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Protein

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

Gene

LINGO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-193634. Axonal growth inhibition (RHOA activation).
SIGNORiQ96FE5.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Alternative name(s):
Leucine-rich repeat and immunoglobulin domain-containing protein 1
Leucine-rich repeat neuronal protein 1
Leucine-rich repeat neuronal protein 6A
Gene namesi
Name:LINGO1
Synonyms:LERN1, LRRN6A
ORF Names:UNQ201/PRO227
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:21205. LINGO1.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini42 – 561520ExtracellularSequence analysisAdd
BLAST
Transmembranei562 – 58221HelicalSequence analysisAdd
BLAST
Topological domaini583 – 62038CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti862. Hereditary essential tremor.
PharmGKBiPA162394087.

Chemistry

GuidetoPHARMACOLOGYi2882.

Polymorphism and mutation databases

BioMutaiLINGO1.
DMDMi74760819.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141Sequence analysisAdd
BLAST
Chaini42 – 620579Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1PRO_0000328642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 48PROSITE-ProRule annotation1 Publication
Disulfide bondi46 ↔ 57PROSITE-ProRule annotation1 Publication
Glycosylationi144 – 1441N-linked (GlcNAc...)1 Publication
Glycosylationi202 – 2021N-linked (GlcNAc...)1 Publication
Glycosylationi264 – 2641N-linked (GlcNAc...)1 Publication
Glycosylationi274 – 2741N-linked (GlcNAc...)1 Publication
Glycosylationi293 – 2931N-linked (GlcNAc...)1 Publication
Glycosylationi341 – 3411N-linked (GlcNAc...)1 Publication
Disulfide bondi373 ↔ 396PROSITE-ProRule annotation1 Publication
Disulfide bondi375 ↔ 421PROSITE-ProRule annotation1 Publication
Disulfide bondi446 ↔ 497PROSITE-ProRule annotation1 Publication
Glycosylationi492 – 4921N-linked (GlcNAc...)1 Publication
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence analysis
Glycosylationi526 – 5261N-linked (GlcNAc...)Sequence analysis
Glycosylationi542 – 5421N-linked (GlcNAc...)Sequence analysis
Modified residuei602 – 6021PhosphoserineBy similarity

Post-translational modificationi

N-glycosylated. Contains predominantly high-mannose glycans.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ96FE5.
PRIDEiQ96FE5.

PTM databases

iPTMnetiQ96FE5.
PhosphoSiteiQ96FE5.

Expressioni

Tissue specificityi

Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.3 Publications

Gene expression databases

BgeeiQ96FE5.
CleanExiHS_LINGO1.
ExpressionAtlasiQ96FE5. baseline and differential.
GenevisibleiQ96FE5. HS.

Interactioni

Subunit structurei

Homotetramer (PubMed:17005555). Forms a ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19 (PubMed:14966521, PubMed:15694321, PubMed:17005555). Interacts with NGRF, RTN4R and MYT1L (By similarity).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-719955,EBI-618309
SPAG5Q96R063EBI-719955,EBI-413317
TRIM27P143733EBI-719955,EBI-719493

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124334. 18 interactions.
DIPiDIP-60981N.
IntActiQ96FE5. 6 interactions.
MINTiMINT-1378183.
STRINGi9606.ENSP00000347451.

