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Q96FH0

- MF2NB_HUMAN

UniProt

Q96FH0 - MF2NB_HUMAN

Protein

Protein MEF2BNB

Gene

MEF2BNB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. heart development Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein MEF2BNB
    Alternative name(s):
    MEF2B neighbor gene protein
    Gene namesi
    Name:MEF2BNB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:37247. MEF2BNB.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 119119Protein MEF2BNBPRO_0000269843Add
    BLAST

    Proteomic databases

    MaxQBiQ96FH0.
    PaxDbiQ96FH0.
    PRIDEiQ96FH0.

    Expressioni

    Gene expression databases

    BgeeiQ96FH0.
    GenevestigatoriQ96FH0.

    Organism-specific databases

    HPAiHPA045700.
    HPA051907.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TEX11Q8IYF32EBI-744076,EBI-742397

    Protein-protein interaction databases

    BioGridi610381. 1 interaction.
    IntActiQ96FH0. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96FH0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MEF2BNB family.Curated

    Phylogenomic databases

    eggNOGiNOG246876.
    HOVERGENiHBG094122.
    OMAiNTHICTI.
    OrthoDBiEOG7QNVP5.
    PhylomeDBiQ96FH0.
    TreeFamiTF313931.

    Family and domain databases

    InterProiIPR019320. UPF0402_NEP.
    [Graphical view]
    PANTHERiPTHR21146. PTHR21146. 1 hit.
    PfamiPF10167. NEP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96FH0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEPEMQLKG KKVTDKFTES VYVLANEPSV ALYRLQEHVR RSLPELAQHK    50
    ADMQRWEEQS QGAIYTVEYA CSAVKNLVDS SVYFRSVEGL LKQAISIRDH 100
    MNASAQGHSP EEPPPPSSA 119
    Length:119
    Mass (Da):13,403
    Last modified:December 1, 2001 - v1
    Checksum:i8D466C5E262FFA96
    GO
    Isoform 2 (identifier: Q96FH0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         109-109: S → R
         110-119: Missing.

    Show »
    Length:109
    Mass (Da):12,483
    Checksum:iA1094880EBD3489B
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei109 – 1091S → R in isoform 2. 1 PublicationVSP_022103
    Alternative sequencei110 – 11910Missing in isoform 2. 1 PublicationVSP_022104

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC004449 mRNA. Translation: AAH04449.1.
    BC010931 mRNA. No translation available.
    BC157837 mRNA. Translation: AAI57838.1.
    BC157868 mRNA. Translation: AAI57869.1.
    CCDSiCCDS46025.1. [Q96FH0-1]
    CCDS54235.1. [Q96FH0-2]
    RefSeqiNP_001139255.1. NM_001145783.1. [Q96FH0-2]
    NP_001139256.1. NM_001145784.1. [Q96FH0-1]
    UniGeneiHs.153629.

    Genome annotation databases

    EnsembliENST00000462790; ENSP00000425864; ENSG00000254901. [Q96FH0-1]
    ENST00000477565; ENSP00000424833; ENSG00000254901. [Q96FH0-2]
    ENST00000488252; ENSP00000467744; ENSG00000254901. [Q96FH0-1]
    GeneIDi729991.
    KEGGihsa:729991.
    UCSCiuc002nlq.3. human. [Q96FH0-1]
    uc002nlr.4. human. [Q96FH0-2]

    Polymorphism databases

    DMDMi74731704.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC004449 mRNA. Translation: AAH04449.1 .
    BC010931 mRNA. No translation available.
    BC157837 mRNA. Translation: AAI57838.1 .
    BC157868 mRNA. Translation: AAI57869.1 .
    CCDSi CCDS46025.1. [Q96FH0-1 ]
    CCDS54235.1. [Q96FH0-2 ]
    RefSeqi NP_001139255.1. NM_001145783.1. [Q96FH0-2 ]
    NP_001139256.1. NM_001145784.1. [Q96FH0-1 ]
    UniGenei Hs.153629.

    3D structure databases

    ProteinModelPortali Q96FH0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 610381. 1 interaction.
    IntActi Q96FH0. 1 interaction.

    Polymorphism databases

    DMDMi 74731704.

    Proteomic databases

    MaxQBi Q96FH0.
    PaxDbi Q96FH0.
    PRIDEi Q96FH0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000462790 ; ENSP00000425864 ; ENSG00000254901 . [Q96FH0-1 ]
    ENST00000477565 ; ENSP00000424833 ; ENSG00000254901 . [Q96FH0-2 ]
    ENST00000488252 ; ENSP00000467744 ; ENSG00000254901 . [Q96FH0-1 ]
    GeneIDi 729991.
    KEGGi hsa:729991.
    UCSCi uc002nlq.3. human. [Q96FH0-1 ]
    uc002nlr.4. human. [Q96FH0-2 ]

    Organism-specific databases

    CTDi 729991.
    GeneCardsi GC19M019288.
    HGNCi HGNC:37247. MEF2BNB.
    HPAi HPA045700.
    HPA051907.
    neXtProti NX_Q96FH0.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG246876.
    HOVERGENi HBG094122.
    OMAi NTHICTI.
    OrthoDBi EOG7QNVP5.
    PhylomeDBi Q96FH0.
    TreeFami TF313931.

    Miscellaneous databases

    NextBioi 131970.
    PROi Q96FH0.

    Gene expression databases

    Bgeei Q96FH0.
    Genevestigatori Q96FH0.

    Family and domain databases

    InterProi IPR019320. UPF0402_NEP.
    [Graphical view ]
    PANTHERi PTHR21146. PTHR21146. 1 hit.
    Pfami PF10167. NEP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Lung carcinoma.

    Entry informationi

    Entry nameiMF2NB_HUMAN
    AccessioniPrimary (citable) accession number: Q96FH0
    Secondary accession number(s): B2RXF9, Q9BT01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The gene for this protein is either identical to or adjacent to that of MEF2B. Some mRNAs that encode this protein also include MEF2B.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3