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Protein

WD repeat-containing protein 89

Gene

WDR89

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ96FK6.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 89
Gene namesi
Name:WDR89
Synonyms:C14orf150
ORF Names:MSTP050
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20489. WDR89.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871067.

Polymorphism and mutation databases

BioMutaiWDR89.
DMDMi74762654.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387WD repeat-containing protein 89PRO_0000254036Add
BLAST

Proteomic databases

EPDiQ96FK6.
MaxQBiQ96FK6.
PaxDbiQ96FK6.
PeptideAtlasiQ96FK6.
PRIDEiQ96FK6.

PTM databases

iPTMnetiQ96FK6.
PhosphoSiteiQ96FK6.

Expressioni

Gene expression databases

BgeeiQ96FK6.
CleanExiHS_WDR89.
ExpressionAtlasiQ96FK6. baseline and differential.
GenevisibleiQ96FK6. HS.

Organism-specific databases

HPAiHPA000813.

Interactioni

Protein-protein interaction databases

BioGridi125208. 11 interactions.
IntActiQ96FK6. 5 interactions.
MINTiMINT-2813970.
STRINGi9606.ENSP00000267522.

Structurei

3D structure databases

ProteinModelPortaliQ96FK6.
SMRiQ96FK6. Positions 70-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati21 – 6545WD 1Add
BLAST
Repeati68 – 10740WD 2Add
BLAST
Repeati112 – 15645WD 3Add
BLAST
Repeati168 – 20841WD 4Add
BLAST
Repeati214 – 25441WD 5Add
BLAST
Repeati319 – 35840WD 6Add
BLAST

Sequence similaritiesi

Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1188. Eukaryota.
ENOG410ZUMD. LUCA.
GeneTreeiENSGT00390000006996.
HOGENOMiHOG000126822.
HOVERGENiHBG055747.
InParanoidiQ96FK6.
OMAiGYKQIYC.
OrthoDBiEOG7RNK0C.
PhylomeDBiQ96FK6.
TreeFamiTF324390.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96FK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIEEQFAN LHIVKCSLGT KEPTYLLGID TSKTVQAGKE NLVAVLCSNG
60 70 80 90 100
SIRIYDKERL NVLREFSGYP GLLNGVRFAN SCDSVYSACT DGTVKCWDAR
110 120 130 140 150
VAREKPVQLF KGYPSNIFIS FDINCNDHII CAGTEKVDDD ALLVFWDARM
160 170 180 190 200
NSQNLSTTKD SLGAYSETHS DDVTQVRFHP SNPNMVVSGS SDGLVNVFDI
210 220 230 240 250
NIDNEEDALV TTCNSISSVS CIGWSGKGYK QIYCMTHDEG FYWWDLNHLD
260 270 280 290 300
TDEPVTRLNI QDVREVVNMK EDALDYLIGG LYHEKTDTLH VIGGTNKGRI
310 320 330 340 350
HLMNCSMSGL THVTSLQGGH AATVRSFCWN VQDDSLLTGG EDAQLLLWKP
360 370 380
GAIEKTFTKK ESMKIASSVH QRVRVHSNDS YKRRKKQ
Length:387
Mass (Da):43,215
Last modified:December 1, 2001 - v1
Checksum:iC0F35E0066643800
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115513 mRNA. Translation: AAO06950.1.
BX248008 mRNA. Translation: CAD62336.1.
AK095324 mRNA. Translation: BAC04530.1.
BC010698 mRNA. Translation: AAH10698.1.
CCDSiCCDS9759.1.
RefSeqiNP_001008726.1. NM_001008726.2.
NP_001245201.1. NM_001258272.1.
NP_542397.1. NM_080666.3.
XP_011534686.1. XM_011536384.1.
XP_011534687.1. XM_011536385.1.
UniGeneiHs.655666.
Hs.741323.

Genome annotation databases

EnsembliENST00000267522; ENSP00000267522; ENSG00000140006.
ENST00000394942; ENSP00000378399; ENSG00000140006.
ENST00000620954; ENSP00000480112; ENSG00000140006.
GeneIDi112840.
KEGGihsa:112840.
UCSCiuc031qox.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115513 mRNA. Translation: AAO06950.1.
BX248008 mRNA. Translation: CAD62336.1.
AK095324 mRNA. Translation: BAC04530.1.
BC010698 mRNA. Translation: AAH10698.1.
CCDSiCCDS9759.1.
RefSeqiNP_001008726.1. NM_001008726.2.
NP_001245201.1. NM_001258272.1.
NP_542397.1. NM_080666.3.
XP_011534686.1. XM_011536384.1.
XP_011534687.1. XM_011536385.1.
UniGeneiHs.655666.
Hs.741323.

3D structure databases

ProteinModelPortaliQ96FK6.
SMRiQ96FK6. Positions 70-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125208. 11 interactions.
IntActiQ96FK6. 5 interactions.
MINTiMINT-2813970.
STRINGi9606.ENSP00000267522.

PTM databases

iPTMnetiQ96FK6.
PhosphoSiteiQ96FK6.

Polymorphism and mutation databases

BioMutaiWDR89.
DMDMi74762654.

Proteomic databases

EPDiQ96FK6.
MaxQBiQ96FK6.
PaxDbiQ96FK6.
PeptideAtlasiQ96FK6.
PRIDEiQ96FK6.

Protocols and materials databases

DNASUi112840.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267522; ENSP00000267522; ENSG00000140006.
ENST00000394942; ENSP00000378399; ENSG00000140006.
ENST00000620954; ENSP00000480112; ENSG00000140006.
GeneIDi112840.
KEGGihsa:112840.
UCSCiuc031qox.2. human.

Organism-specific databases

CTDi112840.
GeneCardsiWDR89.
HGNCiHGNC:20489. WDR89.
HPAiHPA000813.
neXtProtiNX_Q96FK6.
PharmGKBiPA134871067.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1188. Eukaryota.
ENOG410ZUMD. LUCA.
GeneTreeiENSGT00390000006996.
HOGENOMiHOG000126822.
HOVERGENiHBG055747.
InParanoidiQ96FK6.
OMAiGYKQIYC.
OrthoDBiEOG7RNK0C.
PhylomeDBiQ96FK6.
TreeFamiTF324390.

Enzyme and pathway databases

SignaLinkiQ96FK6.

Miscellaneous databases

GenomeRNAii112840.
PROiQ96FK6.

Gene expression databases

BgeeiQ96FK6.
CleanExiHS_WDR89.
ExpressionAtlasiQ96FK6. baseline and differential.
GenevisibleiQ96FK6. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal liver.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiWDR89_HUMAN
AccessioniPrimary (citable) accession number: Q96FK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.