Q96G04 (FA86A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM86A

Gene names

Name:	FAM86A
ORF Names:	SB153

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the FAM86 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96G04-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96G04-2)

The sequence of this isoform differs from the canonical sequence as follows:
     81-114: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	Protein FAM86A		PRO_0000076218
Natural variations
	Alternative sequence	81 – 114	34	Missing in isoform 2.		VSP_017097
	Natural variant	123	1	S → C. Corresponds to variant rs9673733 [ dbSNP | Ensembl ].		VAR_033854
	Natural variant	230	1	V → I. Corresponds to variant rs13099404 [ dbSNP | Ensembl ].		VAR_067704
	Natural variant	270	1	R → W. Corresponds to variant rs3204207 [ dbSNP | Ensembl ].		VAR_060160
	Natural variant	272	1	H → D. Ref.2 Ref.3 Corresponds to variant rs12928528 [ dbSNP | Ensembl ].		VAR_067705
	Natural variant	329	1	T → I. Corresponds to variant rs1047478 [ dbSNP | Ensembl ].		VAR_067706

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 24, 2006. Version 2. Checksum: 1C1B37B9F6D2EE52	FASTA	330	36,915
	10 20 30 40 50 60 MAPEENAGTE LLLQSFERRF LAARTLRSFP WQSLEAKLRD SSDSELLRDI LHKTVKHPVC 70 80 90 100 110 120 VKHPPSVKYA RCFLSELIKK HEAVHTEPLD ELYEALAETL MAKESTQGHR SYLLPSGGSV 130 140 150 160 170 180 TLSESTAIIS YGTTGLVTWD AALYLAEWAI ENPAVFTNRT VLELGSGAGL TGLAICKMCR 190 200 210 220 230 240 PRAYIFSDCH SRVLEQLRGN VLLNGLSLEA DITAKLDSPR VTVAQLDWDV ATVHQLSAFQ 250 260 270 280 290 300 PDVVIAADVL YCPEAIMSLV GVLRRLAACR EHQRAPEVYV AFTVRNPETC QLFTTELGRA 310 320 330 GIRWEVEPRH EQKLFPYEEH LEMAMLNLTL
	Isoform 2 [UniParc]. Checksum: 6198BC10E6254AC9	FASTA	296	33,050
	10 20 30 40 50 60 MAPEENAGTE LLLQSFERRF LAARTLRSFP WQSLEAKLRD SSDSELLRDI LHKTVKHPVC 70 80 90 100 110 120 VKHPPSVKYA RCFLSELIKK PSGGSVTLSE STAIISYGTT GLVTWDAALY LAEWAIENPA 130 140 150 160 170 180 VFTNRTVLEL GSGAGLTGLA ICKMCRPRAY IFSDCHSRVL EQLRGNVLLN GLSLEADITA 190 200 210 220 230 240 KLDSPRVTVA QLDWDVATVH QLSAFQPDVV IAADVLYCPE AIMSLVGVLR RLAACREHQR 250 260 270 280 290 APEVYVAFTV RNPETCQLFT TELGRAGIRW EVEPRHEQKL FPYEEHLEMA MLNLTL

References

[1]	Li N., Zhang M., Wan T., Zhang W., Cao X. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-272.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-272. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY037162 mRNA. Translation: AAK67640.1. CH471112 Genomic DNA. Translation: EAW85235.1. CH471112 Genomic DNA. Translation: EAW85236.1. BC010084 mRNA. Translation: AAH10084.1.
IPI	IPI00290341. IPI00402375.
RefSeq	NP_958802.1. NM_201400.2. NP_963892.1. NM_201598.2.
UniGene	Hs.406461. Hs.592086.
3D structure databases
ProteinModelPortal	Q96G04.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96G04. 1 interaction.
MINT	MINT-1450986.
STRING	9606.ENSP00000398502.
PTM databases
PhosphoSite	Q96G04.
Polymorphism databases
DMDM	85700958.
Proteomic databases
PRIDE	Q96G04.
Protocols and materials databases
DNASU	196483.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000427587; ENSP00000398502; ENSG00000118894. ENST00000458008; ENSP00000389710; ENSG00000118894.
GeneID	196483.
KEGG	hsa:196483.
UCSC	uc002cyo.2. human. uc002cyp.2. human.
Organism-specific databases
CTD	196483.
GeneCards	GC16M005134.
HGNC	HGNC:32221. FAM86A.
HPA	HPA041610.
neXtProt	NX_Q96G04.
PharmGKB	PA142671858.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000067842.
HOVERGEN	HBG059594.
InParanoid	Q96G04.
OMA	TIRNPET.
OrthoDB	EOG47PX6S.
PhylomeDB	Q96G04.
Gene expression databases
Bgee	Q96G04.
CleanEx	HS_FAM86A.
Genevestigator	Q96G04.
GermOnline	ENSG00000118894. Homo sapiens.
Family and domain databases
InterPro	IPR019410. Nicotinamide_N-MeTfrase-like. [Graphical view]
Pfam	PF10294. Methyltransf_16. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	196483.
NextBio	89501.

Entry information

Entry name

FA86A_HUMAN

Accession

Primary (citable) accession number: Q96G04
Secondary accession number(s): D3DUF0, Q96S85

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	January 24, 2006
Last modified:	May 1, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.