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Q96G01 (BICD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein bicaudal D homolog 1

Short name=Bic-D 1
Gene names
Name:BICD1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length975 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.

Subunit structure

Interacts with RAB6A. Interacts (via C-terminus) with RAB6B (GTP-bound); the interaction is direct. Interacts with CLIP-115 and KIFC2 By similarity. Interacts with human cytomegalovirus/HHV-5 protein UL32. Ref.7 Ref.8

Subcellular location

Golgi apparatus.

Tissue specificity

Expressed in the brain, heart and skeletal muscle.

Post-translational modification

Isoform 3 is phosphorylated on Ser-865 and Thr-866.

Sequence similarities

Belongs to the BicD family.

Ontologies

Keywords
   Biological processHost-virus interaction
   Cellular componentGolgi apparatus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA processing

Traceable author statement Ref.1. Source: ProtInc

anatomical structure morphogenesis

Traceable author statement Ref.1. Source: ProtInc

intracellular mRNA localization

Non-traceable author statement Ref.1. Source: UniProtKB

microtubule anchoring at microtubule organizing center

Inferred from sequence or structural similarity PubMed 19825938. Source: BHF-UCL

minus-end-directed organelle transport along microtubule

Inferred from mutant phenotype Ref.6. Source: BHF-UCL

negative regulation of phospholipase C activity

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of receptor-mediated endocytosis

Inferred from mutant phenotype PubMed 20164183. Source: BHF-UCL

protein localization to organelle

Inferred from direct assay Ref.6Ref.8. Source: BHF-UCL

regulation of proteinase activated receptor activity

Inferred from sequence or structural similarity. Source: BHF-UCL

stress granule assembly

Inferred from sequence or structural similarity. Source: BHF-UCL

viral process

Inferred from mutant phenotype Ref.8. Source: BHF-UCL

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoplasmic vesicle

Inferred from direct assay Ref.6Ref.8. Source: BHF-UCL

cytoskeleton

Non-traceable author statement Ref.1. Source: UniProtKB

cytosol

Inferred from direct assay Ref.6. Source: BHF-UCL

host cell viral assembly compartment

Inferred from direct assay Ref.8. Source: BHF-UCL

membrane

Inferred from direct assay Ref.6. Source: BHF-UCL

perinuclear region of cytoplasm

Inferred from direct assay Ref.8. Source: BHF-UCL

trans-Golgi network

Inferred from direct assay Ref.6Ref.8. Source: BHF-UCL

   Molecular_functionRab GTPase binding

Inferred from physical interaction Ref.6. Source: BHF-UCL

cytoskeletal adaptor activity

Inferred from direct assay Ref.6. Source: BHF-UCL

dynactin binding

Inferred from direct assay Ref.6. Source: BHF-UCL

dynein binding

Inferred from direct assay Ref.6. Source: BHF-UCL

proteinase activated receptor binding

Inferred from sequence or structural similarity PubMed 20164183. Source: BHF-UCL

structural constituent of cytoskeleton

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Binary interactions

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96G01-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96G01-2)

The sequence of this isoform differs from the canonical sequence as follows:
     72-93: AFGQSFSIHRKVAEDGETREET → VSCLSPLPFLALTPPTRKAHSS
     94-975: Missing.
Note: Due to intron retention. No experimental confirmation available.
Isoform 3 (identifier: Q96G01-3)

The sequence of this isoform differs from the canonical sequence as follows:
     858-873: QFSPSLCDQSRPRTSG → YACSDLHSTVQWPDFS
     874-975: Missing.
Note: Due to intron retention. Contains a phosphoserine at position 865. Contains a phosphothreonine at position 866.
Isoform 4 (identifier: Q96G01-4)

The sequence of this isoform differs from the canonical sequence as follows:
     821-835: VSGEASVTVPTIDTY → IVSSLLPPYRHSAHN
     836-975: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 975975Protein bicaudal D homolog 1
PRO_0000205357

Regions

Region663 – 803141Interacts with RAB6A
Coiled coil1 – 265265 Potential
Coiled coil319 – 496178 Potential
Coiled coil663 – 803141 Potential

