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Q96G79

- S35A4_HUMAN

UniProt

Q96G79 - S35A4_HUMAN

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Protein

Probable UDP-sugar transporter protein SLC35A4

Gene

SLC35A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. sugar:proton symporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Protein family/group databases

TCDBi2.A.7.12.12. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable UDP-sugar transporter protein SLC35A4
Alternative name(s):
Solute carrier family 35 member A4
Gene namesi
Name:SLC35A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:20753. SLC35A4.

Subcellular locationi

Membrane Curated; Multi-pass membrane protein Curated. Golgi apparatus By similarity

GO - Cellular componenti

  1. Golgi membrane Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134971555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Probable UDP-sugar transporter protein SLC35A4PRO_0000337748Add
BLAST

Proteomic databases

PaxDbiQ96G79.
PRIDEiQ96G79.

PTM databases

PhosphoSiteiQ96G79.

Expressioni

Gene expression databases

BgeeiQ96G79.
CleanExiHS_SLC35A4.
GenevestigatoriQ96G79.

Interactioni

Protein-protein interaction databases

BioGridi125263. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96G79.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4223HelicalSequence AnalysisAdd
BLAST
Transmembranei54 – 7623HelicalSequence AnalysisAdd
BLAST
Transmembranei86 – 10520HelicalSequence AnalysisAdd
BLAST
Transmembranei144 – 16320HelicalSequence AnalysisAdd
BLAST
Transmembranei183 – 20523HelicalSequence AnalysisAdd
BLAST
Transmembranei217 – 23923HelicalSequence AnalysisAdd
BLAST
Transmembranei249 – 27123HelicalSequence AnalysisAdd
BLAST
Transmembranei276 – 29823HelicalSequence AnalysisAdd
BLAST
Transmembranei303 – 32220HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 319299Leu-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302854.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000154235.
HOVERGENiHBG108445.
InParanoidiQ96G79.
KOiK15273.
OMAiLIQARHQ.
OrthoDBiEOG7MSMQ1.
PhylomeDBiQ96G79.
TreeFamiTF315345.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96G79-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVEDGGMPG LGRPRQARWT LMLLLSTAMY GAHAPLLALC HVDGRVPFRP
60 70 80 90 100
SSAVLLTELT KLLLCAFSLL VGWQAWPQGP PPWRQAAPFA LSALLYGANN
110 120 130 140 150
NLVIYLQRYM DPSTYQVLSN LKIGSTAVLY CLCLRHRLSV RQGLALLLLM
160 170 180 190 200
AAGACYAAGG LQVPGNTLPS PPPAAAASPM PLHITPLGLL LLILYCLISG
210 220 230 240 250
LSSVYTELLM KRQRLPLALQ NLFLYTFGVL LNLGLHAGGG SGPGLLEGFS
260 270 280 290 300
GWAALVVLSQ ALNGLLMSAV MKHGSSITRL FVVSCSLVVN AVLSAVLLRL
310 320
QLTAAFFLAT LLIGLAMRLY YGSR
Length:324
Mass (Da):34,593
Last modified:December 1, 2001 - v1
Checksum:i9BD54BA459B6C94A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791G → E in BAF82067. (PubMed:14702039)Curated
Sequence conflicti81 – 811P → L in BAF82067. (PubMed:14702039)Curated
Sequence conflicti306 – 3061F → L in BAF82067. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK289378 mRNA. Translation: BAF82067.1.
AL833972 mRNA. Translation: CAD38817.1.
CH471062 Genomic DNA. Translation: EAW62040.1.
BC009906 mRNA. Translation: AAH09906.1.
CCDSiCCDS4231.1.
RefSeqiNP_542401.1. NM_080670.2.
UniGeneiHs.406840.

Genome annotation databases

EnsembliENST00000323146; ENSP00000327133; ENSG00000176087.
ENST00000514199; ENSP00000424566; ENSG00000176087.
ENST00000612662; ENSP00000479255; ENSG00000176087.
GeneIDi113829.
KEGGihsa:113829.
UCSCiuc003lgg.1. human.

Polymorphism databases

DMDMi74731793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK289378 mRNA. Translation: BAF82067.1 .
AL833972 mRNA. Translation: CAD38817.1 .
CH471062 Genomic DNA. Translation: EAW62040.1 .
BC009906 mRNA. Translation: AAH09906.1 .
CCDSi CCDS4231.1.
RefSeqi NP_542401.1. NM_080670.2.
UniGenei Hs.406840.

3D structure databases

ProteinModelPortali Q96G79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125263. 1 interaction.

Protein family/group databases

TCDBi 2.A.7.12.12. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSitei Q96G79.

Polymorphism databases

DMDMi 74731793.

Proteomic databases

PaxDbi Q96G79.
PRIDEi Q96G79.

Protocols and materials databases

DNASUi 113829.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000323146 ; ENSP00000327133 ; ENSG00000176087 .
ENST00000514199 ; ENSP00000424566 ; ENSG00000176087 .
ENST00000612662 ; ENSP00000479255 ; ENSG00000176087 .
GeneIDi 113829.
KEGGi hsa:113829.
UCSCi uc003lgg.1. human.

Organism-specific databases

CTDi 113829.
GeneCardsi GC05P139944.
HGNCi HGNC:20753. SLC35A4.
neXtProti NX_Q96G79.
PharmGKBi PA134971555.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302854.
GeneTreei ENSGT00550000074563.
HOGENOMi HOG000154235.
HOVERGENi HBG108445.
InParanoidi Q96G79.
KOi K15273.
OMAi LIQARHQ.
OrthoDBi EOG7MSMQ1.
PhylomeDBi Q96G79.
TreeFami TF315345.

Miscellaneous databases

GenomeRNAii 113829.
NextBioi 78920.
PROi Q96G79.

Gene expression databases

Bgeei Q96G79.
CleanExi HS_SLC35A4.
Genevestigatori Q96G79.

Family and domain databases

InterProi IPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
[Graphical view ]
PANTHERi PTHR10231. PTHR10231. 1 hit.
Pfami PF04142. Nuc_sug_transp. 1 hit.
[Graphical view ]
PIRSFi PIRSF005799. UDP-gal_transpt. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  5. "The nucleotide-sugar transporter family: a phylogenetic approach."
    Martinez-Duncker I., Mollicone R., Codogno P., Oriol R.
    Biochimie 85:245-260(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiS35A4_HUMAN
AccessioniPrimary (citable) accession number: Q96G79
Secondary accession number(s): A8K013
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Classified as NST family 1 subfamily D in a phylogenic study. Family 1 seems to be the most recent in evolution.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3