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Q96G46

- DUS3L_HUMAN

UniProt

Q96G46 - DUS3L_HUMAN

Protein

tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like

Gene

DUS3L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.By similarity

    Cofactori

    FAD.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri118 – 14831C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri156 – 18631C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. metal ion binding Source: UniProtKB-KW
    3. poly(A) RNA binding Source: UniProtKB
    4. tRNA dihydrouridine synthase activity Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    FAD, Flavoprotein, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC:1.3.1.-)
    Alternative name(s):
    tRNA-dihydrouridine synthase 3-like
    Gene namesi
    Name:DUS3L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:26920. DUS3L.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671938.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 650649tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-likePRO_0000247342Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications
    Modified residuei236 – 2361Phosphoserine3 Publications
    Modified residuei273 – 2731Phosphothreonine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ96G46.
    PaxDbiQ96G46.
    PRIDEiQ96G46.

    PTM databases

    PhosphoSiteiQ96G46.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96G46.
    BgeeiQ96G46.
    CleanExiHS_DUS3L.
    GenevestigatoriQ96G46.

    Organism-specific databases

    HPAiHPA041854.
    HPA041944.

    Interactioni

    Protein-protein interaction databases

    BioGridi121258. 19 interactions.
    IntActiQ96G46. 1 interaction.
    STRINGi9606.ENSP00000311977.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96G46.
    SMRiQ96G46. Positions 306-575.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Dus family. Dus3 subfamily.Curated
    Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri118 – 14831C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri156 – 18631C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0042.
    HOGENOMiHOG000240610.
    HOVERGENiHBG062413.
    InParanoidiQ96G46.
    KOiK05544.
    OMAiESAAKCF.
    OrthoDBiEOG76HQ12.
    PhylomeDBiQ96G46.
    TreeFamiTF105726.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR001269. tRNA_hU_synthase.
    IPR018517. tRNA_hU_synthase_CS.
    IPR000571. Znf_CCCH.
    [Graphical view]
    PANTHERiPTHR11082. PTHR11082. 1 hit.
    PfamiPF01207. Dus. 1 hit.
    [Graphical view]
    PROSITEiPS01136. UPF0034. 1 hit.
    PS50103. ZF_C3H1. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96G46-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEGTAEAPL ENGGGGDSGA GALERGVAPI KRQYLTTKEQ FHQFLEAKGQ    50
    EKTCRETEVG DPAGNELAEP EAKRIRLEDG QTADGQTEEA AEPGEQLQTQ 100
    KRARGQNKGR PHVKPTNYDK NRLCPSLIQE SAAKCFFGDR CRFLHDVGRY 150
    LETKPADLGP RCVLFETFGR CPYGVTCRFA GAHLRPEGQN LVQEELAARG 200
    TQPPSIRNGL DKALQQQLRK REVRFERAEQ ALRRFSQGPT PAAAVPEGTA 250
    AEGAPRQENC GAQQVPAGPG TSTPPSSPVR TCGPLTDEDV VRLRPCEKKR 300
    LDIRGKLYLA PLTTCGNLPF RRICKRFGAD VTCGEMAVCT NLLQGQMSEW 350
    ALLKRHQCED IFGVQLEGAF PDTMTKCAEL LSRTVEVDFV DINVGCPIDL 400
    VYKKGGGCAL MNRSTKFQQI VRGMNQVLDV PLTVKIRTGV QERVNLAHRL 450
    LPELRDWGVA LVTLHGRSRE QRYTKLADWQ YIEECVQAAS PMPLFGNGDI 500
    LSFEDANRAM QTGVTGIMIA RGALLKPWLF TEIKEQRHWD ISSSERLDIL 550
    RDFTNYGLEH WGSDTQGVEK TRRFLLEWLS FLCRYVPVGL LERLPQRINE 600
    RPPYYLGRDY LETLMASQKA ADWIRISEML LGPVPPSFAF LPKHKANAYK 650
    Length:650
    Mass (Da):72,594
    Last modified:July 25, 2006 - v2
    Checksum:iB785373796AB88E0
    GO
    Isoform 2 (identifier: Q96G46-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         464-482: LHGRSREQRYTKLADWQYI → VGLGTPRALGPRGRPRVPS
         483-650: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:482
    Mass (Da):52,772
    Checksum:iD5E6DB1B7E8827E3
    GO
    Isoform 3 (identifier: Q96G46-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         59-300: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:408
    Mass (Da):46,106
    Checksum:i96931E7C0C377C89
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti134 – 1341K → N in BAB14740. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti185 – 1851R → G.1 Publication
    Corresponds to variant rs2436487 [ dbSNP | Ensembl ].
    VAR_027092
    Natural varianti609 – 6091D → N.
    Corresponds to variant rs12977803 [ dbSNP | Ensembl ].
    VAR_027093

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei59 – 300242Missing in isoform 3. 1 PublicationVSP_019970Add
    BLAST
    Alternative sequencei464 – 48219LHGRS…DWQYI → VGLGTPRALGPRGRPRVPS in isoform 2. 1 PublicationVSP_019971Add
    BLAST
    Alternative sequencei483 – 650168Missing in isoform 2. 1 PublicationVSP_019972Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023958 mRNA. Translation: BAB14740.1.
    AC011499 Genomic DNA. No translation available.
    BC004549 mRNA. Translation: AAH04549.1.
    BC008362 mRNA. Translation: AAH08362.1.
    BC009973 mRNA. Translation: AAH09973.1.
    AL365411 mRNA. Translation: CAB96955.1.
    CCDSiCCDS32880.1. [Q96G46-1]
    CCDS54202.1. [Q96G46-3]
    RefSeqiNP_001155091.1. NM_001161619.1. [Q96G46-3]
    NP_064560.2. NM_020175.2. [Q96G46-1]
    UniGeneiHs.284297.

    Genome annotation databases

    EnsembliENST00000309061; ENSP00000311977; ENSG00000141994. [Q96G46-1]
    ENST00000320699; ENSP00000315558; ENSG00000141994. [Q96G46-3]
    GeneIDi56931.
    KEGGihsa:56931.
    UCSCiuc002mdc.3. human. [Q96G46-1]
    uc002mdd.3. human. [Q96G46-3]

    Polymorphism databases

    DMDMi110808212.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023958 mRNA. Translation: BAB14740.1 .
    AC011499 Genomic DNA. No translation available.
    BC004549 mRNA. Translation: AAH04549.1 .
    BC008362 mRNA. Translation: AAH08362.1 .
    BC009973 mRNA. Translation: AAH09973.1 .
    AL365411 mRNA. Translation: CAB96955.1 .
    CCDSi CCDS32880.1. [Q96G46-1 ]
    CCDS54202.1. [Q96G46-3 ]
    RefSeqi NP_001155091.1. NM_001161619.1. [Q96G46-3 ]
    NP_064560.2. NM_020175.2. [Q96G46-1 ]
    UniGenei Hs.284297.

    3D structure databases

    ProteinModelPortali Q96G46.
    SMRi Q96G46. Positions 306-575.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121258. 19 interactions.
    IntActi Q96G46. 1 interaction.
    STRINGi 9606.ENSP00000311977.

    PTM databases

    PhosphoSitei Q96G46.

    Polymorphism databases

    DMDMi 110808212.

    Proteomic databases

    MaxQBi Q96G46.
    PaxDbi Q96G46.
    PRIDEi Q96G46.

    Protocols and materials databases

    DNASUi 56931.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309061 ; ENSP00000311977 ; ENSG00000141994 . [Q96G46-1 ]
    ENST00000320699 ; ENSP00000315558 ; ENSG00000141994 . [Q96G46-3 ]
    GeneIDi 56931.
    KEGGi hsa:56931.
    UCSCi uc002mdc.3. human. [Q96G46-1 ]
    uc002mdd.3. human. [Q96G46-3 ]

    Organism-specific databases

    CTDi 56931.
    GeneCardsi GC19M005737.
    HGNCi HGNC:26920. DUS3L.
    HPAi HPA041854.
    HPA041944.
    neXtProti NX_Q96G46.
    PharmGKBi PA142671938.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0042.
    HOGENOMi HOG000240610.
    HOVERGENi HBG062413.
    InParanoidi Q96G46.
    KOi K05544.
    OMAi ESAAKCF.
    OrthoDBi EOG76HQ12.
    PhylomeDBi Q96G46.
    TreeFami TF105726.

    Miscellaneous databases

    GenomeRNAii 56931.
    NextBioi 62471.
    PROi Q96G46.

    Gene expression databases

    ArrayExpressi Q96G46.
    Bgeei Q96G46.
    CleanExi HS_DUS3L.
    Genevestigatori Q96G46.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR001269. tRNA_hU_synthase.
    IPR018517. tRNA_hU_synthase_CS.
    IPR000571. Znf_CCCH.
    [Graphical view ]
    PANTHERi PTHR11082. PTHR11082. 1 hit.
    Pfami PF01207. Dus. 1 hit.
    [Graphical view ]
    PROSITEi PS01136. UPF0034. 1 hit.
    PS50103. ZF_C3H1. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Thyroid.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT GLY-185.
      Tissue: Pancreas, Placenta and Uterus.
    4. The European IMAGE consortium
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-650 (ISOFORM 2).
    5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-273, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDUS3L_HUMAN
    AccessioniPrimary (citable) accession number: Q96G46
    Secondary accession number(s): Q96HM5
    , Q9BSU4, Q9H877, Q9NPR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3