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Protein

Dynein light chain 2, cytoplasmic

Gene

DYNLL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-139910. Activation of BMF and translocation to mitochondria.
R-HSA-1632852. Macroautophagy.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-5620924. Intraflagellar transport.
R-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811436. COPI-independent Golgi-to-ER retrograde traffic.
SIGNORiQ96FJ2.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 2, cytoplasmic
Alternative name(s):
8 kDa dynein light chain b
Short name:
DLC8b
Dynein light chain LC8-type 2
Gene namesi
Name:DYNLL2
Synonyms:DLC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:24596. DYNLL2.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • ciliary tip Source: Reactome
  • cilium Source: Reactome
  • cytoplasmic dynein complex Source: Ensembl
  • cytosol Source: Reactome
  • membrane Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • mitochondrion Source: GOC
  • myosin complex Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: Reactome

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi140735.
OpenTargetsiENSG00000264364.
PharmGKBiPA142671920.

Polymorphism and mutation databases

BioMutaiDYNLL2.
DMDMi56748850.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001951321 – 89Dynein light chain 2, cytoplasmicAdd BLAST89

Proteomic databases

EPDiQ96FJ2.
MaxQBiQ96FJ2.
PaxDbiQ96FJ2.
PeptideAtlasiQ96FJ2.
PRIDEiQ96FJ2.
TopDownProteomicsiQ96FJ2.

PTM databases

iPTMnetiQ96FJ2.
PhosphoSitePlusiQ96FJ2.

Expressioni

Gene expression databases

BgeeiENSG00000264364.
CleanExiHS_DYNLL2.
GenevisibleiQ96FJ2. HS.

Organism-specific databases

HPAiHPA039954.

Interactioni

Subunit structurei

Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. Dynein ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1. Interacts with BMF. Component of the myosin V motor complex. Interacts with rabies virus phosphoprotein (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei41Interaction with myosin V motor complexBy similarity1

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi126680. 41 interactors.
IntActiQ96FJ2. 72 interactors.
MINTiMINT-1473886.
STRINGi9606.ENSP00000240343.

Structurei

Secondary structure

189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni1 – 3Combined sources3
Beta strandi6 – 13Combined sources8
Helixi15 – 31Combined sources17
Helixi35 – 50Combined sources16
Beta strandi54 – 66Combined sources13
Beta strandi72 – 78Combined sources7
Beta strandi81 – 87Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XQQX-ray1.31A/B/C/D1-89[»]
3P8MX-ray2.90A/B1-89[»]
4D07X-ray1.85A1-89[»]
ProteinModelPortaliQ96FJ2.
SMRiQ96FJ2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96FJ2.

Family & Domainsi

Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGiKOG3430. Eukaryota.
ENOG4111NK2. LUCA.
GeneTreeiENSGT00390000000378.
HOVERGENiHBG002133.
InParanoidiQ96FJ2.
KOiK10418.
OMAiQIKSADM.
OrthoDBiEOG091G15JY.
PhylomeDBiQ96FJ2.
TreeFamiTF300264.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiView protein in InterPro
IPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiView protein in Pfam
PF01221. Dynein_light. 1 hit.
SMARTiView protein in SMART
SM01375. Dynein_light. 1 hit.
PROSITEiView protein in PROSITE
PS01239. DYNEIN_LIGHT_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96FJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRKAVIKN ADMSEDMQQD AVDCATQAME KYNIEKDIAA YIKKEFDKKY
60 70 80
NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
Length:89
Mass (Da):10,350
Last modified:December 1, 2001 - v1
Checksum:i45364D32C0077F8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112997 mRNA. Translation: AAP97230.1.
AK312125 mRNA. Translation: BAG35061.1.
CH471109 Genomic DNA. Translation: EAW94484.1.
BC010744 mRNA. Translation: AAH10744.1.
CCDSiCCDS11601.1.
RefSeqiNP_542408.1. NM_080677.2.
UniGeneiHs.720595.

Genome annotation databases

EnsembliENST00000579991; ENSP00000477310; ENSG00000264364.
GeneIDi140735.
KEGGihsa:140735.
UCSCiuc010wnn.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112997 mRNA. Translation: AAP97230.1.
AK312125 mRNA. Translation: BAG35061.1.
CH471109 Genomic DNA. Translation: EAW94484.1.
BC010744 mRNA. Translation: AAH10744.1.
CCDSiCCDS11601.1.
RefSeqiNP_542408.1. NM_080677.2.
UniGeneiHs.720595.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XQQX-ray1.31A/B/C/D1-89[»]
3P8MX-ray2.90A/B1-89[»]
4D07X-ray1.85A1-89[»]
ProteinModelPortaliQ96FJ2.
SMRiQ96FJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126680. 41 interactors.
IntActiQ96FJ2. 72 interactors.
MINTiMINT-1473886.
STRINGi9606.ENSP00000240343.

PTM databases

iPTMnetiQ96FJ2.
PhosphoSitePlusiQ96FJ2.

Polymorphism and mutation databases

BioMutaiDYNLL2.
DMDMi56748850.

Proteomic databases

EPDiQ96FJ2.
MaxQBiQ96FJ2.
PaxDbiQ96FJ2.
PeptideAtlasiQ96FJ2.
PRIDEiQ96FJ2.
TopDownProteomicsiQ96FJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000579991; ENSP00000477310; ENSG00000264364.
GeneIDi140735.
KEGGihsa:140735.
UCSCiuc010wnn.2. human.

Organism-specific databases

CTDi140735.
DisGeNETi140735.
GeneCardsiDYNLL2.
HGNCiHGNC:24596. DYNLL2.
HPAiHPA039954.
MIMi608942. gene.
neXtProtiNX_Q96FJ2.
OpenTargetsiENSG00000264364.
PharmGKBiPA142671920.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3430. Eukaryota.
ENOG4111NK2. LUCA.
GeneTreeiENSGT00390000000378.
HOVERGENiHBG002133.
InParanoidiQ96FJ2.
KOiK10418.
OMAiQIKSADM.
OrthoDBiEOG091G15JY.
PhylomeDBiQ96FJ2.
TreeFamiTF300264.

Enzyme and pathway databases

ReactomeiR-HSA-139910. Activation of BMF and translocation to mitochondria.
R-HSA-1632852. Macroautophagy.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-5620924. Intraflagellar transport.
R-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811436. COPI-independent Golgi-to-ER retrograde traffic.
SIGNORiQ96FJ2.

Miscellaneous databases

EvolutionaryTraceiQ96FJ2.
GeneWikiiDYNLL2.
GenomeRNAii140735.
PROiQ96FJ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000264364.
CleanExiHS_DYNLL2.
GenevisibleiQ96FJ2. HS.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiView protein in InterPro
IPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiView protein in Pfam
PF01221. Dynein_light. 1 hit.
SMARTiView protein in SMART
SM01375. Dynein_light. 1 hit.
PROSITEiView protein in PROSITE
PS01239. DYNEIN_LIGHT_1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDYL2_HUMAN
AccessioniPrimary (citable) accession number: Q96FJ2
Secondary accession number(s): B2R5B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 1, 2001
Last modified: March 15, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.