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Protein

Interleukin-17 receptor A

Gene

IL17RA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).6 Publications

GO - Molecular functioni

  • interleukin-17 receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-448424. Interleukin-17 signaling.
SIGNORiQ96F46.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor A
Short name:
IL-17 receptor A
Short name:
IL-17RA
Alternative name(s):
CDw217
CD_antigen: CD217
Gene namesi
Name:IL17RA
Synonyms:IL17R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:5985. IL17RA.

Subcellular locationi

Isoform 1 :
Isoform 2 :

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 320288ExtracellularSequence analysisAdd
BLAST
Transmembranei321 – 34121HelicalSequence analysisAdd
BLAST
Topological domaini342 – 866525CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Candidiasis, familial, 5 (CANDF5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
See also OMIM:613953

Organism-specific databases

MalaCardsiIL17RA.
MIMi613953. phenotype.
Orphaneti1334. Chronic mucocutaneous candidosis.
PharmGKBiPA29801.

Chemistry

GuidetoPHARMACOLOGYi1738.

Polymorphism and mutation databases

DMDMi116242517.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 32321 PublicationAdd
BLAST
Chaini33 – 866834Interleukin-17 receptor APRO_0000011030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 501 Publication
Glycosylationi49 – 491N-linked (GlcNAc...)1 Publication
Glycosylationi54 – 541N-linked (GlcNAc...)1 Publication
Disulfide bondi57 ↔ 1261 Publication
Glycosylationi67 – 671N-linked (GlcNAc...)1 Publication
Disulfide bondi185 ↔ 1961 Publication
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis
Glycosylationi225 – 2251N-linked (GlcNAc...)1 Publication
Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence analysis
Disulfide bondi245 ↔ 2761 Publication
Glycosylationi265 – 2651N-linked (GlcNAc...)1 Publication
Disulfide bondi290 ↔ 2941 Publication
Modified residuei708 – 7081PhosphoserineCombined sources
Modified residuei736 – 7361PhosphoserineBy similarity

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ96F46.
MaxQBiQ96F46.
PaxDbiQ96F46.
PeptideAtlasiQ96F46.
PRIDEiQ96F46.

PTM databases

iPTMnetiQ96F46.
PhosphoSiteiQ96F46.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ96F46.
CleanExiHS_IL17RA.
GenevisibleiQ96F46. HS.

Organism-specific databases

HPAiCAB024996.

Interactioni

Subunit structurei

Forms heterodimers with IL17RE; the heterodimer binds IL17C (PubMed:21993848). Forms heterodimers with IL17RC; the heterodimer binds IL17A and IL17F homodimers as well as the heterodimer formed by IL17A and IL17F (PubMed:16785495, PubMed:18684971).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IL17REQ8NFR92EBI-5591258,EBI-5591275

Protein-protein interaction databases

BioGridi117265. 69 interactions.
IntActiQ96F46. 1 interaction.
STRINGi9606.ENSP00000320936.

Structurei

Secondary structure

1
866
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 363Combined sources
Beta strandi50 – 556Combined sources
Helixi60 – 634Combined sources
Beta strandi73 – 8412Combined sources
Beta strandi86 – 883Combined sources
Beta strandi90 – 10011Combined sources
Helixi104 – 1085Combined sources
Beta strandi111 – 12111Combined sources
Beta strandi124 – 13310Combined sources
Beta strandi143 – 1508Combined sources
Beta strandi153 – 16513Combined sources
Beta strandi175 – 1828Combined sources
Helixi190 – 1923Combined sources
Helixi194 – 1985Combined sources
Turni199 – 2024Combined sources
Beta strandi208 – 2125Combined sources
Turni213 – 2153Combined sources
Beta strandi216 – 2205Combined sources
Beta strandi230 – 2389Combined sources
Beta strandi245 – 2528Combined sources
Helixi257 – 2593Combined sources
Beta strandi266 – 2694Combined sources
Beta strandi276 – 28510Combined sources
Turni288 – 2903Combined sources
Helixi291 – 2933Combined sources
Beta strandi296 – 3016Combined sources
Beta strandi379 – 3835Combined sources
Helixi389 – 40618Combined sources
Beta strandi409 – 4113Combined sources
Helixi413 – 4164Combined sources
Helixi417 – 4226Combined sources
Helixi425 – 43814Combined sources
Beta strandi442 – 4465Combined sources
Helixi449 – 45810Combined sources
Helixi478 – 4869Combined sources
Helixi487 – 4915Combined sources
Helixi493 – 4986Combined sources
Beta strandi499 – 5046Combined sources
Turni505 – 5073Combined sources
Helixi510 – 5123Combined sources
Beta strandi522 – 5254Combined sources
Turni526 – 5283Combined sources
Helixi529 – 5379Combined sources
Helixi557 – 5604Combined sources
Helixi564 – 58017Combined sources
Helixi584 – 5885Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JVFX-ray3.30C32-317[»]
4HSAX-ray3.15C/F32-317[»]
4NUXX-ray2.30A376-591[»]
ProteinModelPortaliQ96F46.
SMRiQ96F46. Positions 33-304, 376-591.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96F46.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini377 – 534158SEFIRPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi810 – 8189Poly-Glu

Sequence similaritiesi

Contains 1 SEFIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH6C. Eukaryota.
ENOG4111HRA. LUCA.
GeneTreeiENSGT00840000129816.
HOGENOMiHOG000015327.
HOVERGENiHBG081775.
InParanoidiQ96F46.
KOiK05164.
OMAiRMHRVGE.
OrthoDBiEOG7P8P7V.
PhylomeDBiQ96F46.
TreeFamiTF329644.

