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Protein

Zinc finger protein 503

Gene

ZNF503

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcriptional repressor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri514 – 542C2H2-typePROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165655-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 503
Gene namesi
Name:ZNF503
Synonyms:NOLZ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23589. ZNF503.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165655.
PharmGKBiPA134904334.

Polymorphism and mutation databases

BioMutaiZNF503.
DMDMi74762652.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002922041 – 646Zinc finger protein 503Add BLAST646

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphoserineBy similarity1
Modified residuei209N6-acetyllysineBy similarity1
Modified residuei231PhosphoserineBy similarity1
Modified residuei237PhosphoserineBy similarity1
Modified residuei636Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ96F45.
MaxQBiQ96F45.
PaxDbiQ96F45.
PeptideAtlasiQ96F45.
PRIDEiQ96F45.

PTM databases

iPTMnetiQ96F45.
PhosphoSitePlusiQ96F45.

Expressioni

Gene expression databases

BgeeiENSG00000165655.
GenevisibleiQ96F45. HS.

Organism-specific databases

HPAiHPA026848.

Interactioni

Protein-protein interaction databases

BioGridi124306. 13 interactors.
IntActiQ96F45. 5 interactors.
STRINGi9606.ENSP00000361602.

Structurei

3D structure databases

ProteinModelPortaliQ96F45.
SMRiQ96F45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 51Gly-richAdd BLAST35
Compositional biasi141 – 322Gly-richAdd BLAST182
Compositional biasi392 – 490Ala-richAdd BLAST99

Sequence similaritiesi

Belongs to the Elbow/Noc family.Curated
Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri514 – 542C2H2-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IH04. Eukaryota.
ENOG4111EZY. LUCA.
GeneTreeiENSGT00390000014618.
HOGENOMiHOG000043108.
HOVERGENiHBG054325.
InParanoidiQ96F45.
OMAiDKKEPGG.
OrthoDBiEOG091G09NU.
PhylomeDBiQ96F45.
TreeFamiTF324968.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR022129. Tscrpt_rep_NocA-like.
IPR007087. Znf_C2H2.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12402. nlz1. 1 hit.
[Graphical view]
PROSITEiPS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96F45-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTAPSLSAL RSSKHSGGGG GGGGGGGADP AWTSALSGNS SGPGPGSSPA
60 70 80 90 100
GSTKPFVHAV PPSDPLRQAN RLPIKVLKML TARTGHILHP EYLQPLPSTP
110 120 130 140 150
VSPIELDAKK SPLALLAQTC SQIGKPDPSP SSKLSSVASN GGGAGGAGGG
160 170 180 190 200
AAGDKDTKSG PLKLSDIGVE DKSSFKPYSK PGSDKKEPGG GGGGGGGGGG
210 220 230 240 250
GGGGVSSEKS GFRVPSATCQ PFTPRTGSPS SSASACSPGG MLSSAGGAPE
260 270 280 290 300
GKDDKKDTDV GGGGKGTGGA SAEGGPTGLA HGRISCGGGI NVDVNQHPDG
310 320 330 340 350
GPGGKALGSD CGGSSGSSSG SGPSAPTSSS VLGSGLVAPV SPYKPGQTVF
360 370 380 390 400
PLPPAGMTYP GSLAGAYAGY PPQFLPHGVA LDPTKPGSLV GAQLAAAAAG
410 420 430 440 450
SLGCSKPAGS SPLAGASPPS VMTASLCRDP YCLSYHCASH LAGAAAASAS
460 470 480 490 500
CAHDPAAAAA ALKSGYPLVY PTHPLHGVHS SLTAAAAAGA TPPSLAGHPL
510 520 530 540 550
YPYGFMLPND PLPHICNWVS ANGPCDKRFA TSEELLSHLR THTAFPGTDK
560 570 580 590 600
LLSGYPSSSS LASAAAAAMA CHMHIPTSGA PGSPGTLALR SPHHALGLSS
610 620 630 640
RYHPYSKSPL PTPGAPVPVP AATGPYYSPY ALYGQRLTTA SALGYQ
Length:646
Mass (Da):62,555
Last modified:December 1, 2001 - v1
Checksum:iF7F341E6C8170B85
GO
Isoform 2 (identifier: Q96F45-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-269: Missing.

