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Protein

Kinesin-like protein KIF12

Gene

KIF12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 111ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136883-MONOMER.
ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF12
Gene namesi
Name:KIF12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:21495. KIF12.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • kinesin complex Source: GO_Central
  • microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931618.

Polymorphism and mutation databases

DMDMi85541032.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254441 – 646Kinesin-like protein KIF12Add BLAST646

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei369PhosphoserineBy similarity1
Modified residuei638PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96FN5.
PeptideAtlasiQ96FN5.
PRIDEiQ96FN5.

PTM databases

iPTMnetiQ96FN5.
PhosphoSitePlusiQ96FN5.

Expressioni

Tissue specificityi

Expressed in fetal liver, adult brain and pancreatic islet as well as in kidney tumors, uterus cancer and pancreatic cancer.1 Publication

Gene expression databases

BgeeiENSG00000136883.
CleanExiHS_KIF12.

Organism-specific databases

HPAiHPA020192.
HPA024127.

Interactioni

Protein-protein interaction databases

BioGridi125234. 2 interactors.
IntActiQ96FN5. 2 interactors.
STRINGi9606.ENSP00000363232.

Structurei

3D structure databases

ProteinModelPortaliQ96FN5.
SMRiQ96FN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 360Kinesin motorPROSITE-ProRule annotationAdd BLAST336

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili372 – 467Sequence analysisAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi475 – 597Pro-richAdd BLAST123

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000049053.
HOVERGENiHBG052248.
InParanoidiQ96FN5.
KOiK10399.
PhylomeDBiQ96FN5.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR028763. Kif12.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PTHR24115:SF418. PTHR24115:SF418. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96FN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEERGSPDGD LARSLEQGPE GPETPIQVVL RVRPMSAAEL RRGQQSVLHC
60 70 80 90 100
SGTRTLQGGP EVAFRFGAVL DAARTQEDVF RACGVRRLGE LALRGFSCTV
110 120 130 140 150
FTFGQTGSGK TYTLTGPPPQ GEGVPVPPSL AGIMQRTFAW LLDRVQHLGA
160 170 180 190 200
PVTLRASYLE IYNEQVRDLL SLGSPRPLPV RWNKTRGFYV EQLRVVEFGS
210 220 230 240 250
LEALMELLQT GLSRRRNSAH TLNQASSRSH ALLTLYISRQ TAQQMPSVDP
260 270 280 290 300
GEPPVGGKLC FVDLAGSEKV AATGSRGELM LEANSINRSL LALGHCISLL
310 320 330 340 350
LDPQRKQSHI PFRDSKLTKL LADSLGGRGV TLMVACVSPS AQCLPETLST
360 370 380 390 400
LRYASRAQRV TTRPQAPKSP VAKQPQRLET EMLQLQEENR RLQFQLDQMD
410 420 430 440 450
CKASGLSGAR VAWAQRNLYG MLQEFMLENE RLRKEKSQLQ NSRDLAQNEQ
460 470 480 490 500
RILAQQVHAL ERRLLSACYH HQQGPGLTPP CPCLMAPAPP CHALPPLYSC
510 520 530 540 550
PCCHICPLCR VPLAHWACLP GEHHLPQVLD PEASGGRPPS ARPPPWAPPC
560 570 580 590 600
SPGSAKCPRE RSHSDWTQTR VLAEMLTEEE VVPSAPPLPV RPPKTSPGLR
610 620 630 640
GGAGVPNLAQ RLEALRDQIG SSLRRGRSQP PCSEGARSPG QVLPPH
Length:646
Mass (Da):70,660
Last modified:January 10, 2006 - v3
Checksum:i0DC0A9732D7BB15A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137850 Genomic DNA. Translation: CAI15901.1.
BC010626 mRNA. Translation: AAH10626.1.
RefSeqiNP_612433.1. NM_138424.1.
UniGeneiHs.28149.

Genome annotation databases

EnsembliENST00000259410; ENSP00000259410; ENSG00000136883.
GeneIDi113220.
KEGGihsa:113220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137850 Genomic DNA. Translation: CAI15901.1.
BC010626 mRNA. Translation: AAH10626.1.
RefSeqiNP_612433.1. NM_138424.1.
UniGeneiHs.28149.

3D structure databases

ProteinModelPortaliQ96FN5.
SMRiQ96FN5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125234. 2 interactors.
IntActiQ96FN5. 2 interactors.
STRINGi9606.ENSP00000363232.

PTM databases

iPTMnetiQ96FN5.
PhosphoSitePlusiQ96FN5.

Polymorphism and mutation databases

DMDMi85541032.

Proteomic databases

PaxDbiQ96FN5.
PeptideAtlasiQ96FN5.
PRIDEiQ96FN5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259410; ENSP00000259410; ENSG00000136883.
GeneIDi113220.
KEGGihsa:113220.

Organism-specific databases

CTDi113220.
GeneCardsiKIF12.
HGNCiHGNC:21495. KIF12.
HPAiHPA020192.
HPA024127.
MIMi611278. gene.
neXtProtiNX_Q96FN5.
PharmGKBiPA134931618.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000049053.
HOVERGENiHBG052248.
InParanoidiQ96FN5.
KOiK10399.
PhylomeDBiQ96FN5.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136883-MONOMER.
ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Miscellaneous databases

GenomeRNAii113220.
PROiQ96FN5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136883.
CleanExiHS_KIF12.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR028763. Kif12.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PTHR24115:SF418. PTHR24115:SF418. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIF12_HUMAN
AccessioniPrimary (citable) accession number: Q96FN5
Secondary accession number(s): Q5TBE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: January 10, 2006
Last modified: November 2, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.