Structurei

Secondary structure

1
620
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi47 – 493Combined sources
Turni50 – 534Combined sources
Beta strandi54 – 563Combined sources
Beta strandi74 – 774Combined sources
Turni88 – 936Combined sources
Beta strandi99 – 1013Combined sources
Turni112 – 1176Combined sources
Beta strandi123 – 1253Combined sources
Beta strandi147 – 1493Combined sources
Turni160 – 1656Combined sources
Beta strandi171 – 1744Combined sources
Beta strandi195 – 2006Combined sources
Helixi208 – 2114Combined sources
Beta strandi219 – 2246Combined sources
Beta strandi243 – 2475Combined sources
Turni257 – 2626Combined sources
Beta strandi266 – 2738Combined sources
Helixi280 – 2834Combined sources
Beta strandi291 – 2933Combined sources
Beta strandi315 – 3173Combined sources
Beta strandi324 – 3263Combined sources
Turni328 – 3303Combined sources
Beta strandi339 – 3413Combined sources
Helixi352 – 3543Combined sources
Helixi358 – 3603Combined sources
Beta strandi363 – 3653Combined sources
Helixi375 – 3773Combined sources
Helixi378 – 3814Combined sources
Turni382 – 3854Combined sources
Beta strandi395 – 3995Combined sources
Helixi400 – 4023Combined sources
Helixi407 – 4093Combined sources
Turni416 – 4194Combined sources
Beta strandi422 – 4276Combined sources
Beta strandi432 – 4376Combined sources
Beta strandi442 – 4443Combined sources
Beta strandi448 – 4525Combined sources
Beta strandi455 – 4595Combined sources
Beta strandi472 – 4765Combined sources
Beta strandi482 – 4865Combined sources
Helixi489 – 4913Combined sources
Beta strandi493 – 5019Combined sources
Beta strandi504 – 51512Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ID5X-ray2.70A/B/C/D40-516[»]
4OQTX-ray3.23A40-517[»]
ProteinModelPortaliQ96FE5.
SMRiQ96FE5. Positions 42-516.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96FE5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 7130LRRNTAdd
BLAST
Repeati72 – 9322LRR 1Add
BLAST
Repeati96 – 11722LRR 2Add
BLAST
Repeati120 – 14122LRR 3Add
BLAST
Repeati144 – 16522LRR 4Add
BLAST
Repeati168 – 18922LRR 5Add
BLAST
Repeati192 – 21322LRR 6Add
BLAST
Repeati216 – 23722LRR 7Add
BLAST
Repeati264 – 28522LRR 8Add
BLAST
Repeati288 – 30922LRR 9Add
BLAST
Repeati312 – 33322LRR 10Add
BLAST
Repeati336 – 35722LRR 11Add
BLAST
Domaini369 – 42355LRRCTAdd
BLAST
Domaini411 – 513103Ig-like C2-typeAdd
BLAST

Domaini

The intracellular domain of LINGO1 interacts with MYT1L.By similarity

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOVERGENiHBG057546.
InParanoidiQ96FE5.
OMAiIRDRKPQ.
OrthoDBiEOG715Q3P.
PhylomeDBiQ96FE5.
TreeFamiTF334360.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 9 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96FE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQVSKRMLAG GVRSMPSPLL ACWQPILLLV LGSVLSGSAT GCPPRCECSA
60 70 80 90 100
QDRAVLCHRK RFVAVPEGIP TETRLLDLGK NRIKTLNQDE FASFPHLEEL
110 120 130 140 150
ELNENIVSAV EPGAFNNLFN LRTLGLRSNR LKLIPLGVFT GLSNLTKLDI
160 170 180 190 200
SENKIVILLD YMFQDLYNLK SLEVGDNDLV YISHRAFSGL NSLEQLTLEK
210 220 230 240 250
CNLTSIPTEA LSHLHGLIVL RLRHLNINAI RDYSFKRLYR LKVLEISHWP
260 270 280 290 300
YLDTMTPNCL YGLNLTSLSI THCNLTAVPY LAVRHLVYLR FLNLSYNPIS
310 320 330 340 350
TIEGSMLHEL LRLQEIQLVG GQLAVVEPYA FRGLNYLRVL NVSGNQLTTL
360 370 380 390 400
EESVFHSVGN LETLILDSNP LACDCRLLWV FRRRWRLNFN RQQPTCATPE
410 420 430 440 450
FVQGKEFKDF PDVLLPNYFT CRRARIRDRK AQQVFVDEGH TVQFVCRADG
460 470 480 490 500
DPPPAILWLS PRKHLVSAKS NGRLTVFPDG TLEVRYAQVQ DNGTYLCIAA
510 520 530 540 550
NAGGNDSMPA HLHVRSYSPD WPHQPNKTFA FISNQPGEGE ANSTRATVPF
560 570 580 590 600
PFDIKTLIIA TTMGFISFLG VVLFCLVLLF LWSRGKGNTK HNIEIEYVPR
610 620
KSDAGISSAD APRKFNMKMI
Length:620
Mass (Da):69,876
Last modified:October 11, 2004 - v2
Checksum:i1A96D311A20180C1
GO
Isoform 2 (identifier: Q96FE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.

Show »
Length:614
Mass (Da):69,146
Checksum:iEFD967E3B716698D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461C → Y in AAH68558 (PubMed:15489334).Curated
Sequence conflicti61 – 611R → C in AAQ88651 (PubMed:12975309).Curated
Sequence conflicti148 – 1481L → Q in AAQ88651 (PubMed:12975309).Curated
Sequence conflicti170 – 1701K → R in AAH68558 (PubMed:15489334).Curated
Sequence conflicti298 – 2981P → R in AAH68558 (PubMed:15489334).Curated
Sequence conflicti353 – 3531S → L in BAB55157 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti183 – 1831S → F.1 Publication
Corresponds to variant rs9855 [ dbSNP | Ensembl ].
VAR_042436

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 66Missing in isoform 2. 1 PublicationVSP_032749

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324320 mRNA. Translation: AAQ97216.1.
AY324322 mRNA. Translation: AAQ97217.1.
AY324323 mRNA. Translation: AAQ97218.1.
AY358284 mRNA. Translation: AAQ88651.1.
AK027500 mRNA. Translation: BAB55157.1.
AK291363 mRNA. Translation: BAF84052.1.
CH471136 Genomic DNA. Translation: EAW99195.1.
CH471136 Genomic DNA. Translation: EAW99196.1.
CH471136 Genomic DNA. Translation: EAW99197.1.
CH471136 Genomic DNA. Translation: EAW99198.1.
BC011057 mRNA. Translation: AAH11057.2.
BC068558 mRNA. Translation: AAH68558.1.
AL834260 mRNA. Translation: CAD38935.1.
CCDSiCCDS45313.1. [Q96FE5-1]
CCDS73766.1. [Q96FE5-2]
RefSeqiNP_001288115.1. NM_001301186.1. [Q96FE5-2]
NP_001288116.1. NM_001301187.1. [Q96FE5-2]
NP_001288118.1. NM_001301189.1. [Q96FE5-2]
NP_001288120.1. NM_001301191.1. [Q96FE5-2]
NP_001288121.1. NM_001301192.1. [Q96FE5-2]
NP_001288123.1. NM_001301194.1. [Q96FE5-2]
NP_001288124.1. NM_001301195.1. [Q96FE5-2]
NP_001288126.1. NM_001301197.1. [Q96FE5-2]
NP_001288127.1. NM_001301198.1. [Q96FE5-2]
NP_001288128.1. NM_001301199.1. [Q96FE5-2]
NP_001288129.1. NM_001301200.1. [Q96FE5-2]
NP_116197.4. NM_032808.6. [Q96FE5-1]
XP_011520419.1. XM_011522117.1. [Q96FE5-2]
XP_011520420.1. XM_011522118.1. [Q96FE5-2]
UniGeneiHs.656765.
Hs.745412.

Genome annotation databases

EnsembliENST00000355300; ENSP00000347451; ENSG00000169783. [Q96FE5-1]
ENST00000561030; ENSP00000453853; ENSG00000169783. [Q96FE5-2]
GeneIDi84894.
KEGGihsa:84894.
UCSCiuc002bct.2. human. [Q96FE5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324320 mRNA. Translation: AAQ97216.1.
AY324322 mRNA. Translation: AAQ97217.1.
AY324323 mRNA. Translation: AAQ97218.1.
AY358284 mRNA. Translation: AAQ88651.1.
AK027500 mRNA. Translation: BAB55157.1.
AK291363 mRNA. Translation: BAF84052.1.
CH471136 Genomic DNA. Translation: EAW99195.1.
CH471136 Genomic DNA. Translation: EAW99196.1.
CH471136 Genomic DNA. Translation: EAW99197.1.
CH471136 Genomic DNA. Translation: EAW99198.1.
BC011057 mRNA. Translation: AAH11057.2.
BC068558 mRNA. Translation: AAH68558.1.
AL834260 mRNA. Translation: CAD38935.1.
CCDSiCCDS45313.1. [Q96FE5-1]
CCDS73766.1. [Q96FE5-2]
RefSeqiNP_001288115.1. NM_001301186.1. [Q96FE5-2]
NP_001288116.1. NM_001301187.1. [Q96FE5-2]
NP_001288118.1. NM_001301189.1. [Q96FE5-2]
NP_001288120.1. NM_001301191.1. [Q96FE5-2]
NP_001288121.1. NM_001301192.1. [Q96FE5-2]
NP_001288123.1. NM_001301194.1. [Q96FE5-2]
NP_001288124.1. NM_001301195.1. [Q96FE5-2]
NP_001288126.1. NM_001301197.1. [Q96FE5-2]
NP_001288127.1. NM_001301198.1. [Q96FE5-2]
NP_001288128.1. NM_001301199.1. [Q96FE5-2]
NP_001288129.1. NM_001301200.1. [Q96FE5-2]
NP_116197.4. NM_032808.6. [Q96FE5-1]
XP_011520419.1. XM_011522117.1. [Q96FE5-2]
XP_011520420.1. XM_011522118.1. [Q96FE5-2]
UniGeneiHs.656765.
Hs.745412.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ID5X-ray2.70A/B/C/D40-516[»]
4OQTX-ray3.23A40-517[»]
ProteinModelPortaliQ96FE5.
SMRiQ96FE5. Positions 42-516.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124334. 18 interactions.
DIPiDIP-60981N.
IntActiQ96FE5. 6 interactions.
MINTiMINT-1378183.
STRINGi9606.ENSP00000347451.

