Q96EX3 (WDR34_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 34

Gene names

Name:

WDR34

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	536 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation. Ref.3
Subunit structure	Interacts (via the WD domains) with MAP3K7 and TAB3. Interacts (via WD domains) with TAB2 (via C-terminus). Interacts (via WD domains) with TRAF6 (via TRAF-type domains). Ref.3
Subcellular location	Cytoplasm Ref.3.
Tissue specificity	Expressed in several cell lines (at protein level). Ref.3
Sequence similarities	Contains 5 WD repeats.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 536	536	WD repeat-containing protein 34		PRO_0000051383
Regions
	Repeat	215 – 255	41	WD 1
	Repeat	264 – 308	45	WD 2
	Repeat	390 – 430	41	WD 3
	Repeat	433 – 473	41	WD 4
	Repeat	480 – 520	41	WD 5
Experimental info
	Sequence conflict	60	1	W → G in AAH11874. Ref.2
	Sequence conflict	60	1	W → G in AAH01614. Ref.2
	Sequence conflict	356	1	G → S in AAH01614. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q96EX3 [UniParc]. Last modified February 21, 2006. Version 2. Checksum: D23C2E0055120A4C	FASTA	536	57,801
	10 20 30 40 50 60 MATRAQPGPL SQAGSAGVAA LATVGVASGP GPGRPGPLQD ETLGVASVPS QWRAVQGIRW 70 80 90 100 110 120 ETKSCQTASI ATASASAQAR NHVDAQVQTE APVPVSVQPP SQYDIPRLAA FLRRVEAMVI 130 140 150 160 170 180 RELNKNWQSH AFDGFEVNWT EQQQMVSCLY TLGYPPAQAQ GLHVTSISWN STGSVVACAY 190 200 210 220 230 240 GRLDHGDWST LKSFVCAWNL DRRDLRPQQP SAVVEVPSAV LCLAFHPTQP SHVAGGLYSG 250 260 270 280 290 300 EVLVWDLSRL EDPLLWRTGL TDDTHTDPVS QVVWLPEPGH SHRFQVLSVA TDGKVLLWQG 310 320 330 340 350 360 IGVGQLQLTE GFALVMQQLP RSTKLKKHPR GETEVGATAV AFSSFDPRLF ILGTEGGFPL 370 380 390 400 410 420 KCSLAAGEAA LTRMPSSVPL RAPAQFTFSP HGGPIYSVSC SPFHRNLFLS AGTDGHVHLY 430 440 450 460 470 480 SMLQAPPLTS LQLSLKYLFA VRWSPVRPLV FAAASGKGDV QLFDLQKSSQ KPTVLIKQTQ 490 500 510 520 530 DESPVYCLEF NSQQTQLLAA GDAQGTVKVW QLSTEFTEQG PREAEDLDCL AAEVAA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Lung.
[3]	"WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway." Gao D., Wang R., Li B., Yang Y., Zhai Z., Chen D.Y. Cell. Mol. Life Sci. 66:2573-2584(2009) [PubMed: 19521662] [Abstract] Cited for: FUNCTION, INTERACTION WITH MAP3K7; TAB2; TAB3 AND TRAF6, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL356481 Genomic DNA. Translation: CAH71407.1. BC001614 mRNA. Translation: AAH01614.3. BC011874 mRNA. Translation: AAH11874.2.
IPI	IPI00306130.
RefSeq	NP_443076.2. NM_052844.3.
UniGene	Hs.495240.
3D structure databases
ProteinModelPortal	Q96EX3.
SMR	Q96EX3. Positions 160-249, 395-516.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96EX3. 1 interaction.
STRING	Q96EX3.
PTM databases
PhosphoSite	Q96EX3.
Polymorphism databases
DMDM	88985038.
Proteomic databases
PRIDE	Q96EX3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372715; ENSP00000361800; ENSG00000119333.
GeneID	89891.
KEGG	hsa:89891.
UCSC	uc004bvq.1. human.
Organism-specific databases
CTD	89891.
GeneCards	GC09M131395.
HGNC	HGNC:28296. WDR34.
HPA	HPA040764. HPA041091.
MIM	613363. gene.
neXtProt	NX_Q96EX3.
PharmGKB	PA134951680.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00550000074241.
HOGENOM	HBG445231.
HOVERGEN	HBG058945.
InParanoid	Q96EX3.
OMA	SGEVLVW.
OrthoDB	EOG43TZVB.
PhylomeDB	Q96EX3.
Gene expression databases
ArrayExpress	Q96EX3.
Bgee	Q96EX3.
CleanEx	HS_WDR34.
Genevestigator	Q96EX3.
GermOnline	ENSG00000119333. Homo sapiens.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 4 hits. [Graphical view]
SMART	SM00320. WD40. 5 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	76421.
SOURCE	Search...

Entry information

Entry name

WDR34_HUMAN

Accession

Primary (citable) accession number: Q96EX3
Secondary accession number(s): Q5VXV4, Q9BV46

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	February 21, 2006
Last modified:	January 25, 2012
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.