Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96F07

- CYFP2_HUMAN

UniProt

Q96F07 - CYFP2_HUMAN

Protein

Cytoplasmic FMR1-interacting protein 2

Gene

CYFIP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (06 Mar 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA.3 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity Source: BHF-UCL
    2. apoptotic process Source: UniProtKB
    3. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
    4. innate immune response Source: Reactome
    5. positive regulation of proteolysis Source: BHF-UCL
    6. single organismal cell-cell adhesion Source: UniProtKB

    Keywords - Biological processi

    Apoptosis, Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_160086. Regulation of actin dynamics for phagocytic cup formation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytoplasmic FMR1-interacting protein 2
    Alternative name(s):
    p53-inducible protein 121
    Gene namesi
    Name:CYFIP2Imported
    Synonyms:KIAA1168, PIR121Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:13760. CYFIP2.

    Subcellular locationi

    Cytoplasm 2 Publications. Cytoplasmperinuclear region. Cell junctionsynapsesynaptosome
    Note: Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.By similarity2 Publications

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasm Source: MGI
    3. cytosol Source: Reactome
    4. extracellular vesicular exosome Source: UniProt
    5. membrane Source: UniProtKB
    6. neuron projection Source: UniProtKB-SubCell
    7. perinuclear region of cytoplasm Source: UniProtKB
    8. synapse Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Synapse, Synaptosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38368.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12781278Cytoplasmic FMR1-interacting protein 2PRO_0000279709Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1062 – 10621N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ96F07.
    PaxDbiQ96F07.
    PRIDEiQ96F07.

    PTM databases

    PhosphoSiteiQ96F07.

    Expressioni

    Tissue specificityi

    Expressed in T-cells. Increased expression is observed in CD4+ T-lymphocytes from patients with multiple sclerosis (at protein level).1 Publication

    Inductioni

    By p53/TP53.1 Publication

    Gene expression databases

    ArrayExpressiQ96F07.
    BgeeiQ96F07.
    CleanExiHS_CYFIP2.
    GenevestigatoriQ96F07.

    Organism-specific databases

    HPAiCAB055519.

    Interactioni

    Subunit structurei

    Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FMR1Q067872EBI-2433893,EBI-366305

    Protein-protein interaction databases

    BioGridi117945. 23 interactions.
    IntActiQ96F07. 14 interactions.
    MINTiMINT-203551.
    STRINGi9606.ENSP00000390948.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96F07.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CYFIP family.Sequence Analysis

    Phylogenomic databases

    eggNOGiNOG306641.
    HOVERGENiHBG053209.
    InParanoidiQ96F07.
    KOiK05749.
    PhylomeDBiQ96F07.