Chemistry

GuidetoPHARMACOLOGYi2882.

PTM databases

iPTMnetiQ96FE5.
PhosphoSiteiQ96FE5.

Polymorphism and mutation databases

BioMutaiLINGO1.
DMDMi74760819.

Proteomic databases

PaxDbiQ96FE5.
PRIDEiQ96FE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355300; ENSP00000347451; ENSG00000169783. [Q96FE5-1]
ENST00000561030; ENSP00000453853; ENSG00000169783. [Q96FE5-2]
GeneIDi84894.
KEGGihsa:84894.
UCSCiuc002bct.2. human. [Q96FE5-1]

Organism-specific databases

CTDi84894.
GeneCardsiLINGO1.
H-InvDBHIX0012466.
HGNCiHGNC:21205. LINGO1.
MIMi609791. gene.
neXtProtiNX_Q96FE5.
Orphaneti862. Hereditary essential tremor.
PharmGKBiPA162394087.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOVERGENiHBG057546.
InParanoidiQ96FE5.
OMAiIRDRKPQ.
OrthoDBiEOG715Q3P.
PhylomeDBiQ96FE5.
TreeFamiTF334360.

Enzyme and pathway databases

ReactomeiR-HSA-193634. Axonal growth inhibition (RHOA activation).
SIGNORiQ96FE5.

Miscellaneous databases

EvolutionaryTraceiQ96FE5.
GeneWikiiLINGO1.
GenomeRNAii84894.
PROiQ96FE5.
SOURCEiSearch...

Gene expression databases

BgeeiQ96FE5.
CleanExiHS_LINGO1.
ExpressionAtlasiQ96FE5. baseline and differential.
GenevisibleiQ96FE5. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 9 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex."
    Carim-Todd L., Escarceller M., Estivill X., Sumoy L.
    Eur. J. Neurosci. 18:3167-3182(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT PHE-183.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 44-620.
    Tissue: Amygdala.
  7. Cited for: FUNCTION, INTERACTION WITH NGFR AND RTN4R.
  8. Cited for: TISSUE SPECIFICITY, FUNCTION.
  9. "A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors."
    Park J.B., Yiu G., Kaneko S., Wang J., Chang J., He X.L., Garcia K.C., He Z.
    Neuron 45:345-351(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TNFRSF19, FUNCTION.
  10. "Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models."
    Inoue H., Lin L., Lee X., Shao Z., Mendes S., Snodgrass-Belt P., Sweigard H., Engber T., Pepinsky B., Yang L., Beal M.F., Mi S., Isacson O.
    Proc. Natl. Acad. Sci. U.S.A. 104:14430-14435(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 40-516, FUNCTION, SUBUNIT, INTERACTION WITH NGFR AND RTN4R, DISULFIDE BONDS, IDENTIFICATION BY MASS SPECTROMETRY, GLYCOSYLATION AT ASN-144; ASN-202; ASN-264; ASN-274; ASN-293; ASN-341 AND ASN-492.

Entry informationi

Entry nameiLIGO1_HUMAN
AccessioniPrimary (citable) accession number: Q96FE5
Secondary accession number(s): D3DW80
, Q6NUK3, Q6UXM3, Q6VVG0, Q6VVG1, Q6VVG2, Q8N3K5, Q96K52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 11, 2004
Last modified: June 8, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.