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Q96F46

- I17RA_HUMAN

UniProt

Q96F46 - I17RA_HUMAN

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Protein
Interleukin-17 receptor A
Gene
IL17RA, IL17R
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.2 Publications

GO - Molecular functioni

  1. interleukin-17 receptor activity Source: UniProtKB
  2. protein binding Source: IntAct

GO - Biological processi

  1. cell surface receptor signaling pathway Source: UniProtKB
  2. cytokine-mediated signaling pathway Source: GOC
  3. fibroblast activation Source: BHF-UCL
  4. positive regulation of cytokine production involved in inflammatory response Source: Ensembl
  5. positive regulation of interleukin-23 production Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor A
Short name:
IL-17 receptor A
Short name:
IL-17RA
Alternative name(s):
CDw217
CD_antigen: CD217
Gene namesi
Name:IL17RA
Synonyms:IL17R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:5985. IL17RA.

Subcellular locationi

Isoform 1 : Membrane; Single-pass type I membrane protein By similarity 1 Publication
Isoform 2 : Secreted 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 320288Extracellular Reviewed prediction
Add
BLAST
Transmembranei321 – 34121Helical; Reviewed prediction
Add
BLAST
Topological domaini342 – 866525Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Candidiasis, familial, 5 (CANDF5) [MIM:613953]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Organism-specific databases

MIMi613953. phenotype.
Orphaneti1334. Chronic mucocutaneous candidiasis.
PharmGKBiPA29801.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 32321 Publication
Add
BLAST
Chaini33 – 866834Interleukin-17 receptor A
PRO_0000011030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 501 Publication
Glycosylationi49 – 491N-linked (GlcNAc...)1 Publication
Glycosylationi54 – 541N-linked (GlcNAc...)1 Publication
Disulfide bondi57 ↔ 1261 Publication
Glycosylationi67 – 671N-linked (GlcNAc...)1 Publication
Disulfide bondi185 ↔ 1961 Publication
Glycosylationi206 – 2061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi225 – 2251N-linked (GlcNAc...)1 Publication
Glycosylationi242 – 2421N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi245 ↔ 2761 Publication
Glycosylationi265 – 2651N-linked (GlcNAc...)1 Publication
Disulfide bondi290 ↔ 2941 Publication

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ96F46.
PaxDbiQ96F46.
PRIDEiQ96F46.

PTM databases

PhosphoSiteiQ96F46.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

ArrayExpressiQ96F46.
BgeeiQ96F46.
CleanExiHS_IL17RA.
GenevestigatoriQ96F46.

Organism-specific databases

HPAiCAB024996.

Interactioni

Subunit structurei

Forms heterodimers with IL17RE; the heterodimer binds IL17C.

Binary interactionsi

WithEntry#Exp.IntActNotes
IL17REQ8NFR92EBI-5591258,EBI-5591275

Protein-protein interaction databases

BioGridi117265. 4 interactions.
IntActiQ96F46. 1 interaction.
STRINGi9606.ENSP00000320936.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 363
Beta strandi50 – 556
Helixi60 – 634
Beta strandi73 – 8412
Beta strandi86 – 883
Beta strandi90 – 10011
Helixi104 – 1085
Beta strandi111 – 12111
Beta strandi124 – 13310
Beta strandi143 – 1508
Beta strandi153 – 16513
Beta strandi175 – 1828
Helixi190 – 1923
Helixi194 – 1985
Turni199 – 2024
Beta strandi208 – 2125
Turni213 – 2153
Beta strandi216 – 2205
Beta strandi230 – 2389
Beta strandi245 – 2528
Helixi257 – 2593
Beta strandi266 – 2694
Beta strandi276 – 28510
Turni288 – 2903
Helixi291 – 2933
Beta strandi296 – 3016
Beta strandi379 – 3835
Helixi389 – 40618
Beta strandi409 – 4113
Helixi413 – 4164
Helixi417 – 4226
Helixi425 – 43814
Beta strandi442 – 4465
Helixi449 – 45810
Helixi478 – 4869
Helixi487 – 4915
Helixi493 – 4986
Beta strandi499 – 5046
Turni505 – 5073
Helixi510 – 5123
Beta strandi522 – 5254
Turni526 – 5283
Helixi529 – 5379
Helixi557 – 5604
Helixi564 – 58017
Helixi584 – 5885

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JVFX-ray3.30C32-317[»]
4HSAX-ray3.15C/F32-317[»]
4NUXX-ray2.30A376-591[»]
ProteinModelPortaliQ96F46.
SMRiQ96F46. Positions 33-304.

Miscellaneous databases

EvolutionaryTraceiQ96F46.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini377 – 534158SEFIR
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi810 – 8189Poly-Glu

Sequence similaritiesi

Contains 1 SEFIR domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40152.
HOGENOMiHOG000015327.
HOVERGENiHBG081775.
InParanoidiQ96F46.
KOiK05164.
OMAiMTWVGRQ.
OrthoDBiEOG7P8P7V.
PhylomeDBiQ96F46.
TreeFamiTF329644.

Family and domain databases

InterProiIPR013568. SEFIR.
[Graphical view]
PfamiPF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96F46-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGAARSPPSA VPGPLLGLLL LLLGVLAPGG ASLRLLDHRA LVCSQPGLNC    50
TVKNSTCLDD SWIHPRNLTP SSPKDLQIQL HFAHTQQGDL FPVAHIEWTL 100
QTDASILYLE GAELSVLQLN TNERLCVRFE FLSKLRHHHR RWRFTFSHFV 150
VDPDQEYEVT VHHLPKPIPD GDPNHQSKNF LVPDCEHARM KVTTPCMSSG 200
SLWDPNITVE TLEAHQLRVS FTLWNESTHY QILLTSFPHM ENHSCFEHMH 250
HIPAPRPEEF HQRSNVTLTL RNLKGCCRHQ VQIQPFFSSC LNDCLRHSAT 300
VSCPEMPDTP EPIPDYMPLW VYWFITGISI LLVGSVILLI VCMTWRLAGP 350
GSEKYSDDTK YTDGLPAADL IPPPLKPRKV WIIYSADHPL YVDVVLKFAQ 400
FLLTACGTEV ALDLLEEQAI SEAGVMTWVG RQKQEMVESN SKIIVLCSRG 450
TRAKWQALLG RGAPVRLRCD HGKPVGDLFT AAMNMILPDF KRPACFGTYV 500
VCYFSEVSCD GDVPDLFGAA PRYPLMDRFE EVYFRIQDLE MFQPGRMHRV 550
GELSGDNYLR SPGGRQLRAA LDRFRDWQVR CPDWFECENL YSADDQDAPS 600
LDEEVFEEPL LPPGTGIVKR APLVREPGSQ ACLAIDPLVG EEGGAAVAKL 650
EPHLQPRGQP APQPLHTLVL AAEEGALVAA VEPGPLADGA AVRLALAGEG 700
EACPLLGSPG AGRNSVLFLP VDPEDSPLGS STPMASPDLL PEDVREHLEG 750
LMLSLFEQSL SCQAQGGCSR PAMVLTDPHT PYEEEQRQSV QSDQGYISRS 800
SPQPPEGLTE MEEEEEEEQD PGKPALPLSP EDLESLRSLQ RQLLFRQLQK 850
NSGWDTMGSE SEGPSA 866
Length:866
Mass (Da):96,122
Last modified:October 17, 2006 - v2
Checksum:i88AF626A83F3FF70
GO
Isoform 2 (identifier: Q96F46-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     315-348: Missing.

Note: Soluble isoform lacking the transmembrane segment.

Show »
Length:832
Mass (Da):92,153
Checksum:iC37767EA444C0FF7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti367 – 3671A → V.1 Publication
Corresponds to variant rs879577 [ dbSNP | Ensembl ].
VAR_027966
Natural varianti562 – 5621P → Q.
Corresponds to variant rs12484684 [ dbSNP | Ensembl ].
VAR_049176
Natural varianti580 – 5801R → H.1 Publication
Corresponds to variant rs17850765 [ dbSNP | Ensembl ].
VAR_027967

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei315 – 34834Missing in isoform 2.
VSP_053496Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U58917 mRNA. Translation: AAB99730.1.
CT841520 mRNA. Translation: CAJ86450.1.
CH471193 Genomic DNA. Translation: EAW57739.1.
BC011624 mRNA. Translation: AAH11624.1.
BX368715 mRNA. No translation available.
CCDSiCCDS13739.1. [Q96F46-1]
RefSeqiNP_001276834.1. NM_001289905.1. [Q96F46-2]
NP_055154.3. NM_014339.6. [Q96F46-1]
UniGeneiHs.48353.

