ID   Q96F31_HUMAN            Unreviewed;       423 AA.
AC   Q96F31;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 2.
DT   27-MAR-2024, entry version 141.
DE   SubName: Full=NFKBIE protein {ECO:0000313|EMBL:AAH11676.2};
DE   Flags: Fragment;
GN   Name=NFKBIE {ECO:0000313|EMBL:AAH11676.2};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH11676.2};
RN   [1] {ECO:0000313|EMBL:AAH11676.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAH63609.1}, and Pancreas
RC   {ECO:0000313|EMBL:AAH11676.2};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the NF-kappa-B inhibitor family.
CC       {ECO:0000256|ARBA:ARBA00038439}.
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DR   EMBL; BC011676; AAH11676.2; -; mRNA.
DR   EMBL; BC063609; AAH63609.1; -; mRNA.
DR   RefSeq; NP_004547.2; NM_004556.2.
DR   AlphaFoldDB; Q96F31; -.
DR   IntAct; Q96F31; 1.
DR   iPTMnet; Q96F31; -.
DR   PeptideAtlas; Q96F31; -.
DR   DNASU; 4794; -.
DR   GeneID; 4794; -.
DR   KEGG; hsa:4794; -.
DR   CTD; 4794; -.
DR   PharmGKB; PA31603; -.
DR   OrthoDB; 621606at2759; -.
DR   BioGRID-ORCS; 4794; 166 hits in 1156 CRISPR screens.
DR   ChiTaRS; NFKBIE; human.
DR   GenomeRNAi; 4794; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR46680; NF-KAPPA-B INHIBITOR ALPHA; 1.
DR   PANTHER; PTHR46680:SF5; NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 3.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
PE   2: Evidence at transcript level;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW   ProRule:PRU00023}; Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REPEAT          292..324
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          326..358
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          359..391
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          1..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..106
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..131
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAH11676.2"
SQ   SEQUENCE   423 AA;  45028 MW;  1633E11CFA7217E8 CRC64;
     WPALRTLSSL RAGPSEPHSP GRRPPRAGRP LCQADPQPGK AARRSLEPDP AQTGPRPARA
     AGMSEARKGP DEAEESQYDS GIESLRSLRS LPESTSAPAS GPSDGSPQPC THPPGPVKEP
     QEKEDADGER ADSTYGSSSL TYTLSLLGGP EAEDPAPRLP LPHVGALSPQ QLEALTYISE
     DGDTLVHLAV IHEAPAVLLC CLALLPQEVL DIQNNLYQTA LHLAVHLDQP GAVRALVLKG
     ASRALQDRHG DTALHVACQR QHLACARCLL EGRPEPGRGT SHSLDLQLQN WQGLACLHIA
     TLQKNQPLME LLLRNGADID VQEGTSGKTA LHLAVETQER GLVQFLLQAG AQVDARMLNG
     CTPLHLAAGR GLMGISSTLC KAGADSLLRN VEDETPQDLT EESLVLLPFD DLKISGKLLL
     CTD
//