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Protein
Submitted name:

RELA protein

Gene

RELA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
  3. sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. acetaldehyde metabolic process Source: Ensembl
  2. aging Source: Ensembl
  3. cellular response to lipopolysaccharide Source: Ensembl
  4. defense response Source: Ensembl
  5. hair follicle development Source: Ensembl
  6. liver development Source: Ensembl
  7. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  8. negative regulation of insulin receptor signaling pathway Source: Ensembl
  9. negative regulation of protein catabolic process Source: Ensembl
  10. organ morphogenesis Source: Ensembl
  11. positive regulation of cell proliferation Source: Ensembl
  12. positive regulation of chondrocyte differentiation Source: Ensembl
  13. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  14. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
  15. positive regulation of Schwann cell differentiation Source: Ensembl
  16. positive regulation of transcription, DNA-templated Source: Ensembl
  17. regulation of inflammatory response Source: Ensembl
  18. response to amino acid Source: Ensembl
  19. response to cAMP Source: Ensembl
  20. response to cobalamin Source: Ensembl
  21. response to cytokine Source: Ensembl
  22. response to drug Source: Ensembl
  23. response to hydrogen peroxide Source: Ensembl
  24. response to insulin Source: Ensembl
  25. response to mechanical stimulus Source: Ensembl
  26. response to morphine Source: Ensembl
  27. response to muramyl dipeptide Source: Ensembl
  28. response to progesterone Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
RELA proteinImported
Gene namesi
Name:RELAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. nucleus Source: Ensembl
  3. protein complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ96F54.
ExpressionAtlasiQ96F54. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ96F54.
SMRiQ96F54. Positions 20-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG017916.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR000451. NFkB/Dor.
IPR008967. p53-like_TF_DNA-bd.
IPR030495. RelA.
IPR011539. RHD.
IPR030492. RHD_CS.
[Graphical view]
PANTHERiPTHR24169. PTHR24169. 1 hit.
PTHR24169:SF1. PTHR24169:SF1. 1 hit.
PfamiPF00554. RHD. 1 hit.
[Graphical view]
PRINTSiPR00057. NFKBTNSCPFCT.
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS01204. REL_1. 1 hit.
PS50254. REL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96F54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDELFPLIFP AEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER
60 70 80 90 100
STDTTKTHPT IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY
110 120 130 140 150
EAELCPDRCI HSFQNLGIQC VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG
160 170 180 190 200
DYDLNAVRLC FQVTVRDPSG RPLRLPPVLS HPIFDNRAPN TAELKICRVN
210 220
RNSGSCLGGD EIFLLCDKVQ
Length:220
Mass (Da):24,763
Last modified:December 1, 2001 - v1
Checksum:i8582210B23DAA620
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011603 mRNA. Translation: AAH11603.1.
UniGeneiHs.502875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011603 mRNA. Translation: AAH11603.1.
UniGeneiHs.502875.

3D structure databases

ProteinModelPortaliQ96F54.
SMRiQ96F54. Positions 20-220.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ96F54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG017916.

Miscellaneous databases

ChiTaRSiRELA. human.

Gene expression databases

BgeeiQ96F54.
ExpressionAtlasiQ96F54. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR000451. NFkB/Dor.
IPR008967. p53-like_TF_DNA-bd.
IPR030495. RelA.
IPR011539. RHD.
IPR030492. RHD_CS.
[Graphical view]
PANTHERiPTHR24169. PTHR24169. 1 hit.
PTHR24169:SF1. PTHR24169:SF1. 1 hit.
PfamiPF00554. RHD. 1 hit.
[Graphical view]
PRINTSiPR00057. NFKBTNSCPFCT.
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS01204. REL_1. 1 hit.
PS50254. REL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PlacentaImported.

Entry informationi

Entry nameiQ96F54_HUMAN
AccessioniPrimary (citable) accession number: Q96F54
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: April 1, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.