Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

U3 small nucleolar ribonucleoprotein protein IMP4

Gene

IMP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.1 Publication

GO - Molecular functioni

GO - Biological processi

  • rRNA processing Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136718-MONOMER.
ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein IMP4
Short name:
U3 snoRNP protein IMP4
Alternative name(s):
Brix domain-containing protein 4
Gene namesi
Name:IMP4
Synonyms:BXDC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:30856. IMP4.

Subcellular locationi

GO - Cellular componenti

  • Mpp10 complex Source: GO_Central
  • nucleolus Source: HGNC
  • nucleoplasm Source: Reactome
  • small-subunit processome Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136718.
PharmGKBiPA142671656.

Polymorphism and mutation databases

BioMutaiIMP4.
DMDMi73621060.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202361 – 291U3 small nucleolar ribonucleoprotein protein IMP4Add BLAST291

Proteomic databases

EPDiQ96G21.
MaxQBiQ96G21.
PaxDbiQ96G21.
PeptideAtlasiQ96G21.
PRIDEiQ96G21.

PTM databases

iPTMnetiQ96G21.
PhosphoSitePlusiQ96G21.

Expressioni

Gene expression databases

BgeeiENSG00000136718.
CleanExiHS_IMP4.
ExpressionAtlasiQ96G21. baseline and differential.
GenevisibleiQ96G21. HS.

Organism-specific databases

HPAiCAB010345.

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ZBTB7BO151564EBI-8641721,EBI-740434

Protein-protein interaction databases

BioGridi124984. 26 interactors.
IntActiQ96G21. 1 interactor.
MINTiMINT-3052989.
STRINGi9606.ENSP00000259239.

Structurei

3D structure databases

ProteinModelPortaliQ96G21.
SMRiQ96G21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 264BrixPROSITE-ProRule annotationAdd BLAST182

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 48Arg-richAdd BLAST46

Sequence similaritiesi

Contains 1 Brix domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2781. Eukaryota.
COG2136. LUCA.
GeneTreeiENSGT00550000074987.
HOGENOMiHOG000172063.
HOVERGENiHBG056795.
InParanoidiQ96G21.
KOiK14561.
OMAiRFEMKPY.
OrthoDBiEOG091G0GP1.
PhylomeDBiQ96G21.
TreeFamiTF300016.

Family and domain databases

Gene3Di3.40.50.10480. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96G21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRREARLRR EYLYRKAREE AQRSAQERKE RLRRALEENR LIPTELRREA
60 70 80 90 100
LALQGSLEFD DAGGEGVTSH VDDEYRWAGV EDPKVMITTS RDPSSRLKMF
110 120 130 140 150
AKELKLVFPG AQRMNRGRHE VGALVRACKA NGVTDLLVVH EHRGTPVGLI
160 170 180 190 200
VSHLPFGPTA YFTLCNVVMR HDIPDLGTMS EAKPHLITHG FSSRLGKRVS
210 220 230 240 250
DILRYLFPVP KDDSHRVITF ANQDDYISFR HHVYKKTDHR NVELTEVGPR
260 270 280 290
FELKLYMIRL GTLEQEATAD VEWRWHPYTN TARKRVFLST E
Length:291
Mass (Da):33,757
Last modified:December 1, 2001 - v1
Checksum:i460A05DFFE70C580
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY364245 mRNA. Translation: AAQ76804.1.
AK289878 mRNA. Translation: BAF82567.1.
AK292345 mRNA. Translation: BAF85034.1.
AK312808 mRNA. Translation: BAG35666.1.
AC132479 Genomic DNA. Translation: AAY24076.1.
BC010042 mRNA. Translation: AAH10042.1.
CCDSiCCDS2160.1.
RefSeqiNP_001307233.1. NM_001320304.1.
NP_001307234.1. NM_001320305.1.
NP_001307235.1. NM_001320306.1.
NP_001307236.1. NM_001320307.1.
NP_001307238.1. NM_001320309.1.
NP_001307239.1. NM_001320310.1.
NP_001307240.1. NM_001320311.1.
NP_219484.1. NM_033416.2.
UniGeneiHs.91579.

Genome annotation databases

EnsembliENST00000259239; ENSP00000259239; ENSG00000136718.
GeneIDi92856.
KEGGihsa:92856.
UCSCiuc002tra.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY364245 mRNA. Translation: AAQ76804.1.
AK289878 mRNA. Translation: BAF82567.1.
AK292345 mRNA. Translation: BAF85034.1.
AK312808 mRNA. Translation: BAG35666.1.
AC132479 Genomic DNA. Translation: AAY24076.1.
BC010042 mRNA. Translation: AAH10042.1.
CCDSiCCDS2160.1.
RefSeqiNP_001307233.1. NM_001320304.1.
NP_001307234.1. NM_001320305.1.
NP_001307235.1. NM_001320306.1.
NP_001307236.1. NM_001320307.1.
NP_001307238.1. NM_001320309.1.
NP_001307239.1. NM_001320310.1.
NP_001307240.1. NM_001320311.1.
NP_219484.1. NM_033416.2.
UniGeneiHs.91579.

3D structure databases

ProteinModelPortaliQ96G21.
SMRiQ96G21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124984. 26 interactors.
IntActiQ96G21. 1 interactor.
MINTiMINT-3052989.
STRINGi9606.ENSP00000259239.

PTM databases

iPTMnetiQ96G21.
PhosphoSitePlusiQ96G21.

Polymorphism and mutation databases

BioMutaiIMP4.
DMDMi73621060.

Proteomic databases

EPDiQ96G21.
MaxQBiQ96G21.
PaxDbiQ96G21.
PeptideAtlasiQ96G21.
PRIDEiQ96G21.

Protocols and materials databases

DNASUi92856.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259239; ENSP00000259239; ENSG00000136718.
GeneIDi92856.
KEGGihsa:92856.
UCSCiuc002tra.2. human.

Organism-specific databases

CTDi92856.
GeneCardsiIMP4.
HGNCiHGNC:30856. IMP4.
HPAiCAB010345.
MIMi612981. gene.
neXtProtiNX_Q96G21.
OpenTargetsiENSG00000136718.
PharmGKBiPA142671656.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2781. Eukaryota.
COG2136. LUCA.
GeneTreeiENSGT00550000074987.
HOGENOMiHOG000172063.
HOVERGENiHBG056795.
InParanoidiQ96G21.
KOiK14561.
OMAiRFEMKPY.
OrthoDBiEOG091G0GP1.
PhylomeDBiQ96G21.
TreeFamiTF300016.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136718-MONOMER.
ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

ChiTaRSiIMP4. human.
GeneWikiiIMP4.
GenomeRNAii92856.
PROiQ96G21.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136718.
CleanExiHS_IMP4.
ExpressionAtlasiQ96G21. baseline and differential.
GenevisibleiQ96G21. HS.

Family and domain databases

Gene3Di3.40.50.10480. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMP4_HUMAN
AccessioniPrimary (citable) accession number: Q96G21
Secondary accession number(s): Q3ZTT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.