    Family and domain databases

    InterProiIPR008081. Cytoplasmic_FMR1-int.
    IPR016536. Cytoplasmic_FMR1-int_sub.
    [Graphical view]
    PANTHERiPTHR12195. PTHR12195. 1 hit.
    PfamiPF05994. FragX_IP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF008153. FMR1_interacting. 1 hit.
    PRINTSiPR01698. CYTOFMRPINTP.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96F07-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTTHVTLEDA LSNVDLLEEL PLPDQQPCIE PPPSSIMYQA NFDTNFEDRN     50
    AFVTGIARYI EQATVHSSMN EMLEEGHEYA VMLYTWRSCS RAIPQVKCNE 100
    QPNRVEIYEK TVEVLEPEVT KLMKFMYFQR KAIERFCSEV KRLCHAERRK 150
    DFVSEAYLLT LGKFINMFAV LDELKNMKCS VKNDHSAYKR AAQFLRKMAD 200
    PQSIQESQNL SMFLANHNRI TQCLHQQLEV IPGYEELLAD IVNICVDYYE 250
    NKMYLTPSEK HMLLKVMGFG LYLMDGNVSN IYKLDAKKRI NLSKIDKFFK 300
    QLQVVPLFGD MQIELARYIK TSAHYEENKS KWTCTQSSIS PQYNICEQMV 350
    QIRDDHIRFI SELARYSNSE VVTGSGLDSQ KSDEEYRELF DLALRGLQLL 400
    SKWSAHVMEV YSWKLVHPTD KFCNKDCPGT AEEYERATRY NYTSEEKFAF 450
    VEVIAMIKGL QVLMGRMESV FNQAIRNTIY AALQDFAQVT LREPLRQAVR 500
    KKKNVLISVL QAIRKTICDW EGGREPPNDP CLRGEKDPKG GFDIKVPRRA 550
    VGPSSTQACQ WSPRALFHPT GGTQGRRGCR SLLYMVRTML ESLIADKSGS 600
    KKTLRSSLDG PIVLAIEDFH KQSFFFTHLL NISEALQQCC DLSQLWFREF 650
    FLELTMGRRI QFPIEMSMPW ILTDHILETK EPSMMEYVLY PLDLYNDSAY 700
    YALTKFKKQF LYDEIEAEVN LCFDQFVYKL ADQIFAYYKA MAGSVLLDKR 750
    FRAECKNYGV IIPYPPSNRY ETLLKQRHVQ LLGRSIDLNR LITQRISAAM 800
    YKSLDQAISR FESEDLTSIV ELEWLLEINR LTHRLLCKHM TLDSFDAMFR 850
    EANHNVSAPY GRITLHVFWE LNFDFLPNYC YNGSTNRFVR TAIPFTQEPQ 900
    RDKPANVQPY YLYGSKPLNI AYSHIYSSYR NFVGPPHFKT ICRLLGYQGI 950
    AVVMEELLKI VKSLLQGTIL QYVKTLIEVM PKICRLPRHE YGSPGILEFF 1000
    HHQLKDIIEY AELKTDVFQS LREVGNAILF CLLIEQALSQ EEVCDLLHAA 1050
    PFQNILPRVY IKEGERLEVR MKRLEAKYAP LHLVPLIERL GTPQQIAIAR 1100
    EGDLLTKERL CCGLSMFEVI LTRIRSYLQD PIWRGPPPTN GVMHVDECVE 1150
    FHRLWSAMQF VYCIPVGTNE FTAEQCFGDG LNWAGCSIIV LLGQQRRFDL 1200
    FDFCYHLLKV QRQDGKDEII KNVPLKKMAD RIRKYQILNN EVFAILNKYM 1250
    KSVETDSSTV EHVRCFQPPI HQSLATTC 1278
    Length:1,278
    Mass (Da):148,399
    Last modified:March 6, 2007 - v2
    Checksum:iD6562B1204DC2463
    GO
    Isoform 21 Publication (identifier: Q96F07-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         558-582: Missing.

    Show »
    Length:1,253
    Mass (Da):145,673
    Checksum:i3D6B1D906991A24F
    GO

    Sequence cautioni

    The sequence BAA86482.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAD97324.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti796 – 7961I → T in AAH11762. (PubMed:15489334)Curated

    RNA editingi

    Partially edited. Editing appears to be brain-specific.1 Publication

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti320 – 3201K → E in RNA edited version. 1 Publication
    Corresponds to variant rs3207362 [ dbSNP | Ensembl ].
    VAR_030953

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei558 – 58225Missing in isoform 2. 3 PublicationsVSP_052349Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF160973 mRNA. Translation: AAD45723.1.
    AB032994 mRNA. Translation: BAA86482.2. Different initiation.
    AL136549 mRNA. Translation: CAB66484.1.
    AK223604 mRNA. Translation: BAD97324.1. Different initiation.
    AC008676 Genomic DNA. No translation available.
    AC009185 Genomic DNA. No translation available.
    AC016571 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61604.1.
    CH471062 Genomic DNA. Translation: EAW61605.1.
    CH471062 Genomic DNA. Translation: EAW61606.1.
    BC011762 mRNA. Translation: AAH11762.1.
    PIRiT46248.
    RefSeqiNP_001032410.1. NM_001037333.2. [Q96F07-2]
    NP_001278650.1. NM_001291721.1.
    NP_001278651.1. NM_001291722.1. [Q96F07-1]
    NP_055191.2. NM_014376.3. [Q96F07-2]
    UniGeneiHs.519702.

    Genome annotation databases

    EnsembliENST00000442283; ENSP00000390948; ENSG00000055163.
    GeneIDi26999.
    KEGGihsa:26999.
    UCSCiuc003lwt.3. human. [Q96F07-1]
    uc021ygm.1. human. [Q96F07-2]

    Polymorphism databases

    DMDMi134034199.

    Keywords - Coding sequence diversityi

    Alternative splicing, RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF160973 mRNA. Translation: AAD45723.1 .
    AB032994 mRNA. Translation: BAA86482.2 . Different initiation.
    AL136549 mRNA. Translation: CAB66484.1 .
    AK223604 mRNA. Translation: BAD97324.1 . Different initiation.
    AC008676 Genomic DNA. No translation available.
    AC009185 Genomic DNA. No translation available.
    AC016571 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61604.1 .
    CH471062 Genomic DNA. Translation: EAW61605.1 .
    CH471062 Genomic DNA. Translation: EAW61606.1 .
    BC011762 mRNA. Translation: AAH11762.1 .
    PIRi T46248.
    RefSeqi NP_001032410.1. NM_001037333.2. [Q96F07-2 ]
    NP_001278650.1. NM_001291721.1.
    NP_001278651.1. NM_001291722.1. [Q96F07-1 ]
    NP_055191.2. NM_014376.3. [Q96F07-2 ]
    UniGenei Hs.519702.

    3D structure databases

    ProteinModelPortali Q96F07.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117945. 23 interactions.
    IntActi Q96F07. 14 interactions.
    MINTi MINT-203551.
    STRINGi 9606.ENSP00000390948.

    PTM databases

    PhosphoSitei Q96F07.

    Polymorphism databases

    DMDMi 134034199.

    Proteomic databases

    MaxQBi Q96F07.
    PaxDbi Q96F07.
    PRIDEi Q96F07.

    Protocols and materials databases

    DNASUi 26999.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000442283 ; ENSP00000390948 ; ENSG00000055163 .
    GeneIDi 26999.
    KEGGi hsa:26999.
    UCSCi uc003lwt.3. human. [Q96F07-1 ]
    uc021ygm.1. human. [Q96F07-2 ]

    Organism-specific databases

    CTDi 26999.
    GeneCardsi GC05P156674.
    HGNCi HGNC:13760. CYFIP2.
    HPAi CAB055519.
    MIMi 606323. gene.
    neXtProti NX_Q96F07.
    PharmGKBi PA38368.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG306641.
    HOVERGENi HBG053209.
    InParanoidi Q96F07.
    KOi K05749.
    PhylomeDBi Q96F07.

    Enzyme and pathway databases

    Reactomei REACT_160086. Regulation of actin dynamics for phagocytic cup formation.

    Miscellaneous databases

    ChiTaRSi CYFIP2. human.
    GeneWikii CYFIP2.
    GenomeRNAii 26999.
    NextBioi 49478.
    PROi Q96F07.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96F07.
    Bgeei Q96F07.
    CleanExi HS_CYFIP2.
    Genevestigatori Q96F07.

    Family and domain databases

    InterProi IPR008081. Cytoplasmic_FMR1-int.
    IPR016536. Cytoplasmic_FMR1-int_sub.
    [Graphical view ]
    PANTHERi PTHR12195. PTHR12195. 1 hit.
    Pfami PF05994. FragX_IP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF008153. FMR1_interacting. 1 hit.
    PRINTSi PR01698. CYTOFMRPINTP.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION.
    2. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
      Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
      DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), RNA EDITING OF POSITION 320.
      Tissue: Brain.
    3. Ohara O., Nagase T., Kikuno R.
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), RNA EDITING OF POSITION 320.
      Tissue: Amygdala.
    5. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: BrainImported.
    6. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: LymphImported.
    9. "CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion."
      Mayne M., Moffatt T., Kong H., McLaren P.J., Fowke K.R., Becker K.G., Namaka M., Schenck A., Bardoni B., Bernstein C.N., Melanson M.
      Eur. J. Immunol. 34:1217-1227(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RAC1, TISSUE SPECIFICITY.
    10. Cited for: RNA EDITING OF POSITION 320.
    11. "CYFIP2, a direct p53 target, is leptomycin-B sensitive."
      Jackson R.S. II, Cho Y.-J., Stein S., Liang P.
      Cell Cycle 6:95-103(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
    12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1062, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCYFP2_HUMAN
    AccessioniPrimary (citable) accession number: Q96F07
    Secondary accession number(s): A6NLT2
    , D3DQJ3, Q53EN5, Q9NTK4, Q9ULQ2, Q9UN29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3