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Protein

RING finger and transmembrane domain-containing protein 2

Gene

RNFT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri384 – 42239RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger and transmembrane domain-containing protein 2
Alternative name(s):
Transmembrane protein 118
Gene namesi
Name:RNFT2
Synonyms:TMEM118
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25905. RNFT2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 181181ExtracellularSequence analysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence analysisAdd
BLAST
Topological domaini203 – 21412CytoplasmicSequence analysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence analysisAdd
BLAST
Topological domaini236 – 25520ExtracellularSequence analysisAdd
BLAST
Transmembranei256 – 27621HelicalSequence analysisAdd
BLAST
Topological domaini277 – 32953CytoplasmicSequence analysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence analysisAdd
BLAST
Topological domaini351 – 44494ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162401944.

Polymorphism and mutation databases

BioMutaiRNFT2.
DMDMi143216906.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444RING finger and transmembrane domain-containing protein 2PRO_0000279508Add
BLAST

Proteomic databases

EPDiQ96EX2.
MaxQBiQ96EX2.
PaxDbiQ96EX2.
PeptideAtlasiQ96EX2.
PRIDEiQ96EX2.

PTM databases

iPTMnetiQ96EX2.
PhosphoSiteiQ96EX2.

Expressioni

Gene expression databases

BgeeiENSG00000135119.
CleanExiHS_RNFT2.
ExpressionAtlasiQ96EX2. baseline and differential.
GenevisibleiQ96EX2. HS.

Organism-specific databases

HPAiHPA064161.

Interactioni

Protein-protein interaction databases

IntActiQ96EX2. 1 interaction.
STRINGi9606.ENSP00000257575.

Structurei

3D structure databases

ProteinModelPortaliQ96EX2.
SMRiQ96EX2. Positions 384-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi108 – 13730His-richAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri384 – 42239RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0802. Eukaryota.
KOG4638. Eukaryota.
ENOG4111HH8. LUCA.
GeneTreeiENSGT00390000014213.
HOGENOMiHOG000237544.
HOVERGENiHBG056546.
InParanoidiQ96EX2.
OMAiVVCWLQK.
OrthoDBiEOG091G0FD6.
PhylomeDBiQ96EX2.
TreeFamiTF331930.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96EX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWLFTVNQVL RKMQRRHSSN TDNIPPERNR SQALSSEASV DEGGVFESLK
60 70 80 90 100
AEAASPPALF SGLSGSLPTS SFPSSLVLGS SAGGGDVFIQ MPASREEGGG
110 120 130 140 150
RGEGGAYHHR QPHHHFHHGG HRGGSLLQHV GGDHRGHSEE GGDEQPGTPA
160 170 180 190 200
PALSELKAVI CWLQKGLPFI LILLAKLCFQ HKLGIAVCIG MASTFAYANS
210 220 230 240 250
TLREQVSLKE KRSVLVILWI LAFLAGNTLY VLYTFSSQQL YNSLIFLKPN
260 270 280 290 300
LEMLDFFDLL WIVGIADFVL KYITIALKCL IVALPKIILA VKSKGKFYLV
310 320 330 340 350
IEELSQLFRS LVPIQLWYKY IMGDDSSNSY FLGGVLIVLY SLCKSFDICG
360 370 380 390 400
RVGGVRKALK LLCTSQNYGV RATGQQCTEA GDICAICQAE FREPLILLCQ
410 420 430 440
HVFCEECLCL WLDRERTCPL CRSVAVDTLR CWKDGATSAH FQVY
Length:444
Mass (Da):48,965
Last modified:March 6, 2007 - v2
Checksum:iFC6BF9199C1EBCF8
GO
Isoform 2 (identifier: Q96EX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-321: QQLYNSLIFL...VPIQLWYKYI → EIAPQHSNLG...SSCGHCHPLW
     322-444: Missing.

Note: No experimental confirmation available.
Show »
Length:321
Mass (Da):35,200
Checksum:iF3BFB80530DA6048
GO
Isoform 3 (identifier: Q96EX2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.
     401-420: HVFCEECLCLWLDRERTCPL → MLLKGHKKLELEKIDESAGV
     421-444: Missing.

Note: No experimental confirmation available.
Show »
Length:330
Mass (Da):36,563
Checksum:i831A04EE0693C131
GO
Isoform 4 (identifier: Q96EX2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.

