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Protein

Phosphoinositide-3-kinase-interacting protein 1

Gene

PIK3IP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.By similarity

GO - Molecular functioni

  • phosphatidylinositol 3-kinase catalytic subunit binding Source: UniProtKB

GO - Biological processi

  • negative regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
  • negative regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide-3-kinase-interacting protein 1
Alternative name(s):
Kringle domain-containing protein HGFL
Gene namesi
Name:PIK3IP1
Synonyms:HGFL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:24942. PIK3IP1.

Subcellular locationi

  • Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 168147ExtracellularSequence analysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence analysisAdd
BLAST
Topological domaini190 – 26172CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162399553.

Polymorphism and mutation databases

BioMutaiPIK3IP1.
DMDMi134034149.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 263242Phosphoinositide-3-kinase-interacting protein 1PRO_0000280347Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 101PROSITE-ProRule annotation
Glycosylationi39 – 391O-linked (GalNAc...)1 Publication
Disulfide bondi46 ↔ 82PROSITE-ProRule annotation
Glycosylationi66 – 661N-linked (GlcNAc...) (complex)1 Publication
Disulfide bondi70 ↔ 96PROSITE-ProRule annotation

Post-translational modificationi

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-66: dHex1Hex5HexNAc4 (major) and dHex1Hex6HexNAc5 (minor).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96FE7.
PeptideAtlasiQ96FE7.
PRIDEiQ96FE7.

PTM databases

iPTMnetiQ96FE7.
PhosphoSiteiQ96FE7.
UniCarbKBiQ96FE7.

Expressioni

Gene expression databases

BgeeiQ96FE7.
CleanExiHS_PIK3IP1.
ExpressionAtlasiQ96FE7. baseline and differential.
GenevisibleiQ96FE7. HS.

Organism-specific databases

HPAiHPA002959.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN1Q9UMX03EBI-10285708,EBI-741480
UBQLN1Q9UMX0-23EBI-10285708,EBI-10173939

GO - Molecular functioni

  • phosphatidylinositol 3-kinase catalytic subunit binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125260. 1 interaction.
IntActiQ96FE7. 1 interaction.
STRINGi9606.ENSP00000215912.

Structurei

3D structure databases

ProteinModelPortaliQ96FE7.
SMRiQ96FE7. Positions 22-84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10178KringlePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 kringle domain.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIHU. Eukaryota.
ENOG4112B5B. LUCA.
GeneTreeiENSGT00390000017774.
HOGENOMiHOG000070070.
HOVERGENiHBG080617.
InParanoidiQ96FE7.
OMAiKEQHDQK.
OrthoDBiEOG7VDXQB.
PhylomeDBiQ96FE7.
TreeFamiTF331319.

Family and domain databases

InterProiIPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
[Graphical view]
PfamiPF00051. Kringle. 1 hit.
[Graphical view]
SMARTiSM00130. KR. 1 hit.
[Graphical view]
SUPFAMiSSF57440. SSF57440. 1 hit.
PROSITEiPS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96FE7-1) [UniParc]FASTAAdd to basket

Also known as: HGFL(L)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLAWVQAFL VSNMLLAEAY GSGGCFWDNG HLYREDQTSP APGLRCLNWL
60 70 80 90 100
DAQSGLASAP VSGAGNHSYC RNPDEDPRGP WCYVSGEAGV PEKRPCEDLR
110 120 130 140 150
CPETTSQALP AFTTEIQEAS EGPGADEVQV FAPANALPAR SEAAAVQPVI
160 170 180 190 200
GISQRVRMNS KEKKDLGTLG YVLGITMMVI IIAIGAGIIL GYSYKRGKDL
210 220 230 240 250
KEQHDQKVCE REMQRITLPL SAFTNPTCEI VDEKTVVVHT SQTPVDPQEG
260
TTPLMGQAGT PGA
Length:263
Mass (Da):28,248
Last modified:March 20, 2007 - v2
Checksum:i197C3EEE8E54A242
GO
Isoform 2 (identifier: Q96FE7-2) [UniParc]FASTAAdd to basket

Also known as: HGFL(S)

The sequence of this isoform differs from the canonical sequence as follows:
     197-234: GKDLKEQHDQ...NPTCEIVDEK → SVASLLGPLR...KQDVENQLKM
     235-263: Missing.

Show »
Length:234
Mass (Da):25,320
Checksum:iC78F64DBD1B8DC0D
GO
Isoform 3 (identifier: Q96FE7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.

Note: No experimental confirmation available.
Show »
Length:106
Mass (Da):11,504
Checksum:i0123D43C3621193E
GO
Isoform 4 (identifier: Q96FE7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-263: YVLGITMMVI...LMGQAGTPGA → GRI

Note: No experimental confirmation available.
Show »
Length:173
Mass (Da):18,491
Checksum:iB42F43F34D1E61EC
GO
Isoform 5 (identifier: Q96FE7-5) [UniParc]FASTAAdd to basket

Also known as: PIK3IP1-v1

The sequence of this isoform differs from the canonical sequence as follows:
     24-102: Missing.

Show »
Length:184
Mass (Da):19,632
Checksum:i06455EB564E5DB29
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti98 – 981D → G in BAC11140 (PubMed:14702039).Curated
Sequence conflicti162 – 1621E → G in BAC11140 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti251 – 2511T → S.3 Publications
Corresponds to variant rs2040533 [ dbSNP | Ensembl ].
VAR_031121

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 157157Missing in isoform 3. 1 PublicationVSP_023638Add
BLAST
Alternative sequencei24 – 10279Missing in isoform 5. 1 PublicationVSP_053370Add
BLAST
Alternative sequencei171 – 26393YVLGI…GTPGA → GRI in isoform 4. 1 PublicationVSP_043368Add
BLAST
Alternative sequencei197 – 23438GKDLK…IVDEK → SVASLLGPLRRRGGRYTKSN FVAFLPKRKQDVENQLKM in isoform 2. 1 PublicationVSP_023639Add
BLAST
Alternative sequencei235 – 26329Missing in isoform 2. 1 PublicationVSP_023640Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF528079 mRNA. Translation: AAO33762.1.
AF528080 mRNA. Translation: AAO33763.1.
GU135609 mRNA. Translation: ACZ26468.1.
CR456340 mRNA. Translation: CAG30226.1.
AK074688 mRNA. Translation: BAC11140.1.
AK299397 mRNA. Translation: BAG61381.1.
AC002073 Genomic DNA. Translation: AAB54054.1.
CH471095 Genomic DNA. Translation: EAW59962.1.
BC011049 mRNA. Translation: AAH11049.1.
BC041903 mRNA. Translation: AAH41903.1.
CCDSiCCDS13893.1. [Q96FE7-1]
CCDS46690.1. [Q96FE7-4]
RefSeqiNP_001129383.1. NM_001135911.1. [Q96FE7-4]
NP_443112.2. NM_052880.4. [Q96FE7-1]
UniGeneiHs.26670.

Genome annotation databases

EnsembliENST00000215912; ENSP00000215912; ENSG00000100100. [Q96FE7-1]
ENST00000402249; ENSP00000385204; ENSG00000100100. [Q96FE7-2]
ENST00000441972; ENSP00000415608; ENSG00000100100. [Q96FE7-4]
GeneIDi113791.
KEGGihsa:113791.
UCSCiuc003akm.4. human. [Q96FE7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF528079 mRNA. Translation: AAO33762.1.
AF528080 mRNA. Translation: AAO33763.1.
GU135609 mRNA. Translation: ACZ26468.1.
CR456340 mRNA. Translation: CAG30226.1.
AK074688 mRNA. Translation: BAC11140.1.
AK299397 mRNA. Translation: BAG61381.1.
AC002073 Genomic DNA. Translation: AAB54054.1.
CH471095 Genomic DNA. Translation: EAW59962.1.
BC011049 mRNA. Translation: AAH11049.1.
BC041903 mRNA. Translation: AAH41903.1.
CCDSiCCDS13893.1. [Q96FE7-1]
CCDS46690.1. [Q96FE7-4]
RefSeqiNP_001129383.1. NM_001135911.1. [Q96FE7-4]
NP_443112.2. NM_052880.4. [Q96FE7-1]
UniGeneiHs.26670.

3D structure databases

ProteinModelPortaliQ96FE7.
SMRiQ96FE7. Positions 22-84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125260. 1 interaction.
IntActiQ96FE7. 1 interaction.
STRINGi9606.ENSP00000215912.

PTM databases

iPTMnetiQ96FE7.
PhosphoSiteiQ96FE7.
UniCarbKBiQ96FE7.

Polymorphism and mutation databases

BioMutaiPIK3IP1.
DMDMi134034149.

Proteomic databases

PaxDbiQ96FE7.
PeptideAtlasiQ96FE7.
PRIDEiQ96FE7.

Protocols and materials databases

DNASUi113791.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215912; ENSP00000215912; ENSG00000100100. [Q96FE7-1]
ENST00000402249; ENSP00000385204; ENSG00000100100. [Q96FE7-2]
ENST00000441972; ENSP00000415608; ENSG00000100100. [Q96FE7-4]
GeneIDi113791.
KEGGihsa:113791.
UCSCiuc003akm.4. human. [Q96FE7-1]

Organism-specific databases

CTDi113791.
GeneCardsiPIK3IP1.
HGNCiHGNC:24942. PIK3IP1.
HPAiHPA002959.
neXtProtiNX_Q96FE7.
PharmGKBiPA162399553.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIHU. Eukaryota.
ENOG4112B5B. LUCA.
GeneTreeiENSGT00390000017774.
HOGENOMiHOG000070070.
HOVERGENiHBG080617.
InParanoidiQ96FE7.
OMAiKEQHDQK.
OrthoDBiEOG7VDXQB.
PhylomeDBiQ96FE7.
TreeFamiTF331319.

Miscellaneous databases

ChiTaRSiPIK3IP1. human.
GeneWikiiPIK3IP1.
GenomeRNAii113791.
PROiQ96FE7.

Gene expression databases

BgeeiQ96FE7.
CleanExiHS_PIK3IP1.
ExpressionAtlasiQ96FE7. baseline and differential.
GenevisibleiQ96FE7. HS.

Family and domain databases

InterProiIPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
[Graphical view]
PfamiPF00051. Kringle. 1 hit.
[Graphical view]
SMARTiSM00130. KR. 1 hit.
[Graphical view]
SUPFAMiSSF57440. SSF57440. 1 hit.
PROSITEiPS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Chiang H., Chang M.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT SER-251.
  2. "Both PIK3IP1 and its novel found splicing isoform, PIK3IP1-v1, are located on cell membrane and induce cell apoptosis."
    Gao P., Zeng W.T., Deng W.W., Li N., Shi T.P., Ma D.
    Beijing Da Xue Xue Bao 40:572-577(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), SUBCELLULAR LOCATION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-251.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Mammary gland and Tongue.
  5. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT SER-251.
    Tissue: Brain.
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-36.
  9. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
    Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
    Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT SER-39 AND ASN-66, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiP3IP1_HUMAN
AccessioniPrimary (citable) accession number: Q96FE7
Secondary accession number(s): B4DRR9
, D1MEI0, O00318, Q49A94, Q86YW2, Q8NCJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 6, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.