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Protein

Protein S100-A16

Gene

S100A16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-binding protein. Binds one calcium ion per monomer.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi23 – 361; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi67 – 782; high affinityAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32044-MONOMER.

Protein family/group databases

TCDBi8.A.81.1.3. the s100 calcium-binding protein (s100) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A16
Alternative name(s):
Aging-associated gene 13 protein
Protein S100-F
S100 calcium-binding protein A16
Gene namesi
Name:S100A16
Synonyms:S100F
ORF Names:AAG13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20441. S100A16.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • nucleolus Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi140576.
OpenTargetsiENSG00000188643.
PharmGKBiPA134931606.

Polymorphism and mutation databases

BioMutaiS100A16.
DMDMi20178113.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440231 – 103Protein S100-A16Add BLAST103

Proteomic databases

EPDiQ96FQ6.
MaxQBiQ96FQ6.
PaxDbiQ96FQ6.
PeptideAtlasiQ96FQ6.
PRIDEiQ96FQ6.
TopDownProteomicsiQ96FQ6.

2D gel databases

SWISS-2DPAGEQ96FQ6.

PTM databases

iPTMnetiQ96FQ6.
PhosphoSitePlusiQ96FQ6.
SwissPalmiQ96FQ6.

Expressioni

Gene expression databases

BgeeiENSG00000188643.
CleanExiHS_S100A16.
GenevisibleiQ96FQ6. HS.

Organism-specific databases

HPAiHPA045841.

Interactioni

Subunit structurei

Homodimer.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
S100A14Q9HCY86EBI-751850,EBI-751842

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi126627. 35 interactors.
IntActiQ96FQ6. 8 interactors.
MINTiMINT-1457417.
STRINGi9606.ENSP00000357692.

Structurei

Secondary structure

1103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 21Combined sources15
Turni28 – 30Combined sources3
Helixi35 – 45Combined sources11
Turni47 – 50Combined sources4
Beta strandi51 – 53Combined sources3
Helixi54 – 65Combined sources12
Helixi66 – 68Combined sources3
Helixi76 – 87Combined sources12
Helixi88 – 90Combined sources3
Helixi91 – 100Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L50NMR-A/B2-103[»]
2L51NMR-A/B2-103[»]
3NXAX-ray2.10A/B/C/D3-102[»]
ProteinModelPortaliQ96FQ6.
SMRiQ96FQ6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96FQ6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini54 – 89EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXNY. Eukaryota.
ENOG41115R5. LUCA.
GeneTreeiENSGT00390000000920.
HOGENOMiHOG000013071.
HOVERGENiHBG001479.
InParanoidiQ96FQ6.
OMAiMADCYTE.
OrthoDBiEOG091G0YU7.
PhylomeDBiQ96FQ6.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96FQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDCYTELEK AVIVLVENFY KYVSKYSLVK NKISKSSFRE MLQKELNHML
60 70 80 90 100
SDTGNRKAAD KLIQNLDANH DGRISFDEYW TLIGGITGPI AKLIHEQEQQ

SSS
Length:103
Mass (Da):11,801
Last modified:December 1, 2001 - v1
Checksum:i7D00C08F85697A6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ585980 Genomic DNA. Translation: CAE51865.1.
AY221961 mRNA. Translation: AAP46152.1.
AY762098 mRNA. Translation: AAW88319.1.
AK290804 mRNA. Translation: BAF83493.1.
BX470102 Genomic DNA. Translation: CAI14758.1.
CH471121 Genomic DNA. Translation: EAW53303.1.
CH471121 Genomic DNA. Translation: EAW53304.1.
BC010541 mRNA. Translation: AAH10541.1.
BC019099 mRNA. Translation: AAH19099.1.
BC095462 mRNA. Translation: AAH95462.1.
CCDSiCCDS1045.1.
RefSeqiNP_001303936.1. NM_001317007.1.
NP_001303937.1. NM_001317008.1.
NP_525127.1. NM_080388.2.
UniGeneiHs.515714.

Genome annotation databases

EnsembliENST00000368703; ENSP00000357692; ENSG00000188643.
ENST00000368704; ENSP00000357693; ENSG00000188643.
ENST00000368705; ENSP00000357694; ENSG00000188643.
ENST00000368706; ENSP00000357695; ENSG00000188643.
GeneIDi140576.
KEGGihsa:140576.
UCSCiuc001fcc.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ585980 Genomic DNA. Translation: CAE51865.1.
AY221961 mRNA. Translation: AAP46152.1.
AY762098 mRNA. Translation: AAW88319.1.
AK290804 mRNA. Translation: BAF83493.1.
BX470102 Genomic DNA. Translation: CAI14758.1.
CH471121 Genomic DNA. Translation: EAW53303.1.
CH471121 Genomic DNA. Translation: EAW53304.1.
BC010541 mRNA. Translation: AAH10541.1.
BC019099 mRNA. Translation: AAH19099.1.
BC095462 mRNA. Translation: AAH95462.1.
CCDSiCCDS1045.1.
RefSeqiNP_001303936.1. NM_001317007.1.
NP_001303937.1. NM_001317008.1.
NP_525127.1. NM_080388.2.
UniGeneiHs.515714.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L50NMR-A/B2-103[»]
2L51NMR-A/B2-103[»]
3NXAX-ray2.10A/B/C/D3-102[»]
ProteinModelPortaliQ96FQ6.
SMRiQ96FQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126627. 35 interactors.
IntActiQ96FQ6. 8 interactors.
MINTiMINT-1457417.
STRINGi9606.ENSP00000357692.

Protein family/group databases

TCDBi8.A.81.1.3. the s100 calcium-binding protein (s100) family.

PTM databases

iPTMnetiQ96FQ6.
PhosphoSitePlusiQ96FQ6.
SwissPalmiQ96FQ6.

Polymorphism and mutation databases

BioMutaiS100A16.
DMDMi20178113.

2D gel databases

SWISS-2DPAGEQ96FQ6.

Proteomic databases

EPDiQ96FQ6.
MaxQBiQ96FQ6.
PaxDbiQ96FQ6.
PeptideAtlasiQ96FQ6.
PRIDEiQ96FQ6.
TopDownProteomicsiQ96FQ6.

Protocols and materials databases

DNASUi140576.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368703; ENSP00000357692; ENSG00000188643.
ENST00000368704; ENSP00000357693; ENSG00000188643.
ENST00000368705; ENSP00000357694; ENSG00000188643.
ENST00000368706; ENSP00000357695; ENSG00000188643.
GeneIDi140576.
KEGGihsa:140576.
UCSCiuc001fcc.5. human.

Organism-specific databases

CTDi140576.
DisGeNETi140576.
GeneCardsiS100A16.
HGNCiHGNC:20441. S100A16.
HPAiHPA045841.
neXtProtiNX_Q96FQ6.
OpenTargetsiENSG00000188643.
PharmGKBiPA134931606.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXNY. Eukaryota.
ENOG41115R5. LUCA.
GeneTreeiENSGT00390000000920.
HOGENOMiHOG000013071.
HOVERGENiHBG001479.
InParanoidiQ96FQ6.
OMAiMADCYTE.
OrthoDBiEOG091G0YU7.
PhylomeDBiQ96FQ6.
TreeFamiTF332727.

Enzyme and pathway databases

BioCyciZFISH:G66-32044-MONOMER.

Miscellaneous databases

ChiTaRSiS100A16. human.
EvolutionaryTraceiQ96FQ6.
GeneWikiiS100A16.
GenomeRNAii140576.
PROiQ96FQ6.

Gene expression databases

BgeeiENSG00000188643.
CleanExiHS_S100A16.
GenevisibleiQ96FQ6. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS10AG_HUMAN
AccessioniPrimary (citable) accession number: Q96FQ6
Secondary accession number(s): A8K439, D3DV52, Q5RHS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.