Family and domain databases

InterProiIPR032356. IL17R_fnIII_D1.
IPR013568. SEFIR_dom.
[Graphical view]
PfamiPF16556. IL17R_fnIII_D1. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96F46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAARSPPSA VPGPLLGLLL LLLGVLAPGG ASLRLLDHRA LVCSQPGLNC
60 70 80 90 100
TVKNSTCLDD SWIHPRNLTP SSPKDLQIQL HFAHTQQGDL FPVAHIEWTL
110 120 130 140 150
QTDASILYLE GAELSVLQLN TNERLCVRFE FLSKLRHHHR RWRFTFSHFV
160 170 180 190 200
VDPDQEYEVT VHHLPKPIPD GDPNHQSKNF LVPDCEHARM KVTTPCMSSG
210 220 230 240 250
SLWDPNITVE TLEAHQLRVS FTLWNESTHY QILLTSFPHM ENHSCFEHMH
260 270 280 290 300
HIPAPRPEEF HQRSNVTLTL RNLKGCCRHQ VQIQPFFSSC LNDCLRHSAT
310 320 330 340 350
VSCPEMPDTP EPIPDYMPLW VYWFITGISI LLVGSVILLI VCMTWRLAGP
360 370 380 390 400
GSEKYSDDTK YTDGLPAADL IPPPLKPRKV WIIYSADHPL YVDVVLKFAQ
410 420 430 440 450
FLLTACGTEV ALDLLEEQAI SEAGVMTWVG RQKQEMVESN SKIIVLCSRG
460 470 480 490 500
TRAKWQALLG RGAPVRLRCD HGKPVGDLFT AAMNMILPDF KRPACFGTYV
510 520 530 540 550
VCYFSEVSCD GDVPDLFGAA PRYPLMDRFE EVYFRIQDLE MFQPGRMHRV
560 570 580 590 600
GELSGDNYLR SPGGRQLRAA LDRFRDWQVR CPDWFECENL YSADDQDAPS
610 620 630 640 650
LDEEVFEEPL LPPGTGIVKR APLVREPGSQ ACLAIDPLVG EEGGAAVAKL
660 670 680 690 700
EPHLQPRGQP APQPLHTLVL AAEEGALVAA VEPGPLADGA AVRLALAGEG
710 720 730 740 750
EACPLLGSPG AGRNSVLFLP VDPEDSPLGS STPMASPDLL PEDVREHLEG
760 770 780 790 800
LMLSLFEQSL SCQAQGGCSR PAMVLTDPHT PYEEEQRQSV QSDQGYISRS
810 820 830 840 850
SPQPPEGLTE MEEEEEEEQD PGKPALPLSP EDLESLRSLQ RQLLFRQLQK
860
NSGWDTMGSE SEGPSA
Length:866
Mass (Da):96,122
Last modified:October 17, 2006 - v2
Checksum:i88AF626A83F3FF70
GO
Isoform 2 (identifier: Q96F46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     315-348: Missing.

Note: Soluble isoform lacking the transmembrane segment.
Show »
Length:832
Mass (Da):92,153
Checksum:iC37767EA444C0FF7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti367 – 3671A → V.1 Publication
Corresponds to variant rs879577 [ dbSNP | Ensembl ].
VAR_027966
Natural varianti562 – 5621P → Q.
Corresponds to variant rs12484684 [ dbSNP | Ensembl ].
VAR_049176
Natural varianti580 – 5801R → H.1 Publication
Corresponds to variant rs17850765 [ dbSNP | Ensembl ].
VAR_027967

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei315 – 34834Missing in isoform 2. 1 PublicationVSP_053496Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58917 mRNA. Translation: AAB99730.1.
CT841520 mRNA. Translation: CAJ86450.1.
CH471193 Genomic DNA. Translation: EAW57739.1.
BC011624 mRNA. Translation: AAH11624.1.
BX368715 mRNA. No translation available.
CCDSiCCDS13739.1. [Q96F46-1]
CCDS77645.1. [Q96F46-2]
RefSeqiNP_001276834.1. NM_001289905.1. [Q96F46-2]
NP_055154.3. NM_014339.6. [Q96F46-1]
UniGeneiHs.48353.

