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Protein

Leucine-rich repeat-containing protein 46

Gene

LRRC46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
  • regulation of protein stability Source: ParkinsonsUK-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 46
Gene namesi
Name:LRRC46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25047. LRRC46.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671506.

Polymorphism and mutation databases

BioMutaiLRRC46.
DMDMi74760826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Leucine-rich repeat-containing protein 46PRO_0000223919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751PhosphoserineBy similarity
Modified residuei182 – 1821PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96FV0.
PeptideAtlasiQ96FV0.
PRIDEiQ96FV0.

PTM databases

iPTMnetiQ96FV0.
PhosphoSiteiQ96FV0.

Expressioni

Gene expression databases

BgeeiQ96FV0.
CleanExiHS_LRRC46.
ExpressionAtlasiQ96FV0. baseline and differential.
GenevisibleiQ96FV0. HS.

Organism-specific databases

HPAiHPA021882.

Interactioni

Protein-protein interaction databases

BioGridi124725. 21 interactions.
IntActiQ96FV0. 1 interaction.
STRINGi9606.ENSP00000269025.

Structurei

3D structure databases

ProteinModelPortaliQ96FV0.
SMRiQ96FV0. Positions 1-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati45 – 6622LRR 1Add
BLAST
Repeati67 – 8822LRR 2Add
BLAST
Repeati89 – 11022LRR 3Add
BLAST
Repeati111 – 13222LRR 4Add
BLAST
Domaini142 – 18443LRRCTAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili201 – 22121Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00720000108813.
HOGENOMiHOG000231068.
HOVERGENiHBG080094.
InParanoidiQ96FV0.
OMAiMFHTLAE.
OrthoDBiEOG7TXKK0.
PhylomeDBiQ96FV0.
TreeFamiTF324815.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96FV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGKSAQGP EEGGVCITEA LITKRNLTFP EDGELSEKMF HTLDELQTVR
60 70 80 90 100
LDREGITTIR NLEGLQNLHS LYLQGNKIQQ IENLACIPSL RFLSLAGNQI
110 120 130 140 150
RQVENLLDLP CLQFLDLSEN LIETLKLDEF PQSLLILNLS GNSCTNQDGY
160 170 180 190 200
RELVTEALPL LLDLDGQPVV ERWISDEEDE ASSDEEFPEL SGPFCSERGF
210 220 230 240 250
LKELEQELSR HREHRQQTAL TEHLLRMEMQ PTLTDLPLLP GVPMAGDSSP
260 270 280 290 300
SATPAQGEET VPEAVSSPQA SSPTKKPCSL IPRGHQSSFW GRKGARAATA
310 320
PKASVAEAPS TTKTTAKRSK K
Length:321
Mass (Da):35,340
Last modified:December 1, 2001 - v1
Checksum:i04788DD11D410BB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292765 mRNA. Translation: BAF85454.1.
AK315665 mRNA. Translation: BAG38031.1.
CH471109 Genomic DNA. Translation: EAW94793.1.
BC010412 mRNA. Translation: AAH10412.1.
CCDSiCCDS11518.1.
RefSeqiNP_219481.1. NM_033413.3.
UniGeneiHs.130767.

Genome annotation databases

EnsembliENST00000269025; ENSP00000269025; ENSG00000141294.
GeneIDi90506.
KEGGihsa:90506.
UCSCiuc002ima.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292765 mRNA. Translation: BAF85454.1.
AK315665 mRNA. Translation: BAG38031.1.
CH471109 Genomic DNA. Translation: EAW94793.1.
BC010412 mRNA. Translation: AAH10412.1.
CCDSiCCDS11518.1.
RefSeqiNP_219481.1. NM_033413.3.
UniGeneiHs.130767.

3D structure databases

ProteinModelPortaliQ96FV0.
SMRiQ96FV0. Positions 1-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124725. 21 interactions.
IntActiQ96FV0. 1 interaction.
STRINGi9606.ENSP00000269025.

PTM databases

iPTMnetiQ96FV0.
PhosphoSiteiQ96FV0.

Polymorphism and mutation databases

BioMutaiLRRC46.
DMDMi74760826.

Proteomic databases

PaxDbiQ96FV0.
PeptideAtlasiQ96FV0.
PRIDEiQ96FV0.

Protocols and materials databases

DNASUi90506.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269025; ENSP00000269025; ENSG00000141294.
GeneIDi90506.
KEGGihsa:90506.
UCSCiuc002ima.3. human.

Organism-specific databases

CTDi90506.
GeneCardsiLRRC46.
HGNCiHGNC:25047. LRRC46.
HPAiHPA021882.
neXtProtiNX_Q96FV0.
PharmGKBiPA142671506.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00720000108813.
HOGENOMiHOG000231068.
HOVERGENiHBG080094.
InParanoidiQ96FV0.
OMAiMFHTLAE.
OrthoDBiEOG7TXKK0.
PhylomeDBiQ96FV0.
TreeFamiTF324815.

Miscellaneous databases

GenomeRNAii90506.
PROiQ96FV0.

Gene expression databases

BgeeiQ96FV0.
CleanExiHS_LRRC46.
ExpressionAtlasiQ96FV0. baseline and differential.
GenevisibleiQ96FV0. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiLRC46_HUMAN
AccessioniPrimary (citable) accession number: Q96FV0
Secondary accession number(s): A8K9Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.