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UniProtKB - Q96EX2 (RNFT2_HUMAN)

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Protein

RING finger and transmembrane domain-containing protein 2

Gene

RNFT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri384 – 422RING-typePROSITE-ProRule annotationAdd BLAST39

GO - Molecular functioni

Complete GO annotation...

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger and transmembrane domain-containing protein 2
Alternative name(s):
Transmembrane protein 118
Gene namesi
Name:RNFT2
Synonyms:TMEM118
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25905. RNFT2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 181ExtracellularSequence analysisAdd BLAST181
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 214CytoplasmicSequence analysisAdd BLAST12
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 255ExtracellularSequence analysisAdd BLAST20
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 329CytoplasmicSequence analysisAdd BLAST53
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 444ExtracellularSequence analysisAdd BLAST94

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135119.
PharmGKBiPA162401944.

Polymorphism and mutation databases

BioMutaiRNFT2.
DMDMi143216906.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002795081 – 444RING finger and transmembrane domain-containing protein 2Add BLAST444

Proteomic databases

EPDiQ96EX2.
MaxQBiQ96EX2.
PaxDbiQ96EX2.
PeptideAtlasiQ96EX2.
PRIDEiQ96EX2.

PTM databases

iPTMnetiQ96EX2.
PhosphoSitePlusiQ96EX2.

Expressioni

Gene expression databases

BgeeiENSG00000135119.
CleanExiHS_RNFT2.
ExpressionAtlasiQ96EX2. baseline and differential.
GenevisibleiQ96EX2. HS.

Organism-specific databases

HPAiHPA064161.

Interactioni

Protein-protein interaction databases

IntActiQ96EX2. 1 interactor.
STRINGi9606.ENSP00000257575.

Structurei

3D structure databases

ProteinModelPortaliQ96EX2.
SMRiQ96EX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 137His-richAdd BLAST30

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri384 – 422RING-typePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0802. Eukaryota.
KOG4638. Eukaryota.
ENOG4111HH8. LUCA.
GeneTreeiENSGT00390000014213.
HOGENOMiHOG000237544.
HOVERGENiHBG056546.
InParanoidiQ96EX2.
OMAiLMCQHVF.
OrthoDBiEOG091G0FD6.
PhylomeDBiQ96EX2.
TreeFamiTF331930.

Family and domain databases

CDDicd00162. RING. 1 hit.
InterProiView protein in InterPro
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96EX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWLFTVNQVL RKMQRRHSSN TDNIPPERNR SQALSSEASV DEGGVFESLK 
        60         70         80         90        100
AEAASPPALF SGLSGSLPTS SFPSSLVLGS SAGGGDVFIQ MPASREEGGG 
       110        120        130        140        150
RGEGGAYHHR QPHHHFHHGG HRGGSLLQHV GGDHRGHSEE GGDEQPGTPA 
       160        170        180        190        200
PALSELKAVI CWLQKGLPFI LILLAKLCFQ HKLGIAVCIG MASTFAYANS 
       210        220        230        240        250
TLREQVSLKE KRSVLVILWI LAFLAGNTLY VLYTFSSQQL YNSLIFLKPN 
       260        270        280        290        300
LEMLDFFDLL WIVGIADFVL KYITIALKCL IVALPKIILA VKSKGKFYLV 
       310        320        330        340        350
IEELSQLFRS LVPIQLWYKY IMGDDSSNSY FLGGVLIVLY SLCKSFDICG 
       360        370        380        390        400
RVGGVRKALK LLCTSQNYGV RATGQQCTEA GDICAICQAE FREPLILLCQ 
       410        420        430        440 
HVFCEECLCL WLDRERTCPL CRSVAVDTLR CWKDGATSAH FQVY
Length:444
Mass (Da):48,965
Last modified:March 6, 2007 - v2
Checksum:iFC6BF9199C1EBCF8
GO
Isoform 2 (identifier: Q96EX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-321: QQLYNSLIFL...VPIQLWYKYI → EIAPQHSNLG...SSCGHCHPLW
     322-444: Missing.

Note: No experimental confirmation available.
Show »
Length:321
Mass (Da):35,200
Checksum:iF3BFB80530DA6048
GO
Isoform 3 (identifier: Q96EX2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.
     401-420: HVFCEECLCLWLDRERTCPL → MLLKGHKKLELEKIDESAGV
     421-444: Missing.

Note: No experimental confirmation available.
Show »
Length:330
Mass (Da):36,563
Checksum:i831A04EE0693C131
GO
Isoform 4 (identifier: Q96EX2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.

Note: No experimental confirmation available.
Show »
Length:192
Mass (Da):21,718
Checksum:iBA3EBD34830FE1F2
GO
Isoform 5 (identifier: Q96EX2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     401-420: HVFCEECLCLWLDRERTCPL → MLLKGHKKLELEKIDESAGV
     421-444: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:420
Mass (Da):46,041
Checksum:i63B155DCCB39C5FA
GO

Sequence cautioni

The sequence AAH11878 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0355131 – 252Missing in isoform 4. 1 PublicationAdd BLAST252
Alternative sequenceiVSP_0355141 – 90Missing in isoform 3. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_023465238 – 321QQLYN…WYKYI → EIAPQHSNLGDRVSETLSKK KKKERREGGRKEGRKERKKA QLWPRCGYPLVSCLYVFLLF LFCHLPHLSLRPVSSSCGHC HPLW in isoform 2. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_023466322 – 444Missing in isoform 2. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_035515401 – 420HVFCE…RTCPL → MLLKGHKKLELEKIDESAGV in isoform 3 and isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_035516421 – 444Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027533 mRNA. Translation: BAB55182.1.
AK093164 mRNA. No translation available.
AC083806 Genomic DNA. No translation available.
AC090013 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW98091.1.
BC011878 mRNA. Translation: AAH11878.1. Different initiation.
CCDSiCCDS44987.1. [Q96EX2-1]
CCDS9180.2. [Q96EX2-5]
RefSeqiNP_001103373.1. NM_001109903.1. [Q96EX2-1]
NP_116203.2. NM_032814.3. [Q96EX2-5]
UniGeneiHs.437195.

Genome annotation databases

EnsembliENST00000257575; ENSP00000257575; ENSG00000135119. [Q96EX2-1]
ENST00000392549; ENSP00000376332; ENSG00000135119. [Q96EX2-1]
ENST00000407967; ENSP00000385669; ENSG00000135119. [Q96EX2-5]
GeneIDi84900.
KEGGihsa:84900.
UCSCiuc001twb.4. human. [Q96EX2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRNFT2_HUMAN
AccessioniPrimary (citable) accession number: Q96EX2
Secondary accession number(s): E9PAM7, Q96SU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: July 5, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM