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Q96EY4

- TMA16_HUMAN

UniProt

Q96EY4 - TMA16_HUMAN

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Protein
Translation machinery-associated protein 16
Gene
TMA16, C4orf43
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Translation machinery-associated protein 16
Gene namesi
Name:TMA16
Synonyms:C4orf43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:25638. TMA16.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162379923.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Translation machinery-associated protein 16
PRO_0000321559Add
BLAST

Proteomic databases

MaxQBiQ96EY4.
PaxDbiQ96EY4.
PeptideAtlasiQ96EY4.
PRIDEiQ96EY4.

PTM databases

PhosphoSiteiQ96EY4.

Expressioni

Gene expression databases

ArrayExpressiQ96EY4.
BgeeiQ96EY4.
CleanExiHS_C4orf43.
GenevestigatoriQ96EY4.

Organism-specific databases

HPAiHPA041571.

Interactioni

Protein-protein interaction databases

BioGridi120600. 6 interactions.
IntActiQ96EY4. 4 interactions.
MINTiMINT-5009409.
STRINGi9606.ENSP00000351380.

Structurei

3D structure databases

ProteinModelPortaliQ96EY4.

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0534 family.

Phylogenomic databases

eggNOGiNOG86313.
HOGENOMiHOG000007908.
HOVERGENiHBG107626.
InParanoidiQ96EY4.
KOiK14860.
PhylomeDBiQ96EY4.
TreeFamiTF324892.

Family and domain databases

InterProiIPR021346. Tma16.
[Graphical view]
PfamiPF11176. DUF2962. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96EY4-1 [UniParc]FASTAAdd to Basket

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MPKAPKGKSA GREKKVIHPY SRKAAQITRE AHKQEKKEKL KNEKALRLNL    50
VGEKLQWFQN HLDPQKKRYS KKDACELIER YLNRFSSELE QIELHNSIRD 100
RQGRRHCSRE TVIKQTMERE RQQFEGYGLE IPDILNASNL KTFREWDFDL 150
KKLPNIKMRK ICANDAIPKT CKRKTIITVD QDLGELELND ESSDSDEEMT 200
AVA 203
Length:203
Mass (Da):23,864
Last modified:February 26, 2008 - v2
Checksum:i624EDA50DD76AC48
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121R → Q.
Corresponds to variant rs34907234 [ dbSNP | Ensembl ].
VAR_054013
Natural varianti65 – 651Q → P.2 Publications
Corresponds to variant rs2304802 [ dbSNP | Ensembl ].
VAR_039349
Natural varianti176 – 1761I → T.2 Publications
Corresponds to variant rs1561736 [ dbSNP | Ensembl ].
VAR_039350

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621L → P in BAA92053. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002046 mRNA. Translation: BAA92053.1.
AC093788 Genomic DNA. No translation available.
BC011842 mRNA. Translation: AAH11842.1.
CCDSiCCDS43278.1.
RefSeqiNP_060822.2. NM_018352.2.
UniGeneiHs.267446.

Genome annotation databases

EnsembliENST00000358572; ENSP00000351380; ENSG00000198498.
GeneIDi55319.
KEGGihsa:55319.
UCSCiuc003iqq.4. human.

Polymorphism databases

DMDMi190360168.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002046 mRNA. Translation: BAA92053.1 .
AC093788 Genomic DNA. No translation available.
BC011842 mRNA. Translation: AAH11842.1 .
CCDSi CCDS43278.1.
RefSeqi NP_060822.2. NM_018352.2.
UniGenei Hs.267446.

3D structure databases

ProteinModelPortali Q96EY4.
ModBasei Search...

Protein-protein interaction databases

BioGridi 120600. 6 interactions.
IntActi Q96EY4. 4 interactions.
MINTi MINT-5009409.
STRINGi 9606.ENSP00000351380.

PTM databases

PhosphoSitei Q96EY4.

Polymorphism databases

DMDMi 190360168.

Proteomic databases

MaxQBi Q96EY4.
PaxDbi Q96EY4.
PeptideAtlasi Q96EY4.
PRIDEi Q96EY4.

Protocols and materials databases

DNASUi 55319.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358572 ; ENSP00000351380 ; ENSG00000198498 .
GeneIDi 55319.
KEGGi hsa:55319.
UCSCi uc003iqq.4. human.

Organism-specific databases

CTDi 55319.
GeneCardsi GC04P164416.
H-InvDB HIX0004607.
HGNCi HGNC:25638. TMA16.
HPAi HPA041571.
neXtProti NX_Q96EY4.
PharmGKBi PA162379923.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG86313.
HOGENOMi HOG000007908.
HOVERGENi HBG107626.
InParanoidi Q96EY4.
KOi K14860.
PhylomeDBi Q96EY4.
TreeFami TF324892.

Miscellaneous databases

GenomeRNAii 55319.
NextBioi 59571.
PROi Q96EY4.

Gene expression databases

ArrayExpressi Q96EY4.
Bgeei Q96EY4.
CleanExi HS_C4orf43.
Genevestigatori Q96EY4.

Family and domain databases

InterProi IPR021346. Tma16.
[Graphical view ]
Pfami PF11176. DUF2962. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-65 AND THR-176.
    Tissue: Placenta.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-65 AND THR-176.
    Tissue: Muscle.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTMA16_HUMAN
AccessioniPrimary (citable) accession number: Q96EY4
Secondary accession number(s): Q0P6E4, Q0P6J1, Q9NUR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

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