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Q96F10

- SAT2_HUMAN

UniProt

Q96F10 - SAT2_HUMAN

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Protein

Diamine acetyltransferase 2

Gene

SAT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N1acetylspermine = putrescine.

Catalytic activityi

Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921Substrate; via carbonyl oxygenBy similarity
Binding sitei140 – 1401Acetyl-CoA1 Publication
Binding sitei152 – 1521SubstrateBy similarity

GO - Molecular functioni

  1. diamine N-acetyltransferase activity Source: UniProt

GO - Biological processi

  1. nor-spermidine metabolic process Source: UniProt
  2. putrescine acetylation Source: UniProt
  3. putrescine catabolic process Source: UniProtKB-UniPathway
  4. spermidine acetylation Source: UniProt
  5. spermine acetylation Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.57. 2681.
UniPathwayiUPA00188; UER00363.

Names & Taxonomyi

Protein namesi
Recommended name:
Diamine acetyltransferase 2 (EC:2.3.1.57)
Alternative name(s):
Polyamine N-acetyltransferase 2
Spermidine/spermine N(1)-acetyltransferase 2
Thialysine N-epsilon-acetyltransferase
Gene namesi
Name:SAT2
Synonyms:SSAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:23160. SAT2.

Subcellular locationi

Cytoplasm
Note: Intracellular organelles.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134979941.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170170Diamine acetyltransferase 2PRO_0000074598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96F10.
PaxDbiQ96F10.
PRIDEiQ96F10.

PTM databases

PhosphoSiteiQ96F10.

Expressioni

Tissue specificityi

Widely expressed.

Inductioni

Not inducible by polyamine analogs.

Gene expression databases

BgeeiQ96F10.
CleanExiHS_SAT2.
ExpressionAtlasiQ96F10. baseline and differential.
GenevestigatoriQ96F10.

Organism-specific databases

HPAiHPA022136.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi125190. 5 interactions.
IntActiQ96F10. 1 interaction.
MINTiMINT-1476751.
STRINGi9606.ENSP00000269298.

Structurei

Secondary structure

1
170
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 85
Helixi11 – 133
Helixi14 – 2815
Helixi38 – 469
Beta strandi47 – 493
Beta strandi53 – 597
Beta strandi70 – 8213
Turni83 – 853
Beta strandi86 – 9611
Helixi98 – 1003
Beta strandi102 – 1043
Helixi105 – 11915
Beta strandi124 – 1307
Helixi134 – 1429
Helixi148 – 1525
Beta strandi154 – 1607
Helixi162 – 1676

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BEIX-ray1.84A/B2-170[»]
2Q4VX-ray1.84A/B2-170[»]
ProteinModelPortaliQ96F10.
SMRiQ96F10. Positions 2-170.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96F10.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 168165N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 282Substrate bindingBy similarity
Regioni94 – 963Acetyl-CoA binding
Regioni102 – 1076Acetyl-CoA binding
Regioni133 – 1353Acetyl-CoA binding

Sequence similaritiesi

Belongs to the acetyltransferase family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0454.
GeneTreeiENSGT00440000039972.
HOGENOMiHOG000078521.
HOVERGENiHBG063175.
InParanoidiQ96F10.
KOiK00657.
OMAiDWVGMRV.
OrthoDBiEOG7M98HM.
PhylomeDBiQ96F10.
TreeFamiTF319736.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96F10-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASVRIREAK EGDCGDILRL IRELAEFEKL SDQVKISEEA LRADGFGDNP
60 70 80 90 100
FYHCLVAEIL PAPGKLLGPC VVGYGIYYFI YSTWKGRTIY LEDIYVMPEY
110 120 130 140 150
RGQGIGSKII KKVAEVALDK GCSQFRLAVL DWNQRAMDLY KALGAQDLTE
160 170
AEGWHFFCFQ GEATRKLAGK
Length:170
Mass (Da):19,155
Last modified:December 1, 2001 - v1
Checksum:i68D46F0E28186C68
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti126 – 1261R → C.
Corresponds to variant rs13894 [ dbSNP | Ensembl ].
VAR_020465

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF348524 mRNA. Translation: AAL83905.1.
BC011751 mRNA. Translation: AAH11751.1.
CCDSiCCDS11116.1.
RefSeqiNP_597998.1. NM_133491.3.
UniGeneiHs.10846.

Genome annotation databases

EnsembliENST00000269298; ENSP00000269298; ENSG00000141504.
GeneIDi112483.
KEGGihsa:112483.
UCSCiuc002gic.2. human.

Polymorphism databases

DMDMi51339204.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF348524 mRNA. Translation: AAL83905.1 .
BC011751 mRNA. Translation: AAH11751.1 .
CCDSi CCDS11116.1.
RefSeqi NP_597998.1. NM_133491.3.
UniGenei Hs.10846.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BEI X-ray 1.84 A/B 2-170 [» ]
2Q4V X-ray 1.84 A/B 2-170 [» ]
ProteinModelPortali Q96F10.
SMRi Q96F10. Positions 2-170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125190. 5 interactions.
IntActi Q96F10. 1 interaction.
MINTi MINT-1476751.
STRINGi 9606.ENSP00000269298.

Chemistry

DrugBanki DB00127. Spermine.

PTM databases

PhosphoSitei Q96F10.

Polymorphism databases

DMDMi 51339204.

Proteomic databases

MaxQBi Q96F10.
PaxDbi Q96F10.
PRIDEi Q96F10.

Protocols and materials databases

DNASUi 112483.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000269298 ; ENSP00000269298 ; ENSG00000141504 .
GeneIDi 112483.
KEGGi hsa:112483.
UCSCi uc002gic.2. human.

Organism-specific databases

CTDi 112483.
GeneCardsi GC17M007529.
HGNCi HGNC:23160. SAT2.
HPAi HPA022136.
MIMi 611463. gene.
neXtProti NX_Q96F10.
PharmGKBi PA134979941.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0454.
GeneTreei ENSGT00440000039972.
HOGENOMi HOG000078521.
HOVERGENi HBG063175.
InParanoidi Q96F10.
KOi K00657.
OMAi DWVGMRV.
OrthoDBi EOG7M98HM.
PhylomeDBi Q96F10.
TreeFami TF319736.

Enzyme and pathway databases

UniPathwayi UPA00188 ; UER00363 .
BRENDAi 2.3.1.57. 2681.

Miscellaneous databases

EvolutionaryTracei Q96F10.
GeneWikii SAT2.
GenomeRNAii 112483.
NextBioi 78600.
PROi Q96F10.
SOURCEi Search...

Gene expression databases

Bgeei Q96F10.
CleanExi HS_SAT2.
ExpressionAtlasi Q96F10. baseline and differential.
Genevestigatori Q96F10.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Coleman C.C.S., Pegg A.E., Chau V.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase."
    Chen Y., Vujcic S., Liang P., Diegelman P., Kramer D.L., Porter C.W.
    Biochem. J. 373:661-667(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Tissue: Lung carcinoma.
  4. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Crystal structure of Homo sapiens thialysine Nepsilon-acetyltransferase (HsSSAT2) in complex with acetyl coenzyme A."
    Han B.W., Bingman C.A., Wesenberg G.E., Phillips G.N. Jr.
    Proteins 64:288-293(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) OF 2-170 IN COMPLEX WITH ACETYL-COA, SUBUNIT.

Entry informationi

Entry nameiSAT2_HUMAN
AccessioniPrimary (citable) accession number: Q96F10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Under physiological conditions, SSAT2 is expressed at lower level that SSAT1 (SSAT). Many tissues express only SSAT1, several tissues express both SSAT1 and SSAT2, and bone, cervix, ovary and pineal gland expressed only SSAT2.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3