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Protein

Major facilitator superfamily domain-containing protein 3

Gene

MFSD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167700-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 3
Gene namesi
Name:MFSD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:25157. MFSD3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167700.
PharmGKBiPA142671464.

Polymorphism and mutation databases

BioMutaiMFSD3.
DMDMi74731607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002733921 – 412Major facilitator superfamily domain-containing protein 3Add BLAST412

Proteomic databases

EPDiQ96ES6.
MaxQBiQ96ES6.
PaxDbiQ96ES6.
PeptideAtlasiQ96ES6.
PRIDEiQ96ES6.

PTM databases

iPTMnetiQ96ES6.
PhosphoSitePlusiQ96ES6.

Expressioni

Gene expression databases

BgeeiENSG00000167700.
CleanExiHS_MFSD3.
GenevisibleiQ96ES6. HS.

Organism-specific databases

HPAiHPA056013.

Interactioni

Protein-protein interaction databases

BioGridi125254. 4 interactors.
IntActiQ96ES6. 5 interactors.
MINTiMINT-1479139.
STRINGi9606.ENSP00000301327.

Structurei

3D structure databases

ProteinModelPortaliQ96ES6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 406Leu-richAdd BLAST402

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3574. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00730000111292.
HOGENOMiHOG000217208.
HOVERGENiHBG080578.
InParanoidiQ96ES6.
OMAiFPLWRIT.
OrthoDBiEOG091G0JAA.
PhylomeDBiQ96ES6.
TreeFamiTF330933.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96ES6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGKLLPLAG LYLVQGLPYG LQSGLLPVLL RAGGLSLTRV GLAKVLYAPW
60 70 80 90 100
LLKLAWAPLV DAQGSARAWV TRSTAGLGLV CGLLAGLPPP GAGQAGLPAA
110 120 130 140 150
VAGLLLLLNL GAAMQDVALD ALAVQLLEPA ELGPGNTVQV VAYKLGAALA
160 170 180 190 200
GGALLALLPT FSWPQLFLLL AATYWLAAAL AWAAPALRRL PQQPPSEQRP
210 220 230 240 250
HTAHLLRDVL AVPGTVWTAG FVLTYKLGEQ GASSLFPLLL LDHGVSAPEL
260 270 280 290 300
GLWNGVGAVV CSIAGSSLGG TLLAKHWKLL PLLRSVLRFR LGGLACQTAL
310 320 330 340 350
VFHLDTLGAS MDAGTILRGS ALLSLCLQHF LGGLVTTVTF TGMMRCSQLA
360 370 380 390 400
PRALQATHYS LLATLELLGK LLLGTLAGGL ADGLGPHPCF LLLLILSAFP
410
VLYLDLAPST FL
Length:412
Mass (Da):42,696
Last modified:December 1, 2001 - v1
Checksum:i1F472D45C64187A3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030141292G → R.Corresponds to variant rs2306387dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011982 mRNA. Translation: AAH11982.1.
CCDSiCCDS6431.1.
RefSeqiNP_612440.1. NM_138431.2.
UniGeneiHs.7678.

Genome annotation databases

EnsembliENST00000301327; ENSP00000301327; ENSG00000167700.
GeneIDi113655.
KEGGihsa:113655.
UCSCiuc003zdi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011982 mRNA. Translation: AAH11982.1.
CCDSiCCDS6431.1.
RefSeqiNP_612440.1. NM_138431.2.
UniGeneiHs.7678.

3D structure databases

ProteinModelPortaliQ96ES6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125254. 4 interactors.
IntActiQ96ES6. 5 interactors.
MINTiMINT-1479139.
STRINGi9606.ENSP00000301327.

PTM databases

iPTMnetiQ96ES6.
PhosphoSitePlusiQ96ES6.

Polymorphism and mutation databases

BioMutaiMFSD3.
DMDMi74731607.

Proteomic databases

EPDiQ96ES6.
MaxQBiQ96ES6.
PaxDbiQ96ES6.
PeptideAtlasiQ96ES6.
PRIDEiQ96ES6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301327; ENSP00000301327; ENSG00000167700.
GeneIDi113655.
KEGGihsa:113655.
UCSCiuc003zdi.2. human.

Organism-specific databases

CTDi113655.
GeneCardsiMFSD3.
HGNCiHGNC:25157. MFSD3.
HPAiHPA056013.
neXtProtiNX_Q96ES6.
OpenTargetsiENSG00000167700.
PharmGKBiPA142671464.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3574. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00730000111292.
HOGENOMiHOG000217208.
HOVERGENiHBG080578.
InParanoidiQ96ES6.
OMAiFPLWRIT.
OrthoDBiEOG091G0JAA.
PhylomeDBiQ96ES6.
TreeFamiTF330933.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167700-MONOMER.

Miscellaneous databases

ChiTaRSiMFSD3. human.
GenomeRNAii113655.
PROiQ96ES6.

Gene expression databases

BgeeiENSG00000167700.
CleanExiHS_MFSD3.
GenevisibleiQ96ES6. HS.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMFSD3_HUMAN
AccessioniPrimary (citable) accession number: Q96ES6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.