Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96F46

- I17RA_HUMAN

UniProt

Q96F46 - I17RA_HUMAN

Protein

Interleukin-17 receptor A

Gene

IL17RA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.2 Publications

    GO - Molecular functioni

    1. interleukin-17 receptor activity Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: UniProtKB
    2. cytokine-mediated signaling pathway Source: GOC
    3. fibroblast activation Source: BHF-UCL
    4. positive regulation of cytokine production involved in inflammatory response Source: Ensembl
    5. positive regulation of interleukin-23 production Source: BHF-UCL

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-17 receptor A
    Short name:
    IL-17 receptor A
    Short name:
    IL-17RA
    Alternative name(s):
    CDw217
    CD_antigen: CD217
    Gene namesi
    Name:IL17RA
    Synonyms:IL17R
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:5985. IL17RA.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Candidiasis, familial, 5 (CANDF5) [MIM:613953]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi613953. phenotype.
    Orphaneti1334. Chronic mucocutaneous candidiasis.
    PharmGKBiPA29801.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 32321 PublicationAdd
    BLAST
    Chaini33 – 866834Interleukin-17 receptor APRO_0000011030Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 501 Publication
    Glycosylationi49 – 491N-linked (GlcNAc...)1 Publication
    Glycosylationi54 – 541N-linked (GlcNAc...)1 Publication
    Disulfide bondi57 ↔ 1261 Publication
    Glycosylationi67 – 671N-linked (GlcNAc...)1 Publication
    Disulfide bondi185 ↔ 1961 Publication
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi225 – 2251N-linked (GlcNAc...)1 Publication
    Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi245 ↔ 2761 Publication
    Glycosylationi265 – 2651N-linked (GlcNAc...)1 Publication
    Disulfide bondi290 ↔ 2941 Publication

    Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ96F46.
    PaxDbiQ96F46.
    PRIDEiQ96F46.

    PTM databases

    PhosphoSiteiQ96F46.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ96F46.
    BgeeiQ96F46.
    CleanExiHS_IL17RA.
    GenevestigatoriQ96F46.

    Organism-specific databases

    HPAiCAB024996.

    Interactioni

    Subunit structurei

    Forms heterodimers with IL17RE; the heterodimer binds IL17C.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    IL17REQ8NFR92EBI-5591258,EBI-5591275

    Protein-protein interaction databases

    BioGridi117265. 4 interactions.
    IntActiQ96F46. 1 interaction.
    STRINGi9606.ENSP00000320936.

    Structurei

    Secondary structure

    1
    866
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi34 – 363
    Beta strandi50 – 556
    Helixi60 – 634
    Beta strandi73 – 8412
    Beta strandi86 – 883
    Beta strandi90 – 10011
    Helixi104 – 1085
    Beta strandi111 – 12111
    Beta strandi124 – 13310
    Beta strandi143 – 1508
    Beta strandi153 – 16513
    Beta strandi175 – 1828
    Helixi190 – 1923
    Helixi194 – 1985
    Turni199 – 2024
    Beta strandi208 – 2125
    Turni213 – 2153
    Beta strandi216 – 2205
    Beta strandi230 – 2389
    Beta strandi245 – 2528
    Helixi257 – 2593
    Beta strandi266 – 2694
    Beta strandi276 – 28510
    Turni288 – 2903
    Helixi291 – 2933
    Beta strandi296 – 3016
    Beta strandi379 – 3835
    Helixi389 – 40618
    Beta strandi409 – 4113
    Helixi413 – 4164
    Helixi417 – 4226
    Helixi425 – 43814
    Beta strandi442 – 4465
    Helixi449 – 45810
    Helixi478 – 4869
    Helixi487 – 4915
    Helixi493 – 4986
    Beta strandi499 – 5046
    Turni505 – 5073
    Helixi510 – 5123
    Beta strandi522 – 5254
    Turni526 – 5283
    Helixi529 – 5379
    Helixi557 – 5604
    Helixi564 – 58017
    Helixi584 – 5885

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3JVFX-ray3.30C32-317[»]
    4HSAX-ray3.15C/F32-317[»]
    4NUXX-ray2.30A376-591[»]
    ProteinModelPortaliQ96F46.
    SMRiQ96F46. Positions 33-304.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96F46.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 320288ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini342 – 866525CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei321 – 34121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini377 – 534158SEFIRPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi810 – 8189Poly-Glu

    Sequence similaritiesi

    Contains 1 SEFIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40152.
    HOGENOMiHOG000015327.
    HOVERGENiHBG081775.
    InParanoidiQ96F46.
    KOiK05164.
    OMAiMTWVGRQ.
    OrthoDBiEOG7P8P7V.
    PhylomeDBiQ96F46.
    TreeFamiTF329644.

