UniProtKB - Q96EX2 (RNFT2_HUMAN)
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Protein
RING finger and transmembrane domain-containing protein 2
Gene
RNFT2
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 384 – 422 | RING-typePROSITE-ProRule annotationAdd BLAST | 39 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: RING finger and transmembrane domain-containing protein 2Alternative name(s): Transmembrane protein 118 |
Gene namesi | Name:RNFT2 Synonyms:TMEM118 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000135119.14 |
HGNCi | HGNC:25905 RNFT2 |
neXtProti | NX_Q96EX2 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 181 | ExtracellularSequence analysisAdd BLAST | 181 | |
Transmembranei | 182 – 202 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 203 – 214 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 215 – 235 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 236 – 255 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 256 – 276 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 277 – 329 | CytoplasmicSequence analysisAdd BLAST | 53 | |
Transmembranei | 330 – 350 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 351 – 444 | ExtracellularSequence analysisAdd BLAST | 94 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000135119 |
PharmGKBi | PA162401944 |
Polymorphism and mutation databases
BioMutai | RNFT2 |
DMDMi | 143216906 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000279508 | 1 – 444 | RING finger and transmembrane domain-containing protein 2Add BLAST | 444 |
Proteomic databases
MaxQBi | Q96EX2 |
PaxDbi | Q96EX2 |
PeptideAtlasi | Q96EX2 |
PRIDEi | Q96EX2 |
PTM databases
iPTMneti | Q96EX2 |
PhosphoSitePlusi | Q96EX2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135119 |
CleanExi | HS_RNFT2 |
ExpressionAtlasi | Q96EX2 baseline and differential |
Genevisiblei | Q96EX2 HS |
Organism-specific databases
HPAi | HPA064161 |
Interactioni
Protein-protein interaction databases
IntActi | Q96EX2 1 interactor. |
STRINGi | 9606.ENSP00000257575 |
Structurei
3D structure databases
ProteinModelPortali | Q96EX2 |
SMRi | Q96EX2 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 108 – 137 | His-richAdd BLAST | 30 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 384 – 422 | RING-typePROSITE-ProRule annotationAdd BLAST | 39 |
Keywords - Domaini
Transmembrane, Transmembrane helix, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0802 Eukaryota KOG4638 Eukaryota ENOG4111HH8 LUCA |
GeneTreei | ENSGT00390000014213 |
HOGENOMi | HOG000237544 |
HOVERGENi | HBG056546 |
InParanoidi | Q96EX2 |
OMAi | LMCQHVF |
OrthoDBi | EOG091G0FD6 |
PhylomeDBi | Q96EX2 |
TreeFami | TF331930 |
Family and domain databases
Gene3Di | 3.30.40.101 hit |
InterProi | View protein in InterPro IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS |
SMARTi | View protein in SMART SM00184 RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit |
s (5)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96EX2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MWLFTVNQVL RKMQRRHSSN TDNIPPERNR SQALSSEASV DEGGVFESLK
60 70 80 90 100
AEAASPPALF SGLSGSLPTS SFPSSLVLGS SAGGGDVFIQ MPASREEGGG
110 120 130 140 150
RGEGGAYHHR QPHHHFHHGG HRGGSLLQHV GGDHRGHSEE GGDEQPGTPA
160 170 180 190 200
PALSELKAVI CWLQKGLPFI LILLAKLCFQ HKLGIAVCIG MASTFAYANS
210 220 230 240 250
TLREQVSLKE KRSVLVILWI LAFLAGNTLY VLYTFSSQQL YNSLIFLKPN
260 270 280 290 300
LEMLDFFDLL WIVGIADFVL KYITIALKCL IVALPKIILA VKSKGKFYLV
310 320 330 340 350
IEELSQLFRS LVPIQLWYKY IMGDDSSNSY FLGGVLIVLY SLCKSFDICG
360 370 380 390 400
RVGGVRKALK LLCTSQNYGV RATGQQCTEA GDICAICQAE FREPLILLCQ
410 420 430 440
HVFCEECLCL WLDRERTCPL CRSVAVDTLR CWKDGATSAH FQVY
Sequence cautioni
The sequence AAH11878 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035513 | 1 – 252 | Missing in isoform 4. 1 PublicationAdd BLAST | 252 | |
Alternative sequenceiVSP_035514 | 1 – 90 | Missing in isoform 3. 1 PublicationAdd BLAST | 90 | |
Alternative sequenceiVSP_023465 | 238 – 321 | QQLYN…WYKYI → EIAPQHSNLGDRVSETLSKK KKKERREGGRKEGRKERKKA QLWPRCGYPLVSCLYVFLLF LFCHLPHLSLRPVSSSCGHC HPLW in isoform 2. 1 PublicationAdd BLAST | 84 | |
Alternative sequenceiVSP_023466 | 322 – 444 | Missing in isoform 2. 1 PublicationAdd BLAST | 123 | |
Alternative sequenceiVSP_035515 | 401 – 420 | HVFCE…RTCPL → MLLKGHKKLELEKIDESAGV in isoform 3 and isoform 5. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_035516 | 421 – 444 | Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST | 24 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027533 mRNA Translation: BAB55182.1 AK093164 mRNA No translation available. AC083806 Genomic DNA No translation available. AC090013 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW98091.1 BC011878 mRNA Translation: AAH11878.1 Different initiation. |
CCDSi | CCDS44987.1 [Q96EX2-1] CCDS9180.2 [Q96EX2-5] |
RefSeqi | NP_001103373.1, NM_001109903.1 [Q96EX2-1] NP_116203.2, NM_032814.3 [Q96EX2-5] |
UniGenei | Hs.437195 |
Genome annotation databases
Ensembli | ENST00000257575; ENSP00000257575; ENSG00000135119 [Q96EX2-1] ENST00000392549; ENSP00000376332; ENSG00000135119 [Q96EX2-1] ENST00000407967; ENSP00000385669; ENSG00000135119 [Q96EX2-5] |
GeneIDi | 84900 |
KEGGi | hsa:84900 |
UCSCi | uc001twb.4 human [Q96EX2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | RNFT2_HUMAN | |
Accessioni | Q96EX2Primary (citable) accession number: Q96EX2 Secondary accession number(s): E9PAM7, Q96SU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2007 |
Last sequence update: | March 6, 2007 | |
Last modified: | February 28, 2018 | |
This is version 124 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |