Reviewed, UniProtKB/Swiss-Prot Q96EZ4 (MYEOV_HUMAN)

Names and origin

Protein names

Recommended name:
    Myeloma-overexpressed gene protein
Alternative name(s):
    Oncogene in multiple myeloma

Gene names

Name:	MYEOV
Synonyms:	OCIM

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Developmental stage

Overexpressed in tumor cells lines with a t(11;14)(q13;q32) translocation.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Disease	Proto-oncogene
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Myeloma-overexpressed gene protein		PRO_0000096668
Natural variations
	Natural variant	159	1	A → V: dbSNP rs7103126.		VAR_016603
	Natural variant	198	1	R → Q: dbSNP rs11539762.		VAR_056948
	Natural variant	271	1	G → R: dbSNP rs11228610.		VAR_056949
	Natural variant	284	1	P → T: dbSNP rs12274095.		VAR_056950
Experimental info
	Sequence conflict	219	1	V → M in CAB65727. Ref.1
	Sequence conflict	219	1	V → M in CAB65726. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96EZ4-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 22DE0BC9F4CB2F1B	FASTA	313	33,496
	10 20 30 40 50 60 MALRICVTYT PALPIGLCTR CCLCLEQSPS WCHCLRGVSF LTFHLHQSVP LGDRDSLLMF 70 80 90 100 110 120 TRQAGHFVEG SKAGRSRGRL CLSQALRVAV RGAFVSLWFA AGAGDRERNK GDKGAQTGAG 130 140 150 160 170 180 LSQEAEDVDV SRARRVTDAP QGTLCGTGNR NSGSQSARAV GVAHLGEAFR VGVEQAISSC 190 200 210 220 230 240 PEEVHGRHGL SMEIMWARMD VALRSPGRGL LAGAGALCVT LAESSCPDYE RGRRACLTLH 250 260 270 280 290 300 RHPTPHCSTW GLPLRVAGSW LTVVTVEALG GWRMGVRRTG QVGPTMHPPP VSGASPLLLH 310 HLLLLLLIII LTC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32)." Janssen J.W.G., Vaandrager J.W., Heuser T., Jauch A., Kluin P.M., Geelen E., Bergsagel P.L., Kuehl W.M., Drexler H.G., Otsuki T., Bartram C.R., Schuuring E. Blood 95:2691-2698(2000) [PubMed: 10753852] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLN-198 AND ARG-271. Tissue: Stomach cancer.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ223366 mRNA. Translation: CAB65727.1. AJ223366 mRNA. Translation: CAB65726.1. Different initiation. BC011815 mRNA. Translation: AAH11815.1.
IPI	IPI00305042.
RefSeq	NP_620123.2.
UniGene	Hs.523848
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q96EZ4.
Genome annotation databases
Ensembl	ENSG00000172927. Homo sapiens. [Contig view]
GeneID	26579.
KEGG	hsa:26579.
Organism-specific databases
GeneCards	GC11P068818.
H-InvDB	HIX0009887.
HGNC	HGNC:7563. MYEOV.
MIM	605625. gene.
PharmGKB	PA31362.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q96EZ4.
HOVERGEN	Q96EZ4.
Gene expression databases
ArrayExpress	Q96EZ4.
Bgee	Q96EZ4.
CleanEx	HS_MYEOV.
GermOnline	ENSG00000172927. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	48930.
SOURCE	Search...

Entry information

Entry name

MYEOV_HUMAN

Accession

Primary (citable) accession number: Q96EZ4
Secondary accession number(s): Q9UGN6, Q9UGN7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	December 1, 2001
Last modified:	May 26, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)