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Q96EY1

- DNJA3_HUMAN

UniProt

Q96EY1 - DNJA3_HUMAN

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Protein
DnaJ homolog subfamily A member 3, mitochondrial
Gene
DNAJA3, HCA57, TID1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi236 – 2361Zinc 1 By similarity
Metal bindingi239 – 2391Zinc 1 By similarity
Metal bindingi253 – 2531Zinc 2 By similarity
Metal bindingi256 – 2561Zinc 2 By similarity
Metal bindingi275 – 2751Zinc 2 By similarity
Metal bindingi278 – 2781Zinc 2 By similarity
Metal bindingi289 – 2891Zinc 1 By similarity
Metal bindingi292 – 2921Zinc 1 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri223 – 30179CR-typeUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. NF-kappaB binding Source: UniProtKB
  3. interferon-gamma receptor binding Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW
  5. protein binding Source: UniProtKB
  6. protein kinase binding Source: UniProtKB
  7. small GTPase regulator activity Source: Ensembl
  8. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. T cell differentiation in thymus Source: Ensembl
  2. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  3. activation-induced cell death of T cells Source: Ensembl
  4. cell aging Source: Ensembl
  5. embryo development Source: Ensembl
  6. mitochondrial DNA replication Source: Ensembl
  7. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  8. negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  9. negative regulation of apoptotic process Source: UniProtKB
  10. negative regulation of cell proliferation Source: UniProtKB
  11. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  12. negative regulation of interferon-gamma-mediated signaling pathway Source: UniProtKB
  13. negative regulation of protein kinase activity Source: UniProtKB
  14. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  15. neuromuscular junction development Source: UniProtKB
  16. positive regulation of T cell proliferation Source: Ensembl
  17. positive regulation of apoptotic process Source: UniProtKB
  18. positive regulation of protein ubiquitination Source: UniProtKB
  19. protein folding Source: UniProtKB
  20. protein stabilization Source: UniProtKB
  21. response to heat Source: InterPro
  22. response to interferon-gamma Source: UniProtKB
  23. skeletal muscle acetylcholine-gated channel clustering Source: UniProtKB
  24. small GTPase mediated signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily A member 3, mitochondrial
Alternative name(s):
DnaJ protein Tid-1
Short name:
hTid-1
Hepatocellular carcinoma-associated antigen 57
Tumorous imaginal discs protein Tid56 homolog
Gene namesi
Name:DNAJA3
Synonyms:HCA57, TID1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:11808. DNAJA3.

Subcellular locationi

Mitochondrion matrix. Cytoplasmcytosol By similarity. Cell junctionsynapsepostsynaptic cell membrane; Peripheral membrane protein By similarity
Note: Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK By similarity.UniRule annotation

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: UniProtKB-SubCell
  4. extrinsic component of plasma membrane Source: UniProtKB
  5. intracellular membrane-bounded organelle Source: HPA
  6. mitochondrial matrix Source: UniProtKB
  7. mitochondrial nucleoid Source: UniProtKB
  8. mitochondrion Source: UniProt
  9. neuromuscular junction Source: UniProtKB
  10. nucleus Source: UniProtKB
  11. postsynaptic membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Mitochondrion, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi121 – 1211H → Q: Loss of modulation of apoptosis. 1 Publication

Organism-specific databases

PharmGKBiPA27410.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 480DnaJ homolog subfamily A member 3, mitochondrialUniRule annotationPRO_0000007256
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581Omega-N-methylarginine; by CARM11 Publication
Modified residuei134 – 1341N6-acetyllysine By similarity
Modified residuei238 – 2381Omega-N-methylarginine; by CARM11 Publication
Modified residuei293 – 2931Omega-N-methylarginine; by CARM11 Publication

Post-translational modificationi

Tyrosine phosphorylated By similarity.UniRule annotation

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ96EY1.
PaxDbiQ96EY1.
PRIDEiQ96EY1.

PTM databases

PhosphoSiteiQ96EY1.

Expressioni

Tissue specificityi

Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.1 Publication

Gene expression databases

ArrayExpressiQ96EY1.
BgeeiQ96EY1.
CleanExiHS_DNAJA3.
GenevestigatoriQ96EY1.

Organism-specific databases

HPAiCAB016095.
HPA040875.
HPA044229.

Interactioni

Subunit structurei

Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1). Isoform 2 interacts with MUSK (via the cytoplasmic domain) By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CARM1Q86X552EBI-356767,EBI-2339854
KDM1AO603412EBI-356767,EBI-710124
METP085812EBI-3952284,EBI-1039152
PRMT6Q96LA82EBI-356767,EBI-912440
STAT5BP516922EBI-356767,EBI-1186119
Stat5bP422323EBI-356767,EBI-617454From a different organism.

Protein-protein interaction databases

BioGridi114547. 46 interactions.
DIPiDIP-33870N.
IntActiQ96EY1. 29 interactions.
MINTiMINT-1151431.
STRINGi9606.ENSP00000262375.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi94 – 985
Helixi106 – 11914
Turni122 – 1243
Helixi131 – 14616
Helixi148 – 1569
Beta strandi222 – 2243
Beta strandi237 – 2448
Beta strandi254 – 2596
Beta strandi261 – 2666
Beta strandi269 – 2746
Beta strandi276 – 2849
Beta strandi290 – 2945
Beta strandi296 – 2983

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CTTNMR-A213-303[»]
2DN9NMR-A93-158[»]
ProteinModelPortaliQ96EY1.
SMRiQ96EY1. Positions 90-191, 213-429.

Miscellaneous databases

EvolutionaryTraceiQ96EY1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 15866J
Add
BLAST
Repeati236 – 2438CXXCXGXG motifUniRule annotation
Repeati253 – 2608CXXCXGXG motifUniRule annotation
Repeati275 – 2828CXXCXGXG motifUniRule annotation
Repeati289 – 2968CXXCXGXG motifUniRule annotation

Domaini

Modulation of apoptosis, i.e. proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2, is J domain-dependent.UniRule annotation

Sequence similaritiesi

Contains 1 J domain.

Keywords - Domaini

Repeat, Transit peptide, Zinc-finger

Phylogenomic databases

eggNOGiCOG0484.
HOVERGENiHBG051371.
InParanoidiQ96EY1.
KOiK09504.
OMAiDTCERCN.
OrthoDBiEOG7B31N2.
PhylomeDBiQ96EY1.
TreeFamiTF105152.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
2.10.230.10. 1 hit.
HAMAPiMF_01152. DnaJ.
InterProiIPR012724. DnaJ.
IPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
IPR001305. HSP_DnaJ_Cys-rich_dom.
[Graphical view]
PfamiPF01556. CTDII. 1 hit.
PF00226. DnaJ. 1 hit.
PF00684. DnaJ_CXXCXGXG. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 1 hit.
SSF57938. SSF57938. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51188. ZF_CR. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96EY1-1) [UniParc]FASTAAdd to Basket

Also known as: Tid-1(L)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAARCSTRWL LVVVGTPRLP AISGRGARPP REGVVGAWLS RKLSVPAFAS    50
SLTSCGPRAL LTLRPGVSLT GTKHNPFICT ASFHTSAPLA KEDYYQILGV 100
PRNASQKEIK KAYYQLAKKY HPDTNKDDPK AKEKFSQLAE AYEVLSDEVK 150
RKQYDAYGSA GFDPGASGSQ HSYWKGGPTV DPEELFRKIF GEFSSSSFGD 200
FQTVFDQPQE YFMELTFNQA AKGVNKEFTV NIMDTCERCN GKGNEPGTKV 250
QHCHYCGGSG METINTGPFV MRSTCRRCGG RGSIIISPCV VCRGAGQAKQ 300
KKRVMIPVPA GVEDGQTVRM PVGKREIFIT FRVQKSPVFR RDGADIHSDL 350
FISIAQALLG GTARAQGLYE TINVTIPPGT QTDQKIRMGG KGIPRINSYG 400
YGDHYIHIKI RVPKRLTSRQ QSLILSYAED ETDVEGTVNG VTLTSSGGST 450
MDSSAGSKAR REAGEDEEGF LSKLKKMFTS 480
Length:480
Mass (Da):52,489
Last modified:November 2, 2010 - v2
Checksum:i5A57B9020992CF59
GO
Isoform 2 (identifier: Q96EY1-2) [UniParc]FASTAAdd to Basket

Also known as: Tid-1(S)

The sequence of this isoform differs from the canonical sequence as follows:
     448-453: GSTMDS → KRSTGN
     454-480: Missing.

Show »
Length:453
Mass (Da):49,611
Checksum:iE235B8DC1DB99FBC
GO
Isoform 3 (identifier: Q96EY1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-186: ARCSTRWLLV...GPTVDPEELF → EPQAERPRLCVFPDLLRPPSAADIETWCQPY
     448-453: GSTMDS → KRSTGN
     454-480: Missing.

Show »
Length:300
Mass (Da):33,082
Checksum:i36D883E568E8ECC8
GO

Sequence cautioni

The sequence AAF66245.1 differs from that shown. Reason: Frameshift at positions 408 and 411.
The sequence AAF66245.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAH12343.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751N → Y.4 Publications
Corresponds to variant rs4785963 [ dbSNP | Ensembl ].
VAR_027965

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3 – 186184ARCST…PEELF → EPQAERPRLCVFPDLLRPPS AADIETWCQPY in isoform 3.
VSP_055728Add
BLAST
Alternative sequencei448 – 4536GSTMDS → KRSTGN in isoform 2 and isoform 3.
VSP_007425
Alternative sequencei454 – 48027Missing in isoform 2 and isoform 3.
VSP_007426Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti320 – 3201M → W in AAF66245. 1 Publication
Isoform 3 (identifier: Q96EY1-3)
Sequence conflicti33 – 331Y → H in BAG58345. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF061749 mRNA. Translation: AAC29066.1.
AF411044 mRNA. Translation: AAL35323.1.
AK295391 mRNA. Translation: BAG58345.1.
AK314218 mRNA. Translation: BAG36892.1.
AC012676 Genomic DNA. No translation available.
BC007225 mRNA. Translation: AAH07225.1.
BC011855 mRNA. Translation: AAH11855.1.
BC012343 mRNA. Translation: AAH12343.1. Different initiation.
BC014062 mRNA. Translation: AAH14062.1.
BC020248 mRNA. Translation: AAH20248.1.
BC030145 mRNA. Translation: AAH30145.1.
BC032100 mRNA. Translation: AAH32100.1.
AF244136 mRNA. Translation: AAF66245.1. Sequence problems.
CCDSiCCDS10515.1. [Q96EY1-1]
CCDS45400.1. [Q96EY1-2]
RefSeqiNP_001128582.1. NM_001135110.2. [Q96EY1-2]
NP_001273445.1. NM_001286516.1.
NP_005138.3. NM_005147.5. [Q96EY1-1]
UniGeneiHs.459779.

Genome annotation databases

EnsembliENST00000262375; ENSP00000262375; ENSG00000103423. [Q96EY1-1]
ENST00000355296; ENSP00000347445; ENSG00000103423. [Q96EY1-2]
ENST00000431375; ENSP00000393970; ENSG00000103423.
GeneIDi9093.
KEGGihsa:9093.
UCSCiuc002cwk.3. human. [Q96EY1-1]
uc002cwl.3. human. [Q96EY1-2]

Polymorphism databases

DMDMi311033374.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF061749 mRNA. Translation: AAC29066.1 .
AF411044 mRNA. Translation: AAL35323.1 .
AK295391 mRNA. Translation: BAG58345.1 .
AK314218 mRNA. Translation: BAG36892.1 .
AC012676 Genomic DNA. No translation available.
BC007225 mRNA. Translation: AAH07225.1 .
BC011855 mRNA. Translation: AAH11855.1 .
BC012343 mRNA. Translation: AAH12343.1 . Different initiation.
BC014062 mRNA. Translation: AAH14062.1 .
BC020248 mRNA. Translation: AAH20248.1 .
BC030145 mRNA. Translation: AAH30145.1 .
BC032100 mRNA. Translation: AAH32100.1 .
AF244136 mRNA. Translation: AAF66245.1 . Sequence problems.
CCDSi CCDS10515.1. [Q96EY1-1 ]
CCDS45400.1. [Q96EY1-2 ]
RefSeqi NP_001128582.1. NM_001135110.2. [Q96EY1-2 ]
NP_001273445.1. NM_001286516.1.
NP_005138.3. NM_005147.5. [Q96EY1-1 ]
UniGenei Hs.459779.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CTT NMR - A 213-303 [» ]
2DN9 NMR - A 93-158 [» ]
ProteinModelPortali Q96EY1.
SMRi Q96EY1. Positions 90-191, 213-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114547. 46 interactions.
DIPi DIP-33870N.
IntActi Q96EY1. 29 interactions.
MINTi MINT-1151431.
STRINGi 9606.ENSP00000262375.

PTM databases

PhosphoSitei Q96EY1.

Polymorphism databases

DMDMi 311033374.

Proteomic databases

MaxQBi Q96EY1.
PaxDbi Q96EY1.
PRIDEi Q96EY1.

Protocols and materials databases

DNASUi 9093.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262375 ; ENSP00000262375 ; ENSG00000103423 . [Q96EY1-1 ]
ENST00000355296 ; ENSP00000347445 ; ENSG00000103423 . [Q96EY1-2 ]
ENST00000431375 ; ENSP00000393970 ; ENSG00000103423 .
GeneIDi 9093.
KEGGi hsa:9093.
UCSCi uc002cwk.3. human. [Q96EY1-1 ]
uc002cwl.3. human. [Q96EY1-2 ]

Organism-specific databases

CTDi 9093.
GeneCardsi GC16P004475.
H-InvDB HIX0012782.
HGNCi HGNC:11808. DNAJA3.
HPAi CAB016095.
HPA040875.
HPA044229.
MIMi 608382. gene.
neXtProti NX_Q96EY1.
PharmGKBi PA27410.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0484.
HOVERGENi HBG051371.
InParanoidi Q96EY1.
KOi K09504.
OMAi DTCERCN.
OrthoDBi EOG7B31N2.
PhylomeDBi Q96EY1.
TreeFami TF105152.

Miscellaneous databases

EvolutionaryTracei Q96EY1.
GeneWikii DNAJA3.
GenomeRNAii 9093.
NextBioi 34071.
PROi Q96EY1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96EY1.
Bgeei Q96EY1.
CleanExi HS_DNAJA3.
Genevestigatori Q96EY1.

Family and domain databases

Gene3Di 1.10.287.110. 1 hit.
2.10.230.10. 1 hit.
HAMAPi MF_01152. DnaJ.
InterProi IPR012724. DnaJ.
IPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
IPR001305. HSP_DnaJ_Cys-rich_dom.
[Graphical view ]
Pfami PF01556. CTDII. 1 hit.
PF00226. DnaJ. 1 hit.
PF00684. DnaJ_CXXCXGXG. 1 hit.
[Graphical view ]
PRINTSi PR00625. JDOMAIN.
SMARTi SM00271. DnaJ. 1 hit.
[Graphical view ]
SUPFAMi SSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 1 hit.
SSF57938. SSF57938. 1 hit.
PROSITEi PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51188. ZF_CR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human DnaJ protein, hTid-1, a homolog of the Drosophila tumor suppressor protein Tid56, can interact with the human papillomavirus type 16 E7 oncoprotein."
    Schilling B., De-Medina T., Syken J., Vidal M., Munger K.
    Virology 247:74-85(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "hTid-1, a human DnaJ protein, modulates the interferon signaling pathway."
    Sarkar S., Pollack B.P., Lin K.-T., Kotenko S.V., Cook J.R., Lewis A., Pestka S.
    J. Biol. Chem. 276:49034-49042(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH JAK2; HSP70 AND IFN-GAMMAR2, VARIANT TYR-75.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT TYR-75.
    Tissue: Corpus callosum and Urinary bladder.
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT TYR-75.
    Tissue: Brain, Colon, Lung, Muscle and Placenta.
  6. "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies."
    Wang Y., Han K.-J., Pang X.-W., Vaughan H.A., Qu W., Dong X.-Y., Peng J.-R., Zhao H.-T., Rui J.-A., Leng X.-S., Cebon J., Burgess A.W., Chen W.-F.
    J. Immunol. 169:1102-1109(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-480 (ISOFORM 2), VARIANT TYR-75.
    Tissue: Hepatoma.
  7. "TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions."
    Syken J., De-Medina T., Muenger K.
    Proc. Natl. Acad. Sci. U.S.A. 96:8499-8504(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, MUTAGENESIS OF HIS-121.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: METHYLATION AT ARG-58; ARG-238 AND ARG-293 BY CARM1, IDENTIFICATION BY MASS SPECTROMETRY.
  10. "Solution structure of J-domain and of zinc finger domain from human DnaJ subfamily A member 3."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 93-303.

Entry informationi

Entry nameiDNJA3_HUMAN
AccessioniPrimary (citable) accession number: Q96EY1
Secondary accession number(s): B2RAJ5
, B4DI33, E7ES32, O75472, Q8WUJ6, Q8WXJ3, Q96D76, Q96IV1, Q9NYH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: November 2, 2010
Last modified: September 3, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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