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Q96G23

- CERS2_HUMAN

UniProt

Q96G23 - CERS2_HUMAN

Protein

Ceramide synthase 2

Gene

CERS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi67 – 12862HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. sphingosine N-acyltransferase activity Source: Ensembl

    GO - Biological processi

    1. ceramide biosynthetic process Source: Ensembl
    2. small molecule metabolic process Source: Reactome
    3. sphingolipid biosynthetic process Source: Reactome
    4. sphingolipid metabolic process Source: Reactome

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_115810. Sphingolipid de novo biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ceramide synthase 2
    Short name:
    CerS2
    Alternative name(s):
    LAG1 longevity assurance homolog 2
    SP260
    Tumor metastasis-suppressor gene 1 protein
    Gene namesi
    Name:CERS2
    Synonyms:LASS2, TMSG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14076. CERS2.

    Subcellular locationi

    Nucleus membrane PROSITE-ProRule annotation; Multi-pass membrane protein Curated. Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: HPA
    2. endoplasmic reticulum membrane Source: Reactome
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane Source: UniProtKB
    5. nuclear membrane Source: HPA

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30300.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380Ceramide synthase 2PRO_0000185509Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi19 – 191N-linked (GlcNAc...)2 Publications
    Modified residuei341 – 3411Phosphoserine5 Publications
    Modified residuei346 – 3461Phosphothreonine4 Publications
    Modified residuei348 – 3481Phosphoserine4 Publications
    Modified residuei349 – 3491Phosphoserine4 Publications

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ96G23.
    PaxDbiQ96G23.
    PRIDEiQ96G23.

    PTM databases

    PhosphoSiteiQ96G23.

    Expressioni

    Tissue specificityi

    Expressed in kidney, liver, brain, heart, placenta and lung.1 Publication

    Gene expression databases

    ArrayExpressiQ96G23.
    BgeeiQ96G23.
    CleanExiHS_LASS2.
    GenevestigatoriQ96G23.

    Organism-specific databases

    HPAiHPA027262.

    Interactioni

    Subunit structurei

    Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Interacts with ELOV1, HSD17B12 and TECR.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ASGR1P073063EBI-1057080,EBI-1172335
    ASGR2P073073EBI-1057080,EBI-1172636
    ATP6V0CP274493EBI-1057080,EBI-721179
    HSP90AA1P079002EBI-1057080,EBI-296047
    SLC22A1O152453EBI-1057080,EBI-1172714

    Protein-protein interaction databases

    BioGridi118992. 23 interactions.
    IntActiQ96G23. 15 interactions.
    STRINGi9606.ENSP00000271688.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96G23.
    SMRiQ96G23. Positions 78-128.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4040LumenalSequence AnalysisAdd
    BLAST
    Topological domaini62 – 13978CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 18020LumenalSequence AnalysisAdd
    BLAST
    Topological domaini202 – 2087CytoplasmicSequence Analysis
    Topological domaini230 – 26334LumenalSequence AnalysisAdd
    BLAST
    Topological domaini285 – 30319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini325 – 38056LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei181 – 20121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini131 – 332202TLCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5058.
    HOVERGENiHBG052310.
    InParanoidiQ96G23.
    KOiK04710.
    OMAiSWFANYV.
    PhylomeDBiQ96G23.
    TreeFamiTF314319.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR016439. Longevity_assurance_LAG1_LAC1.
    IPR006634. TLC-dom.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF03798. TRAM_LAG1_CLN8. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005225. LAG1_LAC1. 1 hit.
    SMARTiSM00389. HOX. 1 hit.
    SM00724. TLC. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS50071. HOMEOBOX_2. 1 hit.
    PS50922. TLC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96G23-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQTLYDYFW WERLWLPVNL TWADLEDRDG RVYAKASDLY ITLPLALLFL    50
    IVRYFFELYV ATPLAALLNI KEKTRLRAPP NATLEHFYLT SGKQPKQVEV 100
    ELLSRQSGLS GRQVERWFRR RRNQDRPSLL KKFREASWRF TFYLIAFIAG 150
    MAVIVDKPWF YDMKKVWEGY PIQSTIPSQY WYYMIELSFY WSLLFSIASD 200
    VKRKDFKEQI IHHVATIILI SFSWFANYIR AGTLIMALHD SSDYLLESAK 250
    MFNYAGWKNT CNNIFIVFAI VFIITRLVIL PFWILHCTLV YPLELYPAFF 300
    GYYFFNSMMG VLQLLHIFWA YLILRMAHKF ITGKLVEDER SDREETESSE 350
    GEEAAAGGGA KSRPLANGHP ILNNNHRKND 380
    Length:380
    Mass (Da):44,876
    Last modified:December 1, 2001 - v1
    Checksum:iC8CEAF6AAD0B4577
    GO

    Sequence cautioni

    The sequence BAA91505.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti154 – 1541I → T in AAF01058. 1 PublicationCurated
    Sequence conflicti345 – 3451E → V in AAF01058. 1 PublicationCurated
    Sequence conflicti353 – 3531E → K in AAF01058. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti115 – 1151E → A.
    Corresponds to variant rs267738 [ dbSNP | Ensembl ].
    VAR_052325

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF177338 mRNA. Translation: AAG17982.2.
    AY091458 mRNA. Translation: AAM12028.1.
    AL590133 Genomic DNA. Translation: CAI13330.1.
    CH471121 Genomic DNA. Translation: EAW53497.1.
    CH471121 Genomic DNA. Translation: EAW53498.1.
    CH471121 Genomic DNA. Translation: EAW53499.1.
    CH471121 Genomic DNA. Translation: EAW53502.1.
    BC001357 mRNA. Translation: AAH01357.2.
    BC010032 mRNA. Translation: AAH10032.1.
    AK001105 mRNA. Translation: BAA91505.1. Different initiation.
    AF189062 mRNA. Translation: AAF01058.4.
    CCDSiCCDS973.1.
    RefSeqiNP_071358.1. NM_022075.4.
    NP_859530.1. NM_181746.3.
    XP_005245164.1. XM_005245107.2.
    UniGeneiHs.744017.

    Genome annotation databases

    EnsembliENST00000271688; ENSP00000271688; ENSG00000143418.
    ENST00000368954; ENSP00000357950; ENSG00000143418.
    GeneIDi29956.
    KEGGihsa:29956.
    UCSCiuc001evy.3. human.

    Polymorphism databases

    DMDMi51316514.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF177338 mRNA. Translation: AAG17982.2 .
    AY091458 mRNA. Translation: AAM12028.1 .
    AL590133 Genomic DNA. Translation: CAI13330.1 .
    CH471121 Genomic DNA. Translation: EAW53497.1 .
    CH471121 Genomic DNA. Translation: EAW53498.1 .
    CH471121 Genomic DNA. Translation: EAW53499.1 .
    CH471121 Genomic DNA. Translation: EAW53502.1 .
    BC001357 mRNA. Translation: AAH01357.2 .
    BC010032 mRNA. Translation: AAH10032.1 .
    AK001105 mRNA. Translation: BAA91505.1 . Different initiation.
    AF189062 mRNA. Translation: AAF01058.4 .
    CCDSi CCDS973.1.
    RefSeqi NP_071358.1. NM_022075.4.
    NP_859530.1. NM_181746.3.
    XP_005245164.1. XM_005245107.2.
    UniGenei Hs.744017.

    3D structure databases

    ProteinModelPortali Q96G23.
    SMRi Q96G23. Positions 78-128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118992. 23 interactions.
    IntActi Q96G23. 15 interactions.
    STRINGi 9606.ENSP00000271688.

    PTM databases

    PhosphoSitei Q96G23.

    Polymorphism databases

    DMDMi 51316514.

    Proteomic databases

    MaxQBi Q96G23.
    PaxDbi Q96G23.
    PRIDEi Q96G23.

    Protocols and materials databases

    DNASUi 29956.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000271688 ; ENSP00000271688 ; ENSG00000143418 .
    ENST00000368954 ; ENSP00000357950 ; ENSG00000143418 .
    GeneIDi 29956.
    KEGGi hsa:29956.
    UCSCi uc001evy.3. human.

    Organism-specific databases

    CTDi 29956.
    GeneCardsi GC01M150934.
    HGNCi HGNC:14076. CERS2.
    HPAi HPA027262.
    MIMi 606920. gene.
    neXtProti NX_Q96G23.
    PharmGKBi PA30300.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5058.
    HOVERGENi HBG052310.
    InParanoidi Q96G23.
    KOi K04710.
    OMAi SWFANYV.
    PhylomeDBi Q96G23.
    TreeFami TF314319.

    Enzyme and pathway databases

    Reactomei REACT_115810. Sphingolipid de novo biosynthesis.

    Miscellaneous databases

    ChiTaRSi CERS2. human.
    GeneWikii LASS2.
    GenomeRNAii 29956.
    NextBioi 52663.
    PROi Q96G23.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96G23.
    Bgeei Q96G23.
    CleanExi HS_LASS2.
    Genevestigatori Q96G23.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR016439. Longevity_assurance_LAG1_LAC1.
    IPR006634. TLC-dom.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF03798. TRAM_LAG1_CLN8. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005225. LAG1_LAC1. 1 hit.
    SMARTi SM00389. HOX. 1 hit.
    SM00724. TLC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS50071. HOMEOBOX_2. 1 hit.
    PS50922. TLC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1."
      Pan H., Qin W.-X., Huo K.-K., Wan D.-F., Yu Y., Xu Z.-G., Hu Q.-D., Gu K.T., Zhou X.-M., Jiang H.-Q., Zhang P.-P., Huang Y., Li Y.-Y., Gu J.-R.
      Genomics 77:58-64(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH ATP6V0C; ASGR1; ASGR2 AND SLC22A1/OCT1.
      Tissue: Liver.
    2. Qin W.-X., Gu J.-R., Wan D.-F., Zhou X.-M., Jiang H.-Q., Zhang P.-P., Huang Y., Qiu X.-K., Qian L.F., He L.P., Li H.N., Yu Y., Yu J.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. Xingfeng C., Yi G.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney and Skin.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 59-380.
      Tissue: Embryo.
    8. "Cancer metastasis-related gene."
      Liu Y., Zheng J., Wu B., Fang W.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 151-380.
      Tissue: Prostatic carcinoma.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341; THR-346; SER-348 AND SER-349, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
      Lewandrowski U., Moebius J., Walter U., Sickmann A.
      Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-19.
      Tissue: Platelet.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341; THR-346; SER-348 AND SER-349, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
      Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341; THR-346; SER-348 AND SER-349, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-19.
      Tissue: Liver.
    15. Cited for: INTERACTION WITH ELOV1; HSD17B12 AND TECR.
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341; THR-346; SER-348 AND SER-349, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCERS2_HUMAN
    AccessioniPrimary (citable) accession number: Q96G23
    Secondary accession number(s): D3DV06
    , Q5SZE5, Q9HD96, Q9NW79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3