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Protein

Sororin

Gene

CDCA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.3 Publications

GO - Molecular functioni

  • chromatin binding Source: UniProtKB

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • double-strand break repair Source: UniProtKB
  • G1/S transition of mitotic cell cycle Source: UniProtKB
  • mitotic chromosome condensation Source: UniProtKB
  • mitotic metaphase plate congression Source: UniProtKB
  • mitotic nuclear division Source: UniProtKB
  • mitotic sister chromatid cohesion Source: UniProtKB
  • positive regulation of cell cycle phase transition Source: UniProtKB
  • positive regulation of exit from mitosis Source: UniProtKB
  • regulation of cohesin loading Source: UniProtKB
  • sister chromatid cohesion Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146670-MONOMER.
ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2468052. Establishment of Sister Chromatid Cohesion.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.

Names & Taxonomyi

Protein namesi
Recommended name:
Sororin
Alternative name(s):
Cell division cycle-associated protein 5
p35
Gene namesi
Name:CDCA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14626. CDCA5.

Subcellular locationi

  • Nucleus 1 Publication
  • Chromosome 1 Publication
  • Cytoplasm 1 Publication

  • Note: Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi166 – 168FGF → AGA: Alters interaction with PDS5A and PDS5B and the cohesin complex. 1 Publication3

Organism-specific databases

DisGeNETi113130.
OpenTargetsiENSG00000146670.
PharmGKBiPA26278.

Polymorphism and mutation databases

BioMutaiCDCA5.
DMDMi68565257.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894491 – 252SororinAdd BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei98PhosphothreonineCombined sources1
Modified residuei107PhosphoserineCombined sources1
Modified residuei111PhosphothreonineCombined sources1
Modified residuei115PhosphothreonineCombined sources1
Modified residuei154PhosphoserineCombined sources1
Modified residuei159PhosphothreonineCombined sources1
Modified residuei209PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPL by CDCA5.1 Publication
Ubiquitinated by the APC/C complex in G1, leading to its degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96FF9.
MaxQBiQ96FF9.
PaxDbiQ96FF9.
PeptideAtlasiQ96FF9.
PRIDEiQ96FF9.

PTM databases

iPTMnetiQ96FF9.
PhosphoSitePlusiQ96FF9.

Expressioni

Gene expression databases

BgeeiENSG00000146670.
CleanExiHS_CDCA5.
ExpressionAtlasiQ96FF9. baseline and differential.
GenevisibleiQ96FF9. HS.

Organism-specific databases

HPAiHPA023691.

Interactioni

Subunit structurei

Interacts with the APC/C complex (By similarity). Interacts with the chromatin-bound cohesin complex; the interaction is indirect, occurs after DNA replication and requires acetylation of the cohesin component SMC3. Interacts (via the FGF motif) with PDS5A and PDS5B; the interaction is direct and prevents the interaction of PDS5A with WAPL.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PDS5AQ29RF73EBI-718805,EBI-1175454

Protein-protein interaction databases

BioGridi125225. 57 interactors.
DIPiDIP-47377N.
IntActiQ96FF9. 43 interactors.
MINTiMINT-1416799.
STRINGi9606.ENSP00000275517.

Structurei

3D structure databases

ProteinModelPortaliQ96FF9.
SMRiQ96FF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi88 – 90KEN box3
Motifi166 – 168FGF motif3

Domaini

The KEN box is required for the association with the APC/C complex.By similarity

Sequence similaritiesi

Belongs to the sororin family.Curated

Phylogenomic databases

eggNOGiENOG410IZXN. Eukaryota.
ENOG410Y6TQ. LUCA.
GeneTreeiENSGT00390000010028.
HOGENOMiHOG000232187.
HOVERGENiHBG080614.
InParanoidiQ96FF9.
KOiK17390.
PhylomeDBiQ96FF9.
TreeFamiTF101070.

Family and domain databases

InterProiIPR018605. Sororin.
[Graphical view]
PfamiPF09666. Sororin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96FF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRRTRSGG AAQRSGPRAP SPTKPLRRSQ RKSGSELPSI LPEIWPKTPS
60 70 80 90 100
AAAVRKPIVL KRIVAHAVEV PAVQSPRRSP RISFFLEKEN EPPGRELTKE
110 120 130 140 150
DLFKTHSVPA TPTSTPVPNP EAESSSKEGE LDARDLEMSK KVRRSYSRLE
160 170 180 190 200
TLGSASTSTP GRRSCFGFEG LLGAEDLSGV SPVVCSKLTE VPRVCAKPWA
210 220 230 240 250
PDMTLPGISP PPEKQKRKKK KMPEILKTEL DEWAAAMNAE FEAAEQFDLL

VE
Length:252
Mass (Da):27,601
Last modified:December 1, 2001 - v1
Checksum:iA4CD6768D3464040
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050777156S → Y.Corresponds to variant rs34020666dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BG354578 mRNA. No translation available.
AK291490 mRNA. Translation: BAF84179.1.
CH471076 Genomic DNA. Translation: EAW74342.1.
BC011000 mRNA. Translation: AAH11000.1.
CCDSiCCDS8091.1.
RefSeqiNP_542399.1. NM_080668.3.
UniGeneiHs.434886.

Genome annotation databases

EnsembliENST00000275517; ENSP00000275517; ENSG00000146670.
GeneIDi113130.
KEGGihsa:113130.
UCSCiuc001ocp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BG354578 mRNA. No translation available.
AK291490 mRNA. Translation: BAF84179.1.
CH471076 Genomic DNA. Translation: EAW74342.1.
BC011000 mRNA. Translation: AAH11000.1.
CCDSiCCDS8091.1.
RefSeqiNP_542399.1. NM_080668.3.
UniGeneiHs.434886.

3D structure databases

ProteinModelPortaliQ96FF9.
SMRiQ96FF9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125225. 57 interactors.
DIPiDIP-47377N.
IntActiQ96FF9. 43 interactors.
MINTiMINT-1416799.
STRINGi9606.ENSP00000275517.

PTM databases

iPTMnetiQ96FF9.
PhosphoSitePlusiQ96FF9.

Polymorphism and mutation databases

BioMutaiCDCA5.
DMDMi68565257.

Proteomic databases

EPDiQ96FF9.
MaxQBiQ96FF9.
PaxDbiQ96FF9.
PeptideAtlasiQ96FF9.
PRIDEiQ96FF9.

Protocols and materials databases

DNASUi113130.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275517; ENSP00000275517; ENSG00000146670.
GeneIDi113130.
KEGGihsa:113130.
UCSCiuc001ocp.3. human.

Organism-specific databases

CTDi113130.
DisGeNETi113130.
GeneCardsiCDCA5.
H-InvDBHIX0009780.
HGNCiHGNC:14626. CDCA5.
HPAiHPA023691.
MIMi609374. gene.
neXtProtiNX_Q96FF9.
OpenTargetsiENSG00000146670.
PharmGKBiPA26278.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZXN. Eukaryota.
ENOG410Y6TQ. LUCA.
GeneTreeiENSGT00390000010028.
HOGENOMiHOG000232187.
HOVERGENiHBG080614.
InParanoidiQ96FF9.
KOiK17390.
PhylomeDBiQ96FF9.
TreeFamiTF101070.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146670-MONOMER.
ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2468052. Establishment of Sister Chromatid Cohesion.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.

Miscellaneous databases

ChiTaRSiCDCA5. human.
GeneWikiiCDCA5.
GenomeRNAii113130.
PROiQ96FF9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146670.
CleanExiHS_CDCA5.
ExpressionAtlasiQ96FF9. baseline and differential.
GenevisibleiQ96FF9. HS.

Family and domain databases

InterProiIPR018605. Sororin.
[Graphical view]
PfamiPF09666. Sororin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDCA5_HUMAN
AccessioniPrimary (citable) accession number: Q96FF9
Secondary accession number(s): A8K625
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Named sororin after the Latin word 'soror', which means 'sister', because of its critical role in sister chromatid cohesion.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.