Reviewed, UniProtKB/Swiss-Prot Q96FJ2 (DYL2_HUMAN)

Names and origin

Protein names

Recommended name:
    Dynein light chain 2, cytoplasmic
Alternative name(s):
    Dynein light chain LC8-type 2

Gene names

Name:	DYNLL2
Synonyms:	DLC2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	89 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in some aspects of dynein-related intracellular transport and motility. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures By similarity.
Subunit structure	Homodimer. Interacts with BMF. Component of the myosin V motor complex as well as the microtubular dynein motor complex. Interacts with rabies virus phosphoprotein By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dynein light chain family.

Ontologies

Keywords
Cellular component	Cytoplasm Dynein Microtubule
Molecular function	Motor protein
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	microtubule-based process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from Experiment. Source: Reactome dynein complex Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW myosin complex Inferred from sequence or structural similarity. Source: UniProtKB plasma membrane Inferred from Experiment. Source: Reactome
Molecular function	microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DYNLL1	P63167	1	EBI-742371,EBI-349105

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 89	89	Dynein light chain 2, cytoplasmic		PRO_0000195132
Sites
	Site	41	1	Interaction with myosin V motor complex By similarity
Amino acid modifications
	Modified residue	5	1	N6-acetyllysine Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q96FJ2-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 45364D32C0077F8E	FASTA	89	10,350
	10 20 30 40 50 60 MSDRKAVIKN ADMSEDMQQD AVDCATQAME KYNIEKDIAA YIKKEFDKKY NPTWHCIVGR 70 80 NFGSYVTHET KHFIYFYLGQ VAILLFKSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequencing of a novel human cDNA homologous to Rattus norvegicus protein inhibitor of neuronal nitric oxide synthase (PIN) mRNA." Zhang H.L., Yu L., Yang J., Fu Q., Cui Y.Y., Zhao S.Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[6]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-5, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF112997 mRNA. Translation: AAP97230.1. AK312125 mRNA. Translation: BAG35061.1. CH471109 Genomic DNA. Translation: EAW94484.1. BC010744 mRNA. Translation: AAH10744.1.
IPI	IPI00062037.
RefSeq	NP_542408.1.
UniGene	Hs.591176
3D structure databases
SMR	Q96FJ2. Positions 1-89.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96FJ2. 8 interactions.
STRING	Q96FJ2.
Proteomic databases
PeptideAtlas	Q96FJ2.
PRIDE	Q96FJ2.
Genome annotation databases
Ensembl	ENST00000240343; ENSP00000240343; ENSG00000121083; Homo sapiens. [Genome view]
GeneID	140735.
KEGG	hsa:140735.
UCSC	uc002ivl.1. human.
Organism-specific databases
CTD	140735.
GeneCards	GC17P053516.
HGNC	HGNC:24596. DYNLL2.
MIM	608942. gene.
PharmGKB	PA142671920.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q96FJ2.
HOVERGEN	Q96FJ2.
OMA	EKFTIEK
Enzyme and pathway databases
Reactome	REACT_578. Apoptosis.
Gene expression databases
ArrayExpress	Q96FJ2.
Bgee	Q96FJ2.
CleanEx	HS_DYNLL2.
Genevestigator	Q96FJ2.
GermOnline	ENSG00000121083. Homo sapiens.
Family and domain databases
InterPro	IPR019763. Dynein_light_1/2_CS. IPR001372. Dynein_light_chain_typ-1/2. [Graphical view]
Gene3D	G3DSA:3.30.740.10. Dynein_light1. 1 hit.
PANTHER	PTHR11886. Dynein_light1. 1 hit.
Pfam	PF01221. Dynein_light. 1 hit. [Graphical view]
PROSITE	PS01239. DYNEIN_LIGHT_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	84325.
SOURCE	Search...

Entry information

Entry name

DYL2_HUMAN

Accession

Primary (citable) accession number: Q96FJ2
Secondary accession number(s): B2R5B4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	December 1, 2001
Last modified:	November 24, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.