Natural variations

Alternative sequence72 – 9322AFGQS…TREET → VSCLSPLPFLALTPPTRKAH SS in isoform 2.
VSP_007961
Alternative sequence94 – 975882Missing in isoform 2.
VSP_007962
Alternative sequence821 – 83515VSGEA…TIDTY → IVSSLLPPYRHSAHN in isoform 4.
VSP_045637
Alternative sequence836 – 975140Missing in isoform 4.
VSP_045638
Alternative sequence858 – 87316QFSPS…PRTSG → YACSDLHSTVQWPDFS in isoform 3.
VSP_007963
Alternative sequence874 – 975102Missing in isoform 3.
VSP_007964
Natural variant7781T → A. Ref.2
Corresponds to variant rs200845476 [ dbSNP | Ensembl ].
VAR_069060

Experimental info

Sequence conflict5881A → P in AAB94805. Ref.1
Sequence conflict7461A → T in AAB94805. Ref.1
Sequence conflict7961D → G in AAB94806. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 14, 2008. Version 3.
Checksum: CCF0FB12013AA294

FASTA975110,750
        10         20         30         40         50         60 
MAAEEVLQTV DHYKTEIERL TKELTETTHE KIQAAEYGLV VLEEKLTLKQ QYDELEAEYD 

        70         80         90        100        110        120 
SLKQELEQLK EAFGQSFSIH RKVAEDGETR EETLLQESAS KEAYYLGKIL EMQNELKQSR 

       130        140        150        160        170        180 
AVVTNVQAEN ERLTAVVQDL KENNEMVELQ RIRMKDEIRE YKFREARLLQ DYTELEEENI 

       190        200        210        220        230        240 
TLQKLVSTLK QNQVEYEGLK HEIKRFEEET VLLNSQLEDA IRLKEIAEHQ LEEALETLKN 

       250        260        270        280        290        300 
EREQKNNLRK ELSQYISLND NHISISVDGL KFAEDGSEPN NDDKMNGHIH GPLVKLNGDY 

       310        320        330        340        350        360 
RTPTLRKGES LNPVSDLFSE LNISEIQKLK QQLMQVEREK AILLANLQES QTQLEHTKGA 

       370        380        390        400        410        420 
LTEQHERVHR LTEHVNAMRG LQSSKELKAE LDGEKGRDSG EEAHDYEVDI NGLEILECKY 

       430        440        450        460        470        480 
RVAVTEVIDL KAEIKALKEK YNKSVENYTD EKAKYESKIQ MYDEQVTSLE KTTKESGEKM 

       490        500        510        520        530        540 
AHMEKELQKM TSIANENHST LNTAQDELVT FSEELAQLYH HVCLCNNETP NRVMLDYYRQ 

       550        560        570        580        590        600 
SRVTRSGSLK GPDDPRGLLS PRLARRGVSS PVETRTSSEP VAKESTEASK EPSPTKTPTI 

       610        620        630        640        650        660 
SPVITAPPSS PVLDTSDIRK EPMNIYNLNA IIRDQIKHLQ KAVDRSLQLS RQRAAARELA 

       670        680        690        700        710        720 
PMIDKDKEAL MEEILKLKSL LSTKREQIAT LRAVLKANKQ TAEVALANLK NKYENEKAMV 

       730        740        750        760        770        780 
TETMTKLRNE LKALKEDAAT FSSLRAMFAT RCDEYVTQLD EMQRQLAAAE DEKKTLNTLL 

       790        800        810        820        830        840 
RMAIQQKLAL TQRLEDLEFD HEQSRRSKGK LGKSKIGSPK VSGEASVTVP TIDTYLLHSQ 

       850        860        870        880        890        900 
GPQTPNIRVS SGTQRKRQFS PSLCDQSRPR TSGASYLQNL LRVPPDPTST ESFLLKGPPS 

       910        920        930        940        950        960 
MSEFIQGHRL SKEKRLTVAP PDCQQPAASV PPQCSQLAGR QDCPTVSPDT ALPEEQPHSS 

       970 
SQCAPLHCLS KPPHP 

« Hide

Isoform 2 [UniParc].

