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Q96F07

- CYFP2_HUMAN

UniProt

Q96F07 - CYFP2_HUMAN

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Protein

Cytoplasmic FMR1-interacting protein 2

Gene

CYFIP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA.3 Publications

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity Source: BHF-UCL
  2. apoptotic process Source: UniProtKB
  3. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
  4. innate immune response Source: Reactome
  5. positive regulation of proteolysis Source: BHF-UCL
  6. single organismal cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_228166. VEGFA-VEGFR2 Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic FMR1-interacting protein 2
Alternative name(s):
p53-inducible protein 121
Gene namesi
Name:CYFIP2Imported
Synonyms:KIAA1168, PIR121Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:13760. CYFIP2.

Subcellular locationi

Cytoplasm 2 Publications. Cytoplasmperinuclear region. Cell junctionsynapsesynaptosome
Note: Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.By similarity2 Publications

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: MGI
  3. cytosol Source: Reactome
  4. extracellular vesicular exosome Source: UniProtKB
  5. membrane Source: UniProtKB
  6. neuron projection Source: UniProtKB-KW
  7. perinuclear region of cytoplasm Source: UniProtKB
  8. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38368.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12781278Cytoplasmic FMR1-interacting protein 2PRO_0000279709Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1062 – 10621N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96F07.
PaxDbiQ96F07.
PRIDEiQ96F07.

PTM databases

PhosphoSiteiQ96F07.

Expressioni

Tissue specificityi

Expressed in T-cells. Increased expression is observed in CD4+ T-lymphocytes from patients with multiple sclerosis (at protein level).1 Publication

Inductioni

By p53/TP53.1 Publication

Gene expression databases

BgeeiQ96F07.
CleanExiHS_CYFIP2.
ExpressionAtlasiQ96F07. baseline and differential.
GenevestigatoriQ96F07.

Organism-specific databases

HPAiCAB055519.

Interactioni

Subunit structurei

Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FMR1Q067872EBI-2433893,EBI-366305

Protein-protein interaction databases

BioGridi117945. 32 interactions.
IntActiQ96F07. 14 interactions.
MINTiMINT-203551.
STRINGi9606.ENSP00000390948.

Structurei

3D structure databases

ProteinModelPortaliQ96F07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CYFIP family.Sequence Analysis

Phylogenomic databases

eggNOGiNOG306641.
GeneTreeiENSGT00500000044831.
HOVERGENiHBG053209.
InParanoidiQ96F07.
KOiK05749.
PhylomeDBiQ96F07.

Family and domain databases

InterProiIPR008081. Cytoplasmic_FMR1-int.
IPR016536. Cytoplasmic_FMR1-int_sub.
[Graphical view]
PANTHERiPTHR12195. PTHR12195. 1 hit.
PfamiPF05994. FragX_IP. 1 hit.
[Graphical view]
PIRSFiPIRSF008153. FMR1_interacting. 1 hit.
PRINTSiPR01698. CYTOFMRPINTP.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96F07-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTHVTLEDA LSNVDLLEEL PLPDQQPCIE PPPSSIMYQA NFDTNFEDRN
60 70 80 90 100
AFVTGIARYI EQATVHSSMN EMLEEGHEYA VMLYTWRSCS RAIPQVKCNE
110 120 130 140 150
QPNRVEIYEK TVEVLEPEVT KLMKFMYFQR KAIERFCSEV KRLCHAERRK
160 170 180 190 200
DFVSEAYLLT LGKFINMFAV LDELKNMKCS VKNDHSAYKR AAQFLRKMAD
210 220 230 240 250
PQSIQESQNL SMFLANHNRI TQCLHQQLEV IPGYEELLAD IVNICVDYYE
260 270 280 290 300
NKMYLTPSEK HMLLKVMGFG LYLMDGNVSN IYKLDAKKRI NLSKIDKFFK
310 320 330 340 350
QLQVVPLFGD MQIELARYIK TSAHYEENKS KWTCTQSSIS PQYNICEQMV
360 370 380 390 400
QIRDDHIRFI SELARYSNSE VVTGSGLDSQ KSDEEYRELF DLALRGLQLL
410 420 430 440 450
SKWSAHVMEV YSWKLVHPTD KFCNKDCPGT AEEYERATRY NYTSEEKFAF
460 470 480 490 500
VEVIAMIKGL QVLMGRMESV FNQAIRNTIY AALQDFAQVT LREPLRQAVR
510 520 530 540 550
KKKNVLISVL QAIRKTICDW EGGREPPNDP CLRGEKDPKG GFDIKVPRRA
560 570 580 590 600
VGPSSTQACQ WSPRALFHPT GGTQGRRGCR SLLYMVRTML ESLIADKSGS
610 620 630 640 650
KKTLRSSLDG PIVLAIEDFH KQSFFFTHLL NISEALQQCC DLSQLWFREF
660 670 680 690 700
FLELTMGRRI QFPIEMSMPW ILTDHILETK EPSMMEYVLY PLDLYNDSAY
710 720 730 740 750
YALTKFKKQF LYDEIEAEVN LCFDQFVYKL ADQIFAYYKA MAGSVLLDKR
760 770 780 790 800
FRAECKNYGV IIPYPPSNRY ETLLKQRHVQ LLGRSIDLNR LITQRISAAM
810 820 830 840 850
YKSLDQAISR FESEDLTSIV ELEWLLEINR LTHRLLCKHM TLDSFDAMFR
860 870 880 890 900
EANHNVSAPY GRITLHVFWE LNFDFLPNYC YNGSTNRFVR TAIPFTQEPQ
910 920 930 940 950
RDKPANVQPY YLYGSKPLNI AYSHIYSSYR NFVGPPHFKT ICRLLGYQGI
960 970 980 990 1000
AVVMEELLKI VKSLLQGTIL QYVKTLIEVM PKICRLPRHE YGSPGILEFF
1010 1020 1030 1040 1050
HHQLKDIIEY AELKTDVFQS LREVGNAILF CLLIEQALSQ EEVCDLLHAA
1060 1070 1080 1090 1100
PFQNILPRVY IKEGERLEVR MKRLEAKYAP LHLVPLIERL GTPQQIAIAR
1110 1120 1130 1140 1150
EGDLLTKERL CCGLSMFEVI LTRIRSYLQD PIWRGPPPTN GVMHVDECVE
1160 1170 1180 1190 1200
FHRLWSAMQF VYCIPVGTNE FTAEQCFGDG LNWAGCSIIV LLGQQRRFDL
1210 1220 1230 1240 1250
FDFCYHLLKV QRQDGKDEII KNVPLKKMAD RIRKYQILNN EVFAILNKYM
1260 1270
KSVETDSSTV EHVRCFQPPI HQSLATTC
Length:1,278
Mass (Da):148,399
Last modified:March 6, 2007 - v2
Checksum:iD6562B1204DC2463
GO
Isoform 21 Publication (identifier: Q96F07-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     558-582: Missing.

Show »
Length:1,253
Mass (Da):145,673
Checksum:i3D6B1D906991A24F
GO

Sequence cautioni

The sequence BAA86482.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAD97324.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti796 – 7961I → T in AAH11762. (PubMed:15489334)Curated

RNA editingi

Partially edited. Editing appears to be brain-specific.1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti320 – 3201K → E in RNA edited version. 1 Publication
Corresponds to variant rs3207362 [ dbSNP | Ensembl ].
VAR_030953

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei558 – 58225Missing in isoform 2. 3 PublicationsVSP_052349Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF160973 mRNA. Translation: AAD45723.1.
AB032994 mRNA. Translation: BAA86482.2. Different initiation.
AL136549 mRNA. Translation: CAB66484.1.
AK223604 mRNA. Translation: BAD97324.1. Different initiation.
AC008676 Genomic DNA. No translation available.
AC009185 Genomic DNA. No translation available.
AC016571 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61604.1.
CH471062 Genomic DNA. Translation: EAW61605.1.
CH471062 Genomic DNA. Translation: EAW61606.1.
BC011762 mRNA. Translation: AAH11762.1.
CCDSiCCDS75364.1. [Q96F07-2]
PIRiT46248.
RefSeqiNP_001032410.1. NM_001037333.2. [Q96F07-2]
NP_001278650.1. NM_001291721.1.
NP_001278651.1. NM_001291722.1. [Q96F07-1]
NP_055191.2. NM_014376.3. [Q96F07-2]
UniGeneiHs.519702.

Genome annotation databases

EnsembliENST00000541131; ENSP00000444645; ENSG00000055163. [Q96F07-2]
ENST00000616178; ENSP00000479719; ENSG00000055163. [Q96F07-1]
ENST00000618329; ENSP00000484819; ENSG00000055163. [Q96F07-2]
ENST00000620254; ENSP00000479968; ENSG00000055163. [Q96F07-2]
GeneIDi26999.
KEGGihsa:26999.
UCSCiuc003lwt.3. human. [Q96F07-1]
uc021ygm.1. human. [Q96F07-2]

Polymorphism databases

DMDMi134034199.

Keywords - Coding sequence diversityi

Alternative splicing, RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF160973 mRNA. Translation: AAD45723.1 .
AB032994 mRNA. Translation: BAA86482.2 . Different initiation.
AL136549 mRNA. Translation: CAB66484.1 .
AK223604 mRNA. Translation: BAD97324.1 . Different initiation.
AC008676 Genomic DNA. No translation available.
AC009185 Genomic DNA. No translation available.
AC016571 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61604.1 .
CH471062 Genomic DNA. Translation: EAW61605.1 .
CH471062 Genomic DNA. Translation: EAW61606.1 .
BC011762 mRNA. Translation: AAH11762.1 .
CCDSi CCDS75364.1. [Q96F07-2 ]
PIRi T46248.
RefSeqi NP_001032410.1. NM_001037333.2. [Q96F07-2 ]
NP_001278650.1. NM_001291721.1.
NP_001278651.1. NM_001291722.1. [Q96F07-1 ]
NP_055191.2. NM_014376.3. [Q96F07-2 ]
UniGenei Hs.519702.

3D structure databases

ProteinModelPortali Q96F07.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117945. 32 interactions.
IntActi Q96F07. 14 interactions.
MINTi MINT-203551.
STRINGi 9606.ENSP00000390948.

PTM databases

PhosphoSitei Q96F07.

Polymorphism databases

DMDMi 134034199.

Proteomic databases

MaxQBi Q96F07.
PaxDbi Q96F07.
PRIDEi Q96F07.

Protocols and materials databases

DNASUi 26999.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000541131 ; ENSP00000444645 ; ENSG00000055163 . [Q96F07-2 ]
ENST00000616178 ; ENSP00000479719 ; ENSG00000055163 . [Q96F07-1 ]
ENST00000618329 ; ENSP00000484819 ; ENSG00000055163 . [Q96F07-2 ]
ENST00000620254 ; ENSP00000479968 ; ENSG00000055163 . [Q96F07-2 ]
GeneIDi 26999.
KEGGi hsa:26999.
UCSCi uc003lwt.3. human. [Q96F07-1 ]
uc021ygm.1. human. [Q96F07-2 ]

Organism-specific databases

CTDi 26999.
GeneCardsi GC05P156674.
HGNCi HGNC:13760. CYFIP2.
HPAi CAB055519.
MIMi 606323. gene.
neXtProti NX_Q96F07.
PharmGKBi PA38368.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG306641.
GeneTreei ENSGT00500000044831.
HOVERGENi HBG053209.
InParanoidi Q96F07.
KOi K05749.
PhylomeDBi Q96F07.

Enzyme and pathway databases

Reactomei REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_228166. VEGFA-VEGFR2 Pathway.

Miscellaneous databases

ChiTaRSi CYFIP2. human.
GeneWikii CYFIP2.
GenomeRNAii 26999.
NextBioi 49478.
PROi Q96F07.
SOURCEi Search...

Gene expression databases

Bgeei Q96F07.
CleanExi HS_CYFIP2.
ExpressionAtlasi Q96F07. baseline and differential.
Genevestigatori Q96F07.

Family and domain databases

InterProi IPR008081. Cytoplasmic_FMR1-int.
IPR016536. Cytoplasmic_FMR1-int_sub.
[Graphical view ]
PANTHERi PTHR12195. PTHR12195. 1 hit.
Pfami PF05994. FragX_IP. 1 hit.
[Graphical view ]
PIRSFi PIRSF008153. FMR1_interacting. 1 hit.
PRINTSi PR01698. CYTOFMRPINTP.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION.
  2. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), RNA EDITING OF POSITION 320.
    Tissue: Brain.
  3. Ohara O., Nagase T., Kikuno R.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), RNA EDITING OF POSITION 320.
    Tissue: Amygdala.
  5. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: BrainImported.
  6. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: LymphImported.
  9. "CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion."
    Mayne M., Moffatt T., Kong H., McLaren P.J., Fowke K.R., Becker K.G., Namaka M., Schenck A., Bardoni B., Bernstein C.N., Melanson M.
    Eur. J. Immunol. 34:1217-1227(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RAC1, TISSUE SPECIFICITY.
  10. Cited for: RNA EDITING OF POSITION 320.
  11. "CYFIP2, a direct p53 target, is leptomycin-B sensitive."
    Jackson R.S. II, Cho Y.-J., Stein S., Liang P.
    Cell Cycle 6:95-103(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1062, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCYFP2_HUMAN
AccessioniPrimary (citable) accession number: Q96F07
Secondary accession number(s): A6NLT2
, D3DQJ3, Q53EN5, Q9NTK4, Q9ULQ2, Q9UN29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: November 26, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3