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Protein

Interleukin-17 receptor A

Gene

IL17RA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).6 Publications

GO - Molecular functioni

  • interleukin-17 receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177663-MONOMER.
ReactomeiR-HSA-448424. Interleukin-17 signaling.
SIGNORiQ96F46.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor A
Short name:
IL-17 receptor A
Short name:
IL-17RA
Alternative name(s):
CDw217
CD_antigen: CD217
Gene namesi
Name:IL17RA
Synonyms:IL17R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:5985. IL17RA.

Subcellular locationi

Isoform 1 :
Isoform 2 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 320ExtracellularSequence analysisAdd BLAST288
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Topological domaini342 – 866CytoplasmicSequence analysisAdd BLAST525

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Candidiasis, familial, 5 (CANDF5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
See also OMIM:613953

Organism-specific databases

DisGeNETi23765.
MalaCardsiIL17RA.
MIMi613953. phenotype.
OpenTargetsiENSG00000177663.
Orphaneti1334. Chronic mucocutaneous candidosis.
PharmGKBiPA29801.

Chemistry databases

ChEMBLiCHEMBL3580485.
GuidetoPHARMACOLOGYi1738.

Polymorphism and mutation databases

DMDMi116242517.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 321 PublicationAdd BLAST32
ChainiPRO_000001103033 – 866Interleukin-17 receptor AAdd BLAST834

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 501 Publication
Glycosylationi49N-linked (GlcNAc...)1 Publication1
Glycosylationi54N-linked (GlcNAc...)1 Publication1
Disulfide bondi57 ↔ 1261 Publication
Glycosylationi67N-linked (GlcNAc...)1 Publication1
Disulfide bondi185 ↔ 1961 Publication
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Glycosylationi225N-linked (GlcNAc...)1 Publication1
Glycosylationi242N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi245 ↔ 2761 Publication
Glycosylationi265N-linked (GlcNAc...)1 Publication1
Disulfide bondi290 ↔ 2941 Publication
Modified residuei708PhosphoserineCombined sources1
Modified residuei736PhosphoserineBy similarity1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ96F46.
MaxQBiQ96F46.
PaxDbiQ96F46.
PeptideAtlasiQ96F46.
PRIDEiQ96F46.

PTM databases

iPTMnetiQ96F46.
PhosphoSitePlusiQ96F46.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000177663.
CleanExiHS_IL17RA.
GenevisibleiQ96F46. HS.

Organism-specific databases

HPAiCAB024996.

Interactioni

Subunit structurei

Forms heterodimers with IL17RE; the heterodimer binds IL17C (PubMed:21993848). Forms heterodimers with IL17RC; the heterodimer binds IL17A and IL17F homodimers as well as the heterodimer formed by IL17A and IL17F (PubMed:16785495, PubMed:18684971).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IL17REQ8NFR92EBI-5591258,EBI-5591275

Protein-protein interaction databases

BioGridi117265. 69 interactors.
IntActiQ96F46. 1 interactor.
STRINGi9606.ENSP00000320936.

Structurei

Secondary structure

1866
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 36Combined sources3
Beta strandi50 – 55Combined sources6
Helixi60 – 63Combined sources4
Beta strandi73 – 84Combined sources12
Beta strandi86 – 88Combined sources3
Beta strandi90 – 100Combined sources11
Helixi104 – 108Combined sources5
Beta strandi111 – 121Combined sources11
Beta strandi124 – 133Combined sources10
Beta strandi143 – 150Combined sources8
Beta strandi153 – 165Combined sources13
Beta strandi175 – 182Combined sources8
Helixi190 – 192Combined sources3
Helixi194 – 198Combined sources5
Turni199 – 202Combined sources4
Beta strandi208 – 212Combined sources5
Turni213 – 215Combined sources3
Beta strandi216 – 220Combined sources5
Beta strandi230 – 238Combined sources9
Beta strandi245 – 252Combined sources8
Helixi257 – 259Combined sources3
Beta strandi266 – 269Combined sources4
Beta strandi276 – 285Combined sources10
Turni288 – 290Combined sources3
Helixi291 – 293Combined sources3
Beta strandi296 – 301Combined sources6
Beta strandi379 – 383Combined sources5
Helixi389 – 406Combined sources18
Beta strandi409 – 411Combined sources3
Helixi413 – 416Combined sources4
Helixi417 – 422Combined sources6
Helixi425 – 438Combined sources14
Beta strandi442 – 446Combined sources5
Helixi449 – 458Combined sources10
Helixi478 – 486Combined sources9
Helixi487 – 491Combined sources5
Helixi493 – 498Combined sources6
Beta strandi499 – 504Combined sources6
Turni505 – 507Combined sources3
Helixi510 – 512Combined sources3
Beta strandi522 – 525Combined sources4
Turni526 – 528Combined sources3
Helixi529 – 537Combined sources9
Helixi557 – 560Combined sources4
Helixi564 – 580Combined sources17
Helixi584 – 588Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JVFX-ray3.30C32-317[»]
4HSAX-ray3.15C/F32-317[»]
4NUXX-ray2.30A376-591[»]
ProteinModelPortaliQ96F46.
SMRiQ96F46.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96F46.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini377 – 534SEFIRPROSITE-ProRule annotationAdd BLAST158

