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Q96F07 (CYFP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytoplasmic FMR1-interacting protein 2
Alternative name(s):
p53-inducible protein 121
Gene names
Name:CYFIP2
Synonyms:KIAA1168, PIR121
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1278 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. Ref.1 Ref.9 Ref.11

Subunit structure

Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex. Ref.9 UniProtKB Q5SQX6 Ref.3

Subcellular location

Cytoplasm. Cytoplasmperinuclear region. Cell junctionsynapsesynaptosome. Note: Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus. Ref.1 Ref.11

Tissue specificity

Expressed in T-cells. Increased expression is observed in CD4+ T-lymphocytes from patients with multiple sclerosis (at protein level). Ref.9

Induction

By p53/TP53. Ref.11

Sequence similarities

Belongs to the CYFIP family.

RNA editing

Edited at position 320.
Partially edited. Editing appears to be brain-specific. Ref.2 Ref.4 Ref.10

Sequence caution

The sequence BAA86482.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAD97324.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

FMR1Q067872EBI-2433893,EBI-366305

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.3 (identifier: Q96F07-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.1 (identifier: Q96F07-2)

The sequence of this isoform differs from the canonical sequence as follows:
     558-582: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12781278Cytoplasmic FMR1-interacting protein 2
PRO_0000279709

Amino acid modifications

Modified residue10621N6-acetyllysine Ref.12

Natural variations

Alternative sequence558 – 58225Missing in isoform 2. Ref.1
VSP_052349
Natural variant3201K → E in RNA edited version. Ref.10
Corresponds to variant rs3207362 [ dbSNP | Ensembl ].
VAR_030953

Experimental info

Sequence conflict7961I → T in AAH11762. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 6, 2007. Version 2.
Checksum: D6562B1204DC2463

FASTA1,278148,399
        10         20         30         40         50         60 
MTTHVTLEDA LSNVDLLEEL PLPDQQPCIE PPPSSIMYQA NFDTNFEDRN AFVTGIARYI 

        70         80         90        100        110        120 
EQATVHSSMN EMLEEGHEYA VMLYTWRSCS RAIPQVKCNE QPNRVEIYEK TVEVLEPEVT 

       130        140        150        160        170        180 
KLMKFMYFQR KAIERFCSEV KRLCHAERRK DFVSEAYLLT LGKFINMFAV LDELKNMKCS 

       190        200        210        220        230        240 
VKNDHSAYKR AAQFLRKMAD PQSIQESQNL SMFLANHNRI TQCLHQQLEV IPGYEELLAD 

       250        260        270        280        290        300 
IVNICVDYYE NKMYLTPSEK HMLLKVMGFG LYLMDGNVSN IYKLDAKKRI NLSKIDKFFK 

       310        320        330        340        350        360 
QLQVVPLFGD MQIELARYIK TSAHYEENKS KWTCTQSSIS PQYNICEQMV QIRDDHIRFI 

       370        380        390        400        410        420 
SELARYSNSE VVTGSGLDSQ KSDEEYRELF DLALRGLQLL SKWSAHVMEV YSWKLVHPTD 

       430        440        450        460        470        480 
KFCNKDCPGT AEEYERATRY NYTSEEKFAF VEVIAMIKGL QVLMGRMESV FNQAIRNTIY 

       490        500        510        520        530        540 
AALQDFAQVT LREPLRQAVR KKKNVLISVL QAIRKTICDW EGGREPPNDP CLRGEKDPKG 

       550        560        570        580        590        600 
GFDIKVPRRA VGPSSTQACQ WSPRALFHPT GGTQGRRGCR SLLYMVRTML ESLIADKSGS 

       610        620        630        640        650        660 
KKTLRSSLDG PIVLAIEDFH KQSFFFTHLL NISEALQQCC DLSQLWFREF FLELTMGRRI 

       670        680        690        700        710        720 
QFPIEMSMPW ILTDHILETK EPSMMEYVLY PLDLYNDSAY YALTKFKKQF LYDEIEAEVN 

       730        740        750        760        770        780 
LCFDQFVYKL ADQIFAYYKA MAGSVLLDKR FRAECKNYGV IIPYPPSNRY ETLLKQRHVQ 

       790        800        810        820        830        840 
LLGRSIDLNR LITQRISAAM YKSLDQAISR FESEDLTSIV ELEWLLEINR LTHRLLCKHM 

       850        860        870        880        890        900 
TLDSFDAMFR EANHNVSAPY GRITLHVFWE LNFDFLPNYC YNGSTNRFVR TAIPFTQEPQ 

       910        920        930        940        950        960 
RDKPANVQPY YLYGSKPLNI AYSHIYSSYR NFVGPPHFKT ICRLLGYQGI AVVMEELLKI 

       970        980        990       1000       1010       1020 
VKSLLQGTIL QYVKTLIEVM PKICRLPRHE YGSPGILEFF HHQLKDIIEY AELKTDVFQS 

      1030       1040       1050       1060       1070       1080 
LREVGNAILF CLLIEQALSQ EEVCDLLHAA PFQNILPRVY IKEGERLEVR MKRLEAKYAP 

      1090       1100       1110       1120       1130       1140 
LHLVPLIERL GTPQQIAIAR EGDLLTKERL CCGLSMFEVI LTRIRSYLQD PIWRGPPPTN 

      1150       1160       1170       1180       1190       1200 
GVMHVDECVE FHRLWSAMQF VYCIPVGTNE FTAEQCFGDG LNWAGCSIIV LLGQQRRFDL 

      1210       1220       1230       1240       1250       1260 
FDFCYHLLKV QRQDGKDEII KNVPLKKMAD RIRKYQILNN EVFAILNKYM KSVETDSSTV 

      1270 
EHVRCFQPPI HQSLATTC 

« Hide

Isoform 2 [UniParc].

Checksum: 3D6B1D906991A24F
Show »

FASTA1,253145,673

References

« Hide 'large scale' references
[1]"Increased apoptosis induction by 121F mutant p53."
Saller E., Tom E., Brunori M., Otter M., Estreicher A., Mack D.H., Iggo R.
EMBO J. 18:4424-4437(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION.
[2]"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), RNA EDITING OF POSITION 320.
Tissue: Brain.
[3]Ohara O., Nagase T., Kikuno R.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[4]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), RNA EDITING OF POSITION 320.
Tissue: Amygdala.
[5]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[6]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Lymph.
[9]"CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion."
Mayne M., Moffatt T., Kong H., McLaren P.J., Fowke K.R., Becker K.G., Namaka M., Schenck A., Bardoni B., Bernstein C.N., Melanson M.
Eur. J. Immunol. 34:1217-1227(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH RAC1, TISSUE SPECIFICITY.
[10]"Evolutionarily conserved human targets of adenosine to inosine RNA editing."
Levanon E.Y., Hallegger M., Kinar Y., Shemesh R., Djinovic-Carugo K., Rechavi G., Jantsch M.F., Eisenberg E.
Nucleic Acids Res. 33:1162-1168(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: RNA EDITING OF POSITION 320.
[11]"CYFIP2, a direct p53 target, is leptomycin-B sensitive."
Jackson R.S. II, Cho Y.-J., Stein S., Liang P.
Cell Cycle 6:95-103(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
[12]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1062, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF160973 mRNA. Translation: AAD45723.1.
AB032994 mRNA. Translation: BAA86482.2. Different initiation.
AL136549 mRNA. Translation: CAB66484.1.
AK223604 mRNA. Translation: BAD97324.1. Different initiation.
AC008676 Genomic DNA. No translation available.
AC009185 Genomic DNA. No translation available.
AC016571 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61604.1.
CH471062 Genomic DNA. Translation: EAW61605.1.
CH471062 Genomic DNA. Translation: EAW61606.1.
BC011762 mRNA. Translation: AAH11762.1.
PIRT46248.
RefSeqNP_001032409.2. NM_001037332.2.
NP_001032410.1. NM_001037333.1.
NP_055191.2. NM_014376.2.
UniGeneHs.519702.

3D structure databases

ProteinModelPortalQ96F07.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117945. 22 interactions.
IntActQ96F07. 13 interactions.
MINTMINT-203551.
STRING9606.ENSP00000390948.

PTM databases

PhosphoSiteQ96F07.

Polymorphism databases

DMDM134034199.

Proteomic databases

PaxDbQ96F07.
PRIDEQ96F07.

Protocols and materials databases

DNASU26999.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000442283; ENSP00000390948; ENSG00000055163.
GeneID26999.
KEGGhsa:26999.
UCSCuc003lwt.3. human. [Q96F07-1]
uc021ygm.1. human. [Q96F07-2]

Organism-specific databases

CTD26999.
GeneCardsGC05P156674.
HGNCHGNC:13760. CYFIP2.
HPACAB055519.
MIM606323. gene.
neXtProtNX_Q96F07.
PharmGKBPA38368.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG306641.
HOVERGENHBG053209.
InParanoidQ96F07.
KOK05749.
PhylomeDBQ96F07.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressQ96F07.
BgeeQ96F07.
CleanExHS_CYFIP2.
GenevestigatorQ96F07.

Family and domain databases

InterProIPR008081. Cytoplasmic_FMR1-int.
IPR016536. Cytoplasmic_FMR1-int_sub.
[Graphical view]
PANTHERPTHR12195. PTHR12195. 1 hit.
PfamPF05994. FragX_IP. 1 hit.
[Graphical view]
PIRSFPIRSF008153. FMR1_interacting. 1 hit.
PRINTSPR01698. CYTOFMRPINTP.
ProtoNetSearch...

Other

ChiTaRSCYFIP2. human.
GeneWikiCYFIP2.
GenomeRNAi26999.
NextBio49478.
PROQ96F07.
SOURCESearch...

Entry information

Entry nameCYFP2_HUMAN
AccessionPrimary (citable) accession number: Q96F07
Secondary accession number(s): A6NLT2 expand/collapse secondary AC list , D3DQJ3, Q53EN5, Q9NTK4, Q9ULQ2, Q9UN29
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: April 16, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM