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Q96FH0 (MF2NB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein MEF2BNB
Alternative name(s):
MEF2B neighbor gene protein
Gene names
Name:MEF2BNB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length119 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the MEF2BNB family.

Caution

The gene for this protein is either identical to or adjacent to that of MEF2B. Some mRNAs that encode this protein also include MEF2B.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processheart development

Inferred from expression pattern PubMed 10458488. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TEX11Q8IYF32EBI-744076,EBI-742397

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96FH0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96FH0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: S → R
     110-119: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 119119Protein MEF2BNB
PRO_0000269843

Natural variations

Alternative sequence1091S → R in isoform 2.
VSP_022103
Alternative sequence110 – 11910Missing in isoform 2.
VSP_022104

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 8D466C5E262FFA96

FASTA11913,403
        10         20         30         40         50         60 
MEEPEMQLKG KKVTDKFTES VYVLANEPSV ALYRLQEHVR RSLPELAQHK ADMQRWEEQS 

        70         80         90        100        110 
QGAIYTVEYA CSAVKNLVDS SVYFRSVEGL LKQAISIRDH MNASAQGHSP EEPPPPSSA 

« Hide

Isoform 2 [UniParc].

Checksum: A1094880EBD3489B
Show »

FASTA10912,483

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Lung carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC004449 mRNA. Translation: AAH04449.1.
BC010931 mRNA. No translation available.
BC157837 mRNA. Translation: AAI57838.1.
BC157868 mRNA. Translation: AAI57869.1.
RefSeqNP_001139255.1. NM_001145783.1.
NP_001139256.1. NM_001145784.1.
UniGeneHs.153629.

3D structure databases

ProteinModelPortalQ96FH0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid610381. 1 interaction.
IntActQ96FH0. 1 interaction.

Polymorphism databases

DMDM74731704.

Proteomic databases

PaxDbQ96FH0.
PRIDEQ96FH0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000462790; ENSP00000425864; ENSG00000254901. [Q96FH0-1]
ENST00000477565; ENSP00000424833; ENSG00000254901. [Q96FH0-2]
ENST00000488252; ENSP00000467744; ENSG00000254901. [Q96FH0-1]
GeneID729991.
KEGGhsa:729991.
UCSCuc002nlq.3. human. [Q96FH0-1]
uc002nlr.4. human. [Q96FH0-2]

Organism-specific databases

CTD729991.
GeneCardsGC19M019288.
HGNCHGNC:37247. MEF2BNB.
HPAHPA045700.
HPA051907.
neXtProtNX_Q96FH0.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG246876.
HOVERGENHBG094122.
OMARDHMNAT.
OrthoDBEOG7QNVP5.
PhylomeDBQ96FH0.
TreeFamTF313931.

Gene expression databases

BgeeQ96FH0.
GenevestigatorQ96FH0.

Family and domain databases

InterProIPR019320. UPF0402_NEP.
[Graphical view]
PANTHERPTHR21146. PTHR21146. 1 hit.
PfamPF10167. NEP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio131970.
PROQ96FH0.

Entry information

Entry nameMF2NB_HUMAN
AccessionPrimary (citable) accession number: Q96FH0
Secondary accession number(s): B2RXF9, Q9BT01
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM