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Q96F46 (I17RA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-17 receptor A

Short name=IL-17 receptor A
Short name=IL-17RA
Alternative name(s):
CDw217
CD_antigen=CD217
Gene names
Name:IL17RA
Synonyms:IL17R
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length866 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. Ref.7 Ref.10

Subunit structure

Forms heterodimers with IL17RE; the heterodimer binds IL17C.

Subcellular location

Isoform 1: Membrane; Single-pass type I membrane protein By similarity Ref.9.

Isoform 2: Secreted Ref.9.

Tissue specificity

Widely expressed. Ref.7

Post-translational modification

Glycosylated. Ref.10

Involvement in disease

Candidiasis, familial, 5 (CANDF5) [MIM:613953]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8

Sequence similarities

Contains 1 SEFIR domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

IL17REQ8NFR92EBI-5591258,EBI-5591275

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96F46-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96F46-2)

The sequence of this isoform differs from the canonical sequence as follows:
     315-348: Missing.
Note: Soluble isoform lacking the transmembrane segment.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Ref.5
Chain33 – 866834Interleukin-17 receptor A
PRO_0000011030

Regions

Topological domain33 – 320288Extracellular Potential
Transmembrane321 – 34121Helical; Potential
Topological domain342 – 866525Cytoplasmic Potential
Domain377 – 534158SEFIR
Compositional bias810 – 8189Poly-Glu

Amino acid modifications

Glycosylation491N-linked (GlcNAc...) Ref.10
Glycosylation541N-linked (GlcNAc...) Ref.10
Glycosylation671N-linked (GlcNAc...) Ref.10
Glycosylation2061N-linked (GlcNAc...) Potential
Glycosylation2251N-linked (GlcNAc...) Ref.10
Glycosylation2421N-linked (GlcNAc...) Potential
Glycosylation2651N-linked (GlcNAc...) Ref.10
Disulfide bond43 ↔ 50 Ref.10
Disulfide bond57 ↔ 126 Ref.10
Disulfide bond185 ↔ 196 Ref.10
Disulfide bond245 ↔ 276 Ref.10
Disulfide bond290 ↔ 294 Ref.10

Natural variations

Alternative sequence315 – 34834Missing in isoform 2.
VSP_053496
Natural variant3671A → V. Ref.4
Corresponds to variant rs879577 [ dbSNP | Ensembl ].
VAR_027966
Natural variant5621P → Q.
Corresponds to variant rs12484684 [ dbSNP | Ensembl ].
VAR_049176
Natural variant5801R → H. Ref.4
Corresponds to variant rs17850765 [ dbSNP | Ensembl ].
VAR_027967

Secondary structure

................................................. 866
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 88AF626A83F3FF70

FASTA86696,122
        10         20         30         40         50         60 
MGAARSPPSA VPGPLLGLLL LLLGVLAPGG ASLRLLDHRA LVCSQPGLNC TVKNSTCLDD 

        70         80         90        100        110        120 
SWIHPRNLTP SSPKDLQIQL HFAHTQQGDL FPVAHIEWTL QTDASILYLE GAELSVLQLN 

       130        140        150        160        170        180 
TNERLCVRFE FLSKLRHHHR RWRFTFSHFV VDPDQEYEVT VHHLPKPIPD GDPNHQSKNF 

       190        200        210        220        230        240 
LVPDCEHARM KVTTPCMSSG SLWDPNITVE TLEAHQLRVS FTLWNESTHY QILLTSFPHM 

       250        260        270        280        290        300 
ENHSCFEHMH HIPAPRPEEF HQRSNVTLTL RNLKGCCRHQ VQIQPFFSSC LNDCLRHSAT 

       310        320        330        340        350        360 
VSCPEMPDTP EPIPDYMPLW VYWFITGISI LLVGSVILLI VCMTWRLAGP GSEKYSDDTK 

       370        380        390        400        410        420 
YTDGLPAADL IPPPLKPRKV WIIYSADHPL YVDVVLKFAQ FLLTACGTEV ALDLLEEQAI 

       430        440        450        460        470        480 
SEAGVMTWVG RQKQEMVESN SKIIVLCSRG TRAKWQALLG RGAPVRLRCD HGKPVGDLFT 

       490        500        510        520        530        540 
AAMNMILPDF KRPACFGTYV VCYFSEVSCD GDVPDLFGAA PRYPLMDRFE EVYFRIQDLE 

       550        560        570        580        590        600 
MFQPGRMHRV GELSGDNYLR SPGGRQLRAA LDRFRDWQVR CPDWFECENL YSADDQDAPS 

       610        620        630        640        650        660 
LDEEVFEEPL LPPGTGIVKR APLVREPGSQ ACLAIDPLVG EEGGAAVAKL EPHLQPRGQP 

       670        680        690        700        710        720 
APQPLHTLVL AAEEGALVAA VEPGPLADGA AVRLALAGEG EACPLLGSPG AGRNSVLFLP 

       730        740        750        760        770        780 
VDPEDSPLGS STPMASPDLL PEDVREHLEG LMLSLFEQSL SCQAQGGCSR PAMVLTDPHT 

       790        800        810        820        830        840 
PYEEEQRQSV QSDQGYISRS SPQPPEGLTE MEEEEEEEQD PGKPALPLSP EDLESLRSLQ 

       850        860 
RQLLFRQLQK NSGWDTMGSE SEGPSA 

« Hide

Isoform 2 [UniParc].