Note: No experimental confirmation available.
Show »
Length:192
Mass (Da):21,718
Checksum:iBA3EBD34830FE1F2
GO
Isoform 5 (identifier: Q96EX2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     401-420: HVFCEECLCLWLDRERTCPL → MLLKGHKKLELEKIDESAGV
     421-444: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:420
Mass (Da):46,041
Checksum:i63B155DCCB39C5FA
GO

Sequence cautioni

The sequence AAH11878 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 252252Missing in isoform 4. 1 PublicationVSP_035513Add
BLAST
Alternative sequencei1 – 9090Missing in isoform 3. 1 PublicationVSP_035514Add
BLAST
Alternative sequencei238 – 32184QQLYN…WYKYI → EIAPQHSNLGDRVSETLSKK KKKERREGGRKEGRKERKKA QLWPRCGYPLVSCLYVFLLF LFCHLPHLSLRPVSSSCGHC HPLW in isoform 2. 1 PublicationVSP_023465Add
BLAST
Alternative sequencei322 – 444123Missing in isoform 2. 1 PublicationVSP_023466Add
BLAST
Alternative sequencei401 – 42020HVFCE…RTCPL → MLLKGHKKLELEKIDESAGV in isoform 3 and isoform 5. 1 PublicationVSP_035515Add
BLAST
Alternative sequencei421 – 44424Missing in isoform 3 and isoform 5. 1 PublicationVSP_035516Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027533 mRNA. Translation: BAB55182.1.
AK093164 mRNA. No translation available.
AC083806 Genomic DNA. No translation available.
AC090013 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW98091.1.
BC011878 mRNA. Translation: AAH11878.1. Different initiation.
CCDSiCCDS44987.1. [Q96EX2-1]
CCDS9180.2. [Q96EX2-5]
RefSeqiNP_001103373.1. NM_001109903.1. [Q96EX2-1]
NP_116203.2. NM_032814.3. [Q96EX2-5]
UniGeneiHs.437195.

Genome annotation databases

EnsembliENST00000257575; ENSP00000257575; ENSG00000135119. [Q96EX2-1]
ENST00000392549; ENSP00000376332; ENSG00000135119. [Q96EX2-1]
ENST00000407967; ENSP00000385669; ENSG00000135119. [Q96EX2-5]
GeneIDi84900.
KEGGihsa:84900.
UCSCiuc001twb.4. human. [Q96EX2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027533 mRNA. Translation: BAB55182.1.
AK093164 mRNA. No translation available.
AC083806 Genomic DNA. No translation available.
AC090013 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW98091.1.
BC011878 mRNA. Translation: AAH11878.1. Different initiation.
CCDSiCCDS44987.1. [Q96EX2-1]
CCDS9180.2. [Q96EX2-5]
RefSeqiNP_001103373.1. NM_001109903.1. [Q96EX2-1]
NP_116203.2. NM_032814.3. [Q96EX2-5]
UniGeneiHs.437195.

3D structure databases

ProteinModelPortaliQ96EX2.
SMRiQ96EX2. Positions 384-422.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96EX2. 1 interaction.
STRINGi9606.ENSP00000257575.

PTM databases

iPTMnetiQ96EX2.
PhosphoSiteiQ96EX2.

Polymorphism and mutation databases

BioMutaiRNFT2.
DMDMi143216906.

Proteomic databases

EPDiQ96EX2.
MaxQBiQ96EX2.
PaxDbiQ96EX2.
PeptideAtlasiQ96EX2.
PRIDEiQ96EX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257575; ENSP00000257575; ENSG00000135119. [Q96EX2-1]
ENST00000392549; ENSP00000376332; ENSG00000135119. [Q96EX2-1]
ENST00000407967; ENSP00000385669; ENSG00000135119. [Q96EX2-5]
GeneIDi84900.
KEGGihsa:84900.
UCSCiuc001twb.4. human. [Q96EX2-1]

Organism-specific databases

CTDi84900.
GeneCardsiRNFT2.
HGNCiHGNC:25905. RNFT2.
HPAiHPA064161.
neXtProtiNX_Q96EX2.
PharmGKBiPA162401944.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0802. Eukaryota.
KOG4638. Eukaryota.
ENOG4111HH8. LUCA.
GeneTreeiENSGT00390000014213.
HOGENOMiHOG000237544.
HOVERGENiHBG056546.
InParanoidiQ96EX2.
OMAiVVCWLQK.
OrthoDBiEOG091G0FD6.
PhylomeDBiQ96EX2.
TreeFamiTF331930.

Miscellaneous databases

ChiTaRSiRNFT2. human.
GenomeRNAii84900.
PROiQ96EX2.

Gene expression databases

BgeeiENSG00000135119.
CleanExiHS_RNFT2.
ExpressionAtlasiQ96EX2. baseline and differential.
GenevisibleiQ96EX2. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRNFT2_HUMAN
AccessioniPrimary (citable) accession number: Q96EX2
Secondary accession number(s): E9PAM7, Q96SU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: September 7, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.