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Protein

P2Y purinoceptor 11

Gene

P2RY11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.

GO - Molecular functioni

  • ATP-activated adenosine receptor activity Source: BHF-UCL
  • G-protein coupled purinergic nucleotide receptor activity Source: InterPro
  • neurotransmitter receptor activity Source: BHF-UCL
  • receptor activity Source: ProtInc

GO - Biological processi

  • activation of adenylate cyclase activity Source: ProtInc
  • calcium-mediated signaling Source: BHF-UCL
  • cellular response to ATP Source: BHF-UCL
  • defense response Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: BHF-UCL
  • neuronal signal transduction Source: BHF-UCL
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-31916-MONOMER.
ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-417957. P2Y receptors.
R-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 11
Short name:
P2Y11
Gene namesi
Name:P2RY11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8540. P2RY11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 64CytoplasmicSequence analysisAdd BLAST14
Transmembranei65 – 85Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini86 – 116ExtracellularSequence analysisAdd BLAST31
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 146CytoplasmicSequence analysis9
Transmembranei147 – 167Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini168 – 206ExtracellularSequence analysisAdd BLAST39
Transmembranei207 – 227Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini228 – 245CytoplasmicSequence analysisAdd BLAST18
Transmembranei246 – 266Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini267 – 308ExtracellularSequence analysisAdd BLAST42
Transmembranei309 – 329Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini330 – 374CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

  • integral component of plasma membrane Source: BHF-UCL
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5032.
MalaCardsiP2RY11.
OpenTargetsiENSG00000244165.
Orphaneti2073. Narcolepsy-cataplexy.
PharmGKBiPA32869.

Chemistry databases

ChEMBLiCHEMBL4867.
GuidetoPHARMACOLOGYi327.

Polymorphism and mutation databases

BioMutaiP2RY11.
DMDMi21263830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700351 – 374P2Y purinoceptor 11Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi102 ↔ 180PROSITE-ProRule annotation
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96G91.
PeptideAtlasiQ96G91.
PRIDEiQ96G91.

PTM databases

iPTMnetiQ96G91.
PhosphoSitePlusiQ96G91.

Expressioni

Tissue specificityi

Highest expression in liver and spleen.1 Publication

Inductioni

Increased by DMSO and retinoic acid.

Gene expression databases

BgeeiENSG00000244165.
GenevisibleiQ96G91. HS.

Organism-specific databases

HPAiHPA014232.

Interactioni

Protein-protein interaction databases

IntActiQ96G91. 1 interactor.
STRINGi9606.ENSP00000323872.

Chemistry databases

BindingDBiQ96G91.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B6Smodel-A1-374[»]
ProteinModelPortaliQ96G91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW3D. Eukaryota.
ENOG4111H44. LUCA.
GeneTreeiENSGT00860000133950.
HOGENOMiHOG000059583.
HOVERGENiHBG105351.
InParanoidiQ96G91.
KOiK08387.
OrthoDBiEOG091G079K.
PhylomeDBiQ96G91.
TreeFamiTF330775.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027677. P2Y11_rcpt.
[Graphical view]
PANTHERiPTHR24237:SF3. PTHR24237:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96G91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANVSGAKS CPANFLAAAD DKLSGFQGDF LWPILVVEFL VAVASNGLAL
60 70 80 90 100
YRFSIRKQRP WHPAVVFSVQ LAVSDLLCAL TLPPLAAYLY PPKHWRYGEA
110 120 130 140 150
ACRLERFLFT CNLLGSVIFI TCISLNRYLG IVHPFFARSH LRPKHAWAVS
160 170 180 190 200
AAGWVLAALL AMPTLSFSHL KRPQQGAGNC SVARPEACIK CLGTADHGLA
210 220 230 240 250
AYRAYSLVLA GLGCGLPLLL TLAAYGALGR AVLRSPGMTV AEKLRVAALV
260 270 280 290 300
ASGVALYASS YVPYHIMRVL NVDARRRWST RCPSFADIAQ ATAALELGPY
310 320 330 340 350
VGYQVMRGLM PLAFCVHPLL YMAAVPSLGC CCRHCPGYRD SWNPEDAKST
360 370
GQALPLNATA APKPSEPQSR ELSQ
Length:374
Mass (Da):40,345
Last modified:May 27, 2002 - v2
Checksum:iC02DF9B3B381D25E
GO

Sequence cautioni

The sequence AAB88674 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC18877 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02007487A → T.Corresponds to variant rs3745601dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030335 mRNA. Translation: AAB88674.1. Different initiation.
AJ298334 mRNA. Translation: CAC29362.1.
AJ300588 mRNA. Translation: CAC18877.1. Different initiation.
AY449733 mRNA. Translation: AAR18077.1.
AK313550 mRNA. Translation: BAG36326.1.
CH471106 Genomic DNA. Translation: EAW84077.1.
BC073827 mRNA. Translation: AAH73827.1.
AF498921 mRNA. Translation: AAM18130.1.
CCDSiCCDS12226.1.
RefSeqiNP_002557.2. NM_002566.4.
UniGeneiHs.14468.

Genome annotation databases

EnsembliENST00000321826; ENSP00000323872; ENSG00000244165.
GeneIDi5032.
KEGGihsa:5032.
UCSCiuc002mnc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030335 mRNA. Translation: AAB88674.1. Different initiation.
AJ298334 mRNA. Translation: CAC29362.1.
AJ300588 mRNA. Translation: CAC18877.1. Different initiation.
AY449733 mRNA. Translation: AAR18077.1.
AK313550 mRNA. Translation: BAG36326.1.
CH471106 Genomic DNA. Translation: EAW84077.1.
BC073827 mRNA. Translation: AAH73827.1.
AF498921 mRNA. Translation: AAM18130.1.
CCDSiCCDS12226.1.
RefSeqiNP_002557.2. NM_002566.4.
UniGeneiHs.14468.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B6Smodel-A1-374[»]
ProteinModelPortaliQ96G91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96G91. 1 interactor.
STRINGi9606.ENSP00000323872.

Chemistry databases

BindingDBiQ96G91.
ChEMBLiCHEMBL4867.
GuidetoPHARMACOLOGYi327.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96G91.
PhosphoSitePlusiQ96G91.

Polymorphism and mutation databases

BioMutaiP2RY11.
DMDMi21263830.

Proteomic databases

PaxDbiQ96G91.
PeptideAtlasiQ96G91.
PRIDEiQ96G91.

Protocols and materials databases

DNASUi5032.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321826; ENSP00000323872; ENSG00000244165.
GeneIDi5032.
KEGGihsa:5032.
UCSCiuc002mnc.4. human.

Organism-specific databases

CTDi5032.
DisGeNETi5032.
GeneCardsiP2RY11.
HGNCiHGNC:8540. P2RY11.
HPAiHPA014232.
MalaCardsiP2RY11.
MIMi602697. gene.
neXtProtiNX_Q96G91.
OpenTargetsiENSG00000244165.
Orphaneti2073. Narcolepsy-cataplexy.
PharmGKBiPA32869.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW3D. Eukaryota.
ENOG4111H44. LUCA.
GeneTreeiENSGT00860000133950.
HOGENOMiHOG000059583.
HOVERGENiHBG105351.
InParanoidiQ96G91.
KOiK08387.
OrthoDBiEOG091G079K.
PhylomeDBiQ96G91.
TreeFamiTF330775.

Enzyme and pathway databases

BioCyciZFISH:G66-31916-MONOMER.
ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-417957. P2Y receptors.
R-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiP2RY11.
GenomeRNAii5032.
PROiQ96G91.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000244165.
GenevisibleiQ96G91. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027677. P2Y11_rcpt.
[Graphical view]
PANTHERiPTHR24237:SF3. PTHR24237:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2Y11_HUMAN
AccessioniPrimary (citable) accession number: Q96G91
Secondary accession number(s): B2R8X9
, O43190, Q9BYU4, Q9H170
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed:11278528).1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.