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Q96EY4

- TMA16_HUMAN

UniProt

Q96EY4 - TMA16_HUMAN

Protein

Translation machinery-associated protein 16

Gene

TMA16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation machinery-associated protein 16
    Gene namesi
    Name:TMA16
    Synonyms:C4orf43
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:25638. TMA16.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162379923.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 203203Translation machinery-associated protein 16PRO_0000321559Add
    BLAST

    Proteomic databases

    MaxQBiQ96EY4.
    PaxDbiQ96EY4.
    PeptideAtlasiQ96EY4.
    PRIDEiQ96EY4.

    PTM databases

    PhosphoSiteiQ96EY4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96EY4.
    BgeeiQ96EY4.
    CleanExiHS_C4orf43.
    GenevestigatoriQ96EY4.

    Organism-specific databases

    HPAiHPA041571.

    Interactioni

    Protein-protein interaction databases

    BioGridi120600. 6 interactions.
    IntActiQ96EY4. 4 interactions.
    MINTiMINT-5009409.
    STRINGi9606.ENSP00000351380.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96EY4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0534 family.Curated

    Phylogenomic databases

    eggNOGiNOG86313.
    HOGENOMiHOG000007908.
    HOVERGENiHBG107626.
    InParanoidiQ96EY4.
    KOiK14860.
    PhylomeDBiQ96EY4.
    TreeFamiTF324892.

    Family and domain databases

    InterProiIPR021346. Tma16.
    [Graphical view]
    PfamiPF11176. DUF2962. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96EY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKAPKGKSA GREKKVIHPY SRKAAQITRE AHKQEKKEKL KNEKALRLNL    50
    VGEKLQWFQN HLDPQKKRYS KKDACELIER YLNRFSSELE QIELHNSIRD 100
    RQGRRHCSRE TVIKQTMERE RQQFEGYGLE IPDILNASNL KTFREWDFDL 150
    KKLPNIKMRK ICANDAIPKT CKRKTIITVD QDLGELELND ESSDSDEEMT 200
    AVA 203
    Length:203
    Mass (Da):23,864
    Last modified:February 26, 2008 - v2
    Checksum:i624EDA50DD76AC48
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 621L → P in BAA92053. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti12 – 121R → Q.
    Corresponds to variant rs34907234 [ dbSNP | Ensembl ].
    VAR_054013
    Natural varianti65 – 651Q → P.2 Publications
    Corresponds to variant rs2304802 [ dbSNP | Ensembl ].
    VAR_039349
    Natural varianti176 – 1761I → T.2 Publications
    Corresponds to variant rs1561736 [ dbSNP | Ensembl ].
    VAR_039350

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002046 mRNA. Translation: BAA92053.1.
    AC093788 Genomic DNA. No translation available.
    BC011842 mRNA. Translation: AAH11842.1.
    CCDSiCCDS43278.1.
    RefSeqiNP_060822.2. NM_018352.2.
    UniGeneiHs.267446.

    Genome annotation databases

    EnsembliENST00000358572; ENSP00000351380; ENSG00000198498.
    GeneIDi55319.
    KEGGihsa:55319.
    UCSCiuc003iqq.4. human.

    Polymorphism databases

    DMDMi190360168.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002046 mRNA. Translation: BAA92053.1 .
    AC093788 Genomic DNA. No translation available.
    BC011842 mRNA. Translation: AAH11842.1 .
    CCDSi CCDS43278.1.
    RefSeqi NP_060822.2. NM_018352.2.
    UniGenei Hs.267446.

    3D structure databases

    ProteinModelPortali Q96EY4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120600. 6 interactions.
    IntActi Q96EY4. 4 interactions.
    MINTi MINT-5009409.
    STRINGi 9606.ENSP00000351380.

    PTM databases

    PhosphoSitei Q96EY4.

    Polymorphism databases

    DMDMi 190360168.

    Proteomic databases

    MaxQBi Q96EY4.
    PaxDbi Q96EY4.
    PeptideAtlasi Q96EY4.
    PRIDEi Q96EY4.

    Protocols and materials databases

    DNASUi 55319.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358572 ; ENSP00000351380 ; ENSG00000198498 .
    GeneIDi 55319.
    KEGGi hsa:55319.
    UCSCi uc003iqq.4. human.

    Organism-specific databases

    CTDi 55319.
    GeneCardsi GC04P164416.
    H-InvDB HIX0004607.
    HGNCi HGNC:25638. TMA16.
    HPAi HPA041571.
    neXtProti NX_Q96EY4.
    PharmGKBi PA162379923.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG86313.
    HOGENOMi HOG000007908.
    HOVERGENi HBG107626.
    InParanoidi Q96EY4.
    KOi K14860.
    PhylomeDBi Q96EY4.
    TreeFami TF324892.

    Miscellaneous databases

    GenomeRNAii 55319.
    NextBioi 59571.
    PROi Q96EY4.

    Gene expression databases

    ArrayExpressi Q96EY4.
    Bgeei Q96EY4.
    CleanExi HS_C4orf43.
    Genevestigatori Q96EY4.

    Family and domain databases

    InterProi IPR021346. Tma16.
    [Graphical view ]
    Pfami PF11176. DUF2962. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-65 AND THR-176.
      Tissue: Placenta.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-65 AND THR-176.
      Tissue: Muscle.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTMA16_HUMAN
    AccessioniPrimary (citable) accession number: Q96EY4
    Secondary accession number(s): Q0P6E4, Q0P6J1, Q9NUR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families
    5. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3