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Protein

CKLF-like MARVEL transmembrane domain-containing protein 7

Gene

CMTM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Protein family/group databases

TCDBi1.A.64.5.1. the plasmolipin (plasmolipin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 7
Alternative name(s):
Chemokine-like factor superfamily member 7
Gene namesi
Name:CMTM7
Synonyms:CKLFSF7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:19178. CMTM7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321HelicalSequence analysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence analysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence analysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular space Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38817.

Polymorphism and mutation databases

BioMutaiCMTM7.
DMDMi34922026.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 175175CKLF-like MARVEL transmembrane domain-containing protein 7PRO_0000186110Add
BLAST

Proteomic databases

EPDiQ96FZ5.
MaxQBiQ96FZ5.
PaxDbiQ96FZ5.
PRIDEiQ96FZ5.

PTM databases

iPTMnetiQ96FZ5.
PhosphoSiteiQ96FZ5.
SwissPalmiQ96FZ5.

Expressioni

Tissue specificityi

Highly expressed in leukocytes.1 Publication

Gene expression databases

BgeeiQ96FZ5.
CleanExiHS_CMTM7.
ExpressionAtlasiQ96FZ5. baseline and differential.
GenevisibleiQ96FZ5. HS.

Interactioni

Protein-protein interaction databases

IntActiQ96FZ5. 1 interaction.
STRINGi9606.ENSP00000335605.

Structurei

3D structure databases

ProteinModelPortaliQ96FZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 166127MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00510000048725.
HOGENOMiHOG000111751.
HOVERGENiHBG050981.
InParanoidiQ96FZ5.
OMAiICVRSSV.
OrthoDBiEOG757D0D.
PhylomeDBiQ96FZ5.
TreeFamiTF317387.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96FZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSHGAGLVRT TCSSGSALGP GAGAAQPSAS PLEGLLDLSY PRTHAALLKV
60 70 80 90 100
AQMVTLLIAF ICVRSSLWTN YSAYSYFEVV TICDLIMILA FYLVHLFRFY
110 120 130 140 150
RVLTCISWPL SELLHYLIGT LLLLIASIVA ASKSYNQSGL VAGAIFGFMA
160 170
TFLCMASIWL SYKISCVTQS TDAAV
Length:175
Mass (Da):18,834
Last modified:December 1, 2001 - v1
Checksum:i4EF44A5738C41F60
GO
Isoform 2 (identifier: Q96FZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-144: Missing.

Note: No experimental confirmation available.
Show »
Length:142
Mass (Da):15,452
Checksum:iD49B361D68BA3992
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei112 – 14433Missing in isoform 2. 2 PublicationsVSP_042566Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479263 mRNA. Translation: AAN73041.1.
DQ132881 mRNA. Translation: AAZ57435.1.
AY174113 mRNA. Translation: AAO44955.1.
AC098475 Genomic DNA. No translation available.
AC104306 Genomic DNA. No translation available.
BC010116 mRNA. Translation: AAH10116.1.
CCDSiCCDS33730.1. [Q96FZ5-1]
CCDS33731.1. [Q96FZ5-2]
RefSeqiNP_612419.1. NM_138410.3. [Q96FZ5-1]
NP_852137.1. NM_181472.2. [Q96FZ5-2]
UniGeneiHs.440494.

Genome annotation databases

EnsembliENST00000334983; ENSP00000335605; ENSG00000153551. [Q96FZ5-1]
ENST00000349718; ENSP00000283621; ENSG00000153551. [Q96FZ5-2]
GeneIDi112616.
KEGGihsa:112616.
UCSCiuc003cey.2. human. [Q96FZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479263 mRNA. Translation: AAN73041.1.
DQ132881 mRNA. Translation: AAZ57435.1.
AY174113 mRNA. Translation: AAO44955.1.
AC098475 Genomic DNA. No translation available.
AC104306 Genomic DNA. No translation available.
BC010116 mRNA. Translation: AAH10116.1.
CCDSiCCDS33730.1. [Q96FZ5-1]
CCDS33731.1. [Q96FZ5-2]
RefSeqiNP_612419.1. NM_138410.3. [Q96FZ5-1]
NP_852137.1. NM_181472.2. [Q96FZ5-2]
UniGeneiHs.440494.

3D structure databases

ProteinModelPortaliQ96FZ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96FZ5. 1 interaction.
STRINGi9606.ENSP00000335605.

Protein family/group databases

TCDBi1.A.64.5.1. the plasmolipin (plasmolipin) family.

PTM databases

iPTMnetiQ96FZ5.
PhosphoSiteiQ96FZ5.
SwissPalmiQ96FZ5.

Polymorphism and mutation databases

BioMutaiCMTM7.
DMDMi34922026.

Proteomic databases

EPDiQ96FZ5.
MaxQBiQ96FZ5.
PaxDbiQ96FZ5.
PRIDEiQ96FZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334983; ENSP00000335605; ENSG00000153551. [Q96FZ5-1]
ENST00000349718; ENSP00000283621; ENSG00000153551. [Q96FZ5-2]
GeneIDi112616.
KEGGihsa:112616.
UCSCiuc003cey.2. human. [Q96FZ5-1]

Organism-specific databases

CTDi112616.
GeneCardsiCMTM7.
H-InvDBHIX0003147.
HGNCiHGNC:19178. CMTM7.
MIMi607890. gene.
neXtProtiNX_Q96FZ5.
PharmGKBiPA38817.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00510000048725.
HOGENOMiHOG000111751.
HOVERGENiHBG050981.
InParanoidiQ96FZ5.
OMAiICVRSSV.
OrthoDBiEOG757D0D.
PhylomeDBiQ96FZ5.
TreeFamiTF317387.

Miscellaneous databases

ChiTaRSiCMTM7. human.
GenomeRNAii112616.
PROiQ96FZ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ96FZ5.
CleanExiHS_CMTM7.
ExpressionAtlasiQ96FZ5. baseline and differential.
GenevisibleiQ96FZ5. HS.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation."
    Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y., Yang T., Ma D.
    Genomics 81:609-617(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Tissue: Placenta.
  2. "An alternatively spliced form of KSS, KSS b."
    Sawada T., Kanai T., Watanabe M.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.

Entry informationi

Entry nameiCKLF7_HUMAN
AccessioniPrimary (citable) accession number: Q96FZ5
Secondary accession number(s): Q5VLK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.