    Family and domain databases

    InterProiIPR013568. SEFIR.
    [Graphical view]
    PfamiPF08357. SEFIR. 1 hit.
    [Graphical view]
    PROSITEiPS51534. SEFIR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96F46-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGAARSPPSA VPGPLLGLLL LLLGVLAPGG ASLRLLDHRA LVCSQPGLNC    50
    TVKNSTCLDD SWIHPRNLTP SSPKDLQIQL HFAHTQQGDL FPVAHIEWTL 100
    QTDASILYLE GAELSVLQLN TNERLCVRFE FLSKLRHHHR RWRFTFSHFV 150
    VDPDQEYEVT VHHLPKPIPD GDPNHQSKNF LVPDCEHARM KVTTPCMSSG 200
    SLWDPNITVE TLEAHQLRVS FTLWNESTHY QILLTSFPHM ENHSCFEHMH 250
    HIPAPRPEEF HQRSNVTLTL RNLKGCCRHQ VQIQPFFSSC LNDCLRHSAT 300
    VSCPEMPDTP EPIPDYMPLW VYWFITGISI LLVGSVILLI VCMTWRLAGP 350
    GSEKYSDDTK YTDGLPAADL IPPPLKPRKV WIIYSADHPL YVDVVLKFAQ 400
    FLLTACGTEV ALDLLEEQAI SEAGVMTWVG RQKQEMVESN SKIIVLCSRG 450
    TRAKWQALLG RGAPVRLRCD HGKPVGDLFT AAMNMILPDF KRPACFGTYV 500
    VCYFSEVSCD GDVPDLFGAA PRYPLMDRFE EVYFRIQDLE MFQPGRMHRV 550
    GELSGDNYLR SPGGRQLRAA LDRFRDWQVR CPDWFECENL YSADDQDAPS 600
    LDEEVFEEPL LPPGTGIVKR APLVREPGSQ ACLAIDPLVG EEGGAAVAKL 650
    EPHLQPRGQP APQPLHTLVL AAEEGALVAA VEPGPLADGA AVRLALAGEG 700
    EACPLLGSPG AGRNSVLFLP VDPEDSPLGS STPMASPDLL PEDVREHLEG 750
    LMLSLFEQSL SCQAQGGCSR PAMVLTDPHT PYEEEQRQSV QSDQGYISRS 800
    SPQPPEGLTE MEEEEEEEQD PGKPALPLSP EDLESLRSLQ RQLLFRQLQK 850
    NSGWDTMGSE SEGPSA 866
    Length:866
    Mass (Da):96,122
    Last modified:October 17, 2006 - v2
    Checksum:i88AF626A83F3FF70
    GO
    Isoform 2 (identifier: Q96F46-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         315-348: Missing.

    Note: Soluble isoform lacking the transmembrane segment.

    Show »
    Length:832
    Mass (Da):92,153
    Checksum:iC37767EA444C0FF7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti367 – 3671A → V.1 Publication
    Corresponds to variant rs879577 [ dbSNP | Ensembl ].
    VAR_027966
    Natural varianti562 – 5621P → Q.
    Corresponds to variant rs12484684 [ dbSNP | Ensembl ].
    VAR_049176
    Natural varianti580 – 5801R → H.1 Publication
    Corresponds to variant rs17850765 [ dbSNP | Ensembl ].
    VAR_027967

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei315 – 34834Missing in isoform 2. 1 PublicationVSP_053496Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58917 mRNA. Translation: AAB99730.1.
    CT841520 mRNA. Translation: CAJ86450.1.
    CH471193 Genomic DNA. Translation: EAW57739.1.
    BC011624 mRNA. Translation: AAH11624.1.
    BX368715 mRNA. No translation available.
    CCDSiCCDS13739.1. [Q96F46-1]
    RefSeqiNP_001276834.1. NM_001289905.1. [Q96F46-2]
    NP_055154.3. NM_014339.6. [Q96F46-1]
    UniGeneiHs.48353.

