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Q96G79 (S35A4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable UDP-sugar transporter protein SLC35A4
Alternative name(s):
Solute carrier family 35 member A4
Gene names
Name:SLC35A4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential. Golgi apparatus By similarity.

Miscellaneous

Classified as NST family 1 subfamily D in a phylogenic study. Family 1 seems to be the most recent in evolution.

Sequence similarities

Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Probable UDP-sugar transporter protein SLC35A4
PRO_0000337748

Regions

Transmembrane20 – 4223Helical; Potential
Transmembrane54 – 7623Helical; Potential
Transmembrane86 – 10520Helical; Potential
Transmembrane144 – 16320Helical; Potential
Transmembrane183 – 20523Helical; Potential
Transmembrane217 – 23923Helical; Potential
Transmembrane249 – 27123Helical; Potential
Transmembrane276 – 29823Helical; Potential
Transmembrane303 – 32220Helical; Potential
Compositional bias21 – 319299Leu-rich

Experimental info

Sequence conflict791G → E in BAF82067. Ref.1
Sequence conflict811P → L in BAF82067. Ref.1
Sequence conflict3061F → L in BAF82067. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q96G79 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 9BD54BA459B6C94A

FASTA32434,593
        10         20         30         40         50         60 
MSVEDGGMPG LGRPRQARWT LMLLLSTAMY GAHAPLLALC HVDGRVPFRP SSAVLLTELT 

        70         80         90        100        110        120 
KLLLCAFSLL VGWQAWPQGP PPWRQAAPFA LSALLYGANN NLVIYLQRYM DPSTYQVLSN 

       130        140        150        160        170        180 
LKIGSTAVLY CLCLRHRLSV RQGLALLLLM AAGACYAAGG LQVPGNTLPS PPPAAAASPM 

       190        200        210        220        230        240 
PLHITPLGLL LLILYCLISG LSSVYTELLM KRQRLPLALQ NLFLYTFGVL LNLGLHAGGG 

       250        260        270        280        290        300 
SGPGLLEGFS GWAALVVLSQ ALNGLLMSAV MKHGSSITRL FVVSCSLVVN AVLSAVLLRL 

       310        320 
QLTAAFFLAT LLIGLAMRLY YGSR 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Adrenal gland.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[5]"The nucleotide-sugar transporter family: a phylogenetic approach."
Martinez-Duncker I., Mollicone R., Codogno P., Oriol R.
Biochimie 85:245-260(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK289378 mRNA. Translation: BAF82067.1.
AL833972 mRNA. Translation: CAD38817.1.
CH471062 Genomic DNA. Translation: EAW62040.1.
BC009906 mRNA. Translation: AAH09906.1.
RefSeqNP_542401.1. NM_080670.2.
UniGeneHs.406840.

3D structure databases

ProteinModelPortalQ96G79.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125263. 1 interaction.

Protein family/group databases

TCDB2.A.7.12.12. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteQ96G79.

Polymorphism databases

DMDM74731793.

Proteomic databases

PaxDbQ96G79.
PRIDEQ96G79.

Protocols and materials databases

DNASU113829.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000323146; ENSP00000327133; ENSG00000176087.
ENST00000514199; ENSP00000424566; ENSG00000176087.
GeneID113829.
KEGGhsa:113829.
UCSCuc003lgg.1. human.

Organism-specific databases

CTD113829.
GeneCardsGC05P139944.
HGNCHGNC:20753. SLC35A4.
neXtProtNX_Q96G79.
PharmGKBPA134971555.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG302854.
HOGENOMHOG000154235.
HOVERGENHBG108445.
InParanoidQ96G79.
KOK15273.
OMAYCLCLRR.
OrthoDBEOG7MSMQ1.
PhylomeDBQ96G79.
TreeFamTF315345.

Gene expression databases

BgeeQ96G79.
CleanExHS_SLC35A4.
GenevestigatorQ96G79.

Family and domain databases

InterProIPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
[Graphical view]
PANTHERPTHR10231. PTHR10231. 1 hit.
PfamPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFPIRSF005799. UDP-gal_transpt. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi113829.
NextBio78920.
PROQ96G79.

Entry information

Entry nameS35A4_HUMAN
AccessionPrimary (citable) accession number: Q96G79
Secondary accession number(s): A8K013
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM