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Protein

Ribosomal RNA processing protein 36 homolog

Gene

RRP36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA.1 Publication

Miscellaneous

Meningioma antigen.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA processing protein 36 homolog
Gene namesi
Name:RRP36
Synonyms:C6orf153
ORF Names:HSPC253
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124541.6
HGNCiHGNC:21374 RRP36
MIMi613475 gene
neXtProtiNX_Q96EU6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124541
PharmGKBiPA165618219

Polymorphism and mutation databases

BioMutaiRRP36
DMDMi74751848

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002521571 – 259Ribosomal RNA processing protein 36 homologAdd BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96EU6
MaxQBiQ96EU6
PaxDbiQ96EU6
PeptideAtlasiQ96EU6
PRIDEiQ96EU6

PTM databases

iPTMnetiQ96EU6
PhosphoSitePlusiQ96EU6

Expressioni

Gene expression databases

BgeeiENSG00000124541
CleanExiHS_C6orf153
ExpressionAtlasiQ96EU6 baseline and differential
GenevisibleiQ96EU6 HS

Organism-specific databases

HPAiHPA029904
HPA029905

Interactioni

Protein-protein interaction databases

BioGridi124584, 6 interactors
IntActiQ96EU6, 4 interactors
MINTiQ96EU6
STRINGi9606.ENSP00000244496

Structurei

3D structure databases

ProteinModelPortaliQ96EU6
SMRiQ96EU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili157 – 205Sequence analysisAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi241 – 244Nuclear localization signalSequence analysis4

Sequence similaritiesi

Belongs to the RRP36 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3190 Eukaryota
ENOG4111T3E LUCA
GeneTreeiENSGT00530000064271
HOVERGENiHBG081113
InParanoidiQ96EU6
KOiK14795
OMAiHYLTKKE
OrthoDBiEOG091G0GA8
PhylomeDBiQ96EU6
TreeFamiTF315154

Family and domain databases

InterProiView protein in InterPro
IPR009292 RRP36
PANTHERiPTHR21738 PTHR21738, 1 hit
PfamiView protein in Pfam
PF06102 RRP36, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96EU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGANYRAGA GAGAGARRPR GARDREEDGG GLEPAAVARD LLRGTSNMSF
60 70 80 90 100
EELLELQSQV GTKTYKQLVA GNSPKKQASR PPIQNACVAD KHRPLEMSAK
110 120 130 140 150
IRVPFLRQVV PISKKVARDP RFDDLSGEYN PEVFDKTYQF LNDIRAKEKE
160 170 180 190 200
LVKKQLKKHL SGEEHEKLQQ LLQRMEQQEM AQQERKQQQE LHLALKQERR
210 220 230 240 250
AQAQQGHRPY FLKKSEQRQL ALAEKFKELK RSKKLENFLS RKRRRNAGKD

RRHLPLSKE
Length:259
Mass (Da):29,823
Last modified:December 1, 2001 - v1
Checksum:i8388ED8B7306CF8E
GO
Isoform 2 (identifier: Q96EU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-23: Missing.

Note: No experimental confirmation available.
Show »
Length:253
Mass (Da):29,129
Checksum:iF493401E8B7F9CAB
GO

Sequence cautioni

The sequence AAH06293 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88V → F in AAF28931 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02778678A → G. Corresponds to variant dbSNP:rs3749903Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02088418 – 23Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136304 Genomic DNA No translation available.
BC006293 mRNA Translation: AAH06293.2 Different initiation.
BC011933 mRNA Translation: AAH11933.1
AF161371 mRNA Translation: AAF28931.1
CCDSiCCDS34453.1 [Q96EU6-1]
RefSeqiNP_001316633.1, NM_001329704.1
NP_149103.1, NM_033112.3 [Q96EU6-1]
UniGeneiHs.309231

Genome annotation databases

EnsembliENST00000244496; ENSP00000244496; ENSG00000124541 [Q96EU6-1]
GeneIDi88745
KEGGihsa:88745
UCSCiuc003otp.2 human [Q96EU6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRRP36_HUMAN
AccessioniPrimary (citable) accession number: Q96EU6
Secondary accession number(s): Q9BRF6, Q9P0C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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