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Q96F54

- Q96F54_HUMAN

UniProt

Q96F54 - Q96F54_HUMAN

Protein
Submitted name:

RELA protein

Gene

RELA

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
    3. sequence-specific DNA binding Source: Ensembl

    GO - Biological processi

    1. acetaldehyde metabolic process Source: Ensembl
    2. aging Source: Ensembl
    3. cellular response to lipopolysaccharide Source: Ensembl
    4. defense response Source: Ensembl
    5. hair follicle development Source: Ensembl
    6. liver development Source: Ensembl
    7. negative regulation of apoptotic process Source: Ensembl
    8. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    9. negative regulation of insulin receptor signaling pathway Source: Ensembl
    10. negative regulation of protein catabolic process Source: Ensembl
    11. organ morphogenesis Source: Ensembl
    12. positive regulation of cell proliferation Source: Ensembl
    13. positive regulation of chondrocyte differentiation Source: Ensembl
    14. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    15. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
    16. positive regulation of Schwann cell differentiation Source: Ensembl
    17. positive regulation of transcription, DNA-templated Source: Ensembl
    18. regulation of inflammatory response Source: Ensembl
    19. response to amino acid Source: Ensembl
    20. response to cAMP Source: Ensembl
    21. response to cobalamin Source: Ensembl
    22. response to cytokine Source: Ensembl
    23. response to drug Source: Ensembl
    24. response to hydrogen peroxide Source: Ensembl
    25. response to insulin Source: Ensembl
    26. response to mechanical stimulus Source: Ensembl
    27. response to morphine Source: Ensembl
    28. response to muramyl dipeptide Source: Ensembl
    29. response to progesterone Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    RELA proteinImported
    Gene namesi
    Name:RELAImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. nucleus Source: Ensembl
    3. protein complex Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ96F54.
    BgeeiQ96F54.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ96F54.
    SMRiQ96F54. Positions 20-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG017916.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProiIPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR000451. NF_Rel_Dor.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view]
    PfamiPF00554. RHD. 1 hit.
    [Graphical view]
    PRINTSiPR00057. NFKBTNSCPFCT.
    SUPFAMiSSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS01204. REL_1. 1 hit.
    PS50254. REL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96F54-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDELFPLIFP AEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER    50
    STDTTKTHPT IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY 100
    EAELCPDRCI HSFQNLGIQC VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG 150
    DYDLNAVRLC FQVTVRDPSG RPLRLPPVLS HPIFDNRAPN TAELKICRVN 200
    RNSGSCLGGD EIFLLCDKVQ 220
    Length:220
    Mass (Da):24,763
    Last modified:December 1, 2001 - v1
    Checksum:i8582210B23DAA620
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC011603 mRNA. Translation: AAH11603.1.
    UniGeneiHs.502875.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC011603 mRNA. Translation: AAH11603.1 .
    UniGenei Hs.502875.

    3D structure databases

    ProteinModelPortali Q96F54.
    SMRi Q96F54. Positions 20-220.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q96F54.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG017916.

    Miscellaneous databases

    ChiTaRSi RELA. human.

    Gene expression databases

    ArrayExpressi Q96F54.
    Bgeei Q96F54.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProi IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR000451. NF_Rel_Dor.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view ]
    Pfami PF00554. RHD. 1 hit.
    [Graphical view ]
    PRINTSi PR00057. NFKBTNSCPFCT.
    SUPFAMi SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS01204. REL_1. 1 hit.
    PS50254. REL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PlacentaImported.

    Entry informationi

    Entry nameiQ96F54_HUMAN
    AccessioniPrimary (citable) accession number: Q96F54
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.