Q96FH0 (MF2NB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein MEF2BNB

Alternative name(s):
MEF2B neighbor gene protein

Gene names

Name:

MEF2BNB

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	119 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the MEF2BNB family.
Caution	The gene for this protein is either identical to or adjacent to that of MEF2B. Some mRNAs that encode this protein also include MEF2B.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	heart development Inferred from expression pattern. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TEX11	Q8IYF3	2	EBI-744076,EBI-742397

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96FH0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96FH0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: S → R
     110-119: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 119	119	Protein MEF2BNB		PRO_0000269843
Natural variations
	Alternative sequence	109	1	S → R in isoform 2.		VSP_022103
	Alternative sequence	110 – 119	10	Missing in isoform 2.		VSP_022104

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 8D466C5E262FFA96	FASTA	119	13,403
	10 20 30 40 50 60 MEEPEMQLKG KKVTDKFTES VYVLANEPSV ALYRLQEHVR RSLPELAQHK ADMQRWEEQS 70 80 90 100 110 QGAIYTVEYA CSAVKNLVDS SVYFRSVEGL LKQAISIRDH MNASAQGHSP EEPPPPSSA
	Isoform 2 [UniParc]. Checksum: A1094880EBD3489B	FASTA	109	12,483
	10 20 30 40 50 60 MEEPEMQLKG KKVTDKFTES VYVLANEPSV ALYRLQEHVR RSLPELAQHK ADMQRWEEQS 70 80 90 100 QGAIYTVEYA CSAVKNLVDS SVYFRSVEGL LKQAISIRDH MNASAQGHR

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Lung carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC004449 mRNA. Translation: AAH04449.1. BC010931 mRNA. No translation available. BC157837 mRNA. Translation: AAI57838.1. BC157868 mRNA. Translation: AAI57869.1.
IPI	IPI00386642. IPI00816037.
RefSeq	NP_001139255.1. NM_001145783.1. NP_001139256.1. NM_001145784.1.
UniGene	Hs.153629.
3D structure databases
ProteinModelPortal	Q96FH0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96FH0. 1 interaction.
STRING	Q96FH0.
Polymorphism databases
DMDM	74731704.
Proteomic databases
PRIDE	Q96FH0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000354191; ENSP00000346128; ENSG00000064489.
GeneID	729991.
KEGG	hsa:729991.
UCSC	uc002nlq.1. human. uc002nlr.2. human.
Organism-specific databases
CTD	729991.
GeneCards	GC19M019288.
HGNC	HGNC:37247. MEF2BNB.
HPA	HPA045700.
neXtProt	NX_Q96FH0.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000011828.
HOGENOM	HBG283469.
HOVERGEN	HBG094122.
OMA	RDHMNAA.
OrthoDB	EOG4FBHVC.
PhylomeDB	Q96FH0.
Gene expression databases
Genevestigator	Q96FH0.
Family and domain databases
InterPro	IPR019320. UPF0402_NEP. [Graphical view]
PANTHER	PTHR21146. DUF_NEP. 1 hit.
Pfam	PF10167. NEP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MF2NB_HUMAN

Accession

Primary (citable) accession number: Q96FH0
Secondary accession number(s): B2RXF9, Q9BT01

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.