Q96G79 (S35A4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable UDP-sugar transporter protein SLC35A4

Alternative name(s):
Solute carrier family 35 member A4

Gene names

Name:

SLC35A4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential. Golgi apparatus By similarity.
Miscellaneous	Classified as NST family 1 subfamily D in a phylogenic study. Family 1 seems to be the most recent in evolution.
Sequence similarities	Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Golgi apparatus Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	sugar:hydrogen symporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 324	324	Probable UDP-sugar transporter protein SLC35A4		PRO_0000337748
Regions
	Transmembrane	20 – 42	23	Helical; Potential
	Transmembrane	54 – 76	23	Helical; Potential
	Transmembrane	86 – 105	20	Helical; Potential
	Transmembrane	144 – 163	20	Helical; Potential
	Transmembrane	183 – 205	23	Helical; Potential
	Transmembrane	217 – 239	23	Helical; Potential
	Transmembrane	249 – 271	23	Helical; Potential
	Transmembrane	276 – 298	23	Helical; Potential
	Transmembrane	303 – 322	20	Helical; Potential
	Compositional bias	21 – 319	299	Leu-rich
Experimental info
	Sequence conflict	79	1	G → E in BAF82067. Ref.1
	Sequence conflict	81	1	P → L in BAF82067. Ref.1
	Sequence conflict	306	1	F → L in BAF82067. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96G79 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 9BD54BA459B6C94A	FASTA	324	34,593
	10 20 30 40 50 60 MSVEDGGMPG LGRPRQARWT LMLLLSTAMY GAHAPLLALC HVDGRVPFRP SSAVLLTELT 70 80 90 100 110 120 KLLLCAFSLL VGWQAWPQGP PPWRQAAPFA LSALLYGANN NLVIYLQRYM DPSTYQVLSN 130 140 150 160 170 180 LKIGSTAVLY CLCLRHRLSV RQGLALLLLM AAGACYAAGG LQVPGNTLPS PPPAAAASPM 190 200 210 220 230 240 PLHITPLGLL LLILYCLISG LSSVYTELLM KRQRLPLALQ NLFLYTFGVL LNLGLHAGGG 250 260 270 280 290 300 SGPGLLEGFS GWAALVVLSQ ALNGLLMSAV MKHGSSITRL FVVSCSLVVN AVLSAVLLRL 310 320 QLTAAFFLAT LLIGLAMRLY YGSR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[5]	"The nucleotide-sugar transporter family: a phylogenetic approach." Martinez-Duncker I., Mollicone R., Codogno P., Oriol R. Biochimie 85:245-260(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK289378 mRNA. Translation: BAF82067.1. AL833972 mRNA. Translation: CAD38817.1. CH471062 Genomic DNA. Translation: EAW62040.1. BC009906 mRNA. Translation: AAH09906.1.
IPI	IPI00062325.
RefSeq	NP_542401.1. NM_080670.2.
UniGene	Hs.406840.
3D structure databases
ProteinModelPortal	Q96G79.
ModBase	Search...
PTM databases
PhosphoSite	Q96G79.
Polymorphism databases
DMDM	74731793.
Proteomic databases
PaxDb	Q96G79.
PRIDE	Q96G79.
Protocols and materials databases
DNASU	113829.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000323146; ENSP00000327133; ENSG00000176087. ENST00000514199; ENSP00000424566; ENSG00000176087.
GeneID	113829.
KEGG	hsa:113829.
UCSC	uc003lgg.1. human.
Organism-specific databases
CTD	113829.
GeneCards	GC05P139944.
HGNC	HGNC:20753. SLC35A4.
neXtProt	NX_Q96G79.
PharmGKB	PA134971555.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG302854.
HOGENOM	HOG000154235.
HOVERGEN	HBG108445.
InParanoid	Q96G79.
KO	K15273.
OMA	YCLCLRR.
OrthoDB	EOG44QT1Z.
PhylomeDB	Q96G79.
Gene expression databases
Bgee	Q96G79.
CleanEx	HS_SLC35A4.
Genevestigator	Q96G79.
Family and domain databases
InterPro	IPR007271. Nuc_sug_transpt. IPR021189. UDP/CMP-sugar_transptr. [Graphical view]
PANTHER	PTHR10231. PTHR10231. 1 hit.
Pfam	PF04142. Nuc_sug_transp. 1 hit. [Graphical view]
PIRSF	PIRSF005799. UDP-gal_transpt. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	113829.
NextBio	78920.

Entry information

Entry name

S35A4_HUMAN

Accession

Primary (citable) accession number: Q96G79
Secondary accession number(s): A8K013

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.