Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribosomal RNA processing protein 36 homolog

Gene

RRP36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124541-MONOMER.
ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA processing protein 36 homolog
Gene namesi
Name:RRP36
Synonyms:C6orf153
ORF Names:HSPC253
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21374. RRP36.

Subcellular locationi

GO - Cellular componenti

  • 90S preribosome Source: GO_Central
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124541.
PharmGKBiPA165618219.

Polymorphism and mutation databases

BioMutaiRRP36.
DMDMi74751848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002521571 – 259Ribosomal RNA processing protein 36 homologAdd BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96EU6.
MaxQBiQ96EU6.
PaxDbiQ96EU6.
PeptideAtlasiQ96EU6.
PRIDEiQ96EU6.

PTM databases

iPTMnetiQ96EU6.
PhosphoSitePlusiQ96EU6.

Expressioni

Gene expression databases

BgeeiENSG00000124541.
CleanExiHS_C6orf153.
ExpressionAtlasiQ96EU6. baseline and differential.
GenevisibleiQ96EU6. HS.

Organism-specific databases

HPAiHPA029904.
HPA029905.

Interactioni

Protein-protein interaction databases

BioGridi124584. 5 interactors.
IntActiQ96EU6. 4 interactors.
MINTiMINT-4830054.
STRINGi9606.ENSP00000244496.

Structurei

3D structure databases

ProteinModelPortaliQ96EU6.
SMRiQ96EU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili157 – 205Sequence analysisAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi241 – 244Nuclear localization signalSequence analysis4

Sequence similaritiesi

Belongs to the RRP36 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3190. Eukaryota.
ENOG4111T3E. LUCA.
GeneTreeiENSGT00530000064271.
HOVERGENiHBG081113.
InParanoidiQ96EU6.
KOiK14795.
OMAiETHYEEN.
OrthoDBiEOG091G0GA8.
PhylomeDBiQ96EU6.
TreeFamiTF315154.

Family and domain databases

InterProiIPR009292. RRP36.
[Graphical view]
PANTHERiPTHR21738. PTHR21738. 1 hit.
PfamiPF06102. DUF947. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96EU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGANYRAGA GAGAGARRPR GARDREEDGG GLEPAAVARD LLRGTSNMSF
60 70 80 90 100
EELLELQSQV GTKTYKQLVA GNSPKKQASR PPIQNACVAD KHRPLEMSAK
110 120 130 140 150
IRVPFLRQVV PISKKVARDP RFDDLSGEYN PEVFDKTYQF LNDIRAKEKE
160 170 180 190 200
LVKKQLKKHL SGEEHEKLQQ LLQRMEQQEM AQQERKQQQE LHLALKQERR
210 220 230 240 250
AQAQQGHRPY FLKKSEQRQL ALAEKFKELK RSKKLENFLS RKRRRNAGKD

RRHLPLSKE
Length:259
Mass (Da):29,823
Last modified:December 1, 2001 - v1
Checksum:i8388ED8B7306CF8E
GO
Isoform 2 (identifier: Q96EU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-23: Missing.

Note: No experimental confirmation available.
Show »
Length:253
Mass (Da):29,129
Checksum:iF493401E8B7F9CAB
GO

Sequence cautioni

The sequence AAH06293 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88V → F in AAF28931 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02778678A → G.Corresponds to variant rs3749903dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02088418 – 23Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136304 Genomic DNA. Translation: CAI19798.1.
BC006293 mRNA. Translation: AAH06293.2. Different initiation.
BC011933 mRNA. Translation: AAH11933.1.
AF161371 mRNA. Translation: AAF28931.1.
CCDSiCCDS34453.1. [Q96EU6-1]
RefSeqiNP_001316633.1. NM_001329704.1.
NP_149103.1. NM_033112.3. [Q96EU6-1]
UniGeneiHs.309231.

Genome annotation databases

EnsembliENST00000244496; ENSP00000244496; ENSG00000124541. [Q96EU6-1]
GeneIDi88745.
KEGGihsa:88745.
UCSCiuc003otp.2. human. [Q96EU6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136304 Genomic DNA. Translation: CAI19798.1.
BC006293 mRNA. Translation: AAH06293.2. Different initiation.
BC011933 mRNA. Translation: AAH11933.1.
AF161371 mRNA. Translation: AAF28931.1.
CCDSiCCDS34453.1. [Q96EU6-1]
RefSeqiNP_001316633.1. NM_001329704.1.
NP_149103.1. NM_033112.3. [Q96EU6-1]
UniGeneiHs.309231.

3D structure databases

ProteinModelPortaliQ96EU6.
SMRiQ96EU6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124584. 5 interactors.
IntActiQ96EU6. 4 interactors.
MINTiMINT-4830054.
STRINGi9606.ENSP00000244496.

PTM databases

iPTMnetiQ96EU6.
PhosphoSitePlusiQ96EU6.

Polymorphism and mutation databases

BioMutaiRRP36.
DMDMi74751848.

Proteomic databases

EPDiQ96EU6.
MaxQBiQ96EU6.
PaxDbiQ96EU6.
PeptideAtlasiQ96EU6.
PRIDEiQ96EU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244496; ENSP00000244496; ENSG00000124541. [Q96EU6-1]
GeneIDi88745.
KEGGihsa:88745.
UCSCiuc003otp.2. human. [Q96EU6-1]

Organism-specific databases

CTDi88745.
GeneCardsiRRP36.
HGNCiHGNC:21374. RRP36.
HPAiHPA029904.
HPA029905.
MIMi613475. gene.
neXtProtiNX_Q96EU6.
OpenTargetsiENSG00000124541.
PharmGKBiPA165618219.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3190. Eukaryota.
ENOG4111T3E. LUCA.
GeneTreeiENSGT00530000064271.
HOVERGENiHBG081113.
InParanoidiQ96EU6.
KOiK14795.
OMAiETHYEEN.
OrthoDBiEOG091G0GA8.
PhylomeDBiQ96EU6.
TreeFamiTF315154.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124541-MONOMER.
ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

ChiTaRSiRRP36. human.
GenomeRNAii88745.
PROiQ96EU6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124541.
CleanExiHS_C6orf153.
ExpressionAtlasiQ96EU6. baseline and differential.
GenevisibleiQ96EU6. HS.

Family and domain databases

InterProiIPR009292. RRP36.
[Graphical view]
PANTHERiPTHR21738. PTHR21738. 1 hit.
PfamiPF06102. DUF947. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRRP36_HUMAN
AccessioniPrimary (citable) accession number: Q96EU6
Secondary accession number(s): Q9BRF6, Q9P0C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Meningioma antigen.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.