Note: No experimental confirmation available.
Show »
Length:609
Mass (Da):59,292
Checksum:i4A1D2536F82CCFD7
GO
Isoform 3 (identifier: Q96F45-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-492: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):28,924
Checksum:i1A8ABB0940871F9C
GO

Sequence cautioni

The sequence BAC03999 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032951509N → K.Corresponds to variant rs35764982dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026394130 – 492Missing in isoform 3. 1 PublicationAdd BLAST363
Alternative sequenceiVSP_026395233 – 269Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007494 mRNA. Translation: AAH07494.1.
BC011625 mRNA. Translation: AAH11625.1.
BC013011 mRNA. Translation: AAH13011.1.
BC021165 mRNA. Translation: AAH21165.1.
AK092897 mRNA. Translation: BAC03999.1. Different initiation.
CCDSiCCDS7350.1. [Q96F45-1]
RefSeqiNP_116161.2. NM_032772.5. [Q96F45-1]
UniGeneiHs.195710.

Genome annotation databases

EnsembliENST00000372524; ENSP00000361602; ENSG00000165655. [Q96F45-1]
GeneIDi84858.
KEGGihsa:84858.
UCSCiuc001jxg.4. human. [Q96F45-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007494 mRNA. Translation: AAH07494.1.
BC011625 mRNA. Translation: AAH11625.1.
BC013011 mRNA. Translation: AAH13011.1.
BC021165 mRNA. Translation: AAH21165.1.
AK092897 mRNA. Translation: BAC03999.1. Different initiation.
CCDSiCCDS7350.1. [Q96F45-1]
RefSeqiNP_116161.2. NM_032772.5. [Q96F45-1]
UniGeneiHs.195710.

3D structure databases

ProteinModelPortaliQ96F45.
SMRiQ96F45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124306. 13 interactors.
IntActiQ96F45. 5 interactors.
STRINGi9606.ENSP00000361602.

PTM databases

iPTMnetiQ96F45.
PhosphoSitePlusiQ96F45.

Polymorphism and mutation databases

BioMutaiZNF503.
DMDMi74762652.

Proteomic databases

EPDiQ96F45.
MaxQBiQ96F45.
PaxDbiQ96F45.
PeptideAtlasiQ96F45.
PRIDEiQ96F45.

Protocols and materials databases

DNASUi84858.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372524; ENSP00000361602; ENSG00000165655. [Q96F45-1]
GeneIDi84858.
KEGGihsa:84858.
UCSCiuc001jxg.4. human. [Q96F45-1]

Organism-specific databases

CTDi84858.
GeneCardsiZNF503.
HGNCiHGNC:23589. ZNF503.
HPAiHPA026848.
MIMi613902. gene.
neXtProtiNX_Q96F45.
OpenTargetsiENSG00000165655.
PharmGKBiPA134904334.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH04. Eukaryota.
ENOG4111EZY. LUCA.
GeneTreeiENSGT00390000014618.
HOGENOMiHOG000043108.
HOVERGENiHBG054325.
InParanoidiQ96F45.
OMAiDKKEPGG.
OrthoDBiEOG091G09NU.
PhylomeDBiQ96F45.
TreeFamiTF324968.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165655-MONOMER.

Miscellaneous databases

ChiTaRSiZNF503. human.
GenomeRNAii84858.
PROiQ96F45.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165655.
GenevisibleiQ96F45. HS.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR022129. Tscrpt_rep_NocA-like.
IPR007087. Znf_C2H2.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12402. nlz1. 1 hit.
[Graphical view]
PROSITEiPS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN503_HUMAN
AccessioniPrimary (citable) accession number: Q96F45
Secondary accession number(s): Q8NAC5, Q96E25, Q96IJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.