Genome annotation databases

EnsembliENST00000319363; ENSP00000320936; ENSG00000177663. [Q96F46-1]
GeneIDi23765.
KEGGihsa:23765.
UCSCiuc002zly.4. human. [Q96F46-1]

Polymorphism databases

DMDMi116242517.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U58917 mRNA. Translation: AAB99730.1 .
CT841520 mRNA. Translation: CAJ86450.1 .
CH471193 Genomic DNA. Translation: EAW57739.1 .
BC011624 mRNA. Translation: AAH11624.1 .
BX368715 mRNA. No translation available.
CCDSi CCDS13739.1. [Q96F46-1 ]
RefSeqi NP_001276834.1. NM_001289905.1. [Q96F46-2 ]
NP_055154.3. NM_014339.6. [Q96F46-1 ]
UniGenei Hs.48353.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3JVF X-ray 3.30 C 32-317 [» ]
4HSA X-ray 3.15 C/F 32-317 [» ]
4NUX X-ray 2.30 A 376-591 [» ]
ProteinModelPortali Q96F46.
SMRi Q96F46. Positions 33-304.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117265. 4 interactions.
IntActi Q96F46. 1 interaction.
STRINGi 9606.ENSP00000320936.

PTM databases

PhosphoSitei Q96F46.

Polymorphism databases

DMDMi 116242517.

Proteomic databases

MaxQBi Q96F46.
PaxDbi Q96F46.
PRIDEi Q96F46.

Protocols and materials databases

DNASUi 23765.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000319363 ; ENSP00000320936 ; ENSG00000177663 . [Q96F46-1 ]
GeneIDi 23765.
KEGGi hsa:23765.
UCSCi uc002zly.4. human. [Q96F46-1 ]

Organism-specific databases

CTDi 23765.
GeneCardsi GC22P017565.
HGNCi HGNC:5985. IL17RA.
HPAi CAB024996.
MIMi 605461. gene.
613953. phenotype.
neXtProti NX_Q96F46.
Orphaneti 1334. Chronic mucocutaneous candidiasis.
PharmGKBi PA29801.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40152.
HOGENOMi HOG000015327.
HOVERGENi HBG081775.
InParanoidi Q96F46.
KOi K05164.
OMAi MTWVGRQ.
OrthoDBi EOG7P8P7V.
PhylomeDBi Q96F46.
TreeFami TF329644.

Miscellaneous databases

EvolutionaryTracei Q96F46.
GeneWikii IL17RA.
GenomeRNAii 23765.
NextBioi 46725.
PROi Q96F46.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96F46.
Bgeei Q96F46.
CleanExi HS_IL17RA.
Genevestigatori Q96F46.

Family and domain databases

InterProi IPR013568. SEFIR.
[Graphical view ]
Pfami PF08357. SEFIR. 1 hit.
[Graphical view ]
PROSITEi PS51534. SEFIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: T-cell.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-367 AND HIS-580.
    Tissue: Uterus.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 33-47.
  6. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 237-431 (ISOFORM 2).
    Tissue: Placenta.
  7. Cited for: FUNCTION, IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE, TISSUE SPECIFICITY.
  8. Cited for: INVOLVEMENT IN CANDF5.
  9. "Identification of a soluble isoform of human IL-17RA generated by alternative splicing."
    Sohda M., Misumi Y., Tashiro K., Yamazaki M., Saku T., Oda K.
    Cytokine 64:642-645(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, SUBCELLULAR LOCATION.
  10. "Structural basis of receptor sharing by interleukin 17 cytokines."
    Ely L.K., Fischer S., Garcia K.C.
    Nat. Immunol. 10:1245-1251(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 32-317 IN COMPLEX WITH IL17F, GLYCOSYLATION AT ASN-49; ASN-54; ASN-67; ASN-225 AND ASN-265, FUNCTION, DISULFIDE BONDS.

Entry informationi

Entry nameiI17RA_HUMAN
AccessioniPrimary (citable) accession number: Q96F46
Secondary accession number(s): O43844, Q20WK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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