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Protein

D-aminoacyl-tRNA deacylase 2

Gene

DTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408). Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408). Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity).By similarity1 Publication

Catalytic activityi

A D-aminoacyl-tRNA + H2O = a D-amino acid + tRNA.By similarity
L-alanyl-tRNA(Thr) + H2O = L-alanine + tRNA(Thr).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, RNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
D-aminoacyl-tRNA deacylase 2Curated (EC:3.1.1.96By similarity)
Alternative name(s):
Animalia-specifc tRNA deacylase1 Publication
Short name:
ATD1 Publication
D-tyrosyl-tRNA(Tyr) deacylase 2Curated
L-alanyl-tRNA deacylase1 Publication (EC:3.1.1.-1 Publication)
Gene namesi
Name:DTD2
Synonyms:C14orf126
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000129480.12
HGNCiHGNC:20277 DTD2
neXtProtiNX_Q96FN9

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000129480
PharmGKBiPA134963117

Polymorphism and mutation databases

BioMutaiDTD2
DMDMi74731729

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002540491 – 168D-aminoacyl-tRNA deacylase 2Add BLAST168

Proteomic databases

EPDiQ96FN9
MaxQBiQ96FN9
PaxDbiQ96FN9
PeptideAtlasiQ96FN9
PRIDEiQ96FN9

PTM databases

iPTMnetiQ96FN9
PhosphoSitePlusiQ96FN9

Expressioni

Gene expression databases

BgeeiENSG00000129480
CleanExiHS_C14orf126
ExpressionAtlasiQ96FN9 baseline and differential
GenevisibleiQ96FN9 HS

Organism-specific databases

HPAiHPA001117

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi125191, 3 interactors
IntActiQ96FN9, 1 interactor
STRINGi9606.ENSP00000312224

Structurei

3D structure databases

ProteinModelPortaliQ96FN9
SMRiQ96FN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi160 – 161Gly-transPro motif, allows the protein to recognize chirality of D-amino acidsBy similarity2

Domaini

A Gly-transPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of most L-amino acids except L-Ala. The trans conformation of the motif is maintained by Arg-151.By similarity

Sequence similaritiesi

Belongs to the DTD family.Curated

Phylogenomic databases

eggNOGiKOG3323 Eukaryota
COG1490 LUCA
GeneTreeiENSGT00390000003234
HOGENOMiHOG000113983
HOVERGENiHBG081465
InParanoidiQ96FN9
OMAiIYICFFK
OrthoDBiEOG091G0WKW
PhylomeDBiQ96FN9
TreeFamiTF329119

Family and domain databases

Gene3Di3.50.80.10, 1 hit
InterProiView protein in InterPro
IPR003732 Daa-tRNA_deacyls_DTD
IPR023509 DTD-like_sf
PANTHERiPTHR10472 PTHR10472, 1 hit
PfamiView protein in Pfam
PF02580 Tyr_Deacylase, 1 hit
SUPFAMiSSF69500 SSF69500, 1 hit

Sequencei

Sequence statusi: Complete.

Q96FN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGSRIPQA RALLQQCLHA RLQIRPADGD VAAQWVEVQR GLVIYVCFFK
60 70 80 90 100
GADKELLPKM VNTLLNVKLS ETENGKHVSI LDLPGNILII PQATLGGRLK
110 120 130 140 150
GRNMQYHSNS GKEEGFELYS QFVTLCEKEV AANSKCAEAR VVVEHGTYGN
160
RQVLKLDTNG PFTHLIEF
Length:168
Mass (Da):18,660
Last modified:December 1, 2001 - v1
Checksum:iF74D05F238C8D0A9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0288026R → W. Corresponds to variant dbSNP:rs17097904Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139353 Genomic DNA No translation available.
AL163973 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65944.1
CH471078 Genomic DNA Translation: EAW65945.1
BC010618 mRNA Translation: AAH10618.1
CCDSiCCDS9643.1
RefSeqiNP_542395.1, NM_080664.2
UniGeneiHs.116014

Genome annotation databases

EnsembliENST00000310850; ENSP00000312224; ENSG00000129480
ENST00000356180; ENSP00000348503; ENSG00000129480
GeneIDi112487
KEGGihsa:112487
UCSCiuc001wrj.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDTD2_HUMAN
AccessioniPrimary (citable) accession number: Q96FN9
Secondary accession number(s): D3DS87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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