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Protein

Protein bicaudal D homolog 1

Gene

BICD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.

GO - Molecular functioni

  • cytoskeletal adaptor activity Source: BHF-UCL
  • dynactin binding Source: BHF-UCL
  • dynein binding Source: BHF-UCL
  • proteinase activated receptor binding Source: BHF-UCL
  • Rab GTPase binding Source: BHF-UCL
  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • intracellular mRNA localization Source: UniProtKB
  • microtubule anchoring at microtubule organizing center Source: BHF-UCL
  • minus-end-directed organelle transport along microtubule Source: BHF-UCL
  • negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  • negative regulation of phospholipase C activity Source: BHF-UCL
  • positive regulation of receptor-mediated endocytosis Source: BHF-UCL
  • protein localization to organelle Source: BHF-UCL
  • regulation of proteinase activated receptor activity Source: BHF-UCL
  • RNA processing Source: ProtInc
  • stress granule assembly Source: BHF-UCL
  • viral process Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein bicaudal D homolog 1
Short name:
Bic-D 1
Gene namesi
Name:BICD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:1049. BICD1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic vesicle Source: BHF-UCL
  • cytoskeleton Source: UniProtKB
  • cytosol Source: BHF-UCL
  • Golgi apparatus Source: UniProtKB
  • host cell viral assembly compartment Source: BHF-UCL
  • membrane Source: BHF-UCL
  • perinuclear region of cytoplasm Source: BHF-UCL
  • trans-Golgi network Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi636.
OpenTargetsiENSG00000151746.
PharmGKBiPA25352.

Polymorphism and mutation databases

BioMutaiBICD1.
DMDMi209572759.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002053571 – 975Protein bicaudal D homolog 1Add BLAST975

Post-translational modificationi

Isoform 3 is phosphorylated on Ser-865 and Thr-866.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96G01.
MaxQBiQ96G01.
PaxDbiQ96G01.
PeptideAtlasiQ96G01.
PRIDEiQ96G01.

PTM databases

iPTMnetiQ96G01.
PhosphoSitePlusiQ96G01.

Expressioni

Tissue specificityi

Expressed in the brain, heart and skeletal muscle.

Gene expression databases

BgeeiENSG00000151746.
CleanExiHS_BICD1.
ExpressionAtlasiQ96G01. baseline and differential.
GenevisibleiQ96G01. HS.

Organism-specific databases

HPAiHPA041309.

Interactioni

Subunit structurei

Interacts with RAB6A. Interacts (via C-terminus) with RAB6B (GTP-bound); the interaction is direct. Interacts with CLIP-115 and KIFC2 (By similarity). Interacts with human cytomegalovirus/HHV-5 protein UL32.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GSK3BP498417EBI-1104509,EBI-373586
STAT3P407632EBI-1104509,EBI-518675

GO - Molecular functioni

  • cytoskeletal adaptor activity Source: BHF-UCL
  • dynactin binding Source: BHF-UCL
  • dynein binding Source: BHF-UCL
  • proteinase activated receptor binding Source: BHF-UCL
  • Rab GTPase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107105. 12 interactors.
IntActiQ96G01. 16 interactors.
MINTiMINT-206187.
STRINGi9606.ENSP00000281474.

Structurei

3D structure databases

ProteinModelPortaliQ96G01.
SMRiQ96G01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni663 – 803Interaction with RAB6AAdd BLAST141

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 265Sequence analysisAdd BLAST265
Coiled coili319 – 496Sequence analysisAdd BLAST178
Coiled coili663 – 803Sequence analysisAdd BLAST141

Sequence similaritiesi

Belongs to the BicD family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0999. Eukaryota.
ENOG410XR47. LUCA.
GeneTreeiENSGT00390000004114.
HOGENOMiHOG000261658.
HOVERGENiHBG050686.
InParanoidiQ96G01.
KOiK18739.
OMAiNHINISV.
OrthoDBiEOG091G01P4.
PhylomeDBiQ96G01.
TreeFamiTF323833.

