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Protein

Protein S100-A16

Gene

S100A16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-binding protein. Binds one calcium ion per monomer (PubMed:17030513). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi67 – 78High affinity1 PublicationPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding, Zinc

Protein family/group databases

TCDBi8.A.81.1.3. the s100 calcium-binding protein (s100) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A16
Alternative name(s):
Aging-associated gene 13 protein
Protein S100-F
S100 calcium-binding protein A16
Gene namesi
Name:S100A16Imported
Synonyms:S100F
ORF Names:AAG13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188643.10.
HGNCiHGNC:20441. S100A16.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi140576.
OpenTargetsiENSG00000188643.
PharmGKBiPA134931606.

Polymorphism and mutation databases

BioMutaiS100A16.
DMDMi20178113.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440231 – 103Protein S100-A16Add BLAST103

Proteomic databases

EPDiQ96FQ6.
MaxQBiQ96FQ6.
PaxDbiQ96FQ6.
PeptideAtlasiQ96FQ6.
PRIDEiQ96FQ6.
TopDownProteomicsiQ96FQ6.

2D gel databases

SWISS-2DPAGEiQ96FQ6.

PTM databases

iPTMnetiQ96FQ6.
PhosphoSitePlusiQ96FQ6.
SwissPalmiQ96FQ6.

Expressioni

Tissue specificityi

Ubiquitous (PubMed:14684152). Highly expressed in esophagus, adipose tissues and colon. Expressed at lower level in lung, brain, pancreas and skeletal muscle. Expression is up-regulated in tumors of bladder, lung, thyroid gland, pancreas and ovary (PubMed:14684152). Expressed in astrocytes (PubMed:17030513).2 Publications

Gene expression databases

BgeeiENSG00000188643.
CleanExiHS_S100A16.
GenevisibleiQ96FQ6. HS.

Organism-specific databases

HPAiHPA045841.

Interactioni

Subunit structurei

Homodimer (PubMed:17030513, PubMed:21046186). Interacts with TP53 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
S100A14Q9HCY88EBI-751850,EBI-751842

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi126627. 39 interactors.
IntActiQ96FQ6. 8 interactors.
MINTiMINT-1457417.
STRINGi9606.ENSP00000357692.

Structurei

Secondary structure

1103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 21Combined sources15
Turni28 – 30Combined sources3
Helixi35 – 45Combined sources11
Turni47 – 50Combined sources4
Beta strandi51 – 53Combined sources3
Helixi54 – 65Combined sources12
Helixi66 – 68Combined sources3
Helixi76 – 87Combined sources12
Helixi88 – 90Combined sources3
Helixi91 – 100Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L50NMR-A/B2-103[»]
2L51NMR-A/B2-103[»]
3NXAX-ray2.10A/B/C/D3-102[»]
ProteinModelPortaliQ96FQ6.
SMRiQ96FQ6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96FQ6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1; degenerate1 PublicationAdd BLAST36
Domaini54 – 89EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Domaini

S100A16 proteins, but not other S100 proteins, have only one functional Ca2+ binding site per monomer. Upon Ca2+ binding, undergoes conformational changes leading to the exposure of hydrophobic patches which could be implicated in the Ca2+ -dependent nuclear export. Binds Zn2+. Ca2+ and Zn2+ do not bind to the same site. Does not bind Cu2+.1 Publication

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXNY. Eukaryota.
ENOG41115R5. LUCA.
GeneTreeiENSGT00390000000920.
HOGENOMiHOG000013071.
HOVERGENiHBG001479.
InParanoidiQ96FQ6.
OMAiMADCYTE.
OrthoDBiEOG091G0YU7.
PhylomeDBiQ96FQ6.
TreeFamiTF332727.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
PfamiView protein in Pfam
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96FQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDCYTELEK AVIVLVENFY KYVSKYSLVK NKISKSSFRE MLQKELNHML
60 70 80 90 100
SDTGNRKAAD KLIQNLDANH DGRISFDEYW TLIGGITGPI AKLIHEQEQQ

SSS
Length:103
Mass (Da):11,801
Last modified:December 1, 2001 - v1
Checksum:i7D00C08F85697A6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ585980 Genomic DNA. Translation: CAE51865.1.
AY221961 mRNA. Translation: AAP46152.1.
AY762098 mRNA. Translation: AAW88319.1.
AK290804 mRNA. Translation: BAF83493.1.
BX470102 Genomic DNA. Translation: CAI14758.1.
CH471121 Genomic DNA. Translation: EAW53303.1.
CH471121 Genomic DNA. Translation: EAW53304.1.
BC010541 mRNA. Translation: AAH10541.1.
BC019099 mRNA. Translation: AAH19099.1.
BC095462 mRNA. Translation: AAH95462.1.
CCDSiCCDS1045.1.
RefSeqiNP_001303936.1. NM_001317007.1.
NP_001303937.1. NM_001317008.1.
NP_525127.1. NM_080388.2.
UniGeneiHs.515714.

Genome annotation databases

EnsembliENST00000368703; ENSP00000357692; ENSG00000188643.
ENST00000368704; ENSP00000357693; ENSG00000188643.
ENST00000368705; ENSP00000357694; ENSG00000188643.
ENST00000368706; ENSP00000357695; ENSG00000188643.
GeneIDi140576.
KEGGihsa:140576.
UCSCiuc001fcc.5. human.

Similar proteinsi

Entry informationi

Entry nameiS10AG_HUMAN
AccessioniPrimary (citable) accession number: Q96FQ6
Secondary accession number(s): A8K439, D3DV52, Q5RHS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: December 1, 2001
Last modified: October 25, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families