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Protein

Major facilitator superfamily domain-containing protein 3

Gene

MFSD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 3
Gene namesi
Name:MFSD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:25157. MFSD3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Transmembranei40 – 6021HelicalSequence analysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence analysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence analysisAdd
BLAST
Transmembranei166 – 18621HelicalSequence analysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence analysisAdd
BLAST
Transmembranei250 – 27021HelicalSequence analysisAdd
BLAST
Transmembranei291 – 31121HelicalSequence analysisAdd
BLAST
Transmembranei321 – 34121HelicalSequence analysisAdd
BLAST
Transmembranei361 – 38121HelicalSequence analysisAdd
BLAST
Transmembranei384 – 40421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671464.

Polymorphism and mutation databases

BioMutaiMFSD3.
DMDMi74731607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Major facilitator superfamily domain-containing protein 3PRO_0000273392Add
BLAST

Proteomic databases

EPDiQ96ES6.
MaxQBiQ96ES6.
PaxDbiQ96ES6.
PeptideAtlasiQ96ES6.
PRIDEiQ96ES6.

PTM databases

iPTMnetiQ96ES6.

Expressioni

Gene expression databases

BgeeiQ96ES6.
CleanExiHS_MFSD3.
GenevisibleiQ96ES6. HS.

Organism-specific databases

HPAiHPA056013.

Interactioni

Protein-protein interaction databases

BioGridi125254. 4 interactions.
IntActiQ96ES6. 4 interactions.
MINTiMINT-1479139.
STRINGi9606.ENSP00000301327.

Structurei

3D structure databases

ProteinModelPortaliQ96ES6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 406402Leu-richAdd
BLAST

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3574. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00730000111292.
HOGENOMiHOG000217208.
HOVERGENiHBG080578.
InParanoidiQ96ES6.
OMAiFPLWRIT.
OrthoDBiEOG75QR42.
PhylomeDBiQ96ES6.
TreeFamiTF330933.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96ES6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGKLLPLAG LYLVQGLPYG LQSGLLPVLL RAGGLSLTRV GLAKVLYAPW
60 70 80 90 100
LLKLAWAPLV DAQGSARAWV TRSTAGLGLV CGLLAGLPPP GAGQAGLPAA
110 120 130 140 150
VAGLLLLLNL GAAMQDVALD ALAVQLLEPA ELGPGNTVQV VAYKLGAALA
160 170 180 190 200
GGALLALLPT FSWPQLFLLL AATYWLAAAL AWAAPALRRL PQQPPSEQRP
210 220 230 240 250
HTAHLLRDVL AVPGTVWTAG FVLTYKLGEQ GASSLFPLLL LDHGVSAPEL
260 270 280 290 300
GLWNGVGAVV CSIAGSSLGG TLLAKHWKLL PLLRSVLRFR LGGLACQTAL
310 320 330 340 350
VFHLDTLGAS MDAGTILRGS ALLSLCLQHF LGGLVTTVTF TGMMRCSQLA
360 370 380 390 400
PRALQATHYS LLATLELLGK LLLGTLAGGL ADGLGPHPCF LLLLILSAFP
410
VLYLDLAPST FL
Length:412
Mass (Da):42,696
Last modified:December 1, 2001 - v1
Checksum:i1F472D45C64187A3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti292 – 2921G → R.
Corresponds to variant rs2306387 [ dbSNP | Ensembl ].
VAR_030141

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011982 mRNA. Translation: AAH11982.1.
CCDSiCCDS6431.1.
RefSeqiNP_612440.1. NM_138431.2.
UniGeneiHs.7678.

Genome annotation databases

EnsembliENST00000301327; ENSP00000301327; ENSG00000167700.
GeneIDi113655.
KEGGihsa:113655.
UCSCiuc003zdi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011982 mRNA. Translation: AAH11982.1.
CCDSiCCDS6431.1.
RefSeqiNP_612440.1. NM_138431.2.
UniGeneiHs.7678.

3D structure databases

ProteinModelPortaliQ96ES6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125254. 4 interactions.
IntActiQ96ES6. 4 interactions.
MINTiMINT-1479139.
STRINGi9606.ENSP00000301327.

PTM databases

iPTMnetiQ96ES6.

Polymorphism and mutation databases

BioMutaiMFSD3.
DMDMi74731607.

Proteomic databases

EPDiQ96ES6.
MaxQBiQ96ES6.
PaxDbiQ96ES6.
PeptideAtlasiQ96ES6.
PRIDEiQ96ES6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301327; ENSP00000301327; ENSG00000167700.
GeneIDi113655.
KEGGihsa:113655.
UCSCiuc003zdi.2. human.

Organism-specific databases

CTDi113655.
GeneCardsiMFSD3.
HGNCiHGNC:25157. MFSD3.
HPAiHPA056013.
neXtProtiNX_Q96ES6.
PharmGKBiPA142671464.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3574. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00730000111292.
HOGENOMiHOG000217208.
HOVERGENiHBG080578.
InParanoidiQ96ES6.
OMAiFPLWRIT.
OrthoDBiEOG75QR42.
PhylomeDBiQ96ES6.
TreeFamiTF330933.

Miscellaneous databases

ChiTaRSiMFSD3. human.
GenomeRNAii113655.
PROiQ96ES6.

Gene expression databases

BgeeiQ96ES6.
CleanExiHS_MFSD3.
GenevisibleiQ96ES6. HS.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiMFSD3_HUMAN
AccessioniPrimary (citable) accession number: Q96ES6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.