Q96EY4 (TMA16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation machinery-associated protein 16

Gene names

Name:	TMA16
Synonyms:	C4orf43

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the UPF0534 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Translation machinery-associated protein 16		PRO_0000321559
Natural variations
	Natural variant	12	1	R → Q. Corresponds to variant rs34907234 [ dbSNP | Ensembl ].		VAR_054013
	Natural variant	65	1	Q → P. Ref.1 Ref.3 Corresponds to variant rs2304802 [ dbSNP | Ensembl ].		VAR_039349
	Natural variant	176	1	I → T. Ref.1 Ref.3 Corresponds to variant rs1561736 [ dbSNP | Ensembl ].		VAR_039350
Experimental info
	Sequence conflict	62	1	L → P in BAA92053. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96EY4 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 624EDA50DD76AC48	FASTA	203	23,864
	10 20 30 40 50 60 MPKAPKGKSA GREKKVIHPY SRKAAQITRE AHKQEKKEKL KNEKALRLNL VGEKLQWFQN 70 80 90 100 110 120 HLDPQKKRYS KKDACELIER YLNRFSSELE QIELHNSIRD RQGRRHCSRE TVIKQTMERE 130 140 150 160 170 180 RQQFEGYGLE IPDILNASNL KTFREWDFDL KKLPNIKMRK ICANDAIPKT CKRKTIITVD 190 200 QDLGELELND ESSDSDEEMT AVA

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-65 AND THR-176. Tissue: Placenta.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-65 AND THR-176. Tissue: Muscle.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK002046 mRNA. Translation: BAA92053.1. AC093788 Genomic DNA. No translation available. BC011842 mRNA. Translation: AAH11842.1.
IPI	IPI00019962.
RefSeq	NP_060822.2. NM_018352.2.
UniGene	Hs.267446.
3D structure databases
ProteinModelPortal	Q96EY4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96EY4. 4 interactions.
STRING	9606.ENSP00000351380.
PTM databases
PhosphoSite	Q96EY4.
Polymorphism databases
DMDM	190360168.
Proteomic databases
PaxDb	Q96EY4.
PeptideAtlas	Q96EY4.
PRIDE	Q96EY4.
Protocols and materials databases
DNASU	55319.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358572; ENSP00000351380; ENSG00000198498.
GeneID	55319.
KEGG	hsa:55319.
UCSC	uc003iqq.4. human.
Organism-specific databases
CTD	55319.
GeneCards	GC04P164416.
H-InvDB	HIX0004607.
HGNC	HGNC:25638. TMA16.
HPA	HPA041571.
neXtProt	NX_Q96EY4.
PharmGKB	PA162379923.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG86313.
HOGENOM	HOG000007908.
HOVERGEN	HBG107626.
InParanoid	Q96EY4.
KO	K14860.
PhylomeDB	Q96EY4.
Gene expression databases
ArrayExpress	Q96EY4.
Bgee	Q96EY4.
CleanEx	HS_C4orf43.
Genevestigator	Q96EY4.
Family and domain databases
InterPro	IPR021346. DUF2962. [Graphical view]
Pfam	PF11176. DUF2962. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55319.
NextBio	59571.

Entry information

Entry name

TMA16_HUMAN

Accession

Primary (citable) accession number: Q96EY4
Secondary accession number(s): Q0P6E4, Q0P6J1, Q9NUR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	April 3, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.