Q96G91 (P2Y11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
P2Y purinoceptor 11
Short name=P2Y11

Gene names

Name:

P2RY11

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Highest expression in liver and spleen. Ref.1
Induction	Increased by DMSO and retinoic acid.
Miscellaneous	A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (Ref.1).
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence AAB88674.1 differs from that shown. Reason: Erroneous initiation. The sequence CAC18877.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	activation of adenylate cyclase activity Traceable author statement. Source: ProtInc activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger Traceable author statement. Source: ProtInc calcium-mediated signaling Inferred from direct assay. Source: BHF-UCL cellular response to ATP Inferred from direct assay. Source: BHF-UCL defense response Traceable author statement. Source: ProtInc neuronal signal transduction Inferred from direct assay. Source: BHF-UCL
Cellular component	integral to plasma membrane Inferred by curator. Source: BHF-UCL
Molecular function	ATP-activated nucleotide receptor activity Inferred from direct assay. Source: BHF-UCL G-protein coupled purinergic nucleotide receptor activity Inferred from electronic annotation. Source: InterPro neurotransmitter receptor activity Inferred from direct assay. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	P2Y purinoceptor 11		PRO_0000070035
Regions
	Topological domain	1 – 29	29	Extracellular Potential
	Transmembrane	30 – 50	21	Helical; Name=1; Potential
	Topological domain	51 – 64	14	Cytoplasmic Potential
	Transmembrane	65 – 85	21	Helical; Name=2; Potential
	Topological domain	86 – 116	31	Extracellular Potential
	Transmembrane	117 – 137	21	Helical; Name=3; Potential
	Topological domain	138 – 146	9	Cytoplasmic Potential
	Transmembrane	147 – 167	21	Helical; Name=4; Potential
	Topological domain	168 – 206	39	Extracellular Potential
	Transmembrane	207 – 227	21	Helical; Name=5; Potential
	Topological domain	228 – 245	18	Cytoplasmic Potential
	Transmembrane	246 – 266	21	Helical; Name=6; Potential
	Topological domain	267 – 308	42	Extracellular Potential
	Transmembrane	309 – 329	21	Helical; Name=7; Potential
	Topological domain	330 – 374	45	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	179	1	N-linked (GlcNAc...) Potential
	Disulfide bond	102 ↔ 180		By similarity
Natural variations
	Natural variant	87	1	A → T. Corresponds to variant rs3745601 [ dbSNP | Ensembl ].		VAR_020074

Sequences

	Sequence		Length	Mass (Da)
	Q96G91 [UniParc]. Last modified May 27, 2002. Version 2. Checksum: C02DF9B3B381D25E	FASTA	374	40,345
	10 20 30 40 50 60 MAANVSGAKS CPANFLAAAD DKLSGFQGDF LWPILVVEFL VAVASNGLAL YRFSIRKQRP 70 80 90 100 110 120 WHPAVVFSVQ LAVSDLLCAL TLPPLAAYLY PPKHWRYGEA ACRLERFLFT CNLLGSVIFI 130 140 150 160 170 180 TCISLNRYLG IVHPFFARSH LRPKHAWAVS AAGWVLAALL AMPTLSFSHL KRPQQGAGNC 190 200 210 220 230 240 SVARPEACIK CLGTADHGLA AYRAYSLVLA GLGCGLPLLL TLAAYGALGR AVLRSPGMTV 250 260 270 280 290 300 AEKLRVAALV ASGVALYASS YVPYHIMRVL NVDARRRWST RCPSFADIAQ ATAALELGPY 310 320 330 340 350 360 VGYQVMRGLM PLAFCVHPLL YMAAVPSLGC CCRHCPGYRD SWNPEDAKST GQALPLNATA 370 APKPSEPQSR ELSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes." Communi D., Suarez-Huerta N., Dussossoy D., Savi P., Boeynaems J.-M. J. Biol. Chem. 276:16561-16566(2001) [PubMed: 11278528] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, TRANS-SPLICING. Tissue: Placenta and Promyelocyte.
[2]	"Isolation of cDNA coding for purinergic receptor P2Y, G protein-coupled, 11 (P2RY11)." King M.M., Aronstam R.S., Sharma S.V. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase." Communi D., Govaerts C., Parmentier M., Boeynaems J.-M. J. Biol. Chem. 272:31969-31973(1997) [PubMed: 9405388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-374. Tissue: Placenta.
[7]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-374.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF030335 mRNA. Translation: AAB88674.1. Different initiation.
AJ298334 mRNA. Translation: CAC29362.1.
AJ300588 mRNA. Translation: CAC18877.1. Different initiation.
AY449733 mRNA. Translation: AAR18077.1.
AK313550 mRNA. Translation: BAG36326.1.
CH471106 Genomic DNA. Translation: EAW84077.1.
BC073827 mRNA. Translation: AAH73827.1.
AF498921 mRNA. Translation: AAM18130.1.

IPI

IPI00101425.

RefSeq

NP_002557.2. NM_002566.4.

UniGene

Hs.14468.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2B6S	model	-	A	1-374	[»]

ProteinModelPortal

Q96G91.

SMR

Q96G91. Positions 115-145, 305-338.

ModBase

Search...

Protein-protein interaction databases

STRING

Q96G91.

Protein family/group databases

GPCRDB

Search...

Polymorphism databases

DMDM

21263830.

Proteomic databases

PRIDE

Q96G91.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000321826; ENSP00000323872; ENSG00000244165.

GeneID

5032.

KEGG

hsa:5032.

UCSC

uc002mnc.1. human.

Organism-specific databases

CTD

5032.

GeneCards

GC19P010222.

HGNC

HGNC:8540. P2RY11.

HPA

HPA014232.

MIM

602697. gene.

neXtProt

NX_Q96G91.

PharmGKB

PA32869.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG05168.

GeneTree

ENSGT00600000084187.

HOVERGEN

HBG105351.

InParanoid

Q96G91.

OrthoDB

EOG4P2Q1Q.

PhylomeDB

Q96G91.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

Q96G91.

Genevestigator

Q96G91.

GermOnline

ENSG00000176130. Homo sapiens.

Family and domain databases

InterPro

IPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR002286. P2_purnocptor.
[Graphical view]

KO

K08387.

Pfam

PF00001. 7tm_1. 1 hit.
[Graphical view]

PRINTS

PR00237. GPCRRHODOPSN.
PR01157. P2YPURNOCPTR.

PROSITE

PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

19388.

SOURCE

Search...

Entry information

Entry name

P2Y11_HUMAN

Accession

Primary (citable) accession number: Q96G91
Secondary accession number(s): B2R8X9 , O43190, Q9BYU4, Q9H170

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	May 27, 2002
Last modified:	January 25, 2012
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.