Checksum: C37767EA444C0FF7
Show »

FASTA83292,153

References

« Hide 'large scale' references
[1]"Molecular characterization of the human interleukin (Il)-17 receptor."
Yao Z., Spriggs M.K., Derry J.M.J., Strockbine L., Park L.S., Vanden Bos T., Zappone J., Painter S.L., Armitage R.J.
Cytokine 9:794-800(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: T-cell.
[2]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-367 AND HIS-580.
Tissue: Uterus.
[5]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 33-47.
[6]"Full-length cDNA libraries and normalization."
Li W.B., Gruber C., Jessee J., Polayes D.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 237-431 (ISOFORM 2).
Tissue: Placenta.
[7]"IL-17C regulates the innate immune function of epithelial cells in an autocrine manner."
Ramirez-Carrozzi V., Sambandam A., Luis E., Lin Z., Jeet S., Lesch J., Hackney J., Kim J., Zhou M., Lai J., Modrusan Z., Sai T., Lee W., Xu M., Caplazi P., Diehl L., de Voss J., Balazs M. expand/collapse author list , Gonzalez L. Jr., Singh H., Ouyang W., Pappu R.
Nat. Immunol. 12:1159-1166(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE, TISSUE SPECIFICITY.
[8]"Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity."
Puel A., Cypowyj S., Bustamante J., Wright J.F., Liu L., Lim H.K., Migaud M., Israel L., Chrabieh M., Audry M., Gumbleton M., Toulon A., Bodemer C., El-Baghdadi J., Whitters M., Paradis T., Brooks J., Collins M. expand/collapse author list , Wolfman N.M., Al-Muhsen S., Galicchio M., Abel L., Picard C., Casanova J.L.
Science 332:65-68(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN CANDF5.
[9]"Identification of a soluble isoform of human IL-17RA generated by alternative splicing."
Sohda M., Misumi Y., Tashiro K., Yamazaki M., Saku T., Oda K.
Cytokine 64:642-645(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING, SUBCELLULAR LOCATION.
[10]"Structural basis of receptor sharing by interleukin 17 cytokines."
Ely L.K., Fischer S., Garcia K.C.
Nat. Immunol. 10:1245-1251(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 32-317 IN COMPLEX WITH IL17F, GLYCOSYLATION AT ASN-49; ASN-54; ASN-67; ASN-225 AND ASN-265, FUNCTION, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U58917 mRNA. Translation: AAB99730.1.
CT841520 mRNA. Translation: CAJ86450.1.
CH471193 Genomic DNA. Translation: EAW57739.1.
BC011624 mRNA. Translation: AAH11624.1.
BX368715 mRNA. No translation available.
RefSeqNP_055154.3. NM_014339.6.
UniGeneHs.48353.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3JVFX-ray3.30C32-317[»]
4HSAX-ray3.15C/F32-317[»]
ProteinModelPortalQ96F46.
SMRQ96F46. Positions 33-304, 375-541.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117265. 4 interactions.
IntActQ96F46. 1 interaction.
STRING9606.ENSP00000320936.

PTM databases

PhosphoSiteQ96F46.

Polymorphism databases

DMDM116242517.

Proteomic databases

PaxDbQ96F46.
PRIDEQ96F46.

Protocols and materials databases

DNASU23765.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000319363; ENSP00000320936; ENSG00000177663. [Q96F46-1]
GeneID23765.
KEGGhsa:23765.
UCSCuc002zly.4. human. [Q96F46-1]

Organism-specific databases

CTD23765.
GeneCardsGC22P017565.
HGNCHGNC:5985. IL17RA.
HPACAB024996.
MIM605461. gene.
613953. phenotype.
neXtProtNX_Q96F46.
Orphanet1334. Chronic mucocutaneous candidiasis.
PharmGKBPA29801.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40152.
HOGENOMHOG000015327.
HOVERGENHBG081775.
InParanoidQ96F46.
KOK05164.
OMAMTWVGRQ.
OrthoDBEOG7P8P7V.
PhylomeDBQ96F46.
TreeFamTF329644.

Gene expression databases

ArrayExpressQ96F46.
BgeeQ96F46.
CleanExHS_IL17RA.
GenevestigatorQ96F46.

Family and domain databases

InterProIPR013568. SEFIR.
[Graphical view]
PfamPF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEPS51534. SEFIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ96F46.
GeneWikiIL17RA.
GenomeRNAi23765.
NextBio46725.
PROQ96F46.
SOURCESearch...

Entry information

Entry nameI17RA_HUMAN
AccessionPrimary (citable) accession number: Q96F46
Secondary accession number(s): O43844, Q20WK1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries