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Q96FJ2

- DYL2_HUMAN

UniProt

Q96FJ2 - DYL2_HUMAN

Protein

Dynein light chain 2, cytoplasmic

Gene

DYNLL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei41 – 411Interaction with myosin V motor complexBy similarity

    GO - Molecular functioni

    1. motor activity Source: UniProtKB-KW

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. apoptotic process Source: Reactome
    3. intrinsic apoptotic signaling pathway Source: Reactome
    4. microtubule-based process Source: InterPro
    5. positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
    6. synaptic target recognition Source: Ensembl
    7. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.
    REACT_2100. Activation of BMF and translocation to mitochondria.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dynein light chain 2, cytoplasmic
    Alternative name(s):
    8 kDa dynein light chain b
    Short name:
    DLC8b
    Dynein light chain LC8-type 2
    Gene namesi
    Name:DYNLL2
    Synonyms:DLC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:24596. DYNLL2.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytosol Source: Reactome
    3. dynein complex Source: UniProtKB-KW
    4. membrane Source: UniProtKB
    5. microtubule Source: UniProtKB-KW
    6. myosin complex Source: UniProtKB
    7. nucleus Source: UniProt
    8. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Dynein, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671920.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8989Dynein light chain 2, cytoplasmicPRO_0000195132Add
    BLAST

    Proteomic databases

    MaxQBiQ96FJ2.
    PaxDbiQ96FJ2.
    PeptideAtlasiQ96FJ2.
    PRIDEiQ96FJ2.

    PTM databases

    PhosphoSiteiQ96FJ2.

    Expressioni

    Gene expression databases

    BgeeiQ96FJ2.
    CleanExiHS_DYNLL2.
    GenevestigatoriQ96FJ2.

    Interactioni

    Subunit structurei

    Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. Dynein ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1. Interacts with BMF. Component of the myosin V motor complex. Interacts with rabies virus phosphoprotein By similarity.By similarity

    Protein-protein interaction databases

    BioGridi126680. 26 interactions.
    IntActiQ96FJ2. 22 interactions.
    MINTiMINT-1473886.
    STRINGi9606.ENSP00000240343.

    Structurei

    Secondary structure

    1
    89
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 138
    Helixi15 – 3117
    Helixi35 – 5016
    Beta strandi54 – 6613
    Beta strandi72 – 787
    Beta strandi81 – 877

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2XQQX-ray1.31A/B/C/D1-89[»]
    3P8MX-ray2.90A/B1-89[»]
    ProteinModelPortaliQ96FJ2.
    SMRiQ96FJ2. Positions 1-89.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96FJ2.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dynein light chain family.Curated

    Phylogenomic databases

    eggNOGiNOG312371.
    HOVERGENiHBG002133.
    InParanoidiQ96FJ2.
    KOiK10418.
    OMAiMSEERYK.
    OrthoDBiEOG7BZVVQ.
    PhylomeDBiQ96FJ2.
    TreeFamiTF300264.

    Family and domain databases

    Gene3Di3.30.740.10. 1 hit.
    InterProiIPR019763. Dynein_light_1/2_CS.
    IPR001372. Dynein_light_chain_typ-1/2.
    [Graphical view]
    PANTHERiPTHR11886. PTHR11886. 1 hit.
    PfamiPF01221. Dynein_light. 1 hit.
    [Graphical view]
    PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96FJ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDRKAVIKN ADMSEDMQQD AVDCATQAME KYNIEKDIAA YIKKEFDKKY   50
    NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG 89
    Length:89
    Mass (Da):10,350
    Last modified:December 1, 2001 - v1
    Checksum:i45364D32C0077F8E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF112997 mRNA. Translation: AAP97230.1.
    AK312125 mRNA. Translation: BAG35061.1.
    CH471109 Genomic DNA. Translation: EAW94484.1.
    BC010744 mRNA. Translation: AAH10744.1.
    CCDSiCCDS11601.1.
    RefSeqiNP_542408.1. NM_080677.2.
    UniGeneiHs.720595.

    Genome annotation databases

    EnsembliENST00000579991; ENSP00000477310; ENSG00000264364.
    GeneIDi140735.
    KEGGihsa:140735.
    UCSCiuc010wnn.1. human.

    Polymorphism databases

    DMDMi56748850.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF112997 mRNA. Translation: AAP97230.1 .
    AK312125 mRNA. Translation: BAG35061.1 .
    CH471109 Genomic DNA. Translation: EAW94484.1 .
    BC010744 mRNA. Translation: AAH10744.1 .
    CCDSi CCDS11601.1.
    RefSeqi NP_542408.1. NM_080677.2.
    UniGenei Hs.720595.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2XQQ X-ray 1.31 A/B/C/D 1-89 [» ]
    3P8M X-ray 2.90 A/B 1-89 [» ]
    ProteinModelPortali Q96FJ2.
    SMRi Q96FJ2. Positions 1-89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126680. 26 interactions.
    IntActi Q96FJ2. 22 interactions.
    MINTi MINT-1473886.
    STRINGi 9606.ENSP00000240343.

    PTM databases

    PhosphoSitei Q96FJ2.

    Polymorphism databases

    DMDMi 56748850.

    Proteomic databases

    MaxQBi Q96FJ2.
    PaxDbi Q96FJ2.
    PeptideAtlasi Q96FJ2.
    PRIDEi Q96FJ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000579991 ; ENSP00000477310 ; ENSG00000264364 .
    GeneIDi 140735.
    KEGGi hsa:140735.
    UCSCi uc010wnn.1. human.

    Organism-specific databases

    CTDi 140735.
    GeneCardsi GC17P056160.
    HGNCi HGNC:24596. DYNLL2.
    MIMi 608942. gene.
    neXtProti NX_Q96FJ2.
    PharmGKBi PA142671920.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG312371.
    HOVERGENi HBG002133.
    InParanoidi Q96FJ2.
    KOi K10418.
    OMAi MSEERYK.
    OrthoDBi EOG7BZVVQ.
    PhylomeDBi Q96FJ2.
    TreeFami TF300264.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.
    REACT_2100. Activation of BMF and translocation to mitochondria.

    Miscellaneous databases

    EvolutionaryTracei Q96FJ2.
    GeneWikii DYNLL2.
    GenomeRNAii 140735.
    NextBioi 84325.
    PROi Q96FJ2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96FJ2.
    CleanExi HS_DYNLL2.
    Genevestigatori Q96FJ2.

    Family and domain databases

    Gene3Di 3.30.740.10. 1 hit.
    InterProi IPR019763. Dynein_light_1/2_CS.
    IPR001372. Dynein_light_chain_typ-1/2.
    [Graphical view ]
    PANTHERi PTHR11886. PTHR11886. 1 hit.
    Pfami PF01221. Dynein_light. 1 hit.
    [Graphical view ]
    PROSITEi PS01239. DYNEIN_LIGHT_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of a novel human cDNA homologous to Rattus norvegicus protein inhibitor of neuronal nitric oxide synthase (PIN) mRNA."
      Zhang H.L., Yu L., Yang J., Fu Q., Cui Y.Y., Zhao S.Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDYL2_HUMAN
    AccessioniPrimary (citable) accession number: Q96FJ2
    Secondary accession number(s): B2R5B4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3