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Q96F25

- ALG14_HUMAN

UniProt

Q96F25 - ALG14_HUMAN

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Protein

UDP-N-acetylglucosamine transferase subunit ALG14 homolog

Gene

ALG14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER.1 Publication

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. dolichol-linked oligosaccharide biosynthetic process Source: Reactome
  3. post-translational protein modification Source: Reactome
  4. protein N-linked glycosylation via asparagine Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_22433. Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine transferase subunit ALG14 homolog
Gene namesi
Name:ALG14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:28287. ALG14.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti353327. Congenital myasthenic syndromes with glycosylation defect.
PharmGKBiPA142672628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216UDP-N-acetylglucosamine transferase subunit ALG14 homologPRO_0000265116Add
BLAST

Proteomic databases

MaxQBiQ96F25.
PaxDbiQ96F25.
PRIDEiQ96F25.

PTM databases

PhosphoSiteiQ96F25.

Expressioni

Gene expression databases

BgeeiQ96F25.
CleanExiHS_ALG14.
GenevestigatoriQ96F25.

Organism-specific databases

HPAiHPA031829.

Interactioni

Subunit structurei

Heterodimer with ALG13 isoform 2 to form a functional enzyme.By similarity

Protein-protein interaction databases

BioGridi128278. 2 interactions.
STRINGi9606.ENSP00000359224.

Structurei

3D structure databases

ProteinModelPortaliQ96F25.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33LumenalSequence Analysis
Topological domaini25 – 216192CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the ALG14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0707.
GeneTreeiENSGT00390000002579.
HOGENOMiHOG000182099.
HOVERGENiHBG059605.
InParanoidiQ96F25.
KOiK07441.
OMAiCIPLCAS.
OrthoDBiEOG7SN8DK.
PhylomeDBiQ96F25.
TreeFamiTF105628.

Family and domain databases

InterProiIPR013969. Oligosacch_biosynth_Alg14.
[Graphical view]
PANTHERiPTHR12154. PTHR12154. 1 hit.
PfamiPF08660. Alg14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96F25-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVCVLVLAAA AGAVAVFLIL RIWVVLRSMD VTPRESLSIL VVAGSGGHTT
60 70 80 90 100
EILRLLGSLS NAYSPRHYVI ADTDEMSANK INSFELDRAD RDPSNMYTKY
110 120 130 140 150
YIHRIPRSRE VQQSWPSTVF TTLHSMWLSF PLIHRVKPDL VLCNGPGTCV
160 170 180 190 200
PICVSALLLG ILGIKKVIIV YVESICRVET LSMSGKILFH LSDYFIVQWP
210
ALKEKYPKSV YLGRIV
Length:216
Mass (Da):24,151
Last modified:December 1, 2001 - v1
Checksum:i0724FEAE33A841E8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141V → M.
Corresponds to variant rs11165298 [ dbSNP | Ensembl ].
VAR_029635

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK289395 mRNA. Translation: BAF82084.1.
CH471097 Genomic DNA. Translation: EAW73027.1.
BC011706 mRNA. Translation: AAH11706.1.
CCDSiCCDS752.1.
RefSeqiNP_659425.1. NM_144988.3.
UniGeneiHs.408927.

Genome annotation databases

EnsembliENST00000370205; ENSP00000359224; ENSG00000172339.
GeneIDi199857.
KEGGihsa:199857.
UCSCiuc001dra.2. human.

Polymorphism databases

DMDMi74731649.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK289395 mRNA. Translation: BAF82084.1 .
CH471097 Genomic DNA. Translation: EAW73027.1 .
BC011706 mRNA. Translation: AAH11706.1 .
CCDSi CCDS752.1.
RefSeqi NP_659425.1. NM_144988.3.
UniGenei Hs.408927.

3D structure databases

ProteinModelPortali Q96F25.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128278. 2 interactions.
STRINGi 9606.ENSP00000359224.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSitei Q96F25.

Polymorphism databases

DMDMi 74731649.

Proteomic databases

MaxQBi Q96F25.
PaxDbi Q96F25.
PRIDEi Q96F25.

Protocols and materials databases

DNASUi 199857.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370205 ; ENSP00000359224 ; ENSG00000172339 .
GeneIDi 199857.
KEGGi hsa:199857.
UCSCi uc001dra.2. human.

Organism-specific databases

CTDi 199857.
GeneCardsi GC01M095449.
HGNCi HGNC:28287. ALG14.
HPAi HPA031829.
MIMi 612866. gene.
neXtProti NX_Q96F25.
Orphaneti 353327. Congenital myasthenic syndromes with glycosylation defect.
PharmGKBi PA142672628.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0707.
GeneTreei ENSGT00390000002579.
HOGENOMi HOG000182099.
HOVERGENi HBG059605.
InParanoidi Q96F25.
KOi K07441.
OMAi CIPLCAS.
OrthoDBi EOG7SN8DK.
PhylomeDBi Q96F25.
TreeFami TF105628.

Enzyme and pathway databases

Reactomei REACT_22433. Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

Miscellaneous databases

ChiTaRSi ALG14. human.
GeneWikii ALG14.
GenomeRNAii 199857.
NextBioi 89753.
PROi Q96F25.
SOURCEi Search...

Gene expression databases

Bgeei Q96F25.
CleanExi HS_ALG14.
Genevestigatori Q96F25.

Family and domain databases

InterProi IPR013969. Oligosacch_biosynth_Alg14.
[Graphical view ]
PANTHERi PTHR12154. PTHR12154. 1 hit.
Pfami PF08660. Alg14. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  4. "Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation."
    Gao X.-D., Tachikawa H., Sato T., Jigami Y., Dean N.
    J. Biol. Chem. 280:36254-36262(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiALG14_HUMAN
AccessioniPrimary (citable) accession number: Q96F25
Secondary accession number(s): A8K030
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3