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Q96G91 (P2Y11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
P2Y purinoceptor 11

Short name=P2Y11
Gene names
Name:P2RY11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Highest expression in liver and spleen. Ref.1

Induction

Increased by DMSO and retinoic acid.

Miscellaneous

A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (Ref.1).

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence AAB88674.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAC18877.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374P2Y purinoceptor 11
PRO_0000070035

Regions

Topological domain1 – 2929Extracellular Potential
Transmembrane30 – 5021Helical; Name=1; Potential
Topological domain51 – 6414Cytoplasmic Potential
Transmembrane65 – 8521Helical; Name=2; Potential
Topological domain86 – 11631Extracellular Potential
Transmembrane117 – 13721Helical; Name=3; Potential
Topological domain138 – 1469Cytoplasmic Potential
Transmembrane147 – 16721Helical; Name=4; Potential
Topological domain168 – 20639Extracellular Potential
Transmembrane207 – 22721Helical; Name=5; Potential
Topological domain228 – 24518Cytoplasmic Potential
Transmembrane246 – 26621Helical; Name=6; Potential
Topological domain267 – 30842Extracellular Potential
Transmembrane309 – 32921Helical; Name=7; Potential
Topological domain330 – 37445Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Disulfide bond102 ↔ 180 By similarity

Natural variations

Natural variant871A → T.
Corresponds to variant rs3745601 [ dbSNP | Ensembl ].
VAR_020074

Sequences

Sequence LengthMass (Da)Tools
Q96G91 [UniParc].

Last modified May 27, 2002. Version 2.
Checksum: C02DF9B3B381D25E

FASTA37440,345
        10         20         30         40         50         60 
MAANVSGAKS CPANFLAAAD DKLSGFQGDF LWPILVVEFL VAVASNGLAL YRFSIRKQRP 

        70         80         90        100        110        120 
WHPAVVFSVQ LAVSDLLCAL TLPPLAAYLY PPKHWRYGEA ACRLERFLFT CNLLGSVIFI 

       130        140        150        160        170        180 
TCISLNRYLG IVHPFFARSH LRPKHAWAVS AAGWVLAALL AMPTLSFSHL KRPQQGAGNC 

       190        200        210        220        230        240 
SVARPEACIK CLGTADHGLA AYRAYSLVLA GLGCGLPLLL TLAAYGALGR AVLRSPGMTV 

       250        260        270        280        290        300 
AEKLRVAALV ASGVALYASS YVPYHIMRVL NVDARRRWST RCPSFADIAQ ATAALELGPY 

       310        320        330        340        350        360 
VGYQVMRGLM PLAFCVHPLL YMAAVPSLGC CCRHCPGYRD SWNPEDAKST GQALPLNATA 

       370 
APKPSEPQSR ELSQ 

« Hide

References

« Hide 'large scale' references
[1]"Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes."
Communi D., Suarez-Huerta N., Dussossoy D., Savi P., Boeynaems J.-M.
J. Biol. Chem. 276:16561-16566(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, TRANS-SPLICING.
Tissue: Placenta and Promyelocyte.
[2]"Isolation of cDNA coding for purinergic receptor P2Y, G protein-coupled, 11 (P2RY11)."
King M.M., Aronstam R.S., Sharma S.V.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase."
Communi D., Govaerts C., Parmentier M., Boeynaems J.-M.
J. Biol. Chem. 272:31969-31973(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-374.
Tissue: Placenta.
[7]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-374.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF030335 mRNA. Translation: AAB88674.1. Different initiation.
AJ298334 mRNA. Translation: CAC29362.1.
AJ300588 mRNA. Translation: CAC18877.1. Different initiation.
AY449733 mRNA. Translation: AAR18077.1.
AK313550 mRNA. Translation: BAG36326.1.
CH471106 Genomic DNA. Translation: EAW84077.1.
BC073827 mRNA. Translation: AAH73827.1.
AF498921 mRNA. Translation: AAM18130.1.
RefSeqNP_002557.2. NM_002566.4.
UniGeneHs.14468.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2B6Smodel-A1-374[»]
ProteinModelPortalQ96G91.
SMRQ96G91. Positions 26-323.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ96G91. 1 interaction.
STRING9606.ENSP00000323872.

Chemistry

BindingDBQ96G91.
ChEMBLCHEMBL4867.
GuidetoPHARMACOLOGY327.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ96G91.

Polymorphism databases

DMDM21263830.

Proteomic databases

PaxDbQ96G91.
PRIDEQ96G91.

Protocols and materials databases

DNASU5032.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000321826; ENSP00000323872; ENSG00000244165.
GeneID5032.
KEGGhsa:5032.
UCSCuc002mnc.3. human.

Organism-specific databases

CTD5032.
GeneCardsGC19P010222.
HGNCHGNC:8540. P2RY11.
HPAHPA014232.
MIM602697. gene.
neXtProtNX_Q96G91.
Orphanet2073. Narcolepsy-cataplexy.
PharmGKBPA32869.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG272199.
HOGENOMHOG000059583.
HOVERGENHBG105351.
InParanoidQ96G91.
KOK08387.
OrthoDBEOG71G9TZ.
PhylomeDBQ96G91.
TreeFamTF330775.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ96G91.
GenevestigatorQ96G91.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027677. P2Y11_rcpt.
[Graphical view]
PANTHERPTHR24237:SF3. PTHR24237:SF3. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiP2RY11.
GenomeRNAi5032.
NextBio19388.
PROQ96G91.
SOURCESearch...

Entry information

Entry nameP2Y11_HUMAN
AccessionPrimary (citable) accession number: Q96G91
Secondary accession number(s): B2R8X9 expand/collapse secondary AC list , O43190, Q9BYU4, Q9H170
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: March 19, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries