Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

Gene

TRMT61A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei114 – 1141S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei135 – 1351S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei163 – 1631S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei181 – 1811S-adenosyl-L-methioninePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BRENDAi2.1.1.220. 2681.
ReactomeiR-HSA-6782315. tRNA modification in the nucleus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC:2.1.1.220)
Alternative name(s):
tRNA(m1A58)-methyltransferase subunit TRMT61A
Short name:
tRNA(m1A58)MTase subunit TRMT61A
Gene namesi
Name:TRMT61A
Synonyms:C14orf172, TRM61
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:23790. TRMT61A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726783.

Polymorphism and mutation databases

BioMutaiTRMT61A.
DMDMi74760827.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 289288tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61APRO_0000233094Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei263 – 2631PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96FX7.
MaxQBiQ96FX7.
PaxDbiQ96FX7.
PeptideAtlasiQ96FX7.
PRIDEiQ96FX7.

PTM databases

iPTMnetiQ96FX7.
PhosphoSiteiQ96FX7.

Expressioni

Gene expression databases

BgeeiENSG00000166166.
ExpressionAtlasiQ96FX7. baseline and differential.
GenevisibleiQ96FX7. HS.

Interactioni

Subunit structurei

tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of TRM6 and TRM61.1 Publication

Protein-protein interaction databases

BioGridi125450. 24 interactions.
IntActiQ96FX7. 5 interactions.
STRINGi9606.ENSP00000374399.

Structurei

Secondary structure

1
289
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Beta strandi15 – 195Combined sources
Beta strandi25 – 295Combined sources
Beta strandi35 – 384Combined sources
Beta strandi41 – 444Combined sources
Helixi45 – 484Combined sources
Turni49 – 513Combined sources
Beta strandi57 – 593Combined sources
Beta strandi61 – 633Combined sources
Beta strandi65 – 695Combined sources
Helixi73 – 775Combined sources
Helixi89 – 9810Combined sources
Beta strandi106 – 1105Combined sources
Helixi116 – 12510Combined sources
Turni126 – 1283Combined sources
Beta strandi130 – 1345Combined sources
Helixi138 – 15013Combined sources
Helixi154 – 1563Combined sources
Beta strandi157 – 1604Combined sources
Helixi164 – 1674Combined sources
Beta strandi175 – 1806Combined sources
Helixi185 – 1884Combined sources
Helixi189 – 1957Combined sources
Beta strandi201 – 2099Combined sources
Helixi210 – 22314Combined sources
Beta strandi226 – 24318Combined sources
Beta strandi265 – 2739Combined sources
Beta strandi280 – 2867Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5CCBX-ray2.00A1-289[»]
5CCXX-ray2.10A1-289[»]
5CD1X-ray3.60A/D1-289[»]
ProteinModelPortaliQ96FX7.
SMRiQ96FX7. Positions 9-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2915. Eukaryota.
COG2519. LUCA.
GeneTreeiENSGT00510000048063.
HOGENOMiHOG000173282.
HOVERGENiHBG061059.
InParanoidiQ96FX7.
KOiK07442.
OMAiTTQMSRL.
OrthoDBiEOG091G0BHV.
PhylomeDBiQ96FX7.
TreeFamiTF315053.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR029063. SAM-dependent_MTases.
IPR014816. tRNA_MeTrfase_Gcd14.
[Graphical view]
PfamiPF08704. GCD14. 1 hit.
[Graphical view]
PIRSFiPIRSF017269. GCD14. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51620. SAM_TRM61. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96FX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFVAYEELI KEGDTAILSL GHGAMVAVRV QRGAQTQTRH GVLRHSVDLI
60 70 80 90 100
GRPFGSKVTC GRGGWVYVLH PTPELWTLNL PHRTQILYST DIALITMMLE
110 120 130 140 150
LRPGSVVCES GTGSGSVSHA IIRTIAPTGH LHTVEFHQQR AEKAREEFQE
160 170 180 190 200
HRVGRWVTVR TQDVCRSGFG VSHVADAVFL DIPSPWEAVG HAWDALKVEG
210 220 230 240 250
GRFCSFSPCI EQVQRTCQAL AARGFSELST LEVLPQVYNV RTVSLPPPDL
260 270 280
GTGTDGPAGS DTSPFRSGTP MKEAVGHTGY LTFATKTPG
Length:289
Mass (Da):31,382
Last modified:December 1, 2001 - v1
Checksum:i5DCD6437A0B6F54D
GO

