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Protein

P2Y purinoceptor 11

Gene

P2RY11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.

GO - Molecular functioni

  • ATP-activated nucleotide receptor activity Source: BHF-UCL
  • G-protein coupled purinergic nucleotide receptor activity Source: InterPro
  • neurotransmitter receptor activity Source: BHF-UCL
  • receptor activity Source: ProtInc

GO - Biological processi

  • activation of adenylate cyclase activity Source: ProtInc
  • adenosine receptor signaling pathway Source: GOC
  • calcium-mediated signaling Source: BHF-UCL
  • cellular response to ATP Source: BHF-UCL
  • defense response Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: BHF-UCL
  • neuronal signal transduction Source: BHF-UCL
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
  • synaptic transmission Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 11
Short name:
P2Y11
Gene namesi
Name:P2RY11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8540. P2RY11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
BLAST
Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini51 – 6414CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei65 – 8521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini86 – 11631ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini138 – 1469CytoplasmicSequence Analysis
Transmembranei147 – 16721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini168 – 20639ExtracellularSequence AnalysisAdd
BLAST
Transmembranei207 – 22721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini228 – 24518CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei246 – 26621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini267 – 30842ExtracellularSequence AnalysisAdd
BLAST
Transmembranei309 – 32921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini330 – 37445CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: BHF-UCL
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti2073. Narcolepsy-cataplexy.
PharmGKBiPA32869.

Polymorphism and mutation databases

BioMutaiP2RY11.
DMDMi21263830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374P2Y purinoceptor 11PRO_0000070035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi102 ↔ 180PROSITE-ProRule annotation
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96G91.
PRIDEiQ96G91.

PTM databases

PhosphoSiteiQ96G91.

Expressioni

Tissue specificityi

Highest expression in liver and spleen.1 Publication

Inductioni

Increased by DMSO and retinoic acid.

Gene expression databases

BgeeiQ96G91.
GenevisibleiQ96G91. HS.

Organism-specific databases

HPAiHPA014232.

Interactioni

Protein-protein interaction databases

IntActiQ96G91. 1 interaction.
STRINGi9606.ENSP00000323872.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B6Smodel-A1-374[»]
ProteinModelPortaliQ96G91.
SMRiQ96G91. Positions 26-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG272199.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000059583.
HOVERGENiHBG105351.
InParanoidiQ96G91.
KOiK08387.
OrthoDBiEOG71G9TZ.
PhylomeDBiQ96G91.
TreeFamiTF330775.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027677. P2Y11_rcpt.
[Graphical view]
PANTHERiPTHR24237:SF3. PTHR24237:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96G91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANVSGAKS CPANFLAAAD DKLSGFQGDF LWPILVVEFL VAVASNGLAL
60 70 80 90 100
YRFSIRKQRP WHPAVVFSVQ LAVSDLLCAL TLPPLAAYLY PPKHWRYGEA
110 120 130 140 150
ACRLERFLFT CNLLGSVIFI TCISLNRYLG IVHPFFARSH LRPKHAWAVS
160 170 180 190 200
AAGWVLAALL AMPTLSFSHL KRPQQGAGNC SVARPEACIK CLGTADHGLA
210 220 230 240 250
AYRAYSLVLA GLGCGLPLLL TLAAYGALGR AVLRSPGMTV AEKLRVAALV
260 270 280 290 300
ASGVALYASS YVPYHIMRVL NVDARRRWST RCPSFADIAQ ATAALELGPY
310 320 330 340 350
VGYQVMRGLM PLAFCVHPLL YMAAVPSLGC CCRHCPGYRD SWNPEDAKST
360 370
GQALPLNATA APKPSEPQSR ELSQ
Length:374
Mass (Da):40,345
Last modified:May 27, 2002 - v2
Checksum:iC02DF9B3B381D25E
GO

Sequence cautioni

The sequence AAB88674.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAC18877.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871A → T.
Corresponds to variant rs3745601 [ dbSNP | Ensembl ].
VAR_020074

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030335 mRNA. Translation: AAB88674.1. Different initiation.
AJ298334 mRNA. Translation: CAC29362.1.
AJ300588 mRNA. Translation: CAC18877.1. Different initiation.
AY449733 mRNA. Translation: AAR18077.1.
AK313550 mRNA. Translation: BAG36326.1.
CH471106 Genomic DNA. Translation: EAW84077.1.
BC073827 mRNA. Translation: AAH73827.1.
AF498921 mRNA. Translation: AAM18130.1.
CCDSiCCDS12226.1.
RefSeqiNP_002557.2. NM_002566.4.
UniGeneiHs.14468.

Genome annotation databases

EnsembliENST00000321826; ENSP00000323872; ENSG00000244165.
GeneIDi5032.
KEGGihsa:5032.
UCSCiuc002mnc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030335 mRNA. Translation: AAB88674.1. Different initiation.
AJ298334 mRNA. Translation: CAC29362.1.
AJ300588 mRNA. Translation: CAC18877.1. Different initiation.
AY449733 mRNA. Translation: AAR18077.1.
AK313550 mRNA. Translation: BAG36326.1.
CH471106 Genomic DNA. Translation: EAW84077.1.
BC073827 mRNA. Translation: AAH73827.1.
AF498921 mRNA. Translation: AAM18130.1.
CCDSiCCDS12226.1.
RefSeqiNP_002557.2. NM_002566.4.
UniGeneiHs.14468.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B6Smodel-A1-374[»]
ProteinModelPortaliQ96G91.
SMRiQ96G91. Positions 26-323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96G91. 1 interaction.
STRINGi9606.ENSP00000323872.

Chemistry

BindingDBiQ96G91.
ChEMBLiCHEMBL4867.
GuidetoPHARMACOLOGYi327.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ96G91.

Polymorphism and mutation databases

BioMutaiP2RY11.
DMDMi21263830.

Proteomic databases

PaxDbiQ96G91.
PRIDEiQ96G91.

Protocols and materials databases

DNASUi5032.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321826; ENSP00000323872; ENSG00000244165.
GeneIDi5032.
KEGGihsa:5032.
UCSCiuc002mnc.3. human.

Organism-specific databases

CTDi5032.
GeneCardsiGC19P010222.
HGNCiHGNC:8540. P2RY11.
HPAiHPA014232.
MIMi602697. gene.
neXtProtiNX_Q96G91.
Orphaneti2073. Narcolepsy-cataplexy.
PharmGKBiPA32869.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG272199.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000059583.
HOVERGENiHBG105351.
InParanoidiQ96G91.
KOiK08387.
OrthoDBiEOG71G9TZ.
PhylomeDBiQ96G91.
TreeFamiTF330775.

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiP2RY11.
GenomeRNAii5032.
NextBioi19388.
PROiQ96G91.
SOURCEiSearch...

Gene expression databases

BgeeiQ96G91.
GenevisibleiQ96G91. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027677. P2Y11_rcpt.
[Graphical view]
PANTHERiPTHR24237:SF3. PTHR24237:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes."
    Communi D., Suarez-Huerta N., Dussossoy D., Savi P., Boeynaems J.-M.
    J. Biol. Chem. 276:16561-16566(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, TRANS-SPLICING.
    Tissue: Placenta and Promyelocyte.
  2. "Isolation of cDNA coding for purinergic receptor P2Y, G protein-coupled, 11 (P2RY11)."
    King M.M., Aronstam R.S., Sharma S.V.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase."
    Communi D., Govaerts C., Parmentier M., Boeynaems J.-M.
    J. Biol. Chem. 272:31969-31973(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-374.
    Tissue: Placenta.
  7. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-374.

Entry informationi

Entry nameiP2Y11_HUMAN
AccessioniPrimary (citable) accession number: Q96G91
Secondary accession number(s): B2R8X9
, O43190, Q9BYU4, Q9H170
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: July 22, 2015
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed:11278528).1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.