3.

Protocols and materials databases

DNASUi84946.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367576; ENSP00000356548; ENSG00000135521.
GeneIDi84946.
KEGGihsa:84946.
UCSCiuc003qjs.4. human.

Organism-specific databases

CTDi84946.
GeneCardsiLTV1.
H-InvDBHIX0200846.
HGNCiHGNC:21173. LTV1.
HPAiHPA030159.
HPA030160.
HPA030161.
neXtProtiNX_Q96GA3.
PharmGKBiPA134893631.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2637. Eukaryota.
ENOG410XP9T. LUCA.
GeneTreeiENSGT00390000002789.
HOGENOMiHOG000047205.
HOVERGENiHBG104438.
InParanoidiQ96GA3.
KOiK14798.
OMAiFWSEETK.
OrthoDBiEOG7P5T19.
PhylomeDBiQ96GA3.
TreeFamiTF314845.

Enzyme and pathway databases

ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

ChiTaRSiLTV1. human.
GenomeRNAii84946.
PROiQ96GA3.

Gene expression databases

BgeeiQ96GA3.
CleanExiHS_LTV1.
GenevisibleiQ96GA3. HS.

Family and domain databases

InterProiIPR007307. LTV.
[Graphical view]
PfamiPF04180. LTV. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 49-475.
    Tissue: Placenta.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLTV1_HUMAN
AccessioniPrimary (citable) accession number: Q96GA3
Secondary accession number(s): Q96JX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.