Checksum: 2D3BAD41EA5BF9F1
Show »

FASTA9310,689
Isoform 3 [UniParc].

Checksum: 71F286342CB246F9
Show »

FASTA87399,868
Isoform 4 [UniParc].

Checksum: 81A4A7FCCB1D7613
Show »

FASTA83595,739

References

« Hide 'large scale' references
[1]"A human homologue (BICD1) of the Drosophila bicaudal-D gene."
Baens M., Marynen P.
Genomics 45:601-606(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 702-975 (ISOFORM 3).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT ALA-778.
Tissue: Cerebellum and Thalamus.
[3]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Skin.
[6]"Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex."
Matanis T., Akhmanova A., Wulf P., Del Nery E., Weide T., Stepanova T., Galjart N., Grosveld F., Goud B., De Zeeuw C.I., Barnekow A., Hoogenraad C.C.
Nat. Cell Biol. 4:986-992(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[7]"A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells."
Wanschers B.F.J.F., van de Vorstenbosch R., Schlager M.A., Splinter D., Akhmanova A., Hoogenraad C.C., Wieringa B., Fransen J.A.
Exp. Cell Res. 313:3408-3420(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RAB6B.
[8]"Bicaudal D1-dependent trafficking of human cytomegalovirus tegument protein pp150 in virus-infected cells."
Indran S.V., Ballestas M.E., Britt W.J.
J. Virol. 84:3162-3177(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HHV-5 PROTEIN UL32.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U90028 mRNA. Translation: AAB94805.1.
U90030 mRNA. Translation: AAB94806.1.
AK290188 mRNA. Translation: BAF82877.1.
AK313430 mRNA. No translation available.
AC016954 Genomic DNA. No translation available.
AC026356 Genomic DNA. No translation available.
AC048344 Genomic DNA. No translation available.
AC087245 Genomic DNA. No translation available.
AC087316 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88534.1.
BC010091 mRNA. No translation available.
RefSeqNP_001003398.1. NM_001003398.1.
NP_001705.2. NM_001714.2.
UniGeneHs.505202.
Hs.633204.

3D structure databases

ProteinModelPortalQ96G01.
SMRQ96G01. Positions 720-793.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107105. 5 interactions.
IntActQ96G01. 13 interactions.
MINTMINT-206187.
STRING9606.ENSP00000281474.

PTM databases

PhosphoSiteQ96G01.

Polymorphism databases

DMDM209572759.

Proteomic databases

PaxDbQ96G01.
PRIDEQ96G01.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000281474; ENSP00000281474; ENSG00000151746. [Q96G01-1]
ENST00000548411; ENSP00000446793; ENSG00000151746. [Q96G01-4]
ENST00000551848; ENSP00000448933; ENSG00000151746. [Q96G01-2]
GeneID636.
KEGGhsa:636.
UCSCuc001rku.3. human. [Q96G01-1]

Organism-specific databases

CTD636.
GeneCardsGC12P032259.
H-InvDBHIX0010532.
HGNCHGNC:1049. BICD1.
HPAHPA041309.
MIM602204. gene.
neXtProtNX_Q96G01.
PharmGKBPA25352.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG291306.
HOGENOMHOG000261658.
HOVERGENHBG050686.
InParanoidQ96G01.
OMAEYKFRET.
OrthoDBEOG7BZVRK.
PhylomeDBQ96G01.
TreeFamTF323833.

Gene expression databases

ArrayExpressQ96G01.
BgeeQ96G01.
CleanExHS_BICD1.
GenevestigatorQ96G01.

Family and domain databases

InterProIPR018477. Bicaudal-D_microtubule-assoc.
[Graphical view]
PANTHERPTHR31233. PTHR31233. 1 hit.
PfamPF09730. BicD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBICD1. human.
GeneWikiBICD1.
GenomeRNAi636.
NextBio2572.
PROQ96G01.
SOURCESearch...

Entry information

Entry nameBICD1_HUMAN
AccessionPrimary (citable) accession number: Q96G01
Secondary accession number(s): A8K2C3 expand/collapse secondary AC list , F8W113, O43892, O43893
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: October 14, 2008
Last modified: April 16, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM