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Q96EY1

- DNJA3_HUMAN

UniProt

Q96EY1 - DNJA3_HUMAN

Protein

DnaJ homolog subfamily A member 3, mitochondrial

Gene

DNAJA3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 2 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi236 – 2361Zinc 1By similarity
    Metal bindingi239 – 2391Zinc 1By similarity
    Metal bindingi253 – 2531Zinc 2By similarity
    Metal bindingi256 – 2561Zinc 2By similarity
    Metal bindingi275 – 2751Zinc 2By similarity
    Metal bindingi278 – 2781Zinc 2By similarity
    Metal bindingi289 – 2891Zinc 1By similarity
    Metal bindingi292 – 2921Zinc 1By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri223 – 30179CR-typeAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. interferon-gamma receptor binding Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. NF-kappaB binding Source: UniProtKB
    5. protein binding Source: UniProtKB
    6. protein kinase binding Source: UniProtKB
    7. small GTPase regulator activity Source: Ensembl
    8. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. activation-induced cell death of T cells Source: Ensembl
    2. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    3. cell aging Source: Ensembl
    4. embryo development Source: Ensembl
    5. mitochondrial DNA replication Source: Ensembl
    6. negative regulation of apoptotic process Source: UniProtKB
    7. negative regulation of cell proliferation Source: UniProtKB
    8. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    9. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    10. negative regulation of interferon-gamma-mediated signaling pathway Source: UniProtKB
    11. negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
    12. negative regulation of protein kinase activity Source: UniProtKB
    13. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    14. neuromuscular junction development Source: UniProtKB
    15. positive regulation of apoptotic process Source: UniProtKB
    16. positive regulation of protein ubiquitination Source: UniProtKB
    17. positive regulation of T cell proliferation Source: Ensembl
    18. protein folding Source: UniProtKB
    19. protein stabilization Source: UniProtKB
    20. response to heat Source: InterPro
    21. response to interferon-gamma Source: UniProtKB
    22. skeletal muscle acetylcholine-gated channel clustering Source: UniProtKB
    23. small GTPase mediated signal transduction Source: Ensembl
    24. T cell differentiation in thymus Source: Ensembl

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DnaJ homolog subfamily A member 3, mitochondrial
    Alternative name(s):
    DnaJ protein Tid-1
    Short name:
    hTid-1
    Hepatocellular carcinoma-associated antigen 57
    Tumorous imaginal discs protein Tid56 homolog
    Gene namesi
    Name:DNAJA3
    Synonyms:HCA57, TID1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:11808. DNAJA3.

    Subcellular locationi

    Mitochondrion matrix. Cytoplasmcytosol By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity; Peripheral membrane protein By similarity
    Note: Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasm Source: UniProtKB
    3. cytosol Source: UniProtKB-SubCell
    4. extrinsic component of plasma membrane Source: UniProtKB
    5. intracellular membrane-bounded organelle Source: HPA
    6. mitochondrial matrix Source: UniProtKB
    7. mitochondrial nucleoid Source: UniProtKB
    8. mitochondrion Source: UniProt
    9. neuromuscular junction Source: UniProtKB
    10. nucleus Source: UniProtKB
    11. postsynaptic membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Membrane, Mitochondrion, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi121 – 1211H → Q: Loss of modulation of apoptosis. 1 Publication

    Organism-specific databases

    PharmGKBiPA27410.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 480DnaJ homolog subfamily A member 3, mitochondrialPRO_0000007256
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei58 – 581Omega-N-methylarginine; by CARM11 Publication
    Modified residuei134 – 1341N6-acetyllysineBy similarity
    Modified residuei238 – 2381Omega-N-methylarginine; by CARM11 Publication
    Modified residuei293 – 2931Omega-N-methylarginine; by CARM11 Publication

    Post-translational modificationi

    Tyrosine phosphorylated.By similarity

    Keywords - PTMi

    Acetylation, Methylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ96EY1.
    PaxDbiQ96EY1.
    PRIDEiQ96EY1.

    PTM databases

    PhosphoSiteiQ96EY1.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.1 Publication

    Gene expression databases

    ArrayExpressiQ96EY1.
    BgeeiQ96EY1.
    CleanExiHS_DNAJA3.
    GenevestigatoriQ96EY1.

    Organism-specific databases

    HPAiCAB016095.
    HPA040875.
    HPA044229.

    Interactioni

    Subunit structurei

    Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1). Isoform 2 interacts with MUSK (via the cytoplasmic domain) By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CARM1Q86X552EBI-356767,EBI-2339854
    KDM1AO603412EBI-356767,EBI-710124
    METP085812EBI-3952284,EBI-1039152
    PRMT6Q96LA82EBI-356767,EBI-912440
    STAT5BP516922EBI-356767,EBI-1186119
    Stat5bP422323EBI-356767,EBI-617454From a different organism.

    Protein-protein interaction databases

    BioGridi114547. 46 interactions.
    DIPiDIP-33870N.
    IntActiQ96EY1. 30 interactions.
    MINTiMINT-1151431.
    STRINGi9606.ENSP00000262375.

    Structurei

    Secondary structure

    1
    480
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi94 – 985
    Helixi106 – 11914
    Turni122 – 1243
    Helixi131 – 14616
    Helixi148 – 1569
    Beta strandi222 – 2243
    Beta strandi237 – 2448
    Beta strandi254 – 2596
    Beta strandi261 – 2666
    Beta strandi269 – 2746
    Beta strandi276 – 2849
    Beta strandi290 – 2945
    Beta strandi296 – 2983

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CTTNMR-A213-303[»]
    2DN9NMR-A93-158[»]
    ProteinModelPortaliQ96EY1.
    SMRiQ96EY1. Positions 90-191, 213-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96EY1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini93 – 15866JAdd
    BLAST
    Repeati236 – 2438CXXCXGXG motif
    Repeati253 – 2608CXXCXGXG motif
    Repeati275 – 2828CXXCXGXG motif
    Repeati289 – 2968CXXCXGXG motif

    Domaini

    Modulation of apoptosis, i.e. proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2, is J domain-dependent.

    Sequence similaritiesi

    Contains 1 CR-type zinc finger.Curated
    Contains 1 J domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri223 – 30179CR-typeAdd
    BLAST

    Keywords - Domaini

    Repeat, Transit peptide, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0484.
    HOVERGENiHBG051371.
    InParanoidiQ96EY1.
    KOiK09504.
    OMAiDTCERCN.
    OrthoDBiEOG7B31N2.
    PhylomeDBiQ96EY1.
    TreeFamiTF105152.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    2.10.230.10. 1 hit.
    HAMAPiMF_01152. DnaJ.
    InterProiIPR012724. DnaJ.
    IPR002939. DnaJ_C.
    IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    IPR008971. HSP40/DnaJ_pept-bd.
    IPR001305. HSP_DnaJ_Cys-rich_dom.
    [Graphical view]
    PfamiPF01556. CTDII. 1 hit.
    PF00226. DnaJ. 1 hit.
    PF00684. DnaJ_CXXCXGXG. 1 hit.
    [Graphical view]
    PRINTSiPR00625. JDOMAIN.
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    SSF49493. SSF49493. 1 hit.
    SSF57938. SSF57938. 1 hit.
    PROSITEiPS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    PS51188. ZF_CR. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96EY1-1) [UniParc]FASTAAdd to Basket

    Also known as: Tid-1(L)

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAARCSTRWL LVVVGTPRLP AISGRGARPP REGVVGAWLS RKLSVPAFAS    50
    SLTSCGPRAL LTLRPGVSLT GTKHNPFICT ASFHTSAPLA KEDYYQILGV 100
    PRNASQKEIK KAYYQLAKKY HPDTNKDDPK AKEKFSQLAE AYEVLSDEVK 150
    RKQYDAYGSA GFDPGASGSQ HSYWKGGPTV DPEELFRKIF GEFSSSSFGD 200
    FQTVFDQPQE YFMELTFNQA AKGVNKEFTV NIMDTCERCN GKGNEPGTKV 250
    QHCHYCGGSG METINTGPFV MRSTCRRCGG RGSIIISPCV VCRGAGQAKQ 300
    KKRVMIPVPA GVEDGQTVRM PVGKREIFIT FRVQKSPVFR RDGADIHSDL 350
    FISIAQALLG GTARAQGLYE TINVTIPPGT QTDQKIRMGG KGIPRINSYG 400
    YGDHYIHIKI RVPKRLTSRQ QSLILSYAED ETDVEGTVNG VTLTSSGGST 450
    MDSSAGSKAR REAGEDEEGF LSKLKKMFTS 480
    Length:480
    Mass (Da):52,489
    Last modified:November 2, 2010 - v2
    Checksum:i5A57B9020992CF59
    GO
    Isoform 2 (identifier: Q96EY1-2) [UniParc]FASTAAdd to Basket

    Also known as: Tid-1(S)

    The sequence of this isoform differs from the canonical sequence as follows:
         448-453: GSTMDS → KRSTGN
         454-480: Missing.

    Show »
    Length:453
    Mass (Da):49,611
    Checksum:iE235B8DC1DB99FBC
    GO
    Isoform 3 (identifier: Q96EY1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         3-186: ARCSTRWLLV...GPTVDPEELF → EPQAERPRLCVFPDLLRPPSAADIETWCQPY
         448-453: GSTMDS → KRSTGN
         454-480: Missing.

    Show »
    Length:300
    Mass (Da):33,082
    Checksum:i36D883E568E8ECC8
    GO

    Sequence cautioni

    The sequence AAF66245.1 differs from that shown. Reason: Frameshift at positions 408 and 411.
    The sequence AAF66245.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH12343.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti320 – 3201M → W in AAF66245. (PubMed:12097419)Curated
    Isoform 3 (identifier: Q96EY1-3)
    Sequence conflicti33 – 331Y → H in BAG58345. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti75 – 751N → Y.4 Publications
    Corresponds to variant rs4785963 [ dbSNP | Ensembl ].
    VAR_027965

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei3 – 186184ARCST…PEELF → EPQAERPRLCVFPDLLRPPS AADIETWCQPY in isoform 3. 1 PublicationVSP_055728Add
    BLAST
    Alternative sequencei448 – 4536GSTMDS → KRSTGN in isoform 2 and isoform 3. 4 PublicationsVSP_007425
    Alternative sequencei454 – 48027Missing in isoform 2 and isoform 3. 4 PublicationsVSP_007426Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061749 mRNA. Translation: AAC29066.1.
    AF411044 mRNA. Translation: AAL35323.1.
    AK295391 mRNA. Translation: BAG58345.1.
    AK314218 mRNA. Translation: BAG36892.1.
    AC012676 Genomic DNA. No translation available.
    BC007225 mRNA. Translation: AAH07225.1.
    BC011855 mRNA. Translation: AAH11855.1.
    BC012343 mRNA. Translation: AAH12343.1. Different initiation.
    BC014062 mRNA. Translation: AAH14062.1.
    BC020248 mRNA. Translation: AAH20248.1.
    BC030145 mRNA. Translation: AAH30145.1.
    BC032100 mRNA. Translation: AAH32100.1.
    AF244136 mRNA. Translation: AAF66245.1. Sequence problems.
    CCDSiCCDS10515.1. [Q96EY1-1]
    CCDS45400.1. [Q96EY1-2]
    RefSeqiNP_001128582.1. NM_001135110.2. [Q96EY1-2]
    NP_001273445.1. NM_001286516.1.
    NP_005138.3. NM_005147.5. [Q96EY1-1]
    UniGeneiHs.459779.

    Genome annotation databases

    EnsembliENST00000262375; ENSP00000262375; ENSG00000103423. [Q96EY1-1]
    ENST00000355296; ENSP00000347445; ENSG00000103423. [Q96EY1-2]
    ENST00000431375; ENSP00000393970; ENSG00000103423. [Q96EY1-3]
    GeneIDi9093.
    KEGGihsa:9093.
    UCSCiuc002cwk.3. human. [Q96EY1-1]
    uc002cwl.3. human. [Q96EY1-2]

    Polymorphism databases

    DMDMi311033374.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061749 mRNA. Translation: AAC29066.1 .
    AF411044 mRNA. Translation: AAL35323.1 .
    AK295391 mRNA. Translation: BAG58345.1 .
    AK314218 mRNA. Translation: BAG36892.1 .
    AC012676 Genomic DNA. No translation available.
    BC007225 mRNA. Translation: AAH07225.1 .
    BC011855 mRNA. Translation: AAH11855.1 .
    BC012343 mRNA. Translation: AAH12343.1 . Different initiation.
    BC014062 mRNA. Translation: AAH14062.1 .
    BC020248 mRNA. Translation: AAH20248.1 .
    BC030145 mRNA. Translation: AAH30145.1 .
    BC032100 mRNA. Translation: AAH32100.1 .
    AF244136 mRNA. Translation: AAF66245.1 . Sequence problems.
    CCDSi CCDS10515.1. [Q96EY1-1 ]
    CCDS45400.1. [Q96EY1-2 ]
    RefSeqi NP_001128582.1. NM_001135110.2. [Q96EY1-2 ]
    NP_001273445.1. NM_001286516.1.
    NP_005138.3. NM_005147.5. [Q96EY1-1 ]
    UniGenei Hs.459779.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CTT NMR - A 213-303 [» ]
    2DN9 NMR - A 93-158 [» ]
    ProteinModelPortali Q96EY1.
    SMRi Q96EY1. Positions 90-191, 213-429.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114547. 46 interactions.
    DIPi DIP-33870N.
    IntActi Q96EY1. 30 interactions.
    MINTi MINT-1151431.
    STRINGi 9606.ENSP00000262375.

    PTM databases

    PhosphoSitei Q96EY1.

    Polymorphism databases

    DMDMi 311033374.

    Proteomic databases

    MaxQBi Q96EY1.
    PaxDbi Q96EY1.
    PRIDEi Q96EY1.

    Protocols and materials databases

    DNASUi 9093.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262375 ; ENSP00000262375 ; ENSG00000103423 . [Q96EY1-1 ]
    ENST00000355296 ; ENSP00000347445 ; ENSG00000103423 . [Q96EY1-2 ]
    ENST00000431375 ; ENSP00000393970 ; ENSG00000103423 . [Q96EY1-3 ]
    GeneIDi 9093.
    KEGGi hsa:9093.
    UCSCi uc002cwk.3. human. [Q96EY1-1 ]
    uc002cwl.3. human. [Q96EY1-2 ]

    Organism-specific databases

    CTDi 9093.
    GeneCardsi GC16P004475.
    H-InvDB HIX0012782.
    HGNCi HGNC:11808. DNAJA3.
    HPAi CAB016095.
    HPA040875.
    HPA044229.
    MIMi 608382. gene.
    neXtProti NX_Q96EY1.
    PharmGKBi PA27410.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0484.
    HOVERGENi HBG051371.
    InParanoidi Q96EY1.
    KOi K09504.
    OMAi DTCERCN.
    OrthoDBi EOG7B31N2.
    PhylomeDBi Q96EY1.
    TreeFami TF105152.

    Miscellaneous databases

    EvolutionaryTracei Q96EY1.
    GeneWikii DNAJA3.
    GenomeRNAii 9093.
    NextBioi 34071.
    PROi Q96EY1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96EY1.
    Bgeei Q96EY1.
    CleanExi HS_DNAJA3.
    Genevestigatori Q96EY1.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    2.10.230.10. 1 hit.
    HAMAPi MF_01152. DnaJ.
    InterProi IPR012724. DnaJ.
    IPR002939. DnaJ_C.
    IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    IPR008971. HSP40/DnaJ_pept-bd.
    IPR001305. HSP_DnaJ_Cys-rich_dom.
    [Graphical view ]
    Pfami PF01556. CTDII. 1 hit.
    PF00226. DnaJ. 1 hit.
    PF00684. DnaJ_CXXCXGXG. 1 hit.
    [Graphical view ]
    PRINTSi PR00625. JDOMAIN.
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    SSF49493. SSF49493. 1 hit.
    SSF57938. SSF57938. 1 hit.
    PROSITEi PS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    PS51188. ZF_CR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human DnaJ protein, hTid-1, a homolog of the Drosophila tumor suppressor protein Tid56, can interact with the human papillomavirus type 16 E7 oncoprotein."
      Schilling B., De-Medina T., Syken J., Vidal M., Munger K.
      Virology 247:74-85(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "hTid-1, a human DnaJ protein, modulates the interferon signaling pathway."
      Sarkar S., Pollack B.P., Lin K.-T., Kotenko S.V., Cook J.R., Lewis A., Pestka S.
      J. Biol. Chem. 276:49034-49042(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH JAK2; HSP70 AND IFN-GAMMAR2, VARIANT TYR-75.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT TYR-75.
      Tissue: Corpus callosum and Urinary bladder.
    4. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT TYR-75.
      Tissue: Brain, Colon, Lung, Muscle and Placenta.
    6. "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies."
      Wang Y., Han K.-J., Pang X.-W., Vaughan H.A., Qu W., Dong X.-Y., Peng J.-R., Zhao H.-T., Rui J.-A., Leng X.-S., Cebon J., Burgess A.W., Chen W.-F.
      J. Immunol. 169:1102-1109(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-480 (ISOFORM 2), VARIANT TYR-75.
      Tissue: Hepatoma.
    7. "TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions."
      Syken J., De-Medina T., Muenger K.
      Proc. Natl. Acad. Sci. U.S.A. 96:8499-8504(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, MUTAGENESIS OF HIS-121.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: METHYLATION AT ARG-58; ARG-238 AND ARG-293 BY CARM1, IDENTIFICATION BY MASS SPECTROMETRY.
    10. "Solution structure of J-domain and of zinc finger domain from human DnaJ subfamily A member 3."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 93-303.

    Entry informationi

    Entry nameiDNJA3_HUMAN
    AccessioniPrimary (citable) accession number: Q96EY1
    Secondary accession number(s): B2RAJ5
    , B4DI33, E7ES32, O75472, Q8WUJ6, Q8WXJ3, Q96D76, Q96IV1, Q9NYH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2003
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 135 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3