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Protein

RNA-binding protein 33

Gene

RBM33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-30725-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 33
Alternative name(s):
Proline-rich protein 8
RNA-binding motif protein 33
Gene namesi
Name:RBM33
Synonyms:PRR8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:27223. RBM33.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184863.
PharmGKBiPA142671093.

Polymorphism and mutation databases

BioMutaiRBM33.
DMDMi215274198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002929822 – 1170RNA-binding protein 33Add BLAST1169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei41PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei470Asymmetric dimethylarginineCombined sources1
Modified residuei741PhosphoserineCombined sources1
Modified residuei765PhosphoserineCombined sources1
Modified residuei951PhosphoserineCombined sources1
Modified residuei973PhosphoserineBy similarity1
Modified residuei991PhosphoserineCombined sources1
Modified residuei1028Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei1028Omega-N-methylarginine; alternateCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ96EV2.
MaxQBiQ96EV2.
PaxDbiQ96EV2.
PeptideAtlasiQ96EV2.
PRIDEiQ96EV2.

PTM databases

iPTMnetiQ96EV2.
PhosphoSitePlusiQ96EV2.

Expressioni

Gene expression databases

BgeeiENSG00000184863.
CleanExiHS_RBM33.
ExpressionAtlasiQ96EV2. baseline and differential.
GenevisibleiQ96EV2. HS.

Organism-specific databases

HPAiHPA019232.
HPA021497.
HPA021768.

Interactioni

Protein-protein interaction databases

BioGridi127585. 22 interactors.
IntActiQ96EV2. 11 interactors.
STRINGi9606.ENSP00000384160.

Structurei

3D structure databases

ProteinModelPortaliQ96EV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1098 – 1170RRMAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili789 – 835Sequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi113 – 263Glu-richAdd BLAST151
Compositional biasi306 – 659Pro-richAdd BLAST354
Compositional biasi605 – 641His-richAdd BLAST37

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG08. Eukaryota.
ENOG410XTRH. LUCA.
GeneTreeiENSGT00530000063891.
HOVERGENiHBG108398.
InParanoidiQ96EV2.
OMAiIMMTPPP.
OrthoDBiEOG091G02KW.
PhylomeDBiQ96EV2.
TreeFamiTF332363.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96EV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAALGASGG AGAGDDDFDQ FDKPGAERSW RRRAADEDWD SELEDDLLGE
60 70 80 90 100
DLLSGKKNQS DLSDEELNDD LLQSDNEDEE NFSSQGVTIS LNATSGMVTS
110 120 130 140 150
FELSDNTNDQ SGEQESEYEQ EQGEDELVYH KSDGSELYTQ EYPEEGQYEG
160 170 180 190 200
HEAELTEDQI EYVEEPEEEQ LYTDEVLDIE INEPLDEFTG GMETLELQKD
210 220 230 240 250
IKEESDEEEE DDEESGRLRF KTERKEGTII RLSDVTRERR NIPETLELSA
260 270 280 290 300
EAKAALLEFE ERERQHKQGR YSSRRGGRRG GPLMCRGVGD QRRESTERGR
310 320 330 340 350
MKDHRPALLP TQPPVVPQAP PPPPPPPQQQ PIRSLFQPQP LQPLLPVQHP
360 370 380 390 400
HHPSPPQGMH MPPQLETPRM MMTPPPVTPQ QPKNIHINPH FKGTVVTPVQ
410 420 430 440 450
VPLLPVPSQP RPAVGPQRFP GPPEFPQHTP GPVPNSFSQP PRLPLQDQWR
460 470 480 490 500
APPPPQDRDP FFLGVSGEPR FPSHLFLEQR SPPPPPPPPT LLNSSHPVPT
510 520 530 540 550
QSPLPFTQPG PAFNQQGQQP VFPRERPVRP ALQPPGPVGI LHFSQPGSAT
560 570 580 590 600
TRPFIPPRQP FLPGPGQPFL PTHTQPNLQG PLHPPLPPPH QPQPQQPQQQ
610 620 630 640 650
PPPQHQPPHQ PPHQPPPQHQ PPPQHPPQHP PQHQHHHHHH HLSVPPPPLM
660 670 680 690 700
PMSQPQFRPH VQTAQPQASS SRMQCPQRQG LRHNTTSQNV SKRPMQQMQP
710 720 730 740 750
TAPRNSNLRE LPIAPSHVIE MSSSRCSATP SAQVKPIVSA SPPSRAVAGS
760 770 780 790 800
RSSQGKTEVK VKPASPVAQP KEEAKTETEF PDEDEETRLY RLKIEEQKRL
810 820 830 840 850
REEILKQKEL RRQQQAGARK KELLERLAQQ QQQLYAPPPP AEQEEQALSP
860 870 880 890 900
SPTNGNPLLP FPGAQVRQNV KNRLLVKNQD VSISNVQPKT SNFVPSSANM
910 920 930 940 950
QYQGQQMKAL KHLRQTRTVP QSQTQPLHKV LPIKPADVEE PAVPQTPRVA
960 970 980 990 1000
SIQGRPQDTK PGVKRTVTHR TNSGGGDGPH ISSKVRVIKL SGGGGESDGF
1010 1020 1030 1040 1050
FHPEGQPQRL PQPPEVGPQP ARKVTLTRGG LQQPPHLPAG PHAHSPVPPG
1060 1070 1080 1090 1100
IKSIQGIHPA KKAIMHGRGR GVAGPMGRGR LMPNKQNLRV VECKPQPCVV
1110 1120 1130 1140 1150
SVEGLSSSTT DAQLKSLLMS VGPIQSLQML PQQRKAIAKF KEPAHALAFQ
1160 1170
QKFHRHMIDL SHINVALIVE
Length:1,170
Mass (Da):129,986
Last modified:November 25, 2008 - v3
Checksum:i08039CCFCACDBBDE
GO
Isoform 2 (identifier: Q96EV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-268: ELSAEAKAALLEFEERERQHKQ → GNFFACLPSSFTLISTSSIVLL
     269-1170: Missing.

Show »
Length:268
Mass (Da):30,238
Checksum:iF70C6616AC624D23
GO

Sequence cautioni

The sequence AAH93947 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH93949 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAS01989 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAS02026 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAS07551 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB70894 differs from that shown. Intron retention.Curated
The sequence EAL23911 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAL23912 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAX04539 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052223574T → A.Corresponds to variant rs3735576dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030143247 – 268ELSAE…RQHKQ → GNFFACLPSSFTLISTSSIV LL in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_030144269 – 1170Missing in isoform 2. 1 PublicationAdd BLAST902

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009403 Genomic DNA. Translation: AAS02026.1. Sequence problems.
AC078834 Genomic DNA. Translation: AAS01989.1. Sequence problems.
AC092460 Genomic DNA. Translation: AAS07551.1. Sequence problems.
CH236954 Genomic DNA. Translation: EAL23911.1. Sequence problems.
CH236954 Genomic DNA. Translation: EAL23912.1. Sequence problems.
CH471149 Genomic DNA. Translation: EAX04539.1. Sequence problems.
BC011923 mRNA. Translation: AAH11923.1.
BC093947 mRNA. Translation: AAH93947.1. Different initiation.
BC093949 mRNA. Translation: AAH93949.1. Different initiation.
AL137724 mRNA. Translation: CAB70894.1. Sequence problems.
CCDSiCCDS5941.2. [Q96EV2-1]
PIRiT46375.
RefSeqiNP_444271.2. NM_053043.2. [Q96EV2-1]
UniGeneiHs.591815.

Genome annotation databases

EnsembliENST00000287912; ENSP00000287912; ENSG00000184863. [Q96EV2-2]
ENST00000401878; ENSP00000384160; ENSG00000184863. [Q96EV2-1]
GeneIDi155435.
KEGGihsa:155435.
UCSCiuc003wme.4. human. [Q96EV2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009403 Genomic DNA. Translation: AAS02026.1. Sequence problems.
AC078834 Genomic DNA. Translation: AAS01989.1. Sequence problems.
AC092460 Genomic DNA. Translation: AAS07551.1. Sequence problems.
CH236954 Genomic DNA. Translation: EAL23911.1. Sequence problems.
CH236954 Genomic DNA. Translation: EAL23912.1. Sequence problems.
CH471149 Genomic DNA. Translation: EAX04539.1. Sequence problems.
BC011923 mRNA. Translation: AAH11923.1.
BC093947 mRNA. Translation: AAH93947.1. Different initiation.
BC093949 mRNA. Translation: AAH93949.1. Different initiation.
AL137724 mRNA. Translation: CAB70894.1. Sequence problems.
CCDSiCCDS5941.2. [Q96EV2-1]
PIRiT46375.
RefSeqiNP_444271.2. NM_053043.2. [Q96EV2-1]
UniGeneiHs.591815.

3D structure databases

ProteinModelPortaliQ96EV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127585. 22 interactors.
IntActiQ96EV2. 11 interactors.
STRINGi9606.ENSP00000384160.

PTM databases

iPTMnetiQ96EV2.
PhosphoSitePlusiQ96EV2.

Polymorphism and mutation databases

BioMutaiRBM33.
DMDMi215274198.

Proteomic databases

EPDiQ96EV2.
MaxQBiQ96EV2.
PaxDbiQ96EV2.
PeptideAtlasiQ96EV2.
PRIDEiQ96EV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287912; ENSP00000287912; ENSG00000184863. [Q96EV2-2]
ENST00000401878; ENSP00000384160; ENSG00000184863. [Q96EV2-1]
GeneIDi155435.
KEGGihsa:155435.
UCSCiuc003wme.4. human. [Q96EV2-1]

Organism-specific databases

CTDi155435.
GeneCardsiRBM33.
H-InvDBHIX0007251.
HGNCiHGNC:27223. RBM33.
HPAiHPA019232.
HPA021497.
HPA021768.
neXtProtiNX_Q96EV2.
OpenTargetsiENSG00000184863.
PharmGKBiPA142671093.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG08. Eukaryota.
ENOG410XTRH. LUCA.
GeneTreeiENSGT00530000063891.
HOVERGENiHBG108398.
InParanoidiQ96EV2.
OMAiIMMTPPP.
OrthoDBiEOG091G02KW.
PhylomeDBiQ96EV2.
TreeFamiTF332363.

Enzyme and pathway databases

BioCyciZFISH:G66-30725-MONOMER.

Miscellaneous databases

ChiTaRSiRBM33. human.
GeneWikiiRBM33.
GenomeRNAii155435.
PROiQ96EV2.

Gene expression databases

BgeeiENSG00000184863.
CleanExiHS_RBM33.
ExpressionAtlasiQ96EV2. baseline and differential.
GenevisibleiQ96EV2. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRBM33_HUMAN
AccessioniPrimary (citable) accession number: Q96EV2
Secondary accession number(s): A4D244
, B5MC24, Q52LF5, Q75LN9, Q75ML5, Q9NSV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.