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Protein

Translation machinery-associated protein 16

Gene

TMA16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Translation machinery-associated protein 16
Gene namesi
Name:TMA16
Synonyms:C4orf43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25638. TMA16.

Subcellular locationi

GO - Cellular componenti

  1. nucleolus Source: HPA
  2. nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162379923.

Polymorphism and mutation databases

BioMutaiTMA16.
DMDMi190360168.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Translation machinery-associated protein 16PRO_0000321559Add
BLAST

Proteomic databases

MaxQBiQ96EY4.
PaxDbiQ96EY4.
PeptideAtlasiQ96EY4.
PRIDEiQ96EY4.

PTM databases

PhosphoSiteiQ96EY4.

Expressioni

Gene expression databases

BgeeiQ96EY4.
CleanExiHS_C4orf43.
ExpressionAtlasiQ96EY4. baseline and differential.
GenevestigatoriQ96EY4.

Organism-specific databases

HPAiHPA041571.
HPA052688.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KLHL2O951983EBI-1045338,EBI-746999
KRTAP10-7P604093EBI-1045338,EBI-10172290

Protein-protein interaction databases

BioGridi120600. 8 interactions.
IntActiQ96EY4. 6 interactions.
MINTiMINT-5009409.
STRINGi9606.ENSP00000351380.

Structurei

3D structure databases

ProteinModelPortaliQ96EY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0534 family.Curated

Phylogenomic databases

eggNOGiNOG86313.
GeneTreeiENSGT00390000004179.
HOGENOMiHOG000007908.
HOVERGENiHBG107626.
InParanoidiQ96EY4.
KOiK14860.
PhylomeDBiQ96EY4.
TreeFamiTF324892.

Family and domain databases

InterProiIPR021346. Tma16.
[Graphical view]
PfamiPF11176. DUF2962. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96EY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKAPKGKSA GREKKVIHPY SRKAAQITRE AHKQEKKEKL KNEKALRLNL
60 70 80 90 100
VGEKLQWFQN HLDPQKKRYS KKDACELIER YLNRFSSELE QIELHNSIRD
110 120 130 140 150
RQGRRHCSRE TVIKQTMERE RQQFEGYGLE IPDILNASNL KTFREWDFDL
160 170 180 190 200
KKLPNIKMRK ICANDAIPKT CKRKTIITVD QDLGELELND ESSDSDEEMT

AVA
Length:203
Mass (Da):23,864
Last modified:February 26, 2008 - v2
Checksum:i624EDA50DD76AC48
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621L → P in BAA92053 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121R → Q.
Corresponds to variant rs34907234 [ dbSNP | Ensembl ].
VAR_054013
Natural varianti65 – 651Q → P.2 Publications
Corresponds to variant rs2304802 [ dbSNP | Ensembl ].
VAR_039349
Natural varianti176 – 1761I → T.2 Publications
Corresponds to variant rs1561736 [ dbSNP | Ensembl ].
VAR_039350

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002046 mRNA. Translation: BAA92053.1.
AC093788 Genomic DNA. No translation available.
BC011842 mRNA. Translation: AAH11842.1.
CCDSiCCDS43278.1.
RefSeqiNP_060822.2. NM_018352.2.
UniGeneiHs.267446.

Genome annotation databases

EnsembliENST00000358572; ENSP00000351380; ENSG00000198498.
GeneIDi55319.
KEGGihsa:55319.
UCSCiuc003iqq.4. human.

Polymorphism and mutation databases

BioMutaiTMA16.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002046 mRNA. Translation: BAA92053.1.
AC093788 Genomic DNA. No translation available.
BC011842 mRNA. Translation: AAH11842.1.
CCDSiCCDS43278.1.
RefSeqiNP_060822.2. NM_018352.2.
UniGeneiHs.267446.

3D structure databases

ProteinModelPortaliQ96EY4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120600. 8 interactions.
IntActiQ96EY4. 6 interactions.
MINTiMINT-5009409.
STRINGi9606.ENSP00000351380.

PTM databases

PhosphoSiteiQ96EY4.

Polymorphism and mutation databases

BioMutaiTMA16.
DMDMi190360168.

Proteomic databases

MaxQBiQ96EY4.
PaxDbiQ96EY4.
PeptideAtlasiQ96EY4.
PRIDEiQ96EY4.

Protocols and materials databases

DNASUi55319.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358572; ENSP00000351380; ENSG00000198498.
GeneIDi55319.
KEGGihsa:55319.
UCSCiuc003iqq.4. human.

Organism-specific databases

CTDi55319.
GeneCardsiGC04P164416.
H-InvDBHIX0004607.
HGNCiHGNC:25638. TMA16.
HPAiHPA041571.
HPA052688.
neXtProtiNX_Q96EY4.
PharmGKBiPA162379923.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG86313.
GeneTreeiENSGT00390000004179.
HOGENOMiHOG000007908.
HOVERGENiHBG107626.
InParanoidiQ96EY4.
KOiK14860.
PhylomeDBiQ96EY4.
TreeFamiTF324892.

Miscellaneous databases

GenomeRNAii55319.
NextBioi59571.
PROiQ96EY4.

Gene expression databases

BgeeiQ96EY4.
CleanExiHS_C4orf43.
ExpressionAtlasiQ96EY4. baseline and differential.
GenevestigatoriQ96EY4.

Family and domain databases

InterProiIPR021346. Tma16.
[Graphical view]
PfamiPF11176. DUF2962. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-65 AND THR-176.
    Tissue: Placenta.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-65 AND THR-176.
    Tissue: Muscle.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTMA16_HUMAN
AccessioniPrimary (citable) accession number: Q96EY4
Secondary accession number(s): Q0P6E4, Q0P6J1, Q9NUR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: April 29, 2015
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.