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi810 – 818Poly-Glu9

Sequence similaritiesi

Contains 1 SEFIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH6C. Eukaryota.
ENOG4111HRA. LUCA.
GeneTreeiENSGT00860000133810.
HOGENOMiHOG000015327.
HOVERGENiHBG081775.
InParanoidiQ96F46.
KOiK05164.
OMAiRMHRVGE.
OrthoDBiEOG091G01XZ.
PhylomeDBiQ96F46.
TreeFamiTF329644.

Family and domain databases

InterProiIPR032356. IL17R_fnIII_D1.
IPR013568. SEFIR_dom.
[Graphical view]
PfamiPF16556. IL17R_fnIII_D1. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96F46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAARSPPSA VPGPLLGLLL LLLGVLAPGG ASLRLLDHRA LVCSQPGLNC
60 70 80 90 100
TVKNSTCLDD SWIHPRNLTP SSPKDLQIQL HFAHTQQGDL FPVAHIEWTL
110 120 130 140 150
QTDASILYLE GAELSVLQLN TNERLCVRFE FLSKLRHHHR RWRFTFSHFV
160 170 180 190 200
VDPDQEYEVT VHHLPKPIPD GDPNHQSKNF LVPDCEHARM KVTTPCMSSG
210 220 230 240 250
SLWDPNITVE TLEAHQLRVS FTLWNESTHY QILLTSFPHM ENHSCFEHMH
260 270 280 290 300
HIPAPRPEEF HQRSNVTLTL RNLKGCCRHQ VQIQPFFSSC LNDCLRHSAT
310 320 330 340 350
VSCPEMPDTP EPIPDYMPLW VYWFITGISI LLVGSVILLI VCMTWRLAGP
360 370 380 390 400
GSEKYSDDTK YTDGLPAADL IPPPLKPRKV WIIYSADHPL YVDVVLKFAQ
410 420 430 440 450
FLLTACGTEV ALDLLEEQAI SEAGVMTWVG RQKQEMVESN SKIIVLCSRG
460 470 480 490 500
TRAKWQALLG RGAPVRLRCD HGKPVGDLFT AAMNMILPDF KRPACFGTYV
510 520 530 540 550
VCYFSEVSCD GDVPDLFGAA PRYPLMDRFE EVYFRIQDLE MFQPGRMHRV
560 570 580 590 600
GELSGDNYLR SPGGRQLRAA LDRFRDWQVR CPDWFECENL YSADDQDAPS
610 620 630 640 650
LDEEVFEEPL LPPGTGIVKR APLVREPGSQ ACLAIDPLVG EEGGAAVAKL
660 670 680 690 700
EPHLQPRGQP APQPLHTLVL AAEEGALVAA VEPGPLADGA AVRLALAGEG
710 720 730 740 750
EACPLLGSPG AGRNSVLFLP VDPEDSPLGS STPMASPDLL PEDVREHLEG
760 770 780 790 800
LMLSLFEQSL SCQAQGGCSR PAMVLTDPHT PYEEEQRQSV QSDQGYISRS
810 820 830 840 850
SPQPPEGLTE MEEEEEEEQD PGKPALPLSP EDLESLRSLQ RQLLFRQLQK
860
NSGWDTMGSE SEGPSA
Length:866
Mass (Da):96,122
Last modified:October 17, 2006 - v2
Checksum:i88AF626A83F3FF70
GO
Isoform 2 (identifier: Q96F46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     315-348: Missing.

