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Q96G91

- P2Y11_HUMAN

UniProt

Q96G91 - P2Y11_HUMAN

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Protein
P2Y purinoceptor 11
Gene
P2RY11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.

GO - Molecular functioni

  1. ATP-activated nucleotide receptor activity Source: BHF-UCL
  2. G-protein coupled purinergic nucleotide receptor activity Source: InterPro
  3. neurotransmitter receptor activity Source: BHF-UCL
  4. receptor activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: BHF-UCL
  2. activation of adenylate cyclase activity Source: ProtInc
  3. adenosine receptor signaling pathway Source: GOC
  4. calcium-mediated signaling Source: BHF-UCL
  5. cellular response to ATP Source: BHF-UCL
  6. defense response Source: ProtInc
  7. neuronal signal transduction Source: BHF-UCL
  8. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
  9. synaptic transmission Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 11
Short name:
P2Y11
Gene namesi
Name:P2RY11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:8540. P2RY11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929Extracellular Reviewed prediction
Add
BLAST
Transmembranei30 – 5021Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini51 – 6414Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei65 – 8521Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini86 – 11631Extracellular Reviewed prediction
Add
BLAST
Transmembranei117 – 13721Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini138 – 1469Cytoplasmic Reviewed prediction
Transmembranei147 – 16721Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini168 – 20639Extracellular Reviewed prediction
Add
BLAST
Transmembranei207 – 22721Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini228 – 24518Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei246 – 26621Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini267 – 30842Extracellular Reviewed prediction
Add
BLAST
Transmembranei309 – 32921Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini330 – 37445Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: BHF-UCL
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti2073. Narcolepsy-cataplexy.
PharmGKBiPA32869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374P2Y purinoceptor 11
PRO_0000070035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi102 ↔ 180 By similarity
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96G91.
PRIDEiQ96G91.

PTM databases

PhosphoSiteiQ96G91.

Expressioni

Tissue specificityi

Highest expression in liver and spleen.1 Publication

Inductioni

Increased by DMSO and retinoic acid.

Gene expression databases

BgeeiQ96G91.
GenevestigatoriQ96G91.

Organism-specific databases

HPAiHPA014232.

Interactioni

Protein-protein interaction databases

IntActiQ96G91. 1 interaction.
STRINGi9606.ENSP00000323872.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B6Smodel-A1-374[»]
ProteinModelPortaliQ96G91.
SMRiQ96G91. Positions 26-323.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG272199.
HOGENOMiHOG000059583.
HOVERGENiHBG105351.
InParanoidiQ96G91.
KOiK08387.
OrthoDBiEOG71G9TZ.
PhylomeDBiQ96G91.
TreeFamiTF330775.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027677. P2Y11_rcpt.
[Graphical view]
PANTHERiPTHR24237:SF3. PTHR24237:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96G91-1 [UniParc]FASTAAdd to Basket

« Hide

MAANVSGAKS CPANFLAAAD DKLSGFQGDF LWPILVVEFL VAVASNGLAL    50
YRFSIRKQRP WHPAVVFSVQ LAVSDLLCAL TLPPLAAYLY PPKHWRYGEA 100
ACRLERFLFT CNLLGSVIFI TCISLNRYLG IVHPFFARSH LRPKHAWAVS 150
AAGWVLAALL AMPTLSFSHL KRPQQGAGNC SVARPEACIK CLGTADHGLA 200
AYRAYSLVLA GLGCGLPLLL TLAAYGALGR AVLRSPGMTV AEKLRVAALV 250
ASGVALYASS YVPYHIMRVL NVDARRRWST RCPSFADIAQ ATAALELGPY 300
VGYQVMRGLM PLAFCVHPLL YMAAVPSLGC CCRHCPGYRD SWNPEDAKST 350
GQALPLNATA APKPSEPQSR ELSQ 374
Length:374
Mass (Da):40,345
Last modified:May 27, 2002 - v2
Checksum:iC02DF9B3B381D25E
GO

Sequence cautioni

The sequence AAB88674.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAC18877.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871A → T.
Corresponds to variant rs3745601 [ dbSNP | Ensembl ].
VAR_020074

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030335 mRNA. Translation: AAB88674.1. Different initiation.
AJ298334 mRNA. Translation: CAC29362.1.
AJ300588 mRNA. Translation: CAC18877.1. Different initiation.
AY449733 mRNA. Translation: AAR18077.1.
AK313550 mRNA. Translation: BAG36326.1.
CH471106 Genomic DNA. Translation: EAW84077.1.
BC073827 mRNA. Translation: AAH73827.1.
AF498921 mRNA. Translation: AAM18130.1.
CCDSiCCDS12226.1.
RefSeqiNP_002557.2. NM_002566.4.
UniGeneiHs.14468.

Genome annotation databases

EnsembliENST00000321826; ENSP00000323872; ENSG00000244165.
GeneIDi5032.
KEGGihsa:5032.
UCSCiuc002mnc.3. human.

Polymorphism databases

DMDMi21263830.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030335 mRNA. Translation: AAB88674.1 . Different initiation.
AJ298334 mRNA. Translation: CAC29362.1 .
AJ300588 mRNA. Translation: CAC18877.1 . Different initiation.
AY449733 mRNA. Translation: AAR18077.1 .
AK313550 mRNA. Translation: BAG36326.1 .
CH471106 Genomic DNA. Translation: EAW84077.1 .
BC073827 mRNA. Translation: AAH73827.1 .
AF498921 mRNA. Translation: AAM18130.1 .
CCDSi CCDS12226.1.
RefSeqi NP_002557.2. NM_002566.4.
UniGenei Hs.14468.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2B6S model - A 1-374 [» ]
ProteinModelPortali Q96G91.
SMRi Q96G91. Positions 26-323.
ModBasei Search...

Protein-protein interaction databases

IntActi Q96G91. 1 interaction.
STRINGi 9606.ENSP00000323872.

Chemistry

BindingDBi Q96G91.
ChEMBLi CHEMBL4867.
GuidetoPHARMACOLOGYi 327.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q96G91.

Polymorphism databases

DMDMi 21263830.

Proteomic databases

PaxDbi Q96G91.
PRIDEi Q96G91.

Protocols and materials databases

DNASUi 5032.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000321826 ; ENSP00000323872 ; ENSG00000244165 .
GeneIDi 5032.
KEGGi hsa:5032.
UCSCi uc002mnc.3. human.

Organism-specific databases

CTDi 5032.
GeneCardsi GC19P010222.
HGNCi HGNC:8540. P2RY11.
HPAi HPA014232.
MIMi 602697. gene.
neXtProti NX_Q96G91.
Orphaneti 2073. Narcolepsy-cataplexy.
PharmGKBi PA32869.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272199.
HOGENOMi HOG000059583.
HOVERGENi HBG105351.
InParanoidi Q96G91.
KOi K08387.
OrthoDBi EOG71G9TZ.
PhylomeDBi Q96G91.
TreeFami TF330775.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikii P2RY11.
GenomeRNAii 5032.
NextBioi 19388.
PROi Q96G91.
SOURCEi Search...

Gene expression databases

Bgeei Q96G91.
Genevestigatori Q96G91.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027677. P2Y11_rcpt.
[Graphical view ]
PANTHERi PTHR24237:SF3. PTHR24237:SF3. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes."
    Communi D., Suarez-Huerta N., Dussossoy D., Savi P., Boeynaems J.-M.
    J. Biol. Chem. 276:16561-16566(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, TRANS-SPLICING.
    Tissue: Placenta and Promyelocyte.
  2. "Isolation of cDNA coding for purinergic receptor P2Y, G protein-coupled, 11 (P2RY11)."
    King M.M., Aronstam R.S., Sharma S.V.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase."
    Communi D., Govaerts C., Parmentier M., Boeynaems J.-M.
    J. Biol. Chem. 272:31969-31973(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-374.
    Tissue: Placenta.
  7. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-374.

Entry informationi

Entry nameiP2Y11_HUMAN
AccessioniPrimary (citable) accession number: Q96G91
Secondary accession number(s): B2R8X9
, O43190, Q9BYU4, Q9H170
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: September 3, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (1 Publication).

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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