Interleukin-17 receptor A precursor

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Q96F46 (I17RA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 109. History...

Clusters with 100%, 90%, 50% identity |

Documents (7) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Interleukin-17 receptor A
Short name=IL-17 receptor A
Short name=IL-17RA

Alternative name(s):
CDw217
CD_antigen=CD217

Gene names

Name:	IL17RA
Synonyms:	IL17R

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	866 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. Ref.6 Ref.8
Subunit structure	Forms heterodimers with IL17RE; the heterodimer binds IL17C.
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Tissue specificity	Widely expressed. Ref.6
Post-translational modification	Glycosylated. Ref.8
Involvement in disease	Familial candidiasis 5 (CANDF5) [MIM:613953]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7
Sequence similarities	Contains 1 SEFIR domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	fibroblast activation Inferred from direct assay PubMed 21145111. Source: BHF-UCL positive regulation of cytokine production involved in inflammatory response Inferred from electronic annotation. Source: Compara positive regulation of interleukin-23 production Inferred from direct assay PubMed 21145111. Source: BHF-UCL
Cellular_component	integral to plasma membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	interleukin-17 receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IL17RE	Q8NFR9	2	EBI-5591258,EBI-5591275

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 32

Ref.5

Chain

33 – 866

834

Interleukin-17 receptor A

PRO_0000011030

Regions

Topological domain

33 – 320

288

Extracellular Potential

Transmembrane

321 – 341

Helical; Potential

Topological domain

342 – 866

525

Cytoplasmic Potential

Domain

377 – 534

158

SEFIR

Compositional bias

810 – 818

Poly-Glu

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Ref.8

Glycosylation

N-linked (GlcNAc...) Ref.8

Glycosylation

N-linked (GlcNAc...) Ref.8

Glycosylation

206

N-linked (GlcNAc...) Potential

Glycosylation

225

N-linked (GlcNAc...) Ref.8

Glycosylation

242

N-linked (GlcNAc...) Potential

Glycosylation

265

N-linked (GlcNAc...) Ref.8

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Natural variations

Natural variant

367

A → V. Ref.4
Corresponds to variant rs879577 [ dbSNP | Ensembl ].

VAR_027966

Natural variant

562

P → Q.
Corresponds to variant rs12484684 [ dbSNP | Ensembl ].

VAR_049176

Natural variant

580

R → H. Ref.4
Corresponds to variant rs17850765 [ dbSNP | Ensembl ].

VAR_027967

Secondary structure

866

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q96F46 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 88AF626A83F3FF70
Show »

FASTA

866

96,122

        10         20         30         40         50         60 
MGAARSPPSA VPGPLLGLLL LLLGVLAPGG ASLRLLDHRA LVCSQPGLNC TVKNSTCLDD 

        70         80         90        100        110        120 
SWIHPRNLTP SSPKDLQIQL HFAHTQQGDL FPVAHIEWTL QTDASILYLE GAELSVLQLN 

       130        140        150        160        170        180 
TNERLCVRFE FLSKLRHHHR RWRFTFSHFV VDPDQEYEVT VHHLPKPIPD GDPNHQSKNF 

       190        200        210        220        230        240 
LVPDCEHARM KVTTPCMSSG SLWDPNITVE TLEAHQLRVS FTLWNESTHY QILLTSFPHM 

       250        260        270        280        290        300 
ENHSCFEHMH HIPAPRPEEF HQRSNVTLTL RNLKGCCRHQ VQIQPFFSSC LNDCLRHSAT 

       310        320        330        340        350        360 
VSCPEMPDTP EPIPDYMPLW VYWFITGISI LLVGSVILLI VCMTWRLAGP GSEKYSDDTK 

       370        380        390        400        410        420 
YTDGLPAADL IPPPLKPRKV WIIYSADHPL YVDVVLKFAQ FLLTACGTEV ALDLLEEQAI 

       430        440        450        460        470        480 
SEAGVMTWVG RQKQEMVESN SKIIVLCSRG TRAKWQALLG RGAPVRLRCD HGKPVGDLFT 

       490        500        510        520        530        540 
AAMNMILPDF KRPACFGTYV VCYFSEVSCD GDVPDLFGAA PRYPLMDRFE EVYFRIQDLE 

       550        560        570        580        590        600 
MFQPGRMHRV GELSGDNYLR SPGGRQLRAA LDRFRDWQVR CPDWFECENL YSADDQDAPS 

       610        620        630        640        650        660 
LDEEVFEEPL LPPGTGIVKR APLVREPGSQ ACLAIDPLVG EEGGAAVAKL EPHLQPRGQP 

