Q96G27 (WBP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WW domain-binding protein 1
Short name=WBP-1

Gene names

Name:

WBP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with NEDD4 By similarity. Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with WWOX. Ref.1 Ref.5 Ref.6
Tissue specificity	Expressed in most tissues but at significantly lower levels in placenta, lung, liver, and kidney.
Domain	The WW-binding 2 motif mediates interaction with WWOX. Both WW-binding motifs mediate interaction with NEDD4 By similarity. Ref.6
Sequence caution	The sequence AAD10950.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	WW domain binding Inferred from physical interaction Ref.6. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	WW domain-binding protein 1		PRO_0000065948
Regions
	Motif	124 – 127	4	WW-binding 1
	Motif	137 – 141	5	WW-binding 2
	Compositional bias	85 – 90	6	Poly-Gln
	Compositional bias	159 – 163	5	Poly-Ser
Experimental info
	Mutagenesis	141	1	Y → A: Abolishes interaction with WWOX. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q96G27 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 009CF5A444E62AC0	FASTA	269	29,140
	10 20 30 40 50 60 MARASSGNGS EEAWGALRAP QQQLRELCPG VNNQPYLCES GHCCGETGCC TYYYELWWFW 70 80 90 100 110 120 LLWTVLILFS CCCAFRHRRA KLRLQQQQRQ REINLLAYHG ACHGAGPFPT GSLLDLRFLS 130 140 150 160 170 180 TFKPPAYEDV VHRPGTPPPP YTVAPGRPLT ASSEQTCCSS SSSCPAHFEG TNVEGVSSHQ 190 200 210 220 230 240 SAPPHQEGEP GAGVTPASTP PSCRYRRLTG DSGIELCPCP ASGEGEPVKE VRVSATLPDL 250 260 EDYSPCALPP ESVPQIFPMG LSSSEGDIP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands." Chen H.I., Einbond A., Kwak S.-J., Linn H., Koepf E., Peterson S., Kelly J.W., Sudol M. J. Biol. Chem. 272:17070-17077(1997) [PubMed: 9202023] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH YAP1. Tissue: Lung.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell, Eye, Lung and Pancreas.
[5]	"Identification of novel human WW domain-containing proteins by cloning of ligand targets." Pirozzi G., McConnell S.J., Uveges A.J., Carter J.M., Sparks A.B., Kay B.K., Fowlkes D.M. J. Biol. Chem. 272:14611-14616(1997) [PubMed: 9169421] [Abstract] Cited for: INTERACTION WITH WWP1 AND WWP2.
[6]	"WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins." Ludes-Meyers J.H., Kil H., Bednarek A.K., Drake J., Bedford M.T., Aldaz C.M. Oncogene 23:5049-5055(2004) [PubMed: 15064722] [Abstract] Cited for: INTERACTION WITH WWOX, DOMAINS, MUTAGENESIS OF TYR-141.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U79457 mRNA. Translation: AAD10950.1. Different initiation. AK315745 mRNA. Translation: BAG38099.1. CH471053 Genomic DNA. Translation: EAW99656.1. BC010012 mRNA. Translation: AAH10012.1. BC064482 mRNA. Translation: AAH64482.1. BC071626 mRNA. Translation: AAH71626.1. BC071850 mRNA. Translation: AAH71850.1.
IPI	IPI00032048.
RefSeq	NP_036609.1. NM_012477.3.
UniGene	Hs.516114.
3D structure databases
ProteinModelPortal	Q96G27.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96G27.
Polymorphism databases
DMDM	25091540.
Proteomic databases
PRIDE	Q96G27.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000233615; ENSP00000233615; ENSG00000239779.
GeneID	23559.
KEGG	hsa:23559.
UCSC	uc002slj.1. human.
Organism-specific databases
CTD	23559.
GeneCards	GC02P074685.
H-InvDB	HIX0002183.
HGNC	HGNC:12737. WBP1.
MIM	606961. gene.
neXtProt	NX_Q96G27.
PharmGKB	PA37348.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07303.
GeneTree	ENSGT00530000063663.
HOVERGEN	HBG029355.
OrthoDB	EOG4B2SZ8.
PhylomeDB	Q96G27.
Gene expression databases
ArrayExpress	Q96G27.
CleanEx	HS_WBP1.
Genevestigator	Q96G27.
GermOnline	ENSG00000173027. Homo sapiens.
Family and domain databases
InterPro	IPR021684. Uncharacterised_WW-bd. [Graphical view]
Pfam	PF11669. WBP-1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	46138.
SOURCE	Search...

Entry information

Entry name

WBP1_HUMAN

Accession

Primary (citable) accession number: Q96G27
Secondary accession number(s): B2RE02, O95637

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.