Sequence cautioni

The sequence BAC05168 differs from that shown.Probable cloning artifact.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti66 – 661V → A.1 Publication
VAR_026053

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133367 Genomic DNA. No translation available.
AL139300 Genomic DNA. No translation available.
BC010167 mRNA. Translation: AAH10167.1.
AK097771 mRNA. Translation: BAC05168.1. Sequence problems.
CCDSiCCDS41994.1.
RefSeqiNP_689520.2. NM_152307.2.
UniGeneiHs.525610.

Genome annotation databases

EnsembliENST00000389749; ENSP00000374399; ENSG00000166166.
GeneIDi115708.
KEGGihsa:115708.
UCSCiuc001yng.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133367 Genomic DNA. No translation available.
AL139300 Genomic DNA. No translation available.
BC010167 mRNA. Translation: AAH10167.1.
AK097771 mRNA. Translation: BAC05168.1. Sequence problems.
CCDSiCCDS41994.1.
RefSeqiNP_689520.2. NM_152307.2.
UniGeneiHs.525610.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5CCBX-ray2.00A1-289[»]
5CCXX-ray2.10A1-289[»]
5CD1X-ray3.60A/D1-289[»]
ProteinModelPortaliQ96FX7.
SMRiQ96FX7. Positions 9-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125450. 24 interactions.
IntActiQ96FX7. 5 interactions.
STRINGi9606.ENSP00000374399.

PTM databases

iPTMnetiQ96FX7.
PhosphoSiteiQ96FX7.

Polymorphism and mutation databases

BioMutaiTRMT61A.
DMDMi74760827.

Proteomic databases

EPDiQ96FX7.
MaxQBiQ96FX7.
PaxDbiQ96FX7.
PeptideAtlasiQ96FX7.
PRIDEiQ96FX7.

Protocols and materials databases

DNASUi115708.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389749; ENSP00000374399; ENSG00000166166.
GeneIDi115708.
KEGGihsa:115708.
UCSCiuc001yng.4. human.

Organism-specific databases

CTDi115708.
GeneCardsiTRMT61A.
H-InvDBHIX0012002.
HGNCiHGNC:23790. TRMT61A.
neXtProtiNX_Q96FX7.
PharmGKBiPA164726783.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2915. Eukaryota.
COG2519. LUCA.
GeneTreeiENSGT00510000048063.
HOGENOMiHOG000173282.
HOVERGENiHBG061059.
InParanoidiQ96FX7.
KOiK07442.
OMAiTTQMSRL.
OrthoDBiEOG091G0BHV.
PhylomeDBiQ96FX7.
TreeFamiTF315053.

Enzyme and pathway databases

BRENDAi2.1.1.220. 2681.
ReactomeiR-HSA-6782315. tRNA modification in the nucleus and cytosol.

Miscellaneous databases

ChiTaRSiTRMT61A. human.
GenomeRNAii115708.
PROiQ96FX7.

Gene expression databases

BgeeiENSG00000166166.
ExpressionAtlasiQ96FX7. baseline and differential.
GenevisibleiQ96FX7. HS.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR029063. SAM-dependent_MTases.
IPR014816. tRNA_MeTrfase_Gcd14.
[Graphical view]
PfamiPF08704. GCD14. 1 hit.
[Graphical view]
PIRSFiPIRSF017269. GCD14. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51620. SAM_TRM61. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRM61_HUMAN
AccessioniPrimary (citable) accession number: Q96FX7
Secondary accession number(s): A6NN78, Q8N7Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.