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Protein

Protein RMD5 homolog B

Gene

RMND5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RMD5 homolog B
Gene namesi
Name:RMND5B
ORF Names:UNQ2508/PRO5996
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:26181. RMND5B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596389.

Polymorphism and mutation databases

DMDMi29840869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Protein RMD5 homolog BPRO_0000065709Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96G75.
PaxDbiQ96G75.
PRIDEiQ96G75.

PTM databases

iPTMnetiQ96G75.
PhosphoSiteiQ96G75.

Expressioni

Gene expression databases

BgeeiQ96G75.
CleanExiHS_RMND5B.
ExpressionAtlasiQ96G75. baseline and differential.
GenevisibleiQ96G75. HS.

Organism-specific databases

HPAiHPA047778.

Interactioni

Protein-protein interaction databases

BioGridi122287. 16 interactions.
IntActiQ96G75. 10 interactions.
MINTiMINT-1195608.
STRINGi9606.ENSP00000320623.

Structurei

3D structure databases

ProteinModelPortaliQ96G75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 14833LisHPROSITE-ProRule annotationAdd
BLAST
Domaini155 – 21258CTLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CTLH domain.PROSITE-ProRule annotation
Contains 1 LisH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2817. Eukaryota.
COG5109. LUCA.
GeneTreeiENSGT00720000108814.
HOGENOMiHOG000211399.
HOVERGENiHBG054339.
InParanoidiQ96G75.
OMAiLETNQWA.
OrthoDBiEOG757CXZ.
PhylomeDBiQ96G75.
TreeFamiTF315176.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR013144. CRA_dom.
IPR024964. CTLH/CRA.
IPR006595. CTLH_C.
IPR006594. LisH.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10607. CLTH. 1 hit.
[Graphical view]
SMARTiSM00757. CRA. 1 hit.
SM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96G75-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQCACVERE LDKVLQKFLT YGQHCERSLE ELLHYVGQLR AELASAALQG
60 70 80 90 100
TPLSATLSLV MSQCCRKIKD TVQKLASDHK DIHSSVSRVG KAIDRNFDSE
110 120 130 140 150
ICGVVSDAVW DAREQQQQIL QMAIVEHLYQ QGMLSVAEEL CQESTLNVDL
160 170 180 190 200
DFKQPFLELN RILEALHEQD LGPALEWAVS HRQRLLELNS SLEFKLHRLH
210 220 230 240 250
FIRLLAGGPA KQLEALSYAR HFQPFARLHQ REIQVMMGSL VYLRLGLEKS
260 270 280 290 300
PYCHLLDSSH WAEICETFTR DACSLLGLSV ESPLSVSFAS GCVALPVLMN
310 320 330 340 350
IKAVIEQRQC TGVWNHKDEL PIEIELGMKC WYHSVFACPI LRQQTSDSNP
360 370 380 390
PIKLICGHVI SRDALNKLIN GGKLKCPYCP MEQNPADGKR IIF
Length:393
Mass (Da):44,414
Last modified:December 1, 2001 - v1
Checksum:i8C0C3E67996A5502
GO
Isoform 2 (identifier: Q96G75-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):37,741
Checksum:iC0E1C3D61E8DD1F2
GO

Sequence cautioni

The sequence BAB15303.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6060Missing in isoform 2. 1 PublicationVSP_013174Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ494789 mRNA. Translation: ABF50942.1.
AY359092 mRNA. Translation: AAQ89450.1.
AK025971 mRNA. Translation: BAB15303.1. Different initiation.
AK125337 mRNA. Translation: BAG54186.1.
AL713670 mRNA. Translation: CAD28476.1.
CH471165 Genomic DNA. Translation: EAW53849.1.
CH471165 Genomic DNA. Translation: EAW53850.1.
BC009911 mRNA. Translation: AAH09911.1.
CCDSiCCDS4431.1. [Q96G75-1]
RefSeqiNP_001275723.1. NM_001288794.1. [Q96G75-1]
NP_001275724.1. NM_001288795.1.
NP_073599.2. NM_022762.4. [Q96G75-1]
XP_005266026.1. XM_005265969.2. [Q96G75-1]
XP_005266028.1. XM_005265971.3. [Q96G75-2]
XP_005266029.1. XM_005265972.2. [Q96G75-2]
UniGeneiHs.27222.

