Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myeloma-overexpressed gene protein

Gene

MYEOV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloma-overexpressed gene protein
Alternative name(s):
Oncogene in multiple myeloma
Gene namesi
Name:MYEOV
Synonyms:OCIM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:7563. MYEOV.

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA31362.

Polymorphism and mutation databases

BioMutaiMYEOV.
DMDMi296439231.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Myeloma-overexpressed gene proteinPRO_0000096668Add
BLAST

Proteomic databases

PaxDbiQ96EZ4.
PeptideAtlasiQ96EZ4.
PRIDEiQ96EZ4.

PTM databases

iPTMnetiQ96EZ4.
PhosphoSiteiQ96EZ4.

Expressioni

Developmental stagei

Overexpressed in tumor cells lines with a t(11;14)(q13;q32) translocation.

Gene expression databases

BgeeiENSG00000172927.
CleanExiHS_MYEOV.
ExpressionAtlasiQ96EZ4. baseline and differential.
GenevisibleiQ96EZ4. HS.

Organism-specific databases

HPAiHPA012949.

Interactioni

Protein-protein interaction databases

BioGridi117748. 2 interactions.
STRINGi9606.ENSP00000308330.

Structurei

3D structure databases

ProteinModelPortaliQ96EZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410JJCZ. Eukaryota.
ENOG4111DFS. LUCA.
GeneTreeiENSGT00400000022774.
HOGENOMiHOG000206543.
HOVERGENiHBG052548.
InParanoidiQ96EZ4.
OMAiHCSTWGL.
OrthoDBiEOG091G0DLJ.
PhylomeDBiQ96EZ4.
TreeFamiTF353299.

Sequencei

Sequence statusi: Complete.

Q96EZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRICVTYT PALPIGLCTR CCLCLEQSPS WCHCLRGVSF LTFHLHQSVP
60 70 80 90 100
LGDRDSLLMF TRQAGHFVEG SKAGRSRGRL CLSQALRVAV RGAFVSLWFA
110 120 130 140 150
AGAGDRERNK GDKGAQTGAG LSQEAEDVDV SRARRVTDAP QGTLCGTGNR
160 170 180 190 200
NSGSQSARVV GVAHLGEAFR VGVEQAISSC PEEVHGRHGL SMEIMWARMD
210 220 230 240 250
VALRSPGRGL LAGAGALCMT LAESSCPDYE RGRRACLTLH RHPTPHCSTW
260 270 280 290 300
GLPLRVAGSW LTVVTVEALG GWRMGVRRTG QVGPTMHPPP VSGASPLLLH
310
HLLLLLLIII LTC
Length:313
Mass (Da):33,556
Last modified:May 18, 2010 - v2
Checksum:i292ABC0D6AFA52B0
GO

Sequence cautioni

The sequence CAB65726 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2191M → V in AAH11815 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti159 – 1591V → A.2 Publications
Corresponds to variant rs7103126 [ dbSNP | Ensembl ].
VAR_016603
Natural varianti198 – 1981R → Q.1 Publication
Corresponds to variant rs11539762 [ dbSNP | Ensembl ].
VAR_056948
Natural varianti271 – 2711G → R.1 Publication
Corresponds to variant rs11228610 [ dbSNP | Ensembl ].
VAR_056949
Natural varianti284 – 2841P → T.
Corresponds to variant rs12274095 [ dbSNP | Ensembl ].
VAR_056950

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223366 mRNA. Translation: CAB65727.1.
AJ223366 mRNA. Translation: CAB65726.1. Different initiation.
AP005379 Genomic DNA. No translation available.
BC011815 mRNA. Translation: AAH11815.1.
CCDSiCCDS8190.1.
RefSeqiNP_001280220.1. NM_001293291.1.
NP_001280223.1. NM_001293294.1.
NP_001280225.1. NM_001293296.1.
NP_001287852.1. NM_001300923.1.
NP_001287853.1. NM_001300924.1.
NP_620123.2. NM_138768.3.
UniGeneiHs.523848.

Genome annotation databases

EnsembliENST00000308946; ENSP00000308330; ENSG00000172927.
ENST00000441339; ENSP00000412482; ENSG00000172927.
GeneIDi26579.
KEGGihsa:26579.
UCSCiuc001oov.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223366 mRNA. Translation: CAB65727.1.
AJ223366 mRNA. Translation: CAB65726.1. Different initiation.
AP005379 Genomic DNA. No translation available.
BC011815 mRNA. Translation: AAH11815.1.
CCDSiCCDS8190.1.
RefSeqiNP_001280220.1. NM_001293291.1.
NP_001280223.1. NM_001293294.1.
NP_001280225.1. NM_001293296.1.
NP_001287852.1. NM_001300923.1.
NP_001287853.1. NM_001300924.1.
NP_620123.2. NM_138768.3.
UniGeneiHs.523848.

3D structure databases

ProteinModelPortaliQ96EZ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117748. 2 interactions.
STRINGi9606.ENSP00000308330.

PTM databases

iPTMnetiQ96EZ4.
PhosphoSiteiQ96EZ4.

Polymorphism and mutation databases

BioMutaiMYEOV.
DMDMi296439231.

Proteomic databases

PaxDbiQ96EZ4.
PeptideAtlasiQ96EZ4.
PRIDEiQ96EZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308946; ENSP00000308330; ENSG00000172927.
ENST00000441339; ENSP00000412482; ENSG00000172927.
GeneIDi26579.
KEGGihsa:26579.
UCSCiuc001oov.3. human.

Organism-specific databases

CTDi26579.
GeneCardsiMYEOV.
H-InvDBHIX0009887.
HGNCiHGNC:7563. MYEOV.
HPAiHPA012949.
MIMi605625. gene.
neXtProtiNX_Q96EZ4.
PharmGKBiPA31362.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JJCZ. Eukaryota.
ENOG4111DFS. LUCA.
GeneTreeiENSGT00400000022774.
HOGENOMiHOG000206543.
HOVERGENiHBG052548.
InParanoidiQ96EZ4.
OMAiHCSTWGL.
OrthoDBiEOG091G0DLJ.
PhylomeDBiQ96EZ4.
TreeFamiTF353299.

Miscellaneous databases

ChiTaRSiMYEOV. human.
GenomeRNAii26579.
PROiQ96EZ4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172927.
CleanExiHS_MYEOV.
ExpressionAtlasiQ96EZ4. baseline and differential.
GenevisibleiQ96EZ4. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiMYEOV_HUMAN
AccessioniPrimary (citable) accession number: Q96EZ4
Secondary accession number(s): Q9UGN6, Q9UGN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.