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Protein

Tetraspanin-17

Gene

TSPAN17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates ADAM10 maturation.By similarity

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-17
Short name:
Tspan-17
Alternative name(s):
F-box only protein 23
Tetraspan protein SB134
Transmembrane 4 superfamily member 17
Gene namesi
Name:TSPAN17
Synonyms:FBXO23, TM4SF17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:13594. TSPAN17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 63ExtracellularSequence analysisAdd BLAST23
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 94CytoplasmicSequence analysis10
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 234ExtracellularSequence analysisAdd BLAST119
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 270CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000048140.
PharmGKBiPA128394740.

Polymorphism and mutation databases

BioMutaiTSPAN17.
DMDMi147744595.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192651 – 270Tetraspanin-17Add BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Glycosylationi171N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96FV3.
PeptideAtlasiQ96FV3.
PRIDEiQ96FV3.

Expressioni

Gene expression databases

BgeeiENSG00000048140.
CleanExiHS_TSPAN17.
ExpressionAtlasiQ96FV3. baseline and differential.
GenevisibleiQ96FV3. HS.

Organism-specific databases

HPAiHPA030447.

Interactioni

Subunit structurei

Interacts with ADAM10.By similarity

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117648. 44 interactors.
IntActiQ96FV3. 3 interactors.
STRINGi9606.ENSP00000309036.

Structurei

3D structure databases

ProteinModelPortaliQ96FV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230652.
HOVERGENiHBG108605.
InParanoidiQ96FV3.
KOiK10303.
PhylomeDBiQ96FV3.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96FV3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGKHQHFQE PEVGCCGKYF LFGFNIVFWV LGALFLAIGL WAWGEKGVLS
60 70 80 90 100
NISALTDLGG LDPVWLFVVV GGVMSVLGFA GCIGALRENT FLLKFFSVFL
110 120 130 140 150
GLIFFLELAT GILAFVFKDW IRDQLNLFIN NNVKAYRDDI DLQNLIDFAQ
160 170 180 190 200
EYWSCCGARG PNDWNLNIYF NCTDLNPSRE RCGVPFSCCV RDPAEDVLNT
210 220 230 240 250
QCGYDVRLKL ELEQQGFIHT KGCVGQFEKW LQDNLIVVAG VFMGIALLQI
260 270
FGICLAQNLV SDIKAVKANW
Length:270
Mass (Da):30,264
Last modified:May 15, 2007 - v2
Checksum:i157F76DF059D9E19
GO
Isoform 2 (identifier: Q96FV3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-270: VSDIKAVKANW → EQME

Show »
Length:263
Mass (Da):29,569
Checksum:i820189FB903DDB14
GO
Isoform 3 (identifier: Q96FV3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-95: Missing.
     153-194: Missing.
     249-249: Q → QVPLWPHVPLPLPGPPSLSPHLSSVLQ

Show »
Length:188
Mass (Da):21,415
Checksum:iD68CC9413038D029
GO
Isoform 4 (identifier: Q96FV3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     270-270: W → WSKWNDDFENHWLTPTISEVLSTAGPQQNSLTGAPGPAPPSRHVFFGLGGLYPEPTFKNW

Show »
Length:329
Mass (Da):36,742
Checksum:i8A7427CFA987ED06
GO

Sequence cautioni

The sequence AAF04524 differs from that shown. Reason: Frameshift at positions 66, 81 and 83.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239A → P in AAK67627 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057278140I → T.Corresponds to variant rs17624798dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01138830 – 95Missing in isoform 3. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_011389153 – 194Missing in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_011390249Q → QVPLWPHVPLPLPGPPSLSP HLSSVLQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_011391260 – 270VSDIKAVKANW → EQME in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_025608270W → WSKWNDDFENHWLTPTISEV LSTAGPQQNSLTGAPGPAPP SRHVFFGLGGLYPEPTFKNW in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037146 mRNA. Translation: AAK67627.1.
AC091934 Genomic DNA. No translation available.
BC010405 mRNA. Translation: AAH10405.1.
BC067105 mRNA. Translation: AAH67105.1.
AF174603 mRNA. Translation: AAF04524.1. Frameshift.
CCDSiCCDS47346.2. [Q96FV3-3]
CCDS54952.1. [Q96FV3-4]
RefSeqiNP_001006617.2. NM_001006616.2. [Q96FV3-3]
NP_569732.2. NM_130465.4. [Q96FV3-4]
UniGeneiHs.532129.

Genome annotation databases

EnsembliENST00000298564; ENSP00000298564; ENSG00000048140. [Q96FV3-2]
ENST00000508164; ENSP00000422053; ENSG00000048140. [Q96FV3-4]
ENST00000515708; ENSP00000426650; ENSG00000048140. [Q96FV3-3]
GeneIDi26262.
KEGGihsa:26262.
UCSCiuc003mes.4. human. [Q96FV3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037146 mRNA. Translation: AAK67627.1.
AC091934 Genomic DNA. No translation available.
BC010405 mRNA. Translation: AAH10405.1.
BC067105 mRNA. Translation: AAH67105.1.
AF174603 mRNA. Translation: AAF04524.1. Frameshift.
CCDSiCCDS47346.2. [Q96FV3-3]
CCDS54952.1. [Q96FV3-4]
RefSeqiNP_001006617.2. NM_001006616.2. [Q96FV3-3]
NP_569732.2. NM_130465.4. [Q96FV3-4]
UniGeneiHs.532129.

3D structure databases

ProteinModelPortaliQ96FV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117648. 44 interactors.
IntActiQ96FV3. 3 interactors.
STRINGi9606.ENSP00000309036.

Polymorphism and mutation databases

BioMutaiTSPAN17.
DMDMi147744595.

Proteomic databases

PaxDbiQ96FV3.
PeptideAtlasiQ96FV3.
PRIDEiQ96FV3.

Protocols and materials databases

DNASUi26262.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298564; ENSP00000298564; ENSG00000048140. [Q96FV3-2]
ENST00000508164; ENSP00000422053; ENSG00000048140. [Q96FV3-4]
ENST00000515708; ENSP00000426650; ENSG00000048140. [Q96FV3-3]
GeneIDi26262.
KEGGihsa:26262.
UCSCiuc003mes.4. human. [Q96FV3-1]

Organism-specific databases

CTDi26262.
GeneCardsiTSPAN17.
HGNCiHGNC:13594. TSPAN17.
HPAiHPA030447.
neXtProtiNX_Q96FV3.
OpenTargetsiENSG00000048140.
PharmGKBiPA128394740.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230652.
HOVERGENiHBG108605.
InParanoidiQ96FV3.
KOiK10303.
PhylomeDBiQ96FV3.

Miscellaneous databases

GenomeRNAii26262.
PROiQ96FV3.

Gene expression databases

BgeeiENSG00000048140.
CleanExiHS_TSPAN17.
ExpressionAtlasiQ96FV3. baseline and differential.
GenevisibleiQ96FV3. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSN17_HUMAN
AccessioniPrimary (citable) accession number: Q96FV3
Secondary accession number(s): Q6NXF7, Q96S98, Q9UKB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 15, 2007
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.