Family and domain databases

InterProiIPR018477. Bicaudal-D_microtubule-assoc.
[Graphical view]
PANTHERiPTHR31233. PTHR31233. 2 hits.
PfamiPF09730. BicD. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96G01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAEEVLQTV DHYKTEIERL TKELTETTHE KIQAAEYGLV VLEEKLTLKQ
60 70 80 90 100
QYDELEAEYD SLKQELEQLK EAFGQSFSIH RKVAEDGETR EETLLQESAS
110 120 130 140 150
KEAYYLGKIL EMQNELKQSR AVVTNVQAEN ERLTAVVQDL KENNEMVELQ
160 170 180 190 200
RIRMKDEIRE YKFREARLLQ DYTELEEENI TLQKLVSTLK QNQVEYEGLK
210 220 230 240 250
HEIKRFEEET VLLNSQLEDA IRLKEIAEHQ LEEALETLKN EREQKNNLRK
260 270 280 290 300
ELSQYISLND NHISISVDGL KFAEDGSEPN NDDKMNGHIH GPLVKLNGDY
310 320 330 340 350
RTPTLRKGES LNPVSDLFSE LNISEIQKLK QQLMQVEREK AILLANLQES
360 370 380 390 400
QTQLEHTKGA LTEQHERVHR LTEHVNAMRG LQSSKELKAE LDGEKGRDSG
410 420 430 440 450
EEAHDYEVDI NGLEILECKY RVAVTEVIDL KAEIKALKEK YNKSVENYTD
460 470 480 490 500
EKAKYESKIQ MYDEQVTSLE KTTKESGEKM AHMEKELQKM TSIANENHST
510 520 530 540 550
LNTAQDELVT FSEELAQLYH HVCLCNNETP NRVMLDYYRQ SRVTRSGSLK
560 570 580 590 600
GPDDPRGLLS PRLARRGVSS PVETRTSSEP VAKESTEASK EPSPTKTPTI
610 620 630 640 650
SPVITAPPSS PVLDTSDIRK EPMNIYNLNA IIRDQIKHLQ KAVDRSLQLS
660 670 680 690 700
RQRAAARELA PMIDKDKEAL MEEILKLKSL LSTKREQIAT LRAVLKANKQ
710 720 730 740 750
TAEVALANLK NKYENEKAMV TETMTKLRNE LKALKEDAAT FSSLRAMFAT
760 770 780 790 800
RCDEYVTQLD EMQRQLAAAE DEKKTLNTLL RMAIQQKLAL TQRLEDLEFD
810 820 830 840 850
HEQSRRSKGK LGKSKIGSPK VSGEASVTVP TIDTYLLHSQ GPQTPNIRVS
860 870 880 890 900
SGTQRKRQFS PSLCDQSRPR TSGASYLQNL LRVPPDPTST ESFLLKGPPS
910 920 930 940 950
MSEFIQGHRL SKEKRLTVAP PDCQQPAASV PPQCSQLAGR QDCPTVSPDT
960 970
ALPEEQPHSS SQCAPLHCLS KPPHP
Length:975
Mass (Da):110,750
Last modified:October 14, 2008 - v3
Checksum:iCCF0FB12013AA294
GO
Isoform 2 (identifier: Q96G01-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-93: AFGQSFSIHRKVAEDGETREET → VSCLSPLPFLALTPPTRKAHSS
     94-975: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:93
Mass (Da):10,689
Checksum:i2D3BAD41EA5BF9F1
GO
Isoform 3 (identifier: Q96G01-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     858-873: QFSPSLCDQSRPRTSG → YACSDLHSTVQWPDFS
     874-975: Missing.

Note: Due to intron retention.
Show »
Length:873
Mass (Da):99,868
Checksum:i71F286342CB246F9
GO
Isoform 4 (identifier: Q96G01-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     821-835: VSGEASVTVPTIDTY → IVSSLLPPYRHSAHN
     836-975: Missing.

Note: No experimental confirmation available.
Show »
Length:835
Mass (Da):95,739
Checksum:i81A4A7FCCB1D7613
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti588A → P in AAB94805 (PubMed:9367685).Curated1
Sequence conflicti746A → T in AAB94805 (PubMed:9367685).Curated1
Sequence conflicti796D → G in AAB94806 (PubMed:9367685).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069060778T → A.1 PublicationCorresponds to variant rs200845476dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00796172 – 93AFGQS…TREET → VSCLSPLPFLALTPPTRKAH SS in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_00796294 – 975Missing in isoform 2. 1 PublicationAdd BLAST882
Alternative sequenceiVSP_045637821 – 835VSGEA…TIDTY → IVSSLLPPYRHSAHN in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_045638836 – 975Missing in isoform 4. 1 PublicationAdd BLAST140
Alternative sequenceiVSP_007963858 – 873QFSPS…PRTSG → YACSDLHSTVQWPDFS in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_007964874 – 975Missing in isoform 3. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90028 mRNA. Translation: AAB94805.1.
U90030 mRNA. Translation: AAB94806.1.
AK290188 mRNA. Translation: BAF82877.1.
AK313430 mRNA. No translation available.
AC016954 Genomic DNA. No translation available.
AC026356 Genomic DNA. No translation available.
AC048344 Genomic DNA. No translation available.
AC087245 Genomic DNA. No translation available.
AC087316 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88534.1.
BC010091 mRNA. No translation available.
CCDSiCCDS44859.1. [Q96G01-4]
CCDS8726.1. [Q96G01-1]
RefSeqiNP_001003398.1. NM_001003398.1. [Q96G01-4]
NP_001705.2. NM_001714.2. [Q96G01-1]
UniGeneiHs.505202.
Hs.633204.

Genome annotation databases

EnsembliENST00000281474; ENSP00000281474; ENSG00000151746. [Q96G01-1]
ENST00000548411; ENSP00000446793; ENSG00000151746. [Q96G01-4]
ENST00000551848; ENSP00000448933; ENSG00000151746. [Q96G01-2]
GeneIDi636.
KEGGihsa:636.
UCSCiuc001rku.4. human. [Q96G01-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90028 mRNA. Translation: AAB94805.1.
U90030 mRNA. Translation: AAB94806.1.
AK290188 mRNA. Translation: BAF82877.1.
AK313430 mRNA. No translation available.
AC016954 Genomic DNA. No translation available.
AC026356 Genomic DNA. No translation available.
AC048344 Genomic DNA. No translation available.
AC087245 Genomic DNA. No translation available.
AC087316 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88534.1.
BC010091 mRNA. No translation available.
CCDSiCCDS44859.1. [Q96G01-4]
CCDS8726.1. [Q96G01-1]
RefSeqiNP_001003398.1. NM_001003398.1. [Q96G01-4]
NP_001705.2. NM_001714.2. [Q96G01-1]
UniGeneiHs.505202.
Hs.633204.

3D structure databases

ProteinModelPortaliQ96G01.
SMRiQ96G01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107105. 12 interactors.
IntActiQ96G01. 16 interactors.
MINTiMINT-206187.
STRINGi9606.ENSP00000281474.

PTM databases

iPTMnetiQ96G01.
PhosphoSitePlusiQ96G01.

Polymorphism and mutation databases

BioMutaiBICD1.
DMDMi209572759.

Proteomic databases

EPDiQ96G01.
MaxQBiQ96G01.
PaxDbiQ96G01.
PeptideAtlasiQ96G01.
PRIDEiQ96G01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281474; ENSP00000281474; ENSG00000151746. [Q96G01-1]
ENST00000548411; ENSP00000446793; ENSG00000151746. [Q96G01-4]
ENST00000551848; ENSP00000448933; ENSG00000151746. [Q96G01-2]
GeneIDi636.
KEGGihsa:636.
UCSCiuc001rku.4. human. [Q96G01-1]

Organism-specific databases

CTDi636.
DisGeNETi636.
GeneCardsiBICD1.
H-InvDBHIX0010532.
HGNCiHGNC:1049. BICD1.
HPAiHPA041309.
MIMi602204. gene.
neXtProtiNX_Q96G01.
OpenTargetsiENSG00000151746.
PharmGKBiPA25352.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0999. Eukaryota.
ENOG410XR47. LUCA.
GeneTreeiENSGT00390000004114.
HOGENOMiHOG000261658.
HOVERGENiHBG050686.
InParanoidiQ96G01.
KOiK18739.
OMAiNHINISV.
OrthoDBiEOG091G01P4.
PhylomeDBiQ96G01.
TreeFamiTF323833.

Enzyme and pathway databases

ReactomeiR-HSA-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Miscellaneous databases

ChiTaRSiBICD1. human.
GeneWikiiBICD1.
GenomeRNAii636.
PROiQ96G01.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151746.
CleanExiHS_BICD1.
ExpressionAtlasiQ96G01. baseline and differential.
GenevisibleiQ96G01. HS.

Family and domain databases

InterProiIPR018477. Bicaudal-D_microtubule-assoc.
[Graphical view]
PANTHERiPTHR31233. PTHR31233. 2 hits.
PfamiPF09730. BicD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBICD1_HUMAN
AccessioniPrimary (citable) accession number: Q96G01
Secondary accession number(s): A8K2C3
, F8W113, O43892, O43893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: October 14, 2008
Last modified: November 2, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.