    Genome annotation databases

    EnsembliENST00000319363; ENSP00000320936; ENSG00000177663. [Q96F46-1]
    GeneIDi23765.
    KEGGihsa:23765.
    UCSCiuc002zly.4. human. [Q96F46-1]

    Polymorphism databases

    DMDMi116242517.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58917 mRNA. Translation: AAB99730.1 .
    CT841520 mRNA. Translation: CAJ86450.1 .
    CH471193 Genomic DNA. Translation: EAW57739.1 .
    BC011624 mRNA. Translation: AAH11624.1 .
    BX368715 mRNA. No translation available.
    CCDSi CCDS13739.1. [Q96F46-1 ]
    RefSeqi NP_001276834.1. NM_001289905.1. [Q96F46-2 ]
    NP_055154.3. NM_014339.6. [Q96F46-1 ]
    UniGenei Hs.48353.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3JVF X-ray 3.30 C 32-317 [» ]
    4HSA X-ray 3.15 C/F 32-317 [» ]
    4NUX X-ray 2.30 A 376-591 [» ]
    ProteinModelPortali Q96F46.
    SMRi Q96F46. Positions 33-304.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117265. 4 interactions.
    IntActi Q96F46. 1 interaction.
    STRINGi 9606.ENSP00000320936.

    PTM databases

    PhosphoSitei Q96F46.

    Polymorphism databases

    DMDMi 116242517.

    Proteomic databases

    MaxQBi Q96F46.
    PaxDbi Q96F46.
    PRIDEi Q96F46.

    Protocols and materials databases

    DNASUi 23765.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319363 ; ENSP00000320936 ; ENSG00000177663 . [Q96F46-1 ]
    GeneIDi 23765.
    KEGGi hsa:23765.
    UCSCi uc002zly.4. human. [Q96F46-1 ]

    Organism-specific databases

    CTDi 23765.
    GeneCardsi GC22P017565.
    HGNCi HGNC:5985. IL17RA.
    HPAi CAB024996.
    MIMi 605461. gene.
    613953. phenotype.
    neXtProti NX_Q96F46.
    Orphaneti 1334. Chronic mucocutaneous candidiasis.
    PharmGKBi PA29801.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40152.
    HOGENOMi HOG000015327.
    HOVERGENi HBG081775.
    InParanoidi Q96F46.
    KOi K05164.
    OMAi MTWVGRQ.
    OrthoDBi EOG7P8P7V.
    PhylomeDBi Q96F46.
    TreeFami TF329644.

    Miscellaneous databases

    EvolutionaryTracei Q96F46.
    GeneWikii IL17RA.
    GenomeRNAii 23765.
    NextBioi 46725.
    PROi Q96F46.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96F46.
    Bgeei Q96F46.
    CleanExi HS_IL17RA.
    Genevestigatori Q96F46.

    Family and domain databases

    InterProi IPR013568. SEFIR.
    [Graphical view ]
    Pfami PF08357. SEFIR. 1 hit.
    [Graphical view ]
    PROSITEi PS51534. SEFIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: T-cell.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-367 AND HIS-580.
      Tissue: Uterus.
    5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 33-47.
    6. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 237-431 (ISOFORM 2).
      Tissue: Placenta.
    7. Cited for: FUNCTION, IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE, TISSUE SPECIFICITY.
    8. Cited for: INVOLVEMENT IN CANDF5.
    9. "Identification of a soluble isoform of human IL-17RA generated by alternative splicing."
      Sohda M., Misumi Y., Tashiro K., Yamazaki M., Saku T., Oda K.
      Cytokine 64:642-645(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, SUBCELLULAR LOCATION.
    10. "Structural basis of receptor sharing by interleukin 17 cytokines."
      Ely L.K., Fischer S., Garcia K.C.
      Nat. Immunol. 10:1245-1251(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 32-317 IN COMPLEX WITH IL17F, GLYCOSYLATION AT ASN-49; ASN-54; ASN-67; ASN-225 AND ASN-265, FUNCTION, DISULFIDE BONDS.

    Entry informationi

    Entry nameiI17RA_HUMAN
    AccessioniPrimary (citable) accession number: Q96F46
    Secondary accession number(s): O43844, Q20WK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3