Note: Soluble isoform lacking the transmembrane segment.
Show »
Length:832
Mass (Da):92,153
Checksum:iC37767EA444C0FF7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027966367A → V.1 PublicationCorresponds to variant rs879577dbSNPEnsembl.1
Natural variantiVAR_049176562P → Q.Corresponds to variant rs12484684dbSNPEnsembl.1
Natural variantiVAR_027967580R → H.1 PublicationCorresponds to variant rs17850765dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053496315 – 348Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58917 mRNA. Translation: AAB99730.1.
CT841520 mRNA. Translation: CAJ86450.1.
CH471193 Genomic DNA. Translation: EAW57739.1.
BC011624 mRNA. Translation: AAH11624.1.
BX368715 mRNA. No translation available.
CCDSiCCDS13739.1. [Q96F46-1]
CCDS77645.1. [Q96F46-2]
RefSeqiNP_001276834.1. NM_001289905.1. [Q96F46-2]
NP_055154.3. NM_014339.6. [Q96F46-1]
UniGeneiHs.48353.

Genome annotation databases

EnsembliENST00000319363; ENSP00000320936; ENSG00000177663. [Q96F46-1]
ENST00000612619; ENSP00000479970; ENSG00000177663. [Q96F46-2]
GeneIDi23765.
KEGGihsa:23765.
UCSCiuc002zly.5. human. [Q96F46-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58917 mRNA. Translation: AAB99730.1.
CT841520 mRNA. Translation: CAJ86450.1.
CH471193 Genomic DNA. Translation: EAW57739.1.
BC011624 mRNA. Translation: AAH11624.1.
BX368715 mRNA. No translation available.
CCDSiCCDS13739.1. [Q96F46-1]
CCDS77645.1. [Q96F46-2]
RefSeqiNP_001276834.1. NM_001289905.1. [Q96F46-2]
NP_055154.3. NM_014339.6. [Q96F46-1]
UniGeneiHs.48353.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JVFX-ray3.30C32-317[»]
4HSAX-ray3.15C/F32-317[»]
4NUXX-ray2.30A376-591[»]
ProteinModelPortaliQ96F46.
SMRiQ96F46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117265. 69 interactors.
IntActiQ96F46. 1 interactor.
STRINGi9606.ENSP00000320936.

Chemistry databases

ChEMBLiCHEMBL3580485.
GuidetoPHARMACOLOGYi1738.

PTM databases

iPTMnetiQ96F46.
PhosphoSitePlusiQ96F46.

Polymorphism and mutation databases

DMDMi116242517.

Proteomic databases

EPDiQ96F46.
MaxQBiQ96F46.
PaxDbiQ96F46.
PeptideAtlasiQ96F46.
PRIDEiQ96F46.

Protocols and materials databases

DNASUi23765.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319363; ENSP00000320936; ENSG00000177663. [Q96F46-1]
ENST00000612619; ENSP00000479970; ENSG00000177663. [Q96F46-2]
GeneIDi23765.
KEGGihsa:23765.
UCSCiuc002zly.5. human. [Q96F46-1]

Organism-specific databases

CTDi23765.
DisGeNETi23765.
GeneCardsiIL17RA.
HGNCiHGNC:5985. IL17RA.
HPAiCAB024996.
MalaCardsiIL17RA.
MIMi605461. gene.
613953. phenotype.
neXtProtiNX_Q96F46.
OpenTargetsiENSG00000177663.
Orphaneti1334. Chronic mucocutaneous candidosis.
PharmGKBiPA29801.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH6C. Eukaryota.
ENOG4111HRA. LUCA.
GeneTreeiENSGT00860000133810.
HOGENOMiHOG000015327.
HOVERGENiHBG081775.
InParanoidiQ96F46.
KOiK05164.
OMAiRMHRVGE.
OrthoDBiEOG091G01XZ.
PhylomeDBiQ96F46.
TreeFamiTF329644.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177663-MONOMER.
ReactomeiR-HSA-448424. Interleukin-17 signaling.
SIGNORiQ96F46.

Miscellaneous databases

ChiTaRSiIL17RA. human.
EvolutionaryTraceiQ96F46.
GeneWikiiIL17RA.
GenomeRNAii23765.
PROiQ96F46.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177663.
CleanExiHS_IL17RA.
GenevisibleiQ96F46. HS.

Family and domain databases

InterProiIPR032356. IL17R_fnIII_D1.
IPR013568. SEFIR_dom.
[Graphical view]
PfamiPF16556. IL17R_fnIII_D1. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI17RA_HUMAN
AccessioniPrimary (citable) accession number: Q96F46
Secondary accession number(s): O43844, Q20WK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.