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Protein

Probable UDP-sugar transporter protein SLC35A4

Gene

SLC35A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processSugar transport, Transport

Protein family/group databases

TCDBi2.A.7.12.12. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable UDP-sugar transporter protein SLC35A4Curated
Alternative name(s):
Solute carrier family 35 member A4Imported
Gene namesi
Name:SLC35A4Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:20753. SLC35A4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 42HelicalSequence analysisAdd BLAST23
Transmembranei54 – 76HelicalSequence analysisAdd BLAST23
Transmembranei86 – 105HelicalSequence analysisAdd BLAST20
Transmembranei144 – 163HelicalSequence analysisAdd BLAST20
Transmembranei183 – 205HelicalSequence analysisAdd BLAST23
Transmembranei217 – 239HelicalSequence analysisAdd BLAST23
Transmembranei249 – 271HelicalSequence analysisAdd BLAST23
Transmembranei276 – 298HelicalSequence analysisAdd BLAST23
Transmembranei303 – 322HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi113829.
OpenTargetsiENSG00000176087.
PharmGKBiPA134971555.

Polymorphism and mutation databases

BioMutaiSLC35A4.
DMDMi74731793.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003377481 – 324Probable UDP-sugar transporter protein SLC35A4Add BLAST324

Proteomic databases

PaxDbiQ96G79.
PeptideAtlasiQ96G79.
PRIDEiQ96G79.

PTM databases

iPTMnetiQ96G79.
PhosphoSitePlusiQ96G79.

Expressioni

Gene expression databases

BgeeiENSG00000176087.
CleanExiHS_SLC35A4.
ExpressionAtlasiQ96G79. baseline and differential.
GenevisibleiQ96G79. HS.

Organism-specific databases

HPAiHPA062210.

Interactioni

Protein-protein interaction databases

BioGridi125263. 1 interactor.
IntActiQ96G79. 7 interactors.
STRINGi9606.ENSP00000327133.

Structurei

3D structure databases

ProteinModelPortaliQ96G79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 319Leu-richAdd BLAST299

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2234. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000154235.
HOVERGENiHBG108445.
InParanoidiQ96G79.
KOiK15273.
OMAiFYCLCLR.
OrthoDBiEOG091G0BN0.
PhylomeDBiQ96G79.
TreeFamiTF315345.

Family and domain databases

InterProiView protein in InterPro
IPR007271. Nuc_sug_transpt.
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiView protein in Pfam
PF04142. Nuc_sug_transp. 1 hit.
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: Q96G79-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVEDGGMPG LGRPRQARWT LMLLLSTAMY GAHAPLLALC HVDGRVPFRP
60 70 80 90 100
SSAVLLTELT KLLLCAFSLL VGWQAWPQGP PPWRQAAPFA LSALLYGANN
110 120 130 140 150
NLVIYLQRYM DPSTYQVLSN LKIGSTAVLY CLCLRHRLSV RQGLALLLLM
160 170 180 190 200
AAGACYAAGG LQVPGNTLPS PPPAAAASPM PLHITPLGLL LLILYCLISG
210 220 230 240 250
LSSVYTELLM KRQRLPLALQ NLFLYTFGVL LNLGLHAGGG SGPGLLEGFS
260 270 280 290 300
GWAALVVLSQ ALNGLLMSAV MKHGSSITRL FVVSCSLVVN AVLSAVLLRL
310 320
QLTAAFFLAT LLIGLAMRLY YGSR
Length:324
Mass (Da):34,593
Last modified:December 1, 2001 - v1
Checksum:i9BD54BA459B6C94A
GO
Isoform 2 (identifier: L0R6Q1-1) [UniParc]FASTAAdd to basket
Also known as: uORF1 Publication
The sequence of this isoform can be found in the external entry L0R6Q1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Product of the upstream open reading frame of this bicistronic gene. This may be the major product of the gene under normal conditions.1 Publication
Length:103
Mass (Da):11,133
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79G → E in BAF82067 (PubMed:14702039).Curated1
Sequence conflicti81P → L in BAF82067 (PubMed:14702039).Curated1
Sequence conflicti306F → L in BAF82067 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289378 mRNA. Translation: BAF82067.1.
AL833972 mRNA. Translation: CAD38817.1.
CH471062 Genomic DNA. Translation: EAW62040.1.
BC009906 mRNA. Translation: AAH09906.1.
CCDSiCCDS4231.1. [Q96G79-1]
RefSeqiNP_542401.1. NM_080670.3. [Q96G79-1]
UniGeneiHs.406840.

Genome annotation databases

EnsembliENST00000323146; ENSP00000327133; ENSG00000176087. [Q96G79-1]
ENST00000514199; ENSP00000424566; ENSG00000176087. [Q96G79-1]
ENST00000612662; ENSP00000479255; ENSG00000176087. [Q96G79-1]
GeneIDi113829.
KEGGihsa:113829.
UCSCiuc003lgg.1. human. [Q96G79-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289378 mRNA. Translation: BAF82067.1.
AL833972 mRNA. Translation: CAD38817.1.
CH471062 Genomic DNA. Translation: EAW62040.1.
BC009906 mRNA. Translation: AAH09906.1.
CCDSiCCDS4231.1. [Q96G79-1]
RefSeqiNP_542401.1. NM_080670.3. [Q96G79-1]
UniGeneiHs.406840.

3D structure databases

ProteinModelPortaliQ96G79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125263. 1 interactor.
IntActiQ96G79. 7 interactors.
STRINGi9606.ENSP00000327133.

Protein family/group databases

TCDBi2.A.7.12.12. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ96G79.
PhosphoSitePlusiQ96G79.

Polymorphism and mutation databases

BioMutaiSLC35A4.
DMDMi74731793.

Proteomic databases

PaxDbiQ96G79.
PeptideAtlasiQ96G79.
PRIDEiQ96G79.

Protocols and materials databases

DNASUi113829.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323146; ENSP00000327133; ENSG00000176087. [Q96G79-1]
ENST00000514199; ENSP00000424566; ENSG00000176087. [Q96G79-1]
ENST00000612662; ENSP00000479255; ENSG00000176087. [Q96G79-1]
GeneIDi113829.
KEGGihsa:113829.
UCSCiuc003lgg.1. human. [Q96G79-1]

Organism-specific databases

CTDi113829.
DisGeNETi113829.
GeneCardsiSLC35A4.
HGNCiHGNC:20753. SLC35A4.
HPAiHPA062210.
neXtProtiNX_Q96G79.
OpenTargetsiENSG00000176087.
PharmGKBiPA134971555.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2234. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000154235.
HOVERGENiHBG108445.
InParanoidiQ96G79.
KOiK15273.
OMAiFYCLCLR.
OrthoDBiEOG091G0BN0.
PhylomeDBiQ96G79.
TreeFamiTF315345.

Miscellaneous databases

ChiTaRSiSLC35A4. human.
GenomeRNAii113829.
PROiPR:Q96G79.

Gene expression databases

BgeeiENSG00000176087.
CleanExiHS_SLC35A4.
ExpressionAtlasiQ96G79. baseline and differential.
GenevisibleiQ96G79. HS.

Family and domain databases

InterProiView protein in InterPro
IPR007271. Nuc_sug_transpt.
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiView protein in Pfam
PF04142. Nuc_sug_transp. 1 hit.
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS35A4_HUMAN
AccessioniPrimary (citable) accession number: Q96G79
Secondary accession number(s): A8K013
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The translation and the expression of this protein may be maintained under stress conditions thanks to the presence of the upstream ORF in transcripts.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.