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Q96FH0

- MF2NB_HUMAN

UniProt

Q96FH0 - MF2NB_HUMAN

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Protein

Protein MEF2BNB

Gene

MEF2BNB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. heart development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MEF2BNB
Alternative name(s):
MEF2B neighbor gene protein
Gene namesi
Name:MEF2BNB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:37247. MEF2BNB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119Protein MEF2BNBPRO_0000269843Add
BLAST

Proteomic databases

MaxQBiQ96FH0.
PaxDbiQ96FH0.
PRIDEiQ96FH0.

Expressioni

Gene expression databases

BgeeiQ96FH0.
ExpressionAtlasiQ96FH0. baseline and differential.
GenevestigatoriQ96FH0.

Organism-specific databases

HPAiHPA045700.
HPA051907.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TEX11Q8IYF32EBI-744076,EBI-742397

Protein-protein interaction databases

BioGridi610381. 3 interactions.
IntActiQ96FH0. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96FH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MEF2BNB family.Curated

Phylogenomic databases

eggNOGiNOG246876.
GeneTreeiENSGT00390000011828.
ENSGT00390000014856.
HOVERGENiHBG094122.
InParanoidiQ96FH0.
OMAiNTHICTI.
OrthoDBiEOG7QNVP5.
PhylomeDBiQ96FH0.
TreeFamiTF313931.

Family and domain databases

InterProiIPR019320. UPF0402_NEP.
[Graphical view]
PANTHERiPTHR21146. PTHR21146. 1 hit.
PfamiPF10167. NEP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96FH0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEPEMQLKG KKVTDKFTES VYVLANEPSV ALYRLQEHVR RSLPELAQHK
60 70 80 90 100
ADMQRWEEQS QGAIYTVEYA CSAVKNLVDS SVYFRSVEGL LKQAISIRDH
110
MNASAQGHSP EEPPPPSSA
Length:119
Mass (Da):13,403
Last modified:December 1, 2001 - v1
Checksum:i8D466C5E262FFA96
GO
Isoform 2 (identifier: Q96FH0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: S → R
     110-119: Missing.

Show »
Length:109
Mass (Da):12,483
Checksum:iA1094880EBD3489B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei109 – 1091S → R in isoform 2. 1 PublicationVSP_022103
Alternative sequencei110 – 11910Missing in isoform 2. 1 PublicationVSP_022104

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC004449 mRNA. Translation: AAH04449.1.
BC010931 mRNA. No translation available.
BC157837 mRNA. Translation: AAI57838.1.
BC157868 mRNA. Translation: AAI57869.1.
CCDSiCCDS46025.1. [Q96FH0-1]
CCDS54235.1. [Q96FH0-2]
RefSeqiNP_001139255.1. NM_001145783.1. [Q96FH0-2]
NP_001139256.1. NM_001145784.1. [Q96FH0-1]
UniGeneiHs.153629.

Genome annotation databases

EnsembliENST00000462790; ENSP00000425864; ENSG00000254901. [Q96FH0-1]
ENST00000477565; ENSP00000424833; ENSG00000254901. [Q96FH0-2]
ENST00000488252; ENSP00000467744; ENSG00000254901. [Q96FH0-1]
GeneIDi729991.
KEGGihsa:729991.
UCSCiuc002nlq.3. human. [Q96FH0-1]
uc002nlr.4. human. [Q96FH0-2]

Polymorphism databases

DMDMi74731704.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC004449 mRNA. Translation: AAH04449.1 .
BC010931 mRNA. No translation available.
BC157837 mRNA. Translation: AAI57838.1 .
BC157868 mRNA. Translation: AAI57869.1 .
CCDSi CCDS46025.1. [Q96FH0-1 ]
CCDS54235.1. [Q96FH0-2 ]
RefSeqi NP_001139255.1. NM_001145783.1. [Q96FH0-2 ]
NP_001139256.1. NM_001145784.1. [Q96FH0-1 ]
UniGenei Hs.153629.

3D structure databases

ProteinModelPortali Q96FH0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 610381. 3 interactions.
IntActi Q96FH0. 1 interaction.

Polymorphism databases

DMDMi 74731704.

Proteomic databases

MaxQBi Q96FH0.
PaxDbi Q96FH0.
PRIDEi Q96FH0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000462790 ; ENSP00000425864 ; ENSG00000254901 . [Q96FH0-1 ]
ENST00000477565 ; ENSP00000424833 ; ENSG00000254901 . [Q96FH0-2 ]
ENST00000488252 ; ENSP00000467744 ; ENSG00000254901 . [Q96FH0-1 ]
GeneIDi 729991.
KEGGi hsa:729991.
UCSCi uc002nlq.3. human. [Q96FH0-1 ]
uc002nlr.4. human. [Q96FH0-2 ]

Organism-specific databases

CTDi 729991.
GeneCardsi GC19M019288.
HGNCi HGNC:37247. MEF2BNB.
HPAi HPA045700.
HPA051907.
neXtProti NX_Q96FH0.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG246876.
GeneTreei ENSGT00390000011828.
ENSGT00390000014856.
HOVERGENi HBG094122.
InParanoidi Q96FH0.
OMAi NTHICTI.
OrthoDBi EOG7QNVP5.
PhylomeDBi Q96FH0.
TreeFami TF313931.

Miscellaneous databases

GenomeRNAii 729991.
NextBioi 131970.
PROi Q96FH0.

Gene expression databases

Bgeei Q96FH0.
ExpressionAtlasi Q96FH0. baseline and differential.
Genevestigatori Q96FH0.

Family and domain databases

InterProi IPR019320. UPF0402_NEP.
[Graphical view ]
PANTHERi PTHR21146. PTHR21146. 1 hit.
Pfami PF10167. NEP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Lung carcinoma.

Entry informationi

Entry nameiMF2NB_HUMAN
AccessioniPrimary (citable) accession number: Q96FH0
Secondary accession number(s): B2RXF9, Q9BT01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The gene for this protein is either identical to or adjacent to that of MEF2B. Some mRNAs that encode this protein also include MEF2B.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3