Q96G21 (IMP4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
U3 small nucleolar ribonucleoprotein protein IMP4
Short name=U3 snoRNP protein IMP4

Alternative name(s):
Brix domain-containing protein 4

Gene names

Name:	IMP4
Synonyms:	BXDC4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Ref.3
Subunit structure	Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10. Ref.3
Subcellular location	Nucleus › nucleolus Ref.3.
Sequence similarities	Contains 1 Brix domain.

Ontologies

Keywords
Biological process	Ribosome biogenesis rRNA processing
Cellular component	Nucleus
Molecular function	Ribonucleoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	rRNA processing Non-traceable author statement Ref.3. Source: HGNC
Cellular_component	nucleolus Inferred from direct assay Ref.3. Source: HGNC ribonucleoprotein complex Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	U3 small nucleolar ribonucleoprotein protein IMP4		PRO_0000120236
Regions
	Domain	83 – 264	182	Brix
	Compositional bias	3 – 48	46	Arg-rich

Sequences

	Sequence		Length	Mass (Da)
	Q96G21 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 460A05DFFE70C580	FASTA	291	33,757
	10 20 30 40 50 60 MLRREARLRR EYLYRKAREE AQRSAQERKE RLRRALEENR LIPTELRREA LALQGSLEFD 70 80 90 100 110 120 DAGGEGVTSH VDDEYRWAGV EDPKVMITTS RDPSSRLKMF AKELKLVFPG AQRMNRGRHE 130 140 150 160 170 180 VGALVRACKA NGVTDLLVVH EHRGTPVGLI VSHLPFGPTA YFTLCNVVMR HDIPDLGTMS 190 200 210 220 230 240 EAKPHLITHG FSSRLGKRVS DILRYLFPVP KDDSHRVITF ANQDDYISFR HHVYKKTDHR 250 260 270 280 290 NVELTEVGPR FELKLYMIRL GTLEQEATAD VEWRWHPYTN TARKRVFLST E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes." Granneman S., Gallagher J.E.G., Vogelzangs J., Horstman W., van Venrooij W.J., Baserga S.J., Pruijn G.J.M. Nucleic Acids Res. 31:1877-1887(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MPHOSPH10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC132479 Genomic DNA. Translation: AAY24076.1. BC010042 mRNA. Translation: AAH10042.1.
IPI	IPI00181116.
RefSeq	NP_219484.1. NM_033416.1.
UniGene	Hs.91579.
3D structure databases
ProteinModelPortal	Q96G21.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000259239.
PTM databases
PhosphoSite	Q96G21.
Polymorphism databases
DMDM	73621060.
Proteomic databases
PaxDb	Q96G21.
PeptideAtlas	Q96G21.
PRIDE	Q96G21.
Protocols and materials databases
DNASU	92856.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000259239; ENSP00000259239; ENSG00000136718.
GeneID	92856.
KEGG	hsa:92856.
UCSC	uc002tra.1. human.
Organism-specific databases
CTD	92856.
GeneCards	GC02P131099.
HGNC	HGNC:30856. IMP4.
MIM	612981. gene.
neXtProt	NX_Q96G21.
PharmGKB	PA142671656.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2136.
HOGENOM	HOG000172063.
HOVERGEN	HBG056795.
InParanoid	Q96G21.
KO	K14561.
OMA	SHFPHGP.
OrthoDB	EOG4JHCG8.
Gene expression databases
ArrayExpress	Q96G21.
Bgee	Q96G21.
CleanEx	HS_IMP4.
Genevestigator	Q96G21.
GermOnline	ENSG00000136718. Homo sapiens.
Family and domain databases
InterPro	IPR004154. Anticodon-bd. IPR007109. Brix. [Graphical view]
Pfam	PF04427. Brix. 1 hit. [Graphical view]
SMART	SM00879. Brix. 1 hit. [Graphical view]
SUPFAM	SSF52954. Anticodon_bd. 1 hit.
PROSITE	PS50833. BRIX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	IMP4. human.
GenomeRNAi	92856.
NextBio	77904.
SOURCE	Search...

Entry information

Entry name

IMP4_HUMAN

Accession

Primary (citable) accession number: Q96G21

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.