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Protein

Kelch domain-containing protein 7B

Gene

KLHDC7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 7B
Gene namesi
Name:KLHDC7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:25145. KLHDC7B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671582.

Polymorphism and mutation databases

BioMutaiKLHDC7B.
DMDMi296434567.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Kelch domain-containing protein 7BPRO_0000229000Add
BLAST

Proteomic databases

PaxDbiQ96G42.
PRIDEiQ96G42.

PTM databases

iPTMnetiQ96G42.
PhosphoSiteiQ96G42.

Expressioni

Gene expression databases

BgeeiQ96G42.
CleanExiHS_KLHDC7B.
GenevisibleiQ96G42. HS.

Organism-specific databases

HPAiHPA000518.

Interactioni

Protein-protein interaction databases

IntActiQ96G42. 1 interaction.
STRINGi9606.ENSP00000379034.

Structurei

3D structure databases

ProteinModelPortaliQ96G42.
SMRiQ96G42. Positions 319-544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati306 – 35449Kelch 1Add
BLAST
Repeati355 – 40551Kelch 2Add
BLAST
Repeati406 – 44843Kelch 3Add
BLAST
Repeati451 – 49343Kelch 4Add
BLAST
Repeati495 – 53844Kelch 5Add
BLAST

Sequence similaritiesi

Contains 5 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000246990.
InParanoidiQ96G42.
OMAiETYALMS.
OrthoDBiEOG7C2R0X.
PhylomeDBiQ96G42.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTiSM00612. Kelch. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96G42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLRSHPFPR QDRPQGSVPR AVPGSPVGPS TSTHSEDRHG PSSSVGTVIG
60 70 80 90 100
TGTGGLVEAG GQPQPRSSET NGSPSPDPPP GLRGEGTREK SLDPLPQAAM
110 120 130 140 150
PRGPAQPPAQ RPPGPAASSS ARRSQPVPQL RKRSRCEIAP SSEQEVRPAA
160 170 180 190 200
SGDPQGEAPG EGGSPAGRSG ALTEKQEEAR KLMVFLQRPG GWGVVEGPRK
210 220 230 240 250
PSSRALEPAT AAALRRRLDL GSCLDVLAFA QQHGEPGLAQ ETYALMSDNL
260 270 280 290 300
LRVLGDPCLY RRLSAADRER ILSLRTGRGR AVLGVLVLPS LYQGGRSGLP
310 320 330 340 350
RGPRGEEPPA AAPVSLPLPA HLHVFNPREN TWRPLTQVPE EAPLRGCGLC
360 370 380 390 400
TMHNYLFLAG GIRGSGAKAV CSNEVFCYNP LTNIWSQVRP MQQARAQLKL
410 420 430 440 450
VALDGLLYAI GGECLYSMEC YDPRTDAWTP RAPLPAGTFP VAHEAVACRG
460 470 480 490 500
DIYVTGGHLF YRLLRYSPVK DAWDECPYSA SHRRSSDIVA LGGFLYRFDL
510 520 530 540 550
LRGVGAAVMR YNTVTGSWSR AASLPLPAPA PLHCTTLGNT IYCLNPQVTA
560 570 580 590
TFTVSGGTAQ FQAKELQPFP LGSTGVLSPF ILTLPPEDRL QTSL
Length:594
Mass (Da):63,314
Last modified:May 18, 2010 - v2
Checksum:i2C681C6B95567559
GO

Sequence cautioni

The sequence AAH09980.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62317 Genomic DNA. No translation available.
BC009980 mRNA. Translation: AAH09980.1. Different initiation.
CCDSiCCDS14097.2.
RefSeqiNP_612442.2. NM_138433.3.
UniGeneiHs.137007.

Genome annotation databases

EnsembliENST00000395676; ENSP00000379034; ENSG00000130487.
GeneIDi113730.
KEGGihsa:113730.
UCSCiuc003bmi.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62317 Genomic DNA. No translation available.
BC009980 mRNA. Translation: AAH09980.1. Different initiation.
CCDSiCCDS14097.2.
RefSeqiNP_612442.2. NM_138433.3.
UniGeneiHs.137007.

3D structure databases

ProteinModelPortaliQ96G42.
SMRiQ96G42. Positions 319-544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96G42. 1 interaction.
STRINGi9606.ENSP00000379034.

PTM databases

iPTMnetiQ96G42.
PhosphoSiteiQ96G42.

Polymorphism and mutation databases

BioMutaiKLHDC7B.
DMDMi296434567.

Proteomic databases

PaxDbiQ96G42.
PRIDEiQ96G42.

Protocols and materials databases

DNASUi113730.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395676; ENSP00000379034; ENSG00000130487.
GeneIDi113730.
KEGGihsa:113730.
UCSCiuc003bmi.3. human.

Organism-specific databases

CTDi113730.
GeneCardsiKLHDC7B.
HGNCiHGNC:25145. KLHDC7B.
HPAiHPA000518.
neXtProtiNX_Q96G42.
PharmGKBiPA142671582.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000246990.
InParanoidiQ96G42.
OMAiETYALMS.
OrthoDBiEOG7C2R0X.
PhylomeDBiQ96G42.
TreeFamiTF328485.

Miscellaneous databases

GenomeRNAii113730.
PROiQ96G42.

Gene expression databases

BgeeiQ96G42.
CleanExiHS_KLHDC7B.
GenevisibleiQ96G42. HS.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTiSM00612. Kelch. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.

Entry informationi

Entry nameiKLD7B_HUMAN
AccessioniPrimary (citable) accession number: Q96G42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-100 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.