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Q96G04

- FA86A_HUMAN

UniProt

Q96G04 - FA86A_HUMAN

Protein

Protein FAM86A

Gene

FAM86A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (24 Jan 2006)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM86A
    Gene namesi
    Name:FAM86A
    ORF Names:SB153
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:32221. FAM86A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671858.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Protein FAM86APRO_0000076218Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ96G04.
    PRIDEiQ96G04.

    PTM databases

    PhosphoSiteiQ96G04.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96G04.
    BgeeiQ96G04.
    CleanExiHS_FAM86A.
    GenevestigatoriQ96G04.

    Organism-specific databases

    HPAiHPA041610.

    Interactioni

    Subunit structurei

    Interacts with FAM86B2 and FAM86C1.1 Publication

    Protein-protein interaction databases

    BioGridi128213. 7 interactions.
    IntActiQ96G04. 1 interaction.
    MINTiMINT-1450986.
    STRINGi9606.ENSP00000398502.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96G04.
    SMRiQ96G04. Positions 130-268.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM86 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000067842.
    HOVERGENiHBG059594.
    InParanoidiQ96G04.
    OMAiTIRNPET.
    OrthoDBiEOG74XS7J.
    PhylomeDBiQ96G04.
    TreeFamiTF326304.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR029426. FAM86.
    IPR019410. Nicotinamide_N-MeTfrase-like.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF14904. FAM86. 1 hit.
    PF10294. Methyltransf_16. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96G04-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPEENAGTE LLLQSFERRF LAARTLRSFP WQSLEAKLRD SSDSELLRDI    50
    LHKTVKHPVC VKHPPSVKYA RCFLSELIKK HEAVHTEPLD ELYEALAETL 100
    MAKESTQGHR SYLLPSGGSV TLSESTAIIS YGTTGLVTWD AALYLAEWAI 150
    ENPAVFTNRT VLELGSGAGL TGLAICKMCR PRAYIFSDCH SRVLEQLRGN 200
    VLLNGLSLEA DITAKLDSPR VTVAQLDWDV ATVHQLSAFQ PDVVIAADVL 250
    YCPEAIMSLV GVLRRLAACR EHQRAPEVYV AFTVRNPETC QLFTTELGRA 300
    GIRWEVEPRH EQKLFPYEEH LEMAMLNLTL 330
    Length:330
    Mass (Da):36,915
    Last modified:January 24, 2006 - v2
    Checksum:i1C1B37B9F6D2EE52
    GO
    Isoform 2 (identifier: Q96G04-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         81-114: Missing.

    Show »
    Length:296
    Mass (Da):33,050
    Checksum:i6198BC10E6254AC9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti123 – 1231S → C.
    Corresponds to variant rs9673733 [ dbSNP | Ensembl ].
    VAR_033854
    Natural varianti230 – 2301V → I.
    Corresponds to variant rs13099404 [ dbSNP | Ensembl ].
    VAR_067704
    Natural varianti270 – 2701R → W.
    Corresponds to variant rs3204207 [ dbSNP | Ensembl ].
    VAR_060160
    Natural varianti272 – 2721H → D.2 Publications
    Corresponds to variant rs12928528 [ dbSNP | Ensembl ].
    VAR_067705
    Natural varianti329 – 3291T → I.
    Corresponds to variant rs1047478 [ dbSNP | Ensembl ].
    VAR_067706

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei81 – 11434Missing in isoform 2. 1 PublicationVSP_017097Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY037162 mRNA. Translation: AAK67640.1.
    CH471112 Genomic DNA. Translation: EAW85235.1.
    CH471112 Genomic DNA. Translation: EAW85236.1.
    BC010084 mRNA. Translation: AAH10084.1.
    CCDSiCCDS10529.1. [Q96G04-1]
    CCDS10530.1. [Q96G04-2]
    RefSeqiNP_001275958.1. NM_001289029.1.
    NP_958802.1. NM_201400.3. [Q96G04-1]
    NP_963892.1. NM_201598.3. [Q96G04-2]
    UniGeneiHs.406461.
    Hs.592086.

    Genome annotation databases

    EnsembliENST00000427587; ENSP00000398502; ENSG00000118894. [Q96G04-1]
    ENST00000458008; ENSP00000389710; ENSG00000118894. [Q96G04-2]
    GeneIDi196483.
    KEGGihsa:196483.
    UCSCiuc002cyo.2. human. [Q96G04-1]
    uc002cyp.2. human. [Q96G04-2]

    Polymorphism databases

    DMDMi85700958.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY037162 mRNA. Translation: AAK67640.1 .
    CH471112 Genomic DNA. Translation: EAW85235.1 .
    CH471112 Genomic DNA. Translation: EAW85236.1 .
    BC010084 mRNA. Translation: AAH10084.1 .
    CCDSi CCDS10529.1. [Q96G04-1 ]
    CCDS10530.1. [Q96G04-2 ]
    RefSeqi NP_001275958.1. NM_001289029.1.
    NP_958802.1. NM_201400.3. [Q96G04-1 ]
    NP_963892.1. NM_201598.3. [Q96G04-2 ]
    UniGenei Hs.406461.
    Hs.592086.

    3D structure databases

    ProteinModelPortali Q96G04.
    SMRi Q96G04. Positions 130-268.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128213. 7 interactions.
    IntActi Q96G04. 1 interaction.
    MINTi MINT-1450986.
    STRINGi 9606.ENSP00000398502.

    PTM databases

    PhosphoSitei Q96G04.

    Polymorphism databases

    DMDMi 85700958.

    Proteomic databases

    MaxQBi Q96G04.
    PRIDEi Q96G04.

    Protocols and materials databases

    DNASUi 196483.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000427587 ; ENSP00000398502 ; ENSG00000118894 . [Q96G04-1 ]
    ENST00000458008 ; ENSP00000389710 ; ENSG00000118894 . [Q96G04-2 ]
    GeneIDi 196483.
    KEGGi hsa:196483.
    UCSCi uc002cyo.2. human. [Q96G04-1 ]
    uc002cyp.2. human. [Q96G04-2 ]

    Organism-specific databases

    CTDi 196483.
    GeneCardsi GC16M005134.
    HGNCi HGNC:32221. FAM86A.
    HPAi HPA041610.
    MIMi 615263. gene.
    neXtProti NX_Q96G04.
    PharmGKBi PA142671858.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000067842.
    HOVERGENi HBG059594.
    InParanoidi Q96G04.
    OMAi TIRNPET.
    OrthoDBi EOG74XS7J.
    PhylomeDBi Q96G04.
    TreeFami TF326304.

    Miscellaneous databases

    GenomeRNAii 196483.
    NextBioi 89501.
    PROi Q96G04.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96G04.
    Bgeei Q96G04.
    CleanExi HS_FAM86A.
    Genevestigatori Q96G04.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR029426. FAM86.
    IPR019410. Nicotinamide_N-MeTfrase-like.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF14904. FAM86. 1 hit.
    PF10294. Methyltransf_16. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Li N., Zhang M., Wan T., Zhang W., Cao X.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-272.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-272.
      Tissue: Lung.
    4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity."
      Cloutier P., Lavallee-Adam M., Faubert D., Blanchette M., Coulombe B.
      PLoS Genet. 9:E1003210-E1003210(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FAM86B2 AND FAM86C1, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiFA86A_HUMAN
    AccessioniPrimary (citable) accession number: Q96G04
    Secondary accession number(s): D3DUF0, Q96S85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3