Genome annotation databases

EnsembliENST00000313386; ENSP00000320623; ENSG00000145916. [Q96G75-1]
ENST00000515098; ENSP00000420875; ENSG00000145916. [Q96G75-1]
GeneIDi64777.
KEGGihsa:64777.
UCSCiuc003mim.5. human. [Q96G75-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ494789 mRNA. Translation: ABF50942.1.
AY359092 mRNA. Translation: AAQ89450.1.
AK025971 mRNA. Translation: BAB15303.1. Different initiation.
AK125337 mRNA. Translation: BAG54186.1.
AL713670 mRNA. Translation: CAD28476.1.
CH471165 Genomic DNA. Translation: EAW53849.1.
CH471165 Genomic DNA. Translation: EAW53850.1.
BC009911 mRNA. Translation: AAH09911.1.
CCDSiCCDS4431.1. [Q96G75-1]
RefSeqiNP_001275723.1. NM_001288794.1. [Q96G75-1]
NP_001275724.1. NM_001288795.1.
NP_073599.2. NM_022762.4. [Q96G75-1]
XP_005266026.1. XM_005265969.2. [Q96G75-1]
XP_005266028.1. XM_005265971.3. [Q96G75-2]
XP_005266029.1. XM_005265972.2. [Q96G75-2]
UniGeneiHs.27222.

3D structure databases

ProteinModelPortaliQ96G75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122287. 16 interactions.
IntActiQ96G75. 10 interactions.
MINTiMINT-1195608.
STRINGi9606.ENSP00000320623.

PTM databases

iPTMnetiQ96G75.
PhosphoSiteiQ96G75.

Polymorphism and mutation databases

DMDMi29840869.

Proteomic databases

MaxQBiQ96G75.
PaxDbiQ96G75.
PRIDEiQ96G75.

Protocols and materials databases

DNASUi64777.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313386; ENSP00000320623; ENSG00000145916. [Q96G75-1]
ENST00000515098; ENSP00000420875; ENSG00000145916. [Q96G75-1]
GeneIDi64777.
KEGGihsa:64777.
UCSCiuc003mim.5. human. [Q96G75-1]

Organism-specific databases

CTDi64777.
GeneCardsiRMND5B.
HGNCiHGNC:26181. RMND5B.
HPAiHPA047778.
neXtProtiNX_Q96G75.
PharmGKBiPA144596389.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2817. Eukaryota.
COG5109. LUCA.
GeneTreeiENSGT00720000108814.
HOGENOMiHOG000211399.
HOVERGENiHBG054339.
InParanoidiQ96G75.
OMAiLETNQWA.
OrthoDBiEOG757CXZ.
PhylomeDBiQ96G75.
TreeFamiTF315176.

Miscellaneous databases

ChiTaRSiRMND5B. human.
GeneWikiiRMND5B.
GenomeRNAii64777.
PROiQ96G75.

Gene expression databases

BgeeiQ96G75.
CleanExiHS_RMND5B.
ExpressionAtlasiQ96G75. baseline and differential.
GenevisibleiQ96G75. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR013144. CRA_dom.
IPR024964. CTLH/CRA.
IPR006595. CTLH_C.
IPR006594. LisH.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10607. CLTH. 1 hit.
[Graphical view]
SMARTiSM00757. CRA. 1 hit.
SM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human gene RMND5B."
    Tang W., Yuan W., Wu X.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary cancer.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRMD5B_HUMAN
AccessioniPrimary (citable) accession number: Q96G75
Secondary accession number(s): Q1HE27, Q6UVY7, Q9H6F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.