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Protein

Dynein light chain 2, cytoplasmic

Gene

DYNLL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei41 – 411Interaction with myosin V motor complexBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_2100. Activation of BMF and translocation to mitochondria.
REACT_268024. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 2, cytoplasmic
Alternative name(s):
8 kDa dynein light chain b
Short name:
DLC8b
Dynein light chain LC8-type 2
Gene namesi
Name:DYNLL2
Synonyms:DLC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:24596. DYNLL2.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • ciliary tip Source: Reactome
  • cytosol Source: Reactome
  • dynein complex Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • myosin complex Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: Reactome
  • primary cilium Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671920.

Polymorphism and mutation databases

BioMutaiDYNLL2.
DMDMi56748850.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8989Dynein light chain 2, cytoplasmicPRO_0000195132Add
BLAST

Proteomic databases

MaxQBiQ96FJ2.
PaxDbiQ96FJ2.
PeptideAtlasiQ96FJ2.
PRIDEiQ96FJ2.

PTM databases

PhosphoSiteiQ96FJ2.

Expressioni

Gene expression databases

BgeeiQ96FJ2.
CleanExiHS_DYNLL2.
GenevisibleiQ96FJ2. HS.

Interactioni

Subunit structurei

Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. Dynein ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1. Interacts with BMF. Component of the myosin V motor complex. Interacts with rabies virus phosphoprotein (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
P0C2064EBI-742371,EBI-9675596From a different organism.
Q856013EBI-742371,EBI-9676175From a different organism.
BMFQ96LC93EBI-742371,EBI-3919268
C12orf40Q86WS43EBI-742371,EBI-10286004
CCDC36Q8IYA83EBI-742371,EBI-8638439
DNAL4O960154EBI-742371,EBI-742362
HMBOX1Q6NT763EBI-742371,EBI-2549423
MEOX2A4D1273EBI-742371,EBI-10172134
MORN3Q6PF183EBI-742371,EBI-9675802
RASGRP3Q8IV613EBI-742371,EBI-1047876
SECISBP2LQ930733EBI-742371,EBI-2805647

Protein-protein interaction databases

BioGridi126680. 34 interactions.
IntActiQ96FJ2. 33 interactions.
MINTiMINT-1473886.
STRINGi9606.ENSP00000240343.

Structurei

Secondary structure

89
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni1 – 33Combined sources
Beta strandi6 – 138Combined sources
Helixi15 – 3117Combined sources
Helixi35 – 5016Combined sources
Beta strandi54 – 6613Combined sources
Beta strandi72 – 787Combined sources
Beta strandi81 – 877Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XQQX-ray1.31A/B/C/D1-89[»]
3P8MX-ray2.90A/B1-89[»]
4D07X-ray1.85A1-89[»]
ProteinModelPortaliQ96FJ2.
SMRiQ96FJ2. Positions 1-89.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96FJ2.

Family & Domainsi

Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGiNOG312371.
GeneTreeiENSGT00390000000378.
HOVERGENiHBG002133.
InParanoidiQ96FJ2.
KOiK10418.
OMAiLAILIWK.
OrthoDBiEOG7BZVVQ.
PhylomeDBiQ96FJ2.
TreeFamiTF300264.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiIPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiPF01221. Dynein_light. 1 hit.
[Graphical view]
PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96FJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRKAVIKN ADMSEDMQQD AVDCATQAME KYNIEKDIAA YIKKEFDKKY
60 70 80
NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
Length:89
Mass (Da):10,350
Last modified:December 1, 2001 - v1
Checksum:i45364D32C0077F8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112997 mRNA. Translation: AAP97230.1.
AK312125 mRNA. Translation: BAG35061.1.
CH471109 Genomic DNA. Translation: EAW94484.1.
BC010744 mRNA. Translation: AAH10744.1.
CCDSiCCDS11601.1.
RefSeqiNP_542408.1. NM_080677.2.
UniGeneiHs.720595.

Genome annotation databases

EnsembliENST00000579991; ENSP00000477310; ENSG00000264364.
GeneIDi140735.
KEGGihsa:140735.
UCSCiuc010wnn.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112997 mRNA. Translation: AAP97230.1.
AK312125 mRNA. Translation: BAG35061.1.
CH471109 Genomic DNA. Translation: EAW94484.1.
BC010744 mRNA. Translation: AAH10744.1.
CCDSiCCDS11601.1.
RefSeqiNP_542408.1. NM_080677.2.
UniGeneiHs.720595.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XQQX-ray1.31A/B/C/D1-89[»]
3P8MX-ray2.90A/B1-89[»]
4D07X-ray1.85A1-89[»]
ProteinModelPortaliQ96FJ2.
SMRiQ96FJ2. Positions 1-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126680. 34 interactions.
IntActiQ96FJ2. 33 interactions.
MINTiMINT-1473886.
STRINGi9606.ENSP00000240343.

PTM databases

PhosphoSiteiQ96FJ2.

Polymorphism and mutation databases

BioMutaiDYNLL2.
DMDMi56748850.

Proteomic databases

MaxQBiQ96FJ2.
PaxDbiQ96FJ2.
PeptideAtlasiQ96FJ2.
PRIDEiQ96FJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000579991; ENSP00000477310; ENSG00000264364.
GeneIDi140735.
KEGGihsa:140735.
UCSCiuc010wnn.1. human.

Organism-specific databases

CTDi140735.
GeneCardsiGC17P056160.
HGNCiHGNC:24596. DYNLL2.
MIMi608942. gene.
neXtProtiNX_Q96FJ2.
PharmGKBiPA142671920.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG312371.
GeneTreeiENSGT00390000000378.
HOVERGENiHBG002133.
InParanoidiQ96FJ2.
KOiK10418.
OMAiLAILIWK.
OrthoDBiEOG7BZVVQ.
PhylomeDBiQ96FJ2.
TreeFamiTF300264.

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_2100. Activation of BMF and translocation to mitochondria.
REACT_268024. Intraflagellar transport.

Miscellaneous databases

EvolutionaryTraceiQ96FJ2.
GeneWikiiDYNLL2.
GenomeRNAii140735.
NextBioi84325.
PROiQ96FJ2.
SOURCEiSearch...

Gene expression databases

BgeeiQ96FJ2.
CleanExiHS_DYNLL2.
GenevisibleiQ96FJ2. HS.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiIPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiPF01221. Dynein_light. 1 hit.
[Graphical view]
PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of a novel human cDNA homologous to Rattus norvegicus protein inhibitor of neuronal nitric oxide synthase (PIN) mRNA."
    Zhang H.L., Yu L., Yang J., Fu Q., Cui Y.Y., Zhao S.Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiDYL2_HUMAN
AccessioniPrimary (citable) accession number: Q96FJ2
Secondary accession number(s): B2R5B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.