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Protein

Probable D-tyrosyl-tRNA(Tyr) deacylase 2

Gene

DTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential).Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D-tyrosyl-tRNA(Tyr) deacylase 2 (EC:3.1.-.-)
Alternative name(s):
D-tyrosyl-tRNA deacylase 2
Gene namesi
Name:DTD2
Synonyms:C14orf126
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20277. DTD2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134963117.

Polymorphism and mutation databases

BioMutaiDTD2.
DMDMi74731729.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168Probable D-tyrosyl-tRNA(Tyr) deacylase 2PRO_0000254049Add
BLAST

Proteomic databases

EPDiQ96FN9.
MaxQBiQ96FN9.
PaxDbiQ96FN9.
PeptideAtlasiQ96FN9.
PRIDEiQ96FN9.

PTM databases

iPTMnetiQ96FN9.
PhosphoSiteiQ96FN9.

Expressioni

Gene expression databases

BgeeiENSG00000129480.
CleanExiHS_C14orf126.
ExpressionAtlasiQ96FN9. baseline and differential.
GenevisibleiQ96FN9. HS.

Organism-specific databases

HPAiHPA001117.

Interactioni

Protein-protein interaction databases

BioGridi125191. 3 interactions.
STRINGi9606.ENSP00000312224.

Structurei

3D structure databases

ProteinModelPortaliQ96FN9.
SMRiQ96FN9. Positions 11-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DTD family.Curated

Phylogenomic databases

eggNOGiKOG3323. Eukaryota.
COG1490. LUCA.
GeneTreeiENSGT00390000003234.
HOGENOMiHOG000113983.
HOVERGENiHBG081465.
InParanoidiQ96FN9.
OMAiAQWVEIQ.
OrthoDBiEOG091G0WKW.
PhylomeDBiQ96FN9.
TreeFamiTF329119.

Family and domain databases

Gene3Di3.50.80.10. 1 hit.
InterProiIPR003732. Daa-tRNA_deacyls_DTD.
IPR023509. DTD-like_dom.
[Graphical view]
PANTHERiPTHR10472. PTHR10472. 1 hit.
PfamiPF02580. Tyr_Deacylase. 1 hit.
[Graphical view]
SUPFAMiSSF69500. SSF69500. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96FN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGSRIPQA RALLQQCLHA RLQIRPADGD VAAQWVEVQR GLVIYVCFFK
60 70 80 90 100
GADKELLPKM VNTLLNVKLS ETENGKHVSI LDLPGNILII PQATLGGRLK
110 120 130 140 150
GRNMQYHSNS GKEEGFELYS QFVTLCEKEV AANSKCAEAR VVVEHGTYGN
160
RQVLKLDTNG PFTHLIEF
Length:168
Mass (Da):18,660
Last modified:December 1, 2001 - v1
Checksum:iF74D05F238C8D0A9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61R → W.
Corresponds to variant rs17097904 [ dbSNP | Ensembl ].
VAR_028802

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139353 Genomic DNA. No translation available.
AL163973 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65944.1.
CH471078 Genomic DNA. Translation: EAW65945.1.
BC010618 mRNA. Translation: AAH10618.1.
CCDSiCCDS9643.1.
RefSeqiNP_542395.1. NM_080664.2.
UniGeneiHs.116014.

Genome annotation databases

EnsembliENST00000310850; ENSP00000312224; ENSG00000129480.
ENST00000356180; ENSP00000348503; ENSG00000129480.
GeneIDi112487.
KEGGihsa:112487.
UCSCiuc001wrj.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139353 Genomic DNA. No translation available.
AL163973 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65944.1.
CH471078 Genomic DNA. Translation: EAW65945.1.
BC010618 mRNA. Translation: AAH10618.1.
CCDSiCCDS9643.1.
RefSeqiNP_542395.1. NM_080664.2.
UniGeneiHs.116014.

3D structure databases

ProteinModelPortaliQ96FN9.
SMRiQ96FN9. Positions 11-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125191. 3 interactions.
STRINGi9606.ENSP00000312224.

PTM databases

iPTMnetiQ96FN9.
PhosphoSiteiQ96FN9.

Polymorphism and mutation databases

BioMutaiDTD2.
DMDMi74731729.

Proteomic databases

EPDiQ96FN9.
MaxQBiQ96FN9.
PaxDbiQ96FN9.
PeptideAtlasiQ96FN9.
PRIDEiQ96FN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310850; ENSP00000312224; ENSG00000129480.
ENST00000356180; ENSP00000348503; ENSG00000129480.
GeneIDi112487.
KEGGihsa:112487.
UCSCiuc001wrj.5. human.

Organism-specific databases

CTDi112487.
GeneCardsiDTD2.
HGNCiHGNC:20277. DTD2.
HPAiHPA001117.
neXtProtiNX_Q96FN9.
PharmGKBiPA134963117.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3323. Eukaryota.
COG1490. LUCA.
GeneTreeiENSGT00390000003234.
HOGENOMiHOG000113983.
HOVERGENiHBG081465.
InParanoidiQ96FN9.
OMAiAQWVEIQ.
OrthoDBiEOG091G0WKW.
PhylomeDBiQ96FN9.
TreeFamiTF329119.

Miscellaneous databases

GenomeRNAii112487.
PROiQ96FN9.

Gene expression databases

BgeeiENSG00000129480.
CleanExiHS_C14orf126.
ExpressionAtlasiQ96FN9. baseline and differential.
GenevisibleiQ96FN9. HS.

Family and domain databases

Gene3Di3.50.80.10. 1 hit.
InterProiIPR003732. Daa-tRNA_deacyls_DTD.
IPR023509. DTD-like_dom.
[Graphical view]
PANTHERiPTHR10472. PTHR10472. 1 hit.
PfamiPF02580. Tyr_Deacylase. 1 hit.
[Graphical view]
SUPFAMiSSF69500. SSF69500. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDTD2_HUMAN
AccessioniPrimary (citable) accession number: Q96FN9
Secondary accession number(s): D3DS87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.