Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RING finger and transmembrane domain-containing protein 2

Gene

RNFT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri384 – 422RING-typePROSITE-ProRule annotationAdd BLAST39

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger and transmembrane domain-containing protein 2
Alternative name(s):
Transmembrane protein 118
Gene namesi
Name:RNFT2
Synonyms:TMEM118
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000135119.14
HGNCiHGNC:25905 RNFT2
neXtProtiNX_Q96EX2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 181ExtracellularSequence analysisAdd BLAST181
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 214CytoplasmicSequence analysisAdd BLAST12
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 255ExtracellularSequence analysisAdd BLAST20
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 329CytoplasmicSequence analysisAdd BLAST53
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 444ExtracellularSequence analysisAdd BLAST94

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135119
PharmGKBiPA162401944

Polymorphism and mutation databases

BioMutaiRNFT2
DMDMi143216906

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002795081 – 444RING finger and transmembrane domain-containing protein 2Add BLAST444

Proteomic databases

MaxQBiQ96EX2
PaxDbiQ96EX2
PeptideAtlasiQ96EX2
PRIDEiQ96EX2

PTM databases

iPTMnetiQ96EX2
PhosphoSitePlusiQ96EX2

Expressioni

Gene expression databases

BgeeiENSG00000135119
CleanExiHS_RNFT2
ExpressionAtlasiQ96EX2 baseline and differential
GenevisibleiQ96EX2 HS

Organism-specific databases

HPAiHPA064161

Interactioni

Protein-protein interaction databases

IntActiQ96EX2 1 interactor.
STRINGi9606.ENSP00000257575

Structurei

3D structure databases

ProteinModelPortaliQ96EX2
SMRiQ96EX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 137His-richAdd BLAST30

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri384 – 422RING-typePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0802 Eukaryota
KOG4638 Eukaryota
ENOG4111HH8 LUCA
GeneTreeiENSGT00390000014213
HOGENOMiHOG000237544
HOVERGENiHBG056546
InParanoidiQ96EX2
OMAiLMCQHVF
OrthoDBiEOG091G0FD6
PhylomeDBiQ96EX2
TreeFamiTF331930

Family and domain databases

Gene3Di3.30.40.101 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96EX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWLFTVNQVL RKMQRRHSSN TDNIPPERNR SQALSSEASV DEGGVFESLK
60 70 80 90 100
AEAASPPALF SGLSGSLPTS SFPSSLVLGS SAGGGDVFIQ MPASREEGGG
110 120 130 140 150
RGEGGAYHHR QPHHHFHHGG HRGGSLLQHV GGDHRGHSEE GGDEQPGTPA
160 170 180 190 200
PALSELKAVI CWLQKGLPFI LILLAKLCFQ HKLGIAVCIG MASTFAYANS
210 220 230 240 250
TLREQVSLKE KRSVLVILWI LAFLAGNTLY VLYTFSSQQL YNSLIFLKPN
260 270 280 290 300
LEMLDFFDLL WIVGIADFVL KYITIALKCL IVALPKIILA VKSKGKFYLV
310 320 330 340 350
IEELSQLFRS LVPIQLWYKY IMGDDSSNSY FLGGVLIVLY SLCKSFDICG
360 370 380 390 400
RVGGVRKALK LLCTSQNYGV RATGQQCTEA GDICAICQAE FREPLILLCQ
410 420 430 440
HVFCEECLCL WLDRERTCPL CRSVAVDTLR CWKDGATSAH FQVY
Length:444
Mass (Da):48,965
Last modified:March 6, 2007 - v2
Checksum:iFC6BF9199C1EBCF8
GO
Isoform 2 (identifier: Q96EX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-321: QQLYNSLIFL...VPIQLWYKYI → EIAPQHSNLG...SSCGHCHPLW
     322-444: Missing.

Note: No experimental confirmation available.
Show »
Length:321
Mass (Da):35,200
Checksum:iF3BFB80530DA6048
GO
Isoform 3 (identifier: Q96EX2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.
     401-420: HVFCEECLCLWLDRERTCPL → MLLKGHKKLELEKIDESAGV
     421-444: Missing.

Note: No experimental confirmation available.
Show »
Length:330
Mass (Da):36,563
Checksum:i831A04EE0693C131
GO
Isoform 4 (identifier: Q96EX2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.

Note: No experimental confirmation available.
Show »
Length:192
Mass (Da):21,718
Checksum:iBA3EBD34830FE1F2
GO
Isoform 5 (identifier: Q96EX2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     401-420: HVFCEECLCLWLDRERTCPL → MLLKGHKKLELEKIDESAGV
     421-444: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:420
Mass (Da):46,041
Checksum:i63B155DCCB39C5FA
GO

Sequence cautioni

The sequence AAH11878 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0355131 – 252Missing in isoform 4. 1 PublicationAdd BLAST252
Alternative sequenceiVSP_0355141 – 90Missing in isoform 3. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_023465238 – 321QQLYN…WYKYI → EIAPQHSNLGDRVSETLSKK KKKERREGGRKEGRKERKKA QLWPRCGYPLVSCLYVFLLF LFCHLPHLSLRPVSSSCGHC HPLW in isoform 2. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_023466322 – 444Missing in isoform 2. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_035515401 – 420HVFCE…RTCPL → MLLKGHKKLELEKIDESAGV in isoform 3 and isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_035516421 – 444Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027533 mRNA Translation: BAB55182.1
AK093164 mRNA No translation available.
AC083806 Genomic DNA No translation available.
AC090013 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW98091.1
BC011878 mRNA Translation: AAH11878.1 Different initiation.
CCDSiCCDS44987.1 [Q96EX2-1]
CCDS9180.2 [Q96EX2-5]
RefSeqiNP_001103373.1, NM_001109903.1 [Q96EX2-1]
NP_116203.2, NM_032814.3 [Q96EX2-5]
UniGeneiHs.437195

Genome annotation databases

EnsembliENST00000257575; ENSP00000257575; ENSG00000135119 [Q96EX2-1]
ENST00000392549; ENSP00000376332; ENSG00000135119 [Q96EX2-1]
ENST00000407967; ENSP00000385669; ENSG00000135119 [Q96EX2-5]
GeneIDi84900
KEGGihsa:84900
UCSCiuc001twb.4 human [Q96EX2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRNFT2_HUMAN
AccessioniPrimary (citable) accession number: Q96EX2
Secondary accession number(s): E9PAM7, Q96SU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: February 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome