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Q96G04 (FA86A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM86A
Gene names
Name:FAM86A
ORF Names:SB153
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with FAM86B2 and FAM86C1. Ref.5

Subcellular location

Cytoplasm Ref.5.

Sequence similarities

Belongs to the FAM86 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
Polymorphism
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96G04-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96G04-2)

The sequence of this isoform differs from the canonical sequence as follows:
     81-114: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330Protein FAM86A
PRO_0000076218

Amino acid modifications

Modified residue11N-acetylmethionine Ref.4

Natural variations

Alternative sequence81 – 11434Missing in isoform 2.
VSP_017097
Natural variant1231S → C.
Corresponds to variant rs9673733 [ dbSNP | Ensembl ].
VAR_033854
Natural variant2301V → I.
Corresponds to variant rs13099404 [ dbSNP | Ensembl ].
VAR_067704
Natural variant2701R → W.
Corresponds to variant rs3204207 [ dbSNP | Ensembl ].
VAR_060160
Natural variant2721H → D. Ref.2 Ref.3
Corresponds to variant rs12928528 [ dbSNP | Ensembl ].
VAR_067705
Natural variant3291T → I.
Corresponds to variant rs1047478 [ dbSNP | Ensembl ].
VAR_067706

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 24, 2006. Version 2.
Checksum: 1C1B37B9F6D2EE52

FASTA33036,915
        10         20         30         40         50         60 
MAPEENAGTE LLLQSFERRF LAARTLRSFP WQSLEAKLRD SSDSELLRDI LHKTVKHPVC 

        70         80         90        100        110        120 
VKHPPSVKYA RCFLSELIKK HEAVHTEPLD ELYEALAETL MAKESTQGHR SYLLPSGGSV 

       130        140        150        160        170        180 
TLSESTAIIS YGTTGLVTWD AALYLAEWAI ENPAVFTNRT VLELGSGAGL TGLAICKMCR 

       190        200        210        220        230        240 
PRAYIFSDCH SRVLEQLRGN VLLNGLSLEA DITAKLDSPR VTVAQLDWDV ATVHQLSAFQ 

       250        260        270        280        290        300 
PDVVIAADVL YCPEAIMSLV GVLRRLAACR EHQRAPEVYV AFTVRNPETC QLFTTELGRA 

       310        320        330 
GIRWEVEPRH EQKLFPYEEH LEMAMLNLTL 

« Hide

Isoform 2 [UniParc].

Checksum: 6198BC10E6254AC9
Show »

FASTA29633,050

References

« Hide 'large scale' references
[1]Li N., Zhang M., Wan T., Zhang W., Cao X.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-272.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-272.
Tissue: Lung.
[4]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity."
Cloutier P., Lavallee-Adam M., Faubert D., Blanchette M., Coulombe B.
PLoS Genet. 9:E1003210-E1003210(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FAM86B2 AND FAM86C1, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY037162 mRNA. Translation: AAK67640.1.
CH471112 Genomic DNA. Translation: EAW85235.1.
CH471112 Genomic DNA. Translation: EAW85236.1.
BC010084 mRNA. Translation: AAH10084.1.
CCDSCCDS10529.1. [Q96G04-1]
CCDS10530.1. [Q96G04-2]
RefSeqNP_001275958.1. NM_001289029.1.
NP_958802.1. NM_201400.3. [Q96G04-1]
NP_963892.1. NM_201598.3. [Q96G04-2]
UniGeneHs.406461.
Hs.592086.

3D structure databases

ProteinModelPortalQ96G04.
SMRQ96G04. Positions 130-268.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128213. 7 interactions.
IntActQ96G04. 1 interaction.
MINTMINT-1450986.
STRING9606.ENSP00000398502.

PTM databases

PhosphoSiteQ96G04.

Polymorphism databases

DMDM85700958.

Proteomic databases

MaxQBQ96G04.
PRIDEQ96G04.

Protocols and materials databases

DNASU196483.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000427587; ENSP00000398502; ENSG00000118894. [Q96G04-1]
ENST00000458008; ENSP00000389710; ENSG00000118894. [Q96G04-2]
GeneID196483.
KEGGhsa:196483.
UCSCuc002cyo.2. human. [Q96G04-1]
uc002cyp.2. human. [Q96G04-2]

Organism-specific databases

CTD196483.
GeneCardsGC16M005134.
HGNCHGNC:32221. FAM86A.
HPAHPA041610.
MIM615263. gene.
neXtProtNX_Q96G04.
PharmGKBPA142671858.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000067842.
HOVERGENHBG059594.
InParanoidQ96G04.
OMATIRNPET.
OrthoDBEOG74XS7J.
PhylomeDBQ96G04.
TreeFamTF326304.

Gene expression databases

ArrayExpressQ96G04.
BgeeQ96G04.
CleanExHS_FAM86A.
GenevestigatorQ96G04.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR029426. FAM86.
IPR019410. Nicotinamide_N-MeTfrase-like.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF14904. FAM86. 1 hit.
PF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi196483.
NextBio89501.
PROQ96G04.
SOURCESearch...

Entry information

Entry nameFA86A_HUMAN
AccessionPrimary (citable) accession number: Q96G04
Secondary accession number(s): D3DUF0, Q96S85
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: July 9, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM