Reviewed,
UniProtKB/Swiss-Prot Q96F86 (EDC3_HUMAN)
Last modified
July 22, 2008.
Version 51.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Enhancer of mRNA-decapping protein 3 Alternative name(s): YjeF domain-containing protein 1 LSM16 homolog | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 508 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | In the process of mRNA degradation, may play a role in mRNA decapping. |
| Subunit structure | Forms a complex with DCP1A, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with DCP1A and DDX6. Interacts with ZFP36. |
| Subcellular location | |
| Sequence similarities | Belongs to the EDC3 family. Contains 1 YjeF N-terminal domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| PTM | Phosphoprotein |
| Technical term | 3D-structure |
Gene Ontology (GO) | |
| Molecular function | protein binding Ref.4 Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| DDX6 | P26196 | 1 | EBI-997311,EBI-351257 | |
| YWHAB | P31946 | 1 | EBI-997311,EBI-359815 | |
| YWHAG | P61981 | 1 | EBI-997311,EBI-359832 | |
| YWHAQ | P27348 | 1 | EBI-997311,EBI-359854 | |
| YWHAZ | P63104 | 1 | EBI-997311,EBI-347088 | |
| ZFP36 | P26651 | 1 | EBI-997311,EBI-374248 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 508 | 508 | Enhancer of mRNA-decapping protein 3 | |||||
Regions | ||||||||
| Domain | 283 – 487 | 205 | YjeF N-terminal | |||||
| Region | 1 – 79 | 79 | Required for P-body targeting and interaction with DCP1A By similarity | |||||
| Region | 191 – 296 | 106 | Required for interaction with DDX6 By similarity | |||||
Amino acid modifications | ||||||||
| Modified residue | 131 | 1 | Phosphoserine | |||||
| Modified residue | 161 | 1 | Phosphoserine | |||||
Experimental info | ||||||||
| Sequence conflict | 74 | 1 | Q → R in BAB15001. Ref.2 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. Gu J.Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed: 15498874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye and Placenta. |
| [4] | "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping." Fenger-Groen M., Fillman C., Norrild B., Lykke-Andersen J. Mol. Cell 20:905-915(2005) [PubMed: 16364915] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH DCP1A; DCP2; DDX6; EDC4 AND ZFP36, SUBCELLULAR LOCATION, FUNCTION. |
| [5] | "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131, MASS SPECTROMETRY. Tissue: Epithelium. |
| [6] | "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131, MASS SPECTROMETRY. |
| [7] | "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161, MASS SPECTROMETRY. |
| [8] | "A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting." Tritschler F., Eulalio A., Truffault V., Hartmann M.D., Helms S., Schmidt S., Coles M., Izaurralde E., Weichenrieder O. Mol. Cell. Biol. 27:8600-8611(2007) [PubMed: 17923697] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.31 ANGSTROMS) OF 1-82. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AF193058 mRNA. Translation: AAG22486.1. AK024781 mRNA. Translation: BAB15001.1. BC011534 mRNA. Translation: AAH11534.1. BC021271 mRNA. Translation: AAH21271.1. | |||||||||||||
| RefSeq | NP_079359.2. | ||||||||||||
| UniGene | Hs.96852 | ||||||||||||
3D structure databases | |||||||||||||
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| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q96F86. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | Q96F86. | ||||||||||||
Proteomic databases | |||||||||||||
| PeptideAtlas | Q96F86. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000179151. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 80153. | ||||||||||||
| KEGG | hsa:80153. | ||||||||||||
Organism-specific databases | |||||||||||||
| H-InvDB | HIX0020864. | ||||||||||||
| HGNC | HGNC:26114. EDC3. | ||||||||||||
| MIM | 609842. gene. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
| GeneCards | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | Q96F86. | ||||||||||||
| HOVERGEN | Q96F86. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q96F86. | ||||||||||||
| CleanEx | HS_EDC3. | ||||||||||||
| GermOnline | ENSG00000179151. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR004443. YjeF_N. [Graphical view] | ||||||||||||
| Pfam | PF03853. YjeF_N. 1 hit. [Graphical view] | ||||||||||||
| PROSITE | PS51385. YJEF_N. 1 hit. [Graphical view] | ||||||||||||
| ProDom | Q96F86. [Graphical view] [Entries sharing at least one domain] | ||||||||||||
| BLOCKS | Search... | ||||||||||||
Other Resources | |||||||||||||
| SOURCE | Search... | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Entry information
| Entry name | EDC3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96F86 Secondary accession number(s): Q9H797 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 15 Human chromosome 15: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

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