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Q96ER9 (CCD51_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil domain-containing protein 51
Gene names
Name:CCDC51
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence caution

The sequence AAH11993.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96ER9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96ER9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-109: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 411411Coiled-coil domain-containing protein 51
PRO_0000288868

Regions

Transmembrane202 – 22221Helical; Potential
Transmembrane387 – 40721Helical; Potential
Coiled coil111 – 17363 Potential

Natural variations

Alternative sequence1 – 109109Missing in isoform 2.
VSP_025800
Natural variant3601F → S.
Corresponds to variant rs7618609 [ dbSNP | Ensembl ].
VAR_032515

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 29, 2007. Version 2.
Checksum: D99F1D8AF9EB8C04

FASTA41145,811
        10         20         30         40         50         60 
MMGRSPGFAM QHIVGVPHVL VRRGLLGRDL FMTRTLCSPG PSQPGEKRPE EVALGLHHRL 

        70         80         90        100        110        120 
PALGRALGHS IQQRATSTAK TWWDRYEEFV GLNEVREAQG KVTEAEKVFM VARGLVREAR 

       130        140        150        160        170        180 
EDLEVHQAKL KEVRDRLDRV SREDSQYLEL ATLEHRMLQE EKRLRTAYLR AEDSEREKFS 

       190        200        210        220        230        240 
LFSAAVRESH EKERTRAERT KNWSLIGSVL GALIGVAGST YVNRVRLQEL KALLLEAQKG 

       250        260        270        280        290        300 
PVSLQEAIRE QASSYSRQQR DLHNLMVDLR GLVHAAGPGQ DSGSQAGSPP TRDRDVDVLS 

       310        320        330        340        350        360 
AALKEQLSHS RQVHSCLEGL REQLDGLEKT CSQMAGVVQL VKSAAHPGLV EPADGAMPSF 

       370        380        390        400        410 
LLEQGSMILA LSDTEQRLEA QVNRNTIYST LVTCVTFVAT LPVLYMLFKA S 

« Hide

Isoform 2 [UniParc].

Checksum: 12C2189386744A44
Show »

FASTA30233,657

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Ovary.
[3]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK022498 mRNA. Translation: BAB14060.1.
BC011993 mRNA. Translation: AAH11993.1. Different initiation.
RefSeqNP_001243893.1. NM_001256964.1.
NP_001243894.1. NM_001256965.2.
NP_001243895.1. NM_001256966.2.
NP_001243896.1. NM_001256967.2.
NP_001243897.1. NM_001256968.2.
NP_001243898.1. NM_001256969.2.
NP_078937.3. NM_024661.4.
UniGeneHs.187657.
Hs.740720.

3D structure databases

ProteinModelPortalQ96ER9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122831. 2 interactions.
STRING9606.ENSP00000296441.

PTM databases

PhosphoSiteQ96ER9.

Polymorphism databases

DMDM152032342.

Proteomic databases

PaxDbQ96ER9.
PRIDEQ96ER9.

Protocols and materials databases

DNASU79714.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000395694; ENSP00000379047; ENSG00000164051. [Q96ER9-1]
ENST00000395696; ENSP00000379049; ENSG00000164051. [Q96ER9-1]
ENST00000412398; ENSP00000401194; ENSG00000164051. [Q96ER9-2]
ENST00000442740; ENSP00000392898; ENSG00000164051. [Q96ER9-2]
ENST00000447018; ENSP00000412300; ENSG00000164051. [Q96ER9-2]
GeneID79714.
KEGGhsa:79714.
UCSCuc003ctc.3. human. [Q96ER9-1]

Organism-specific databases

CTD79714.
GeneCardsGC03M048450.
H-InvDBHIX0003284.
HGNCHGNC:25714. CCDC51.
HPAHPA010980.
HPA011408.
neXtProtNX_Q96ER9.
PharmGKBPA142672167.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG83482.
HOGENOMHOG000111419.
HOVERGENHBG100936.
InParanoidQ96ER9.
OMAMTRTLCS.
OrthoDBEOG7W6WN1.
PhylomeDBQ96ER9.
TreeFamTF318449.

Gene expression databases

ArrayExpressQ96ER9.
BgeeQ96ER9.
CleanExHS_CCDC51.
GenevestigatorQ96ER9.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi79714.
NextBio69051.
PROQ96ER9.

Entry information

Entry nameCCD51_HUMAN
AccessionPrimary (citable) accession number: Q96ER9
Secondary accession number(s): Q9HA01
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: April 16, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM