Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96FL8

- S47A1_HUMAN

UniProt

Q96FL8 - S47A1_HUMAN

Protein

Multidrug and toxin extrusion protein 1

Gene

SLC47A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.5 Publications

    Kineticsi

    1. KM=0.38 mM for TEA2 Publications
    2. KM=0.10 mM for MPP2 Publications
    3. KM=0.17 mM for cimetidine2 Publications
    4. KM=0.78 mM for metformin2 Publications
    5. KM=2.1 mM for guanidine2 Publications
    6. KM=1.23 mM for procainamide2 Publications
    7. KM=0.07 mM for topotecan2 Publications
    8. KM=0.47 mM for estrone sulfate2 Publications
    9. KM=2.64 mM for acyclovir2 Publications
    10. KM=5.12 mM for ganciclovir2 Publications

    Vmax=1.185 nmol/min/mg enzyme toward TEA2 Publications

    Vmax=0.735 nmol/min/mg enzyme toward MPP2 Publications

    Vmax=0.135 nmol/min/mg enzyme toward cimetidine2 Publications

    Vmax=2.23 nmol/min/mg enzyme toward metformin2 Publications

    Vmax=0.89 nmol/min/mg enzyme toward guanidine2 Publications

    Vmax=3.78 nmol/min/mg enzyme toward procainamide2 Publications

    Vmax=0.21 nmol/min/mg enzyme toward topotecan2 Publications

    Vmax=0.265 nmol/min/mg enzyme toward estrone sulfate2 Publications

    Vmax=0.62 nmol/min/mg enzyme toward acyclovir2 Publications

    Vmax=1.08 nmol/min/mg enzyme toward ganciclovir2 Publications

    pH dependencei

    Optimum pH is 8.5. Active from pH 6 to 8.5.2 Publications

    GO - Molecular functioni

    1. drug transmembrane transporter activity Source: Ensembl
    2. monovalent cation:proton antiporter activity Source: Ensembl

    GO - Biological processi

    1. organic cation transport Source: Ensembl
    2. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

    Protein family/group databases

    TCDBi2.A.66.1.14. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug and toxin extrusion protein 1
    Short name:
    MATE-1
    Short name:
    hMATE-1
    Alternative name(s):
    Solute carrier family 47 member 1
    Gene namesi
    Name:SLC47A1
    Synonyms:MATE1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:25588. SLC47A1.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
    Note: Predominantly localized at the plasma membrane but also found in intracellular organelles.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane-bounded vesicle Source: Ensembl
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi273 – 2731E → Q: No change in subcellular location and abolition of MATE1-dependent TEA transport activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA162403808.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Multidrug and toxin extrusion protein 1PRO_0000312845Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ96FL8.
    PaxDbiQ96FL8.
    PRIDEiQ96FL8.

    PTM databases

    PhosphoSiteiQ96FL8.

    Expressioni

    Tissue specificityi

    Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes).2 Publications

    Gene expression databases

    ArrayExpressiQ96FL8.
    BgeeiQ96FL8.
    CleanExiHS_SLC47A1.
    GenevestigatoriQ96FL8.

    Organism-specific databases

    HPAiHPA021987.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000270570.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96FL8.
    SMRiQ96FL8. Positions 28-454.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini59 – 7214ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini94 – 12330CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini145 – 1528ExtracellularSequence Analysis
    Topological domaini174 – 1763CytoplasmicSequence Analysis
    Topological domaini198 – 21619ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini238 – 25619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini277 – 29519ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini317 – 33620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini358 – 37013ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini392 – 40817CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini430 – 4378ExtracellularSequence Analysis
    Topological domaini459 – 54688CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini568 – 5703ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei177 – 19721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei296 – 31621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei337 – 35721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei371 – 39121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei409 – 42921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei438 – 45821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei547 – 56721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0534.
    HOGENOMiHOG000060313.
    HOVERGENiHBG056043.
    KOiK03327.
    OMAiFPRYLVM.
    OrthoDBiEOG7RRF71.
    PhylomeDBiQ96FL8.
    TreeFamiTF324441.

    Family and domain databases

    InterProiIPR002528. MATE.
    [Graphical view]
    PfamiPF01554. MatE. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00797. matE. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96FL8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAPEEPAPV RGGPEATLEV RGSRCLRLSA FREELRALLV LAGPAFLVQL    50
    MVFLISFISS VFCGHLGKLE LDAVTLAIAV INVTGVSVGF GLSSACDTLI 100
    SQTYGSQNLK HVGVILQRSA LVLLLCCFPC WALFLNTQHI LLLFRQDPDV 150
    SRLTQTYVTI FIPALPATFL YMLQVKYLLN QGIVLPQIVT GVAANLVNAL 200
    ANYLFLHQLH LGVIGSALAN LISQYTLALL LFLYILGKKL HQATWGGWSL 250
    ECLQDWASFL RLAIPSMLML CMEWWAYEVG SFLSGILGMV ELGAQSIVYE 300
    LAIIVYMVPA GFSVAASVRV GNALGAGDME QARKSSTVSL LITVLFAVAF 350
    SVLLLSCKDH VGYIFTTDRD IINLVAQVVP IYAVSHLFEA LACTSGGVLR 400
    GSGNQKVGAI VNTIGYYVVG LPIGIALMFA TTLGVMGLWS GIIICTVFQA 450
    VCFLGFIIQL NWKKACQQAQ VHANLKVNNV PRSGNSALPQ DPLHPGCPEN 500
    LEGILTNDVG KTGEPQSDQQ MRQEEPLPEH PQDGAKLSRK QLVLRRGLLL 550
    LGVFLILLVG ILVRFYVRIQ 570
    Length:570
    Mass (Da):61,922
    Last modified:December 1, 2001 - v1
    Checksum:iCA940CBC2F6F5CC4
    GO
    Isoform 2 (identifier: Q96FL8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         286-290: ILGMV → LYEDG
         291-570: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:290
    Mass (Da):31,907
    Checksum:i662AE04699124D14
    GO
    Isoform 3 (identifier: Q96FL8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         559-570: VGILVRFYVRIQ → AGVRWCDHSSLQPRTLGLQAILLCQPPE

    Note: No experimental confirmation available.

    Show »
    Length:586
    Mass (Da):63,549
    Checksum:iA1BF0F64D815E7A8
    GO

    Sequence cautioni

    The sequence AAH50592.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501L → R in BAD96345. 1 PublicationCurated
    Sequence conflicti309 – 3091P → L in BAA91852. (PubMed:14702039)Curated
    Sequence conflicti448 – 4481F → L in BAD96345. 1 PublicationCurated
    Sequence conflicti507 – 5071N → D in BAD96345. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti338 – 3381V → I.
    Corresponds to variant rs35790011 [ dbSNP | Ensembl ].
    VAR_037587

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei286 – 2905ILGMV → LYEDG in isoform 2. 1 PublicationVSP_029903
    Alternative sequencei291 – 570280Missing in isoform 2. 1 PublicationVSP_029904Add
    BLAST
    Alternative sequencei559 – 57012VGILV…YVRIQ → AGVRWCDHSSLQPRTLGLQA ILLCQPPE in isoform 3. 1 PublicationVSP_029905Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001709 mRNA. Translation: BAA91852.1.
    AK222625 mRNA. Translation: BAD96345.1.
    CH471212 Genomic DNA. Translation: EAW50893.1.
    CH471212 Genomic DNA. Translation: EAW50894.1.
    BC010661 mRNA. Translation: AAH10661.1.
    BC050592 mRNA. Translation: AAH50592.1. Different initiation.
    BC058882 mRNA. Translation: AAH58882.1.
    CCDSiCCDS11209.1. [Q96FL8-1]
    RefSeqiNP_060712.2. NM_018242.2. [Q96FL8-1]
    UniGeneiHs.232054.

    Genome annotation databases

    EnsembliENST00000270570; ENSP00000270570; ENSG00000142494. [Q96FL8-1]
    ENST00000395585; ENSP00000378951; ENSG00000142494. [Q96FL8-3]
    GeneIDi55244.
    KEGGihsa:55244.
    UCSCiuc002gvx.3. human. [Q96FL8-3]
    uc002gvy.1. human. [Q96FL8-1]

    Polymorphism databases

    DMDMi74731723.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001709 mRNA. Translation: BAA91852.1 .
    AK222625 mRNA. Translation: BAD96345.1 .
    CH471212 Genomic DNA. Translation: EAW50893.1 .
    CH471212 Genomic DNA. Translation: EAW50894.1 .
    BC010661 mRNA. Translation: AAH10661.1 .
    BC050592 mRNA. Translation: AAH50592.1 . Different initiation.
    BC058882 mRNA. Translation: AAH58882.1 .
    CCDSi CCDS11209.1. [Q96FL8-1 ]
    RefSeqi NP_060712.2. NM_018242.2. [Q96FL8-1 ]
    UniGenei Hs.232054.

    3D structure databases

    ProteinModelPortali Q96FL8.
    SMRi Q96FL8. Positions 28-454.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000270570.

    Chemistry

    ChEMBLi CHEMBL1743126.
    GuidetoPHARMACOLOGYi 1216.

    Protein family/group databases

    TCDBi 2.A.66.1.14. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

    PTM databases

    PhosphoSitei Q96FL8.

    Polymorphism databases

    DMDMi 74731723.

    Proteomic databases

    MaxQBi Q96FL8.
    PaxDbi Q96FL8.
    PRIDEi Q96FL8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270570 ; ENSP00000270570 ; ENSG00000142494 . [Q96FL8-1 ]
    ENST00000395585 ; ENSP00000378951 ; ENSG00000142494 . [Q96FL8-3 ]
    GeneIDi 55244.
    KEGGi hsa:55244.
    UCSCi uc002gvx.3. human. [Q96FL8-3 ]
    uc002gvy.1. human. [Q96FL8-1 ]

    Organism-specific databases

    CTDi 55244.
    GeneCardsi GC17P019398.
    H-InvDB HIX0013619.
    HGNCi HGNC:25588. SLC47A1.
    HPAi HPA021987.
    MIMi 609832. gene.
    neXtProti NX_Q96FL8.
    PharmGKBi PA162403808.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0534.
    HOGENOMi HOG000060313.
    HOVERGENi HBG056043.
    KOi K03327.
    OMAi FPRYLVM.
    OrthoDBi EOG7RRF71.
    PhylomeDBi Q96FL8.
    TreeFami TF324441.

    Enzyme and pathway databases

    Reactomei REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

    Miscellaneous databases

    GeneWikii SLC47A1.
    GenomeRNAii 55244.
    NextBioi 59282.
    PROi Q96FL8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96FL8.
    Bgeei Q96FL8.
    CleanExi HS_SLC47A1.
    Genevestigatori Q96FL8.

    Family and domain databases

    InterProi IPR002528. MATE.
    [Graphical view ]
    Pfami PF01554. MatE. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00797. matE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cerebellum.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Colon and Eye.
    5. "A human transporter protein that mediates the final excretion step for toxic organic cations."
      Otsuka M., Matsumoto T., Morimoto R., Arioka S., Omote H., Moriyama Y.
      Proc. Natl. Acad. Sci. U.S.A. 102:17923-17928(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF GLU-273, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES.
    6. "Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations."
      Hiasa M., Matsumoto T., Komatsu T., Moriyama Y.
      Am. J. Physiol. 291:C678-C686(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations."
      Omote H., Hiasa M., Matsumoto T., Otsuka M., Moriyama Y.
      Trends Pharmacol. Sci. 27:587-593(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters."
      Tanihara Y., Masuda S., Sato T., Katsura T., Ogawa O., Inui K.
      Biochem. Pharmacol. 74:359-371(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
    9. "Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity."
      Yokoo S., Yonezawa A., Masuda S., Fukatsu A., Katsura T., Inui K.
      Biochem. Pharmacol. 74:477-487(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family."
      Chen Y., Zhang S., Sorani M., Giacomini K.M.
      J. Pharmacol. Exp. Ther. 322:695-700(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS47A1_HUMAN
    AccessioniPrimary (citable) accession number: Q96FL8
    Secondary accession number(s): Q53HF5
    , Q6PD77, Q86VL4, Q9NVA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3