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Q96G79

- S35A4_HUMAN

UniProt

Q96G79 - S35A4_HUMAN

Protein

Probable UDP-sugar transporter protein SLC35A4

Gene

SLC35A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sugar:proton symporter activity Source: InterPro

    Keywords - Biological processi

    Sugar transport, Transport

    Protein family/group databases

    TCDBi2.A.7.12.12. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable UDP-sugar transporter protein SLC35A4
    Alternative name(s):
    Solute carrier family 35 member A4
    Gene namesi
    Name:SLC35A4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:20753. SLC35A4.

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated. Golgi apparatus By similarity

    GO - Cellular componenti

    1. Golgi membrane Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134971555.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Probable UDP-sugar transporter protein SLC35A4PRO_0000337748Add
    BLAST

    Proteomic databases

    PaxDbiQ96G79.
    PRIDEiQ96G79.

    PTM databases

    PhosphoSiteiQ96G79.

    Expressioni

    Gene expression databases

    BgeeiQ96G79.
    CleanExiHS_SLC35A4.
    GenevestigatoriQ96G79.

    Interactioni

    Protein-protein interaction databases

    BioGridi125263. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96G79.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei54 – 7623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei183 – 20523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei249 – 27123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei276 – 29823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei303 – 32220HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi21 – 319299Leu-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG302854.
    HOGENOMiHOG000154235.
    HOVERGENiHBG108445.
    InParanoidiQ96G79.
    KOiK15273.
    OMAiLIQARHQ.
    OrthoDBiEOG7MSMQ1.
    PhylomeDBiQ96G79.
    TreeFamiTF315345.

    Family and domain databases

    InterProiIPR007271. Nuc_sug_transpt.
    IPR021189. UDP/CMP-sugar_transptr.
    [Graphical view]
    PANTHERiPTHR10231. PTHR10231. 1 hit.
    PfamiPF04142. Nuc_sug_transp. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96G79-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVEDGGMPG LGRPRQARWT LMLLLSTAMY GAHAPLLALC HVDGRVPFRP    50
    SSAVLLTELT KLLLCAFSLL VGWQAWPQGP PPWRQAAPFA LSALLYGANN 100
    NLVIYLQRYM DPSTYQVLSN LKIGSTAVLY CLCLRHRLSV RQGLALLLLM 150
    AAGACYAAGG LQVPGNTLPS PPPAAAASPM PLHITPLGLL LLILYCLISG 200
    LSSVYTELLM KRQRLPLALQ NLFLYTFGVL LNLGLHAGGG SGPGLLEGFS 250
    GWAALVVLSQ ALNGLLMSAV MKHGSSITRL FVVSCSLVVN AVLSAVLLRL 300
    QLTAAFFLAT LLIGLAMRLY YGSR 324
    Length:324
    Mass (Da):34,593
    Last modified:December 1, 2001 - v1
    Checksum:i9BD54BA459B6C94A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti79 – 791G → E in BAF82067. (PubMed:14702039)Curated
    Sequence conflicti81 – 811P → L in BAF82067. (PubMed:14702039)Curated
    Sequence conflicti306 – 3061F → L in BAF82067. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK289378 mRNA. Translation: BAF82067.1.
    AL833972 mRNA. Translation: CAD38817.1.
    CH471062 Genomic DNA. Translation: EAW62040.1.
    BC009906 mRNA. Translation: AAH09906.1.
    CCDSiCCDS4231.1.
    RefSeqiNP_542401.1. NM_080670.2.
    UniGeneiHs.406840.

    Genome annotation databases

    EnsembliENST00000323146; ENSP00000327133; ENSG00000176087.
    ENST00000514199; ENSP00000424566; ENSG00000176087.
    GeneIDi113829.
    KEGGihsa:113829.
    UCSCiuc003lgg.1. human.

    Polymorphism databases

    DMDMi74731793.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK289378 mRNA. Translation: BAF82067.1 .
    AL833972 mRNA. Translation: CAD38817.1 .
    CH471062 Genomic DNA. Translation: EAW62040.1 .
    BC009906 mRNA. Translation: AAH09906.1 .
    CCDSi CCDS4231.1.
    RefSeqi NP_542401.1. NM_080670.2.
    UniGenei Hs.406840.

    3D structure databases

    ProteinModelPortali Q96G79.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125263. 1 interaction.

    Protein family/group databases

    TCDBi 2.A.7.12.12. the drug/metabolite transporter (dmt) superfamily.

    PTM databases

    PhosphoSitei Q96G79.

    Polymorphism databases

    DMDMi 74731793.

    Proteomic databases

    PaxDbi Q96G79.
    PRIDEi Q96G79.

    Protocols and materials databases

    DNASUi 113829.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000323146 ; ENSP00000327133 ; ENSG00000176087 .
    ENST00000514199 ; ENSP00000424566 ; ENSG00000176087 .
    GeneIDi 113829.
    KEGGi hsa:113829.
    UCSCi uc003lgg.1. human.

    Organism-specific databases

    CTDi 113829.
    GeneCardsi GC05P139944.
    HGNCi HGNC:20753. SLC35A4.
    neXtProti NX_Q96G79.
    PharmGKBi PA134971555.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302854.
    HOGENOMi HOG000154235.
    HOVERGENi HBG108445.
    InParanoidi Q96G79.
    KOi K15273.
    OMAi LIQARHQ.
    OrthoDBi EOG7MSMQ1.
    PhylomeDBi Q96G79.
    TreeFami TF315345.

    Miscellaneous databases

    GenomeRNAii 113829.
    NextBioi 78920.
    PROi Q96G79.

    Gene expression databases

    Bgeei Q96G79.
    CleanExi HS_SLC35A4.
    Genevestigatori Q96G79.

    Family and domain databases

    InterProi IPR007271. Nuc_sug_transpt.
    IPR021189. UDP/CMP-sugar_transptr.
    [Graphical view ]
    PANTHERi PTHR10231. PTHR10231. 1 hit.
    Pfami PF04142. Nuc_sug_transp. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005799. UDP-gal_transpt. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adrenal gland.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    5. "The nucleotide-sugar transporter family: a phylogenetic approach."
      Martinez-Duncker I., Mollicone R., Codogno P., Oriol R.
      Biochimie 85:245-260(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiS35A4_HUMAN
    AccessioniPrimary (citable) accession number: Q96G79
    Secondary accession number(s): A8K013
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Classified as NST family 1 subfamily D in a phylogenic study. Family 1 seems to be the most recent in evolution.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3