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Protein

Dynein light chain 2, cytoplasmic

Gene

DYNLL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-139910 Activation of BMF and translocation to mitochondria
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-1632852 Macroautophagy
R-HSA-2132295 MHC class II antigen presentation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-5620924 Intraflagellar transport
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-68877 Mitotic Prometaphase
SIGNORiQ96FJ2

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 2, cytoplasmic
Alternative name(s):
8 kDa dynein light chain b
Short name:
DLC8b
Dynein light chain LC8-type 2
Gene namesi
Name:DYNLL2
Synonyms:DLC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000264364.2
HGNCiHGNC:24596 DYNLL2
MIMi608942 gene
neXtProtiNX_Q96FJ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi140735
OpenTargetsiENSG00000264364
PharmGKBiPA142671920

Polymorphism and mutation databases

BioMutaiDYNLL2
DMDMi56748850

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001951321 – 89Dynein light chain 2, cytoplasmicAdd BLAST89

Proteomic databases

EPDiQ96FJ2
MaxQBiQ96FJ2
PaxDbiQ96FJ2
PeptideAtlasiQ96FJ2
PRIDEiQ96FJ2
TopDownProteomicsiQ96FJ2

PTM databases

iPTMnetiQ96FJ2
PhosphoSitePlusiQ96FJ2

Expressioni

Gene expression databases

BgeeiENSG00000264364
CleanExiHS_DYNLL2
GenevisibleiQ96FJ2 HS

Organism-specific databases

HPAiHPA039954

Interactioni

Subunit structurei

Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. Dynein ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1. Interacts with BMF. Component of the myosin V motor complex. Interacts with rabies virus phosphoprotein (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei41Interaction with myosin V motor complexBy similarity1

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126680, 68 interactors
CORUMiQ96FJ2
IntActiQ96FJ2, 72 interactors
MINTiQ96FJ2
STRINGi9606.ENSP00000240343

Structurei

Secondary structure

189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni1 – 3Combined sources3
Beta strandi6 – 13Combined sources8
Helixi15 – 31Combined sources17
Helixi35 – 50Combined sources16
Beta strandi54 – 66Combined sources13
Beta strandi72 – 78Combined sources7
Beta strandi81 – 87Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XQQX-ray1.31A/B/C/D1-89[»]
3P8MX-ray2.90A/B1-89[»]
4D07X-ray1.85A1-89[»]
ProteinModelPortaliQ96FJ2
SMRiQ96FJ2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96FJ2

Family & Domainsi

Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGiKOG3430 Eukaryota
ENOG4111NK2 LUCA
GeneTreeiENSGT00390000000378
HOVERGENiHBG002133
InParanoidiQ96FJ2
KOiK10418
OMAiKGPTWHC
OrthoDBiEOG091G15JY
PhylomeDBiQ96FJ2
TreeFamiTF300264

Family and domain databases

Gene3Di3.30.740.10, 1 hit
InterProiView protein in InterPro
IPR037177 DLC_sf
IPR019763 Dynein_light_1/2_CS
IPR001372 Dynein_light_chain_typ-1/2
PANTHERiPTHR11886 PTHR11886, 1 hit
PfamiView protein in Pfam
PF01221 Dynein_light, 1 hit
SMARTiView protein in SMART
SM01375 Dynein_light, 1 hit
SUPFAMiSSF54648 SSF54648, 1 hit
PROSITEiView protein in PROSITE
PS01239 DYNEIN_LIGHT_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q96FJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRKAVIKN ADMSEDMQQD AVDCATQAME KYNIEKDIAA YIKKEFDKKY
60 70 80
NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
Length:89
Mass (Da):10,350
Last modified:December 1, 2001 - v1
Checksum:i45364D32C0077F8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112997 mRNA Translation: AAP97230.1
AK312125 mRNA Translation: BAG35061.1
CH471109 Genomic DNA Translation: EAW94484.1
BC010744 mRNA Translation: AAH10744.1
CCDSiCCDS11601.1
RefSeqiNP_542408.1, NM_080677.2
UniGeneiHs.720595

Genome annotation databases

EnsembliENST00000579991; ENSP00000477310; ENSG00000264364
GeneIDi140735
KEGGihsa:140735
UCSCiuc010wnn.2 human

Similar proteinsi

Entry informationi

Entry nameiDYL2_HUMAN
AccessioniPrimary (citable) accession number: Q96FJ2
Secondary accession number(s): B2R5B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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