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Protein

WW domain-binding protein 1

Gene

WBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • WW domain binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-binding protein 1
Short name:
WBP-1
Gene namesi
Name:WBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:12737. WBP1.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi141 – 1411Y → A: Abolishes interaction with WWOX. 1 Publication

Organism-specific databases

PharmGKBiPA37348.

Polymorphism and mutation databases

BioMutaiWBP1.
DMDMi25091540.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269WW domain-binding protein 1PRO_0000065948Add
BLAST

Proteomic databases

EPDiQ96G27.
MaxQBiQ96G27.
PaxDbiQ96G27.
PeptideAtlasiQ96G27.
PRIDEiQ96G27.

PTM databases

iPTMnetiQ96G27.
PhosphoSiteiQ96G27.

Expressioni

Tissue specificityi

Expressed in most tissues but at significantly lower levels in placenta, lung, liver, and kidney.

Gene expression databases

BgeeiQ96G27.
CleanExiHS_WBP1.
ExpressionAtlasiQ96G27. baseline and differential.
GenevisibleiQ96G27. HS.

Organism-specific databases

HPAiHPA057067.

Interactioni

Subunit structurei

Interacts with NEDD4 (By similarity). Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with WWOX.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
WWOXQ9NZC73EBI-3867685,EBI-4320739
YAP1P469373EBI-3867685,EBI-1044059

GO - Molecular functioni

  • WW domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117103. 37 interactions.
IntActiQ96G27. 3 interactions.
STRINGi9606.ENSP00000233615.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JMQNMR-P135-144[»]
1K5RNMR-B135-143[»]
ProteinModelPortaliQ96G27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi124 – 1274WW-binding 1
Motifi137 – 1415WW-binding 2

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi85 – 906Poly-Gln
Compositional biasi159 – 1635Poly-Ser

Domaini

The WW-binding 2 motif mediates interaction with WWOX. Both WW-binding motifs mediate interaction with NEDD4 (By similarity).By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWXA. Eukaryota.
ENOG41104IZ. LUCA.
GeneTreeiENSGT00530000063663.
HOGENOMiHOG000231948.
HOVERGENiHBG029355.
InParanoidiQ96G27.
PhylomeDBiQ96G27.
TreeFamiTF330726.

Family and domain databases

InterProiIPR021684. WBP1-like.
[Graphical view]
PfamiPF11669. WBP-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96G27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARASSGNGS EEAWGALRAP QQQLRELCPG VNNQPYLCES GHCCGETGCC
60 70 80 90 100
TYYYELWWFW LLWTVLILFS CCCAFRHRRA KLRLQQQQRQ REINLLAYHG
110 120 130 140 150
ACHGAGPFPT GSLLDLRFLS TFKPPAYEDV VHRPGTPPPP YTVAPGRPLT
160 170 180 190 200
ASSEQTCCSS SSSCPAHFEG TNVEGVSSHQ SAPPHQEGEP GAGVTPASTP
210 220 230 240 250
PSCRYRRLTG DSGIELCPCP ASGEGEPVKE VRVSATLPDL EDYSPCALPP
260
ESVPQIFPMG LSSSEGDIP
Length:269
Mass (Da):29,140
Last modified:December 1, 2001 - v1
Checksum:i009CF5A444E62AC0
GO

Sequence cautioni

The sequence AAD10950.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79457 mRNA. Translation: AAD10950.1. Different initiation.
AK315745 mRNA. Translation: BAG38099.1.
CH471053 Genomic DNA. Translation: EAW99656.1.
BC010012 mRNA. Translation: AAH10012.1.
BC064482 mRNA. Translation: AAH64482.1.
BC071626 mRNA. Translation: AAH71626.1.
BC071850 mRNA. Translation: AAH71850.1.
CCDSiCCDS1943.1.
RefSeqiNP_036609.1. NM_012477.3.
UniGeneiHs.516114.

Genome annotation databases

EnsembliENST00000233615; ENSP00000233615; ENSG00000239779.
GeneIDi23559.
KEGGihsa:23559.
UCSCiuc002slj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79457 mRNA. Translation: AAD10950.1. Different initiation.
AK315745 mRNA. Translation: BAG38099.1.
CH471053 Genomic DNA. Translation: EAW99656.1.
BC010012 mRNA. Translation: AAH10012.1.
BC064482 mRNA. Translation: AAH64482.1.
BC071626 mRNA. Translation: AAH71626.1.
BC071850 mRNA. Translation: AAH71850.1.
CCDSiCCDS1943.1.
RefSeqiNP_036609.1. NM_012477.3.
UniGeneiHs.516114.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JMQNMR-P135-144[»]
1K5RNMR-B135-143[»]
ProteinModelPortaliQ96G27.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117103. 37 interactions.
IntActiQ96G27. 3 interactions.
STRINGi9606.ENSP00000233615.

PTM databases

iPTMnetiQ96G27.
PhosphoSiteiQ96G27.

Polymorphism and mutation databases

BioMutaiWBP1.
DMDMi25091540.

Proteomic databases

EPDiQ96G27.
MaxQBiQ96G27.
PaxDbiQ96G27.
PeptideAtlasiQ96G27.
PRIDEiQ96G27.

Protocols and materials databases

DNASUi23559.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233615; ENSP00000233615; ENSG00000239779.
GeneIDi23559.
KEGGihsa:23559.
UCSCiuc002slj.3. human.

Organism-specific databases

CTDi23559.
GeneCardsiWBP1.
H-InvDBHIX0077795.
HGNCiHGNC:12737. WBP1.
HPAiHPA057067.
MIMi606961. gene.
neXtProtiNX_Q96G27.
PharmGKBiPA37348.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWXA. Eukaryota.
ENOG41104IZ. LUCA.
GeneTreeiENSGT00530000063663.
HOGENOMiHOG000231948.
HOVERGENiHBG029355.
InParanoidiQ96G27.
PhylomeDBiQ96G27.
TreeFamiTF330726.

Miscellaneous databases

GeneWikiiWBP1.
GenomeRNAii23559.
PROiQ96G27.
SOURCEiSearch...

Gene expression databases

BgeeiQ96G27.
CleanExiHS_WBP1.
ExpressionAtlasiQ96G27. baseline and differential.
GenevisibleiQ96G27. HS.

Family and domain databases

InterProiIPR021684. WBP1-like.
[Graphical view]
PfamiPF11669. WBP-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands."
    Chen H.I., Einbond A., Kwak S.-J., Linn H., Koepf E., Peterson S., Kelly J.W., Sudol M.
    J. Biol. Chem. 272:17070-17077(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH YAP1.
    Tissue: Lung.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell, Eye, Lung and Pancreas.
  5. "Identification of novel human WW domain-containing proteins by cloning of ligand targets."
    Pirozzi G., McConnell S.J., Uveges A.J., Carter J.M., Sparks A.B., Kay B.K., Fowlkes D.M.
    J. Biol. Chem. 272:14611-14616(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WWP1 AND WWP2.
  6. "WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins."
    Ludes-Meyers J.H., Kil H., Bednarek A.K., Drake J., Bedford M.T., Aldaz C.M.
    Oncogene 23:5049-5055(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WWOX, DOMAINS, MUTAGENESIS OF TYR-141.

Entry informationi

Entry nameiWBP1_HUMAN
AccessioniPrimary (citable) accession number: Q96G27
Secondary accession number(s): B2RE02, O95637
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.