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Protein

Signal-induced proliferation-associated protein 1

Gene

SIPA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.1 Publication

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB

GO - Biological processi

  • cell proliferation Source: ProtInc
  • cellular response to water deprivation Source: Ensembl
  • cytoskeleton organization Source: UniProtKB
  • intracellular signal transduction Source: UniProtKB
  • negative regulation of cell adhesion Source: UniProtKB
  • negative regulation of cell cycle Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • regulation of small GTPase mediated signal transduction Source: InterPro
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-392517. Rap1 signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-induced proliferation-associated protein 1
Short name:
Sipa-1
Alternative name(s):
GTPase-activating protein Spa-1
p130 SPA-1
Gene namesi
Name:SIPA1
Synonyms:SPA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:10885. SIPA1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • membrane Source: UniProtKB-KW
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • protein complex Source: Ensembl
  • transport vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6494.
OpenTargetsiENSG00000213445.
PharmGKBiPA35785.

Polymorphism and mutation databases

BioMutaiSIPA1.
DMDMi20455286.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567441 – 1042Signal-induced proliferation-associated protein 1Add BLAST1042

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphothreonineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1
Modified residuei839PhosphoserineCombined sources1
Modified residuei912PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96FS4.
MaxQBiQ96FS4.
PaxDbiQ96FS4.
PeptideAtlasiQ96FS4.
PRIDEiQ96FS4.

PTM databases

iPTMnetiQ96FS4.
PhosphoSitePlusiQ96FS4.

Expressioni

Tissue specificityi

Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.

Inductioni

Repressed by 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells.

Gene expression databases

BgeeiENSG00000213445.
CleanExiHS_SIPA1.
ExpressionAtlasiQ96FS4. baseline and differential.
GenevisibleiQ96FS4. HS.

Organism-specific databases

HPAiCAB020833.
HPA039867.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDKN1AP389362EBI-1054981,EBI-375077

Protein-protein interaction databases

BioGridi112385. 19 interactors.
IntActiQ96FS4. 16 interactors.
STRINGi9606.ENSP00000377771.

Structurei

3D structure databases

ProteinModelPortaliQ96FS4.
SMRiQ96FS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini321 – 539Rap-GAPPROSITE-ProRule annotationAdd BLAST219
Domaini687 – 763PDZPROSITE-ProRule annotationAdd BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili972 – 1034Sequence analysisAdd BLAST63

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 Rap-GAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3686. Eukaryota.
ENOG410XTIX. LUCA.
GeneTreeiENSGT00760000119182.
HOGENOMiHOG000154327.
HOVERGENiHBG061666.
InParanoidiQ96FS4.
KOiK08013.
OMAiRSAPKVC.
OrthoDBiEOG091G016P.
PhylomeDBiQ96FS4.
TreeFamiTF318626.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR000331. Rap_GAP_dom.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
PF02145. Rap_GAP. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF111347. SSF111347. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96FS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMWAGGVGS PRRGMAPAST DDLFARKLRQ PARPPLTPHT FEPRPVRGPL
60 70 80 90 100
LRSGSDAGEA RPPTPASPRA RAHSHEEASR PAATSTRLFT DPLALLGLPA
110 120 130 140 150
EEPEPAFPPV LEPRWFAHYD VQSLLFDWAP RSQGMGSHSE ASSGTLASAE
160 170 180 190 200
DQAASSDLLH GAPGFVCELG GEGELGLGGP ASPPVPPALP NAAVSILEEP
210 220 230 240 250
QNRTSAYSLE HADLGAGYYR KYFYGKEHQN FFGMDESLGP VAVSLRREEK
260 270 280 290 300
EGSGGGTLHS YRVIVRTTQL RTLRGTISED ALPPGPPRGL SPRKLLEHVA
310 320 330 340 350
PQLSPSCLRL GSASPKVPRT LLTLDEQVLS FQRKVGILYC RAGQGSEEEM
360 370 380 390 400
YNNQEAGPAF MQFLTLLGDV VRLKGFESYR AQLDTKTDST GTHSLYTTYQ
410 420 430 440 450
DHEIMFHVST MLPYTPNNQQ QLLRKRHIGN DIVTIVFQEP GSKPFCPTTI
460 470 480 490 500
RSHFQHVFLV VRAHTPCTPH TTYRVAVSRT QDTPAFGPAL PAGGGPFAAN
510 520 530 540 550
ADFRAFLLAK ALNGEQAAGH ARQFHAMATR TRQQYLQDLA TNEVTTTSLD
560 570 580 590 600
SASRFGLPSL GGRRRAAPRG PGAELQAAGS LVWGVRAAPG ARVAAGAQAS
610 620 630 640 650
GPEGIEVPCL LGISAEALVL VAPRDGRVVF NCACRDVLAW TFSEQQLDLY
660 670 680 690 700
HGRGEAITLR FDGSPGQAVG EVVARLQLVS RGCETRELAL PRDGQGRLGF
710 720 730 740 750
EVDAEGFVTH VERFTFAETA GLRPGARLLR VCGQTLPSLR PEAAAQLLRS
760 770 780 790 800
APKVCVTVLP PDESGRPRRS FSELYTLSLQ EPSRRGAPDP VQDEVQGVTL
810 820 830 840 850
LPTTKQLLHL CLQDGGSPPG PGDLAEERTE FLHSQNSLSP RSSLSDEAPV
860 870 880 890 900
LPNTTPDLLL ATTAKPSVPS ADSETPLTQD RPGSPSGSED KGNPAPELRA
910 920 930 940 950
SFLPRTLSLR NSISRIMSEA GSGTLEDEWQ AISEIASTCN TILESLSREG
960 970 980 990 1000
QPIPESGDPK GTPKSDAEPE PGNLSEKVSH LESMLRKLQE DLQKEKADRA
1010 1020 1030 1040
ALEEEVRSLR HNNRRLQAES ESAATRLLLA SKQLGSPTAD LA
Length:1,042
Mass (Da):112,149
Last modified:December 1, 2001 - v1
Checksum:iFB52C7231EA3B6B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30Q → H in AAC32559 (PubMed:9651531).Curated1
Sequence conflicti30Q → H in AAC32547 (PubMed:9651531).Curated1
Sequence conflicti53 – 56SGSD → RAAN in AAC32559 (PubMed:9651531).Curated4
Sequence conflicti53 – 56SGSD → RAAN in AAC32547 (PubMed:9651531).Curated4
Sequence conflicti93L → Q in AAC32559 (PubMed:9651531).Curated1
Sequence conflicti93L → Q in AAC32547 (PubMed:9651531).Curated1
Sequence conflicti468T → R in AAC32559 (PubMed:9651531).Curated1
Sequence conflicti658T → P in AAC32547 (PubMed:9651531).Curated1
Sequence conflicti721 – 724GLRP → AAA in AAC32559 (PubMed:9651531).Curated4
Sequence conflicti721 – 724GLRP → AAA in AAC32547 (PubMed:9651531).Curated4
Sequence conflicti781 – 782EP → DA in AAC32559 (PubMed:9651531).Curated2
Sequence conflicti796Q → H in BAA22197 (PubMed:9346962).Curated1
Sequence conflicti888S → C in BAA22197 (PubMed:9346962).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04914880R → Q.Corresponds to variant rs35045265dbSNPEnsembl.1
Natural variantiVAR_049149106A → S.Corresponds to variant rs3741379dbSNPEnsembl.1
Natural variantiVAR_049150174E → D.Corresponds to variant rs34912782dbSNPEnsembl.1
Natural variantiVAR_049151182S → F.1 PublicationCorresponds to variant rs3741378dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005666 mRNA. Translation: BAA22197.1.
AF052238
, AF052233, AF052234, AF052235, AF052236, AF052237 Genomic DNA. Translation: AAC32559.1.
AF029789 mRNA. Translation: AAC32547.1.
BC010492 mRNA. Translation: AAH10492.1.
BC110353 mRNA. Translation: AAI10354.1.
CCDSiCCDS8108.1.
RefSeqiNP_006738.3. NM_006747.3.
NP_694985.29. NM_153253.29.
XP_005274246.1. XM_005274189.2.
XP_011543516.1. XM_011545214.1.
UniGeneiHs.530477.

Genome annotation databases

EnsembliENST00000394224; ENSP00000377771; ENSG00000213445.
ENST00000534313; ENSP00000436269; ENSG00000213445.
GeneIDi6494.
KEGGihsa:6494.
UCSCiuc001ofb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005666 mRNA. Translation: BAA22197.1.
AF052238
, AF052233, AF052234, AF052235, AF052236, AF052237 Genomic DNA. Translation: AAC32559.1.
AF029789 mRNA. Translation: AAC32547.1.
BC010492 mRNA. Translation: AAH10492.1.
BC110353 mRNA. Translation: AAI10354.1.
CCDSiCCDS8108.1.
RefSeqiNP_006738.3. NM_006747.3.
NP_694985.29. NM_153253.29.
XP_005274246.1. XM_005274189.2.
XP_011543516.1. XM_011545214.1.
UniGeneiHs.530477.

3D structure databases

ProteinModelPortaliQ96FS4.
SMRiQ96FS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112385. 19 interactors.
IntActiQ96FS4. 16 interactors.
STRINGi9606.ENSP00000377771.

PTM databases

iPTMnetiQ96FS4.
PhosphoSitePlusiQ96FS4.

Polymorphism and mutation databases

BioMutaiSIPA1.
DMDMi20455286.

Proteomic databases

EPDiQ96FS4.
MaxQBiQ96FS4.
PaxDbiQ96FS4.
PeptideAtlasiQ96FS4.
PRIDEiQ96FS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394224; ENSP00000377771; ENSG00000213445.
ENST00000534313; ENSP00000436269; ENSG00000213445.
GeneIDi6494.
KEGGihsa:6494.
UCSCiuc001ofb.3. human.

Organism-specific databases

CTDi6494.
DisGeNETi6494.
GeneCardsiSIPA1.
HGNCiHGNC:10885. SIPA1.
HPAiCAB020833.
HPA039867.
MIMi602180. gene.
neXtProtiNX_Q96FS4.
OpenTargetsiENSG00000213445.
PharmGKBiPA35785.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3686. Eukaryota.
ENOG410XTIX. LUCA.
GeneTreeiENSGT00760000119182.
HOGENOMiHOG000154327.
HOVERGENiHBG061666.
InParanoidiQ96FS4.
KOiK08013.
OMAiRSAPKVC.
OrthoDBiEOG091G016P.
PhylomeDBiQ96FS4.
TreeFamiTF318626.

Enzyme and pathway databases

ReactomeiR-HSA-392517. Rap1 signalling.

Miscellaneous databases

GeneWikiiSIPA1.
GenomeRNAii6494.
PROiQ96FS4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213445.
CleanExiHS_SIPA1.
ExpressionAtlasiQ96FS4. baseline and differential.
GenevisibleiQ96FS4. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR000331. Rap_GAP_dom.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
PF02145. Rap_GAP. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF111347. SSF111347. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIPA1_HUMAN
AccessioniPrimary (citable) accession number: Q96FS4
Secondary accession number(s): O14518
, O60484, O60618, Q2YD83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.