Genome annotation databases

EnsembliENST00000319363; ENSP00000320936; ENSG00000177663. [Q96F46-1]
ENST00000612619; ENSP00000479970; ENSG00000177663. [Q96F46-2]
GeneIDi23765.
KEGGihsa:23765.
UCSCiuc002zly.5. human. [Q96F46-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58917 mRNA. Translation: AAB99730.1.
CT841520 mRNA. Translation: CAJ86450.1.
CH471193 Genomic DNA. Translation: EAW57739.1.
BC011624 mRNA. Translation: AAH11624.1.
BX368715 mRNA. No translation available.
CCDSiCCDS13739.1. [Q96F46-1]
CCDS77645.1. [Q96F46-2]
RefSeqiNP_001276834.1. NM_001289905.1. [Q96F46-2]
NP_055154.3. NM_014339.6. [Q96F46-1]
UniGeneiHs.48353.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JVFX-ray3.30C32-317[»]
4HSAX-ray3.15C/F32-317[»]
4NUXX-ray2.30A376-591[»]
ProteinModelPortaliQ96F46.
SMRiQ96F46. Positions 33-304, 376-591.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117265. 69 interactions.
IntActiQ96F46. 1 interaction.
STRINGi9606.ENSP00000320936.

Chemistry

GuidetoPHARMACOLOGYi1738.

PTM databases

iPTMnetiQ96F46.
PhosphoSiteiQ96F46.

Polymorphism and mutation databases

DMDMi116242517.

Proteomic databases

EPDiQ96F46.
MaxQBiQ96F46.
PaxDbiQ96F46.
PeptideAtlasiQ96F46.
PRIDEiQ96F46.

Protocols and materials databases

DNASUi23765.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319363; ENSP00000320936; ENSG00000177663. [Q96F46-1]
ENST00000612619; ENSP00000479970; ENSG00000177663. [Q96F46-2]
GeneIDi23765.
KEGGihsa:23765.
UCSCiuc002zly.5. human. [Q96F46-1]

Organism-specific databases

CTDi23765.
GeneCardsiIL17RA.
HGNCiHGNC:5985. IL17RA.
HPAiCAB024996.
MalaCardsiIL17RA.
MIMi605461. gene.
613953. phenotype.
neXtProtiNX_Q96F46.
Orphaneti1334. Chronic mucocutaneous candidosis.
PharmGKBiPA29801.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH6C. Eukaryota.
ENOG4111HRA. LUCA.
GeneTreeiENSGT00840000129816.
HOGENOMiHOG000015327.
HOVERGENiHBG081775.
InParanoidiQ96F46.
KOiK05164.
OMAiRMHRVGE.
OrthoDBiEOG7P8P7V.
PhylomeDBiQ96F46.
TreeFamiTF329644.

Enzyme and pathway databases

ReactomeiR-HSA-448424. Interleukin-17 signaling.
SIGNORiQ96F46.

Miscellaneous databases

ChiTaRSiIL17RA. human.
EvolutionaryTraceiQ96F46.
GeneWikiiIL17RA.
GenomeRNAii23765.
PROiQ96F46.
SOURCEiSearch...

Gene expression databases

BgeeiQ96F46.
CleanExiHS_IL17RA.
GenevisibleiQ96F46. HS.

Family and domain databases

InterProiIPR032356. IL17R_fnIII_D1.
IPR013568. SEFIR_dom.
[Graphical view]
PfamiPF16556. IL17R_fnIII_D1. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    Tissue: T-cell.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-367 AND HIS-580.
    Tissue: Uterus.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 33-47.
  6. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 237-431 (ISOFORM 2).
    Tissue: Placenta.
  7. "Interleukin 17 signals through a heteromeric receptor complex."
    Toy D., Kugler D., Wolfson M., Vanden Bos T., Gurgel J., Derry J., Tocker J., Peschon J.
    J. Immunol. 177:36-39(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  8. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  9. Cited for: FUNCTION, SUBUNIT.
  10. Cited for: FUNCTION, IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE, TISSUE SPECIFICITY.
  11. Cited for: INVOLVEMENT IN CANDF5.
  12. "Identification of a soluble isoform of human IL-17RA generated by alternative splicing."
    Sohda M., Misumi Y., Tashiro K., Yamazaki M., Saku T., Oda K.
    Cytokine 64:642-645(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, SUBCELLULAR LOCATION.
  13. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-708, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  14. "Structural basis of receptor sharing by interleukin 17 cytokines."
    Ely L.K., Fischer S., Garcia K.C.
    Nat. Immunol. 10:1245-1251(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 32-317 IN COMPLEX WITH IL17F, GLYCOSYLATION AT ASN-49; ASN-54; ASN-67; ASN-225 AND ASN-265, FUNCTION, DISULFIDE BONDS.

Entry informationi

Entry nameiI17RA_HUMAN
AccessioniPrimary (citable) accession number: Q96F46
Secondary accession number(s): O43844, Q20WK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 17, 2006
Last modified: July 6, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.