Q96EZ4 (MYEOV_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myeloma-overexpressed gene protein

Alternative name(s):
Oncogene in multiple myeloma

Gene names

Name:	MYEOV
Synonyms:	OCIM

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Developmental stage	Overexpressed in tumor cells lines with a t(11;14)(q13;q32) translocation.
Sequence caution	The sequence CAB65726.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Disease	Proto-oncogene
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Myeloma-overexpressed gene protein		PRO_0000096668
Natural variations
	Natural variant	159	1	V → A. Ref.1 Ref.3 Corresponds to variant rs7103126 [ dbSNP | Ensembl ].		VAR_016603
	Natural variant	198	1	R → Q. Ref.1 Corresponds to variant rs11539762 [ dbSNP | Ensembl ].		VAR_056948
	Natural variant	271	1	G → R. Ref.1 Corresponds to variant rs11228610 [ dbSNP | Ensembl ].		VAR_056949
	Natural variant	284	1	P → T. Corresponds to variant rs12274095 [ dbSNP | Ensembl ].		VAR_056950
Experimental info
	Sequence conflict	219	1	M → V in AAH11815. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q96EZ4 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 292ABC0D6AFA52B0	FASTA	313	33,556
	10 20 30 40 50 60 MALRICVTYT PALPIGLCTR CCLCLEQSPS WCHCLRGVSF LTFHLHQSVP LGDRDSLLMF 70 80 90 100 110 120 TRQAGHFVEG SKAGRSRGRL CLSQALRVAV RGAFVSLWFA AGAGDRERNK GDKGAQTGAG 130 140 150 160 170 180 LSQEAEDVDV SRARRVTDAP QGTLCGTGNR NSGSQSARVV GVAHLGEAFR VGVEQAISSC 190 200 210 220 230 240 PEEVHGRHGL SMEIMWARMD VALRSPGRGL LAGAGALCMT LAESSCPDYE RGRRACLTLH 250 260 270 280 290 300 RHPTPHCSTW GLPLRVAGSW LTVVTVEALG GWRMGVRRTG QVGPTMHPPP VSGASPLLLH 310 HLLLLLLIII LTC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32)." Janssen J.W.G., Vaandrager J.W., Heuser T., Jauch A., Kluin P.M., Geelen E., Bergsagel P.L., Kuehl W.M., Drexler H.G., Otsuki T., Bartram C.R., Schuuring E. Blood 95:2691-2698(2000) [PubMed: 10753852] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ALA-159; GLN-198 AND ARG-271. Tissue: Stomach cancer.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-159. Tissue: Brain.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ223366 mRNA. Translation: CAB65727.1. AJ223366 mRNA. Translation: CAB65726.1. Different initiation. AP005379 Genomic DNA. No translation available. BC011815 mRNA. Translation: AAH11815.1.
IPI	IPI00305042.
RefSeq	NP_620123.2. NM_138768.2.
UniGene	Hs.523848.
3D structure databases
ProteinModelPortal	Q96EZ4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96EZ4.
Polymorphism databases
DMDM	296439231.
Proteomic databases
PRIDE	Q96EZ4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308946; ENSP00000308330; ENSG00000172927.
GeneID	26579.
KEGG	hsa:26579.
Organism-specific databases
CTD	26579.
GeneCards	GC11P069061.
H-InvDB	HIX0009887.
HGNC	HGNC:7563. MYEOV.
HPA	HPA012949.
MIM	605625. gene.
neXtProt	NX_Q96EZ4.
PharmGKB	PA31362.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21479.
GeneTree	ENSGT00400000022774.
HOVERGEN	HBG052548.
OMA	SCPEEVH.
OrthoDB	EOG4RXZ0T.
PhylomeDB	Q96EZ4.
Gene expression databases
ArrayExpress	Q96EZ4.
Bgee	Q96EZ4.
CleanEx	HS_MYEOV.
Genevestigator	Q96EZ4.
GermOnline	ENSG00000172927. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	48930.
SOURCE	Search...

Entry information

Entry name

MYEOV_HUMAN

Accession

Primary (citable) accession number: Q96EZ4
Secondary accession number(s): Q9UGN6, Q9UGN7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.