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Protein

Leucine-rich repeat-containing protein 46

Gene

LRRC46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
  • regulation of protein stability Source: ParkinsonsUK-UCL
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141294-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 46
Gene namesi
Name:LRRC46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25047. LRRC46.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141294.
PharmGKBiPA142671506.

Polymorphism and mutation databases

BioMutaiLRRC46.
DMDMi74760826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239191 – 321Leucine-rich repeat-containing protein 46Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175PhosphoserineBy similarity1
Modified residuei182PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96FV0.
PeptideAtlasiQ96FV0.
PRIDEiQ96FV0.

PTM databases

iPTMnetiQ96FV0.
PhosphoSitePlusiQ96FV0.

Expressioni

Gene expression databases

BgeeiENSG00000141294.
CleanExiHS_LRRC46.
ExpressionAtlasiQ96FV0. baseline and differential.
GenevisibleiQ96FV0. HS.

Organism-specific databases

HPAiHPA021882.

Interactioni

Protein-protein interaction databases

BioGridi124725. 21 interactors.
IntActiQ96FV0. 1 interactor.
STRINGi9606.ENSP00000269025.

Structurei

3D structure databases

ProteinModelPortaliQ96FV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 66LRR 1Add BLAST22
Repeati67 – 88LRR 2Add BLAST22
Repeati89 – 110LRR 3Add BLAST22
Repeati111 – 132LRR 4Add BLAST22
Domaini142 – 184LRRCTAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili201 – 221Sequence analysisAdd BLAST21

Sequence similaritiesi

Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00860000133819.
HOGENOMiHOG000231068.
HOVERGENiHBG080094.
InParanoidiQ96FV0.
OMAiMFHTLAE.
OrthoDBiEOG091G0ZR0.
PhylomeDBiQ96FV0.
TreeFamiTF324815.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96FV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGKSAQGP EEGGVCITEA LITKRNLTFP EDGELSEKMF HTLDELQTVR
60 70 80 90 100
LDREGITTIR NLEGLQNLHS LYLQGNKIQQ IENLACIPSL RFLSLAGNQI
110 120 130 140 150
RQVENLLDLP CLQFLDLSEN LIETLKLDEF PQSLLILNLS GNSCTNQDGY
160 170 180 190 200
RELVTEALPL LLDLDGQPVV ERWISDEEDE ASSDEEFPEL SGPFCSERGF
210 220 230 240 250
LKELEQELSR HREHRQQTAL TEHLLRMEMQ PTLTDLPLLP GVPMAGDSSP
260 270 280 290 300
SATPAQGEET VPEAVSSPQA SSPTKKPCSL IPRGHQSSFW GRKGARAATA
310 320
PKASVAEAPS TTKTTAKRSK K
Length:321
Mass (Da):35,340
Last modified:December 1, 2001 - v1
Checksum:i04788DD11D410BB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292765 mRNA. Translation: BAF85454.1.
AK315665 mRNA. Translation: BAG38031.1.
CH471109 Genomic DNA. Translation: EAW94793.1.
BC010412 mRNA. Translation: AAH10412.1.
CCDSiCCDS11518.1.
RefSeqiNP_219481.1. NM_033413.3.
UniGeneiHs.130767.

Genome annotation databases

EnsembliENST00000269025; ENSP00000269025; ENSG00000141294.
GeneIDi90506.
KEGGihsa:90506.
UCSCiuc002ima.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292765 mRNA. Translation: BAF85454.1.
AK315665 mRNA. Translation: BAG38031.1.
CH471109 Genomic DNA. Translation: EAW94793.1.
BC010412 mRNA. Translation: AAH10412.1.
CCDSiCCDS11518.1.
RefSeqiNP_219481.1. NM_033413.3.
UniGeneiHs.130767.

3D structure databases

ProteinModelPortaliQ96FV0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124725. 21 interactors.
IntActiQ96FV0. 1 interactor.
STRINGi9606.ENSP00000269025.

PTM databases

iPTMnetiQ96FV0.
PhosphoSitePlusiQ96FV0.

Polymorphism and mutation databases

BioMutaiLRRC46.
DMDMi74760826.

Proteomic databases

PaxDbiQ96FV0.
PeptideAtlasiQ96FV0.
PRIDEiQ96FV0.

Protocols and materials databases

DNASUi90506.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269025; ENSP00000269025; ENSG00000141294.
GeneIDi90506.
KEGGihsa:90506.
UCSCiuc002ima.3. human.

Organism-specific databases

CTDi90506.
GeneCardsiLRRC46.
HGNCiHGNC:25047. LRRC46.
HPAiHPA021882.
neXtProtiNX_Q96FV0.
OpenTargetsiENSG00000141294.
PharmGKBiPA142671506.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00860000133819.
HOGENOMiHOG000231068.
HOVERGENiHBG080094.
InParanoidiQ96FV0.
OMAiMFHTLAE.
OrthoDBiEOG091G0ZR0.
PhylomeDBiQ96FV0.
TreeFamiTF324815.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141294-MONOMER.

Miscellaneous databases

GenomeRNAii90506.
PROiQ96FV0.

Gene expression databases

BgeeiENSG00000141294.
CleanExiHS_LRRC46.
ExpressionAtlasiQ96FV0. baseline and differential.
GenevisibleiQ96FV0. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC46_HUMAN
AccessioniPrimary (citable) accession number: Q96FV0
Secondary accession number(s): A8K9Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.