       670        680        690        700        710        720 
APQPLHTLVL AAEEGALVAA VEPGPLADGA AVRLALAGEG EACPLLGSPG AGRNSVLFLP 

       730        740        750        760        770        780 
VDPEDSPLGS STPMASPDLL PEDVREHLEG LMLSLFEQSL SCQAQGGCSR PAMVLTDPHT 

       790        800        810        820        830        840 
PYEEEQRQSV QSDQGYISRS SPQPPEGLTE MEEEEEEEQD PGKPALPLSP EDLESLRSLQ 

       850        860 
RQLLFRQLQK NSGWDTMGSE SEGPSA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of the human interleukin (Il)-17 receptor." Yao Z., Spriggs M.K., Derry J.M.J., Strockbine L., Park L.S., Vanden Bos T., Zappone J., Painter S.L., Armitage R.J. Cytokine 9:794-800(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: T-cell.
[2]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-367 AND HIS-580. Tissue: Uterus.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 33-47.
[6]	"IL-17C regulates the innate immune function of epithelial cells in an autocrine manner." Ramirez-Carrozzi V., Sambandam A., Luis E., Lin Z., Jeet S., Lesch J., Hackney J., Kim J., Zhou M., Lai J., Modrusan Z., Sai T., Lee W., Xu M., Caplazi P., Diehl L., de Voss J., Balazs M. Pappu R. Nat. Immunol. 12:1159-1166(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE, TISSUE SPECIFICITY.
[7]	"Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity." Puel A., Cypowyj S., Bustamante J., Wright J.F., Liu L., Lim H.K., Migaud M., Israel L., Chrabieh M., Audry M., Gumbleton M., Toulon A., Bodemer C., El-Baghdadi J., Whitters M., Paradis T., Brooks J., Collins M. Casanova J.L. Science 332:65-68(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN CANDF5.
[8]	"Structural basis of receptor sharing by interleukin 17 cytokines." Ely L.K., Fischer S., Garcia K.C. Nat. Immunol. 10:1245-1251(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 32-317 IN COMPLEX WITH IL17F, GLYCOSYLATION AT ASN-49; ASN-54; ASN-67; ASN-225 AND ASN-265, FUNCTION, DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U58917 mRNA. Translation: AAB99730.1.
CT841520 mRNA. Translation: CAJ86450.1.
CH471193 Genomic DNA. Translation: EAW57739.1.
BC011624 mRNA. Translation: AAH11624.1.

IPI

IPI00304993.

RefSeq

NP_055154.3. NM_014339.6.

UniGene

Hs.48353.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3JVF	X-ray	3.30	C	32-317	[»]

ProteinModelPortal

Q96F46.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q96F46. 1 interaction.

STRING

9606.ENSP00000320936.

PTM databases

PhosphoSite

Q96F46.

Polymorphism databases

DMDM

116242517.

Proteomic databases

PaxDb

Q96F46.

PRIDE

Q96F46.

Protocols and materials databases

DNASU

23765.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000319363; ENSP00000320936; ENSG00000177663.

GeneID

23765.

KEGG

hsa:23765.

UCSC

uc002zly.3. human.

Organism-specific databases

CTD

23765.

GeneCards

GC22P017565.

HGNC

HGNC:5985. IL17RA.

HPA

CAB024996.

MIM

605461. gene.
613953. phenotype.

neXtProt

NX_Q96F46.

Orphanet

1334. Chronic mucocutaneous candidiasis.

PharmGKB

PA29801.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG40152.

HOGENOM

HOG000015327.

HOVERGEN

HBG081775.

InParanoid

Q96F46.

K05164.

OMA

MTWVGRQ.

OrthoDB

EOG4ZCT3T.

PhylomeDB

Q96F46.

Gene expression databases

ArrayExpress

Q96F46.

Bgee

Q96F46.

CleanEx

HS_IL17RA.

Genevestigator

Q96F46.

GermOnline

ENSG00000177663. Homo sapiens.

Family and domain databases

InterPro

IPR013568. SEFIR.
[Graphical view]

Pfam

PF08357. SEFIR. 1 hit.
[Graphical view]

PROSITE

PS51534. SEFIR. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q96F46.

GenomeRNAi

23765.

NextBio

46725.

SOURCE

Search...

Entry information

Entry name

I17RA_HUMAN

Accession

Primary (citable) accession number: Q96F46
Secondary accession number(s): O43844, Q20WK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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CD nomenclature of surface proteins of human leucocytes and list of entries

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Human chromosome 22: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents