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Q96FJ2

- DYL2_HUMAN

UniProt

Q96FJ2 - DYL2_HUMAN

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Protein

Dynein light chain 2, cytoplasmic

Gene

DYNLL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei41 – 411Interaction with myosin V motor complexBy similarity

GO - Molecular functioni

  1. motor activity Source: UniProtKB-KW

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. apoptotic process Source: Reactome
  3. intrinsic apoptotic signaling pathway Source: Reactome
  4. microtubule-based process Source: InterPro
  5. positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
  6. synaptic target recognition Source: Ensembl
  7. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_2100. Activation of BMF and translocation to mitochondria.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 2, cytoplasmic
Alternative name(s):
8 kDa dynein light chain b
Short name:
DLC8b
Dynein light chain LC8-type 2
Gene namesi
Name:DYNLL2
Synonyms:DLC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:24596. DYNLL2.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytosol Source: Reactome
  3. dynein complex Source: UniProtKB-KW
  4. membrane Source: UniProtKB
  5. microtubule Source: UniProtKB-KW
  6. myosin complex Source: UniProtKB
  7. nucleus Source: UniProt
  8. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671920.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8989Dynein light chain 2, cytoplasmicPRO_0000195132Add
BLAST

Proteomic databases

MaxQBiQ96FJ2.
PaxDbiQ96FJ2.
PeptideAtlasiQ96FJ2.
PRIDEiQ96FJ2.

PTM databases

PhosphoSiteiQ96FJ2.

Expressioni

Gene expression databases

BgeeiQ96FJ2.
CleanExiHS_DYNLL2.
GenevestigatoriQ96FJ2.

Interactioni

Subunit structurei

Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. Dynein ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1. Interacts with BMF. Component of the myosin V motor complex. Interacts with rabies virus phosphoprotein (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
P0C2064EBI-742371,EBI-9675596From a different organism.
Q856013EBI-742371,EBI-9676175From a different organism.

Protein-protein interaction databases

BioGridi126680. 26 interactions.
IntActiQ96FJ2. 25 interactions.
MINTiMINT-1473886.
STRINGi9606.ENSP00000240343.

Structurei

Secondary structure

1
89
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 138
Helixi15 – 3117
Helixi35 – 5016
Beta strandi54 – 6613
Beta strandi72 – 787
Beta strandi81 – 877

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XQQX-ray1.31A/B/C/D1-89[»]
3P8MX-ray2.90A/B1-89[»]
ProteinModelPortaliQ96FJ2.
SMRiQ96FJ2. Positions 1-89.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96FJ2.

Family & Domainsi

Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGiNOG312371.
GeneTreeiENSGT00390000000378.
HOVERGENiHBG002133.
InParanoidiQ96FJ2.
KOiK10418.
OMAiMSEERYK.
OrthoDBiEOG7BZVVQ.
PhylomeDBiQ96FJ2.
TreeFamiTF300264.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiIPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiPF01221. Dynein_light. 1 hit.
[Graphical view]
PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96FJ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDRKAVIKN ADMSEDMQQD AVDCATQAME KYNIEKDIAA YIKKEFDKKY
60 70 80
NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
Length:89
Mass (Da):10,350
Last modified:December 1, 2001 - v1
Checksum:i45364D32C0077F8E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF112997 mRNA. Translation: AAP97230.1.
AK312125 mRNA. Translation: BAG35061.1.
CH471109 Genomic DNA. Translation: EAW94484.1.
BC010744 mRNA. Translation: AAH10744.1.
CCDSiCCDS11601.1.
RefSeqiNP_542408.1. NM_080677.2.
UniGeneiHs.720595.

Genome annotation databases

EnsembliENST00000579991; ENSP00000477310; ENSG00000264364.
GeneIDi140735.
KEGGihsa:140735.
UCSCiuc010wnn.1. human.

Polymorphism databases

DMDMi56748850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF112997 mRNA. Translation: AAP97230.1 .
AK312125 mRNA. Translation: BAG35061.1 .
CH471109 Genomic DNA. Translation: EAW94484.1 .
BC010744 mRNA. Translation: AAH10744.1 .
CCDSi CCDS11601.1.
RefSeqi NP_542408.1. NM_080677.2.
UniGenei Hs.720595.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2XQQ X-ray 1.31 A/B/C/D 1-89 [» ]
3P8M X-ray 2.90 A/B 1-89 [» ]
ProteinModelPortali Q96FJ2.
SMRi Q96FJ2. Positions 1-89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126680. 26 interactions.
IntActi Q96FJ2. 25 interactions.
MINTi MINT-1473886.
STRINGi 9606.ENSP00000240343.

PTM databases

PhosphoSitei Q96FJ2.

Polymorphism databases

DMDMi 56748850.

Proteomic databases

MaxQBi Q96FJ2.
PaxDbi Q96FJ2.
PeptideAtlasi Q96FJ2.
PRIDEi Q96FJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000579991 ; ENSP00000477310 ; ENSG00000264364 .
GeneIDi 140735.
KEGGi hsa:140735.
UCSCi uc010wnn.1. human.

Organism-specific databases

CTDi 140735.
GeneCardsi GC17P056160.
HGNCi HGNC:24596. DYNLL2.
MIMi 608942. gene.
neXtProti NX_Q96FJ2.
PharmGKBi PA142671920.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG312371.
GeneTreei ENSGT00390000000378.
HOVERGENi HBG002133.
InParanoidi Q96FJ2.
KOi K10418.
OMAi MSEERYK.
OrthoDBi EOG7BZVVQ.
PhylomeDBi Q96FJ2.
TreeFami TF300264.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_2100. Activation of BMF and translocation to mitochondria.

Miscellaneous databases

EvolutionaryTracei Q96FJ2.
GeneWikii DYNLL2.
GenomeRNAii 140735.
NextBioi 84325.
PROi Q96FJ2.
SOURCEi Search...

Gene expression databases

Bgeei Q96FJ2.
CleanExi HS_DYNLL2.
Genevestigatori Q96FJ2.

Family and domain databases

Gene3Di 3.30.740.10. 1 hit.
InterProi IPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view ]
PANTHERi PTHR11886. PTHR11886. 1 hit.
Pfami PF01221. Dynein_light. 1 hit.
[Graphical view ]
PROSITEi PS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of a novel human cDNA homologous to Rattus norvegicus protein inhibitor of neuronal nitric oxide synthase (PIN) mRNA."
    Zhang H.L., Yu L., Yang J., Fu Q., Cui Y.Y., Zhao S.Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDYL2_HUMAN
AccessioniPrimary (citable) accession number: Q96FJ2
Secondary accession number(s): B2R5B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3