Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96G91

- P2Y11_HUMAN

UniProt

Q96G91 - P2Y11_HUMAN

Protein

P2Y purinoceptor 11

Gene

P2RY11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (27 May 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.

    GO - Molecular functioni

    1. ATP-activated nucleotide receptor activity Source: BHF-UCL
    2. G-protein coupled purinergic nucleotide receptor activity Source: InterPro
    3. neurotransmitter receptor activity Source: BHF-UCL
    4. receptor activity Source: ProtInc

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: ProtInc
    2. adenosine receptor signaling pathway Source: GOC
    3. calcium-mediated signaling Source: BHF-UCL
    4. cellular response to ATP Source: BHF-UCL
    5. defense response Source: ProtInc
    6. G-protein coupled receptor signaling pathway Source: BHF-UCL
    7. neuronal signal transduction Source: BHF-UCL
    8. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
    9. synaptic transmission Source: GOC

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_18289. P2Y receptors.
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P2Y purinoceptor 11
    Short name:
    P2Y11
    Gene namesi
    Name:P2RY11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:8540. P2RY11.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: BHF-UCL
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti2073. Narcolepsy-cataplexy.
    PharmGKBiPA32869.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374P2Y purinoceptor 11PRO_0000070035Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi102 ↔ 180PROSITE-ProRule annotation
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ96G91.
    PRIDEiQ96G91.

    PTM databases

    PhosphoSiteiQ96G91.

    Expressioni

    Tissue specificityi

    Highest expression in liver and spleen.1 Publication

    Inductioni

    Increased by DMSO and retinoic acid.

    Gene expression databases

    BgeeiQ96G91.
    GenevestigatoriQ96G91.

    Organism-specific databases

    HPAiHPA014232.

    Interactioni

    Protein-protein interaction databases

    IntActiQ96G91. 1 interaction.
    STRINGi9606.ENSP00000323872.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2B6Smodel-A1-374[»]
    ProteinModelPortaliQ96G91.
    SMRiQ96G91. Positions 26-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini51 – 6414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini86 – 11631ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 1469CytoplasmicSequence Analysis
    Topological domaini168 – 20639ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini228 – 24518CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini267 – 30842ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini330 – 37445CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei207 – 22721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei246 – 26621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei309 – 32921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG272199.
    HOGENOMiHOG000059583.
    HOVERGENiHBG105351.
    InParanoidiQ96G91.
    KOiK08387.
    OrthoDBiEOG71G9TZ.
    PhylomeDBiQ96G91.
    TreeFamiTF330775.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR027677. P2Y11_rcpt.
    [Graphical view]
    PANTHERiPTHR24237:SF3. PTHR24237:SF3. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96G91-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAANVSGAKS CPANFLAAAD DKLSGFQGDF LWPILVVEFL VAVASNGLAL    50
    YRFSIRKQRP WHPAVVFSVQ LAVSDLLCAL TLPPLAAYLY PPKHWRYGEA 100
    ACRLERFLFT CNLLGSVIFI TCISLNRYLG IVHPFFARSH LRPKHAWAVS 150
    AAGWVLAALL AMPTLSFSHL KRPQQGAGNC SVARPEACIK CLGTADHGLA 200
    AYRAYSLVLA GLGCGLPLLL TLAAYGALGR AVLRSPGMTV AEKLRVAALV 250
    ASGVALYASS YVPYHIMRVL NVDARRRWST RCPSFADIAQ ATAALELGPY 300
    VGYQVMRGLM PLAFCVHPLL YMAAVPSLGC CCRHCPGYRD SWNPEDAKST 350
    GQALPLNATA APKPSEPQSR ELSQ 374
    Length:374
    Mass (Da):40,345
    Last modified:May 27, 2002 - v2
    Checksum:iC02DF9B3B381D25E
    GO

    Sequence cautioni

    The sequence AAB88674.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAC18877.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti87 – 871A → T.
    Corresponds to variant rs3745601 [ dbSNP | Ensembl ].
    VAR_020074

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030335 mRNA. Translation: AAB88674.1. Different initiation.
    AJ298334 mRNA. Translation: CAC29362.1.
    AJ300588 mRNA. Translation: CAC18877.1. Different initiation.
    AY449733 mRNA. Translation: AAR18077.1.
    AK313550 mRNA. Translation: BAG36326.1.
    CH471106 Genomic DNA. Translation: EAW84077.1.
    BC073827 mRNA. Translation: AAH73827.1.
    AF498921 mRNA. Translation: AAM18130.1.
    CCDSiCCDS12226.1.
    RefSeqiNP_002557.2. NM_002566.4.
    UniGeneiHs.14468.

    Genome annotation databases

    EnsembliENST00000321826; ENSP00000323872; ENSG00000244165.
    GeneIDi5032.
    KEGGihsa:5032.
    UCSCiuc002mnc.3. human.

    Polymorphism databases

    DMDMi21263830.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030335 mRNA. Translation: AAB88674.1 . Different initiation.
    AJ298334 mRNA. Translation: CAC29362.1 .
    AJ300588 mRNA. Translation: CAC18877.1 . Different initiation.
    AY449733 mRNA. Translation: AAR18077.1 .
    AK313550 mRNA. Translation: BAG36326.1 .
    CH471106 Genomic DNA. Translation: EAW84077.1 .
    BC073827 mRNA. Translation: AAH73827.1 .
    AF498921 mRNA. Translation: AAM18130.1 .
    CCDSi CCDS12226.1.
    RefSeqi NP_002557.2. NM_002566.4.
    UniGenei Hs.14468.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2B6S model - A 1-374 [» ]
    ProteinModelPortali Q96G91.
    SMRi Q96G91. Positions 26-323.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q96G91. 1 interaction.
    STRINGi 9606.ENSP00000323872.

    Chemistry

    BindingDBi Q96G91.
    ChEMBLi CHEMBL4867.
    GuidetoPHARMACOLOGYi 327.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q96G91.

    Polymorphism databases

    DMDMi 21263830.

    Proteomic databases

    PaxDbi Q96G91.
    PRIDEi Q96G91.

    Protocols and materials databases

    DNASUi 5032.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321826 ; ENSP00000323872 ; ENSG00000244165 .
    GeneIDi 5032.
    KEGGi hsa:5032.
    UCSCi uc002mnc.3. human.

    Organism-specific databases

    CTDi 5032.
    GeneCardsi GC19P010222.
    HGNCi HGNC:8540. P2RY11.
    HPAi HPA014232.
    MIMi 602697. gene.
    neXtProti NX_Q96G91.
    Orphaneti 2073. Narcolepsy-cataplexy.
    PharmGKBi PA32869.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272199.
    HOGENOMi HOG000059583.
    HOVERGENi HBG105351.
    InParanoidi Q96G91.
    KOi K08387.
    OrthoDBi EOG71G9TZ.
    PhylomeDBi Q96G91.
    TreeFami TF330775.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_18289. P2Y receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii P2RY11.
    GenomeRNAii 5032.
    NextBioi 19388.
    PROi Q96G91.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96G91.
    Genevestigatori Q96G91.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR027677. P2Y11_rcpt.
    [Graphical view ]
    PANTHERi PTHR24237:SF3. PTHR24237:SF3. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes."
      Communi D., Suarez-Huerta N., Dussossoy D., Savi P., Boeynaems J.-M.
      J. Biol. Chem. 276:16561-16566(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, TRANS-SPLICING.
      Tissue: Placenta and Promyelocyte.
    2. "Isolation of cDNA coding for purinergic receptor P2Y, G protein-coupled, 11 (P2RY11)."
      King M.M., Aronstam R.S., Sharma S.V.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase."
      Communi D., Govaerts C., Parmentier M., Boeynaems J.-M.
      J. Biol. Chem. 272:31969-31973(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-374.
      Tissue: Placenta.
    7. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-374.

    Entry informationi

    Entry nameiP2Y11_HUMAN
    AccessioniPrimary (citable) accession number: Q96G91
    Secondary accession number(s): B2R8X9
    , O43190, Q9BYU4, Q9H170
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: May